Abstract: The invention relates to analyte monitoring/drug (pharmaceutical agent) delivery device. The invention is suited for monitoring various blood constituents such as glucose. The device has a housing that at least partially encloses a plurality of microneedles disposed on a carrier and an electronics portion. Each microneedle is in fluid communication with a corresponding microchannel. Each microneedle is individually addressable. That is, each microneedle can be extended and retracted individually via an actuator. The electronics portion includes a processor and associated circuitry (e.g., memory, supporting electronics and the like), a motor or the like, a sensor, a power supply (e.g., battery) and optionally an interface. In general, the processor controls the operation of the device and is data communication with the actuator, motor, sensor and interface. The invention provides for autonomous operation, that is, without intervention of the user.

Abstract: A site marker deployment device includes a housing defining a first portion, an outer cannula at least partially interposed within the first portion and having a proximal end and a distal end defined by an outer cannula aperture, an inner member at least partially interposed within the outer cannula, a first biasing portion, a second biasing portion, wherein the second biasing portion will selectively urge the outer cannula to move proximally relative to the inner member, and a site marker selectively disposed within the outer cannula adjacent the inner member, near the distal end of the outer cannula. The first biasing portion will selectively urge a site marker at least partially within the outer cannula.

Abstract: Various embodiments of an elongate surgical device configured to travel along a tortuous body lumen to a surgical site are provided herein. In one embodiment, the device can include a tensioning element extending through a channel formed along a length of the device and the tensioning element can translate an articulation force to the working end of the device. During such articulation of the device, a portion of the channel can be configured to allow the tensioning element to exit the channel and move away from a longitudinal axis of the device thereby optimizing a mechanical advantage relative to the distal end of the device and thus maximizing the force capable of being delivered thereto. Additionally, various embodiments of a method for articulating a working end of an elongate surgical device are provided herein.

Abstract: A goniometer for use in measuring the range of motion of a patient is provided. The goniometer includes a first arm and a second arm that are pivotally attached. A scale is present and is used in determining the angular orientation between the first arm and the second arm. Also, a level member is included and is carried by one of the first arm and second arm. An associated method is also provided.

Abstract: This invention relates to a method and apparatus for assessing proprioception in a subject. One embodiment of an apparatus of the invention comprises two articulating members attachable to a pair of limbs of a subject, and provides data relating to geometry and/or location and/or motion of each limb in 2- or 3-dimensional space. The apparatus may include means for monitoring gaze direction. The apparatus may comprise a robotic linkage. One embodiment of the method comprises obtaining data relating to the geometry and/or location and/or motion of the limbs, or portions thereof, of a subject as the subject performs a matching task. Another embodiment comprises obtaining data relating to the location of a limb of a subject, together with data relating to gaze direction as the subject looks toward the perceived location of limb.

Abstract: An apparatus for treating tissue within a lumen may include a therapeutic or diagnostic instrument. A cleaning device may also be supported by the instrument. The cleaning device has a portion of a cleaning surface positioned proximal to the distal end of the cleaning device.

Abstract: A method of analyzing a composition of a human body having a plurality of body segments is disclosed. The method can include applying a current signal to a body. The method can further include simultaneously measuring a plurality of voltage signals from a plurality of measuring positions of the body during a predetermined period, and processing at least two of the plurality of voltage signals to determine a composition parameter of a body segment so as to assess or analyze composition of the body.

Abstract: Methods and systems are provided for determining a condition of a selected region of epithelial tissue and/or an organ in a body as well as to diagnose disease, susceptibility, premalignancy or cancer and to measure response to therapy, introduction of a drug and to assess the margins of a tumor or resection. The methods utilize through the tissue or organ electrical measurements with alternating current applied using one or more surface or internal electrodes and measuring the electrical response using one or more surface electrodes, preferably in combination with one or more electrodes in direct or indirect contact with epithelium comprising the organ or tissue under test. The methods are also useful in combination with DC measurements on the surface of the organ or tissue under test. Measurement of impedance, admittance, electropotential and dielectric properties is particularly useful, particularly as a function of frequency and position on and in the tissue or organ.

Abstract: A system and method is provided that allows for determining the local impedance of one or more electrodes of an electrode catheter. Such local impedance may be utilized to identify the relative position of an electrode catheter to a sheath of a guiding introducer. In another arrangement, local impedance of a catheter electrode can be utilized to calibrate a catheter electrode to provide improved contact sensing.

Abstract: In order to provide a lancet which has a simple structure and which can secure safety, in particular, after use, and a lancet device including the same, a lancet (20) includes a casing (22), and a puncture body (23) which is accommodated in the casing (22) so as to be movable in a puncturing direction. For removing the lancet (20) from a main body (30), the lancet (20) has a convex portion (22b) formed on an inner surface (22a) of the casing (22) and a recessed portion (groove (23c)) formed on the puncture body (23), which form fitting for holding the puncture body (23) so as to be immovable in the puncturing direction in the casing (22).

Abstract: Embodiments are directed to micro-scale or meso-scale hydraulically or pneumatically actuated devices, methods for forming such devices using multi-layer, multi-material electrochemical fabrication methods and particularly fabricating (i.e. building up) a plurality of components of devices that are moveable relative to one another in pre-assembled configurations wherein special features are designed into the devices (e.g. wide gaps in fabrication positions and narrowed gaps in working regions of component movement, mechanisms that inhibit the return of device components to fabrication positions after being moved into working regions, used of cylindrical interference and/or checkerboard bushings, etching holes in selected locations to allow removal of sacrificial material) to allow such fabrication to occur without violating intra-layer minimum feature size constraints while still obtaining effective gaps between components that are smaller than the minimum features size limits.

Abstract: The profile of the spinal column and changes in the profile of the spinal column are continuously measured during movement along the entire spinal column in all degrees of freedom of its deformation.

Abstract: A portable computing device or microprocessor/storage system including temperature sensors used to collect temperature readings of a breast tissue of a subject. The device would collect data from the sensors at regular time intervals over a period of time. All of the generated temperature data is stored in the portable computing or storage device. The sensors are placed on the greatest areas of interest on the breast, based on where most cancers develop, by using a sensor placeholder. The sensor placeholder would be lobate shaped, with the sensor placeholder aligning with the glandular regions of the breast where cancers are most likely to develop. The temperature data is then analyzed by one or more classifier systems and classified as either suspect or non-suspect tissue.

Abstract: A portable computing device or microprocessor/storage system including temperature sensors used to collect temperature readings of a breast tissue of a subject. The device would collect data from the sensors at regular time intervals over a period of time. All of the generated temperature data is stored in the portable computing or storage device. The sensors are placed on the greatest areas of interest on the breast, based on where most cancers develop, by using a sensor placeholder. The sensor placeholder would be lobate shaped, with the sensor placeholder aligning with the glandular regions of the breast where cancers are most likely to develop. The temperature data is then analyzed by one or more classifier systems and classified as either suspect or non-suspect tissue.

Abstract: A system for delivering a touch sensitive screen task to a subject includes a touch sensitive display for presenting visual stimuli to a subject and for providing a response of the subject, hand position monitoring unit(s) for receiving input indicative of the position of a hand of the subject and for providing output signals representing said position and a controller/processor unit operatively coupled to the touch sensitive display unit and to the hand position monitoring unit(s) for receiving output signals from the hand position monitoring unit(s) and for processing the output signals to control the displaying of the visual stimuli on the touch sensitive display unit. A method for operating the system includes receiving from the subject signals representing a response of the subject to visual stimuli, receiving signals indicative of the position of the subject's hand and processing the signals to control the presenting of visual stimuli.

Abstract: A system for detecting abnormal eye movement in a subject to indicate possible impairment of the subject. The subject may be presented with a visual pattern to observe. The visual pattern may cause the subject's eyes to move. Images of the eye movements may be captured. An eye motion pattern may be computed from the images. The eye motion pattern may be classified relative to other eye motion patterns or a guide. The classification may indicate whether there appears to be an abnormal movement of the eye and thus an impairment of the subject. An identification of the subject may be obtained according to a biometric from the images and used to retrieve the subject's baseline eye motion pattern. A comparison of the computed eye motion pattern and the baseline eye motion pattern may indicate whether there is abnormal movement of the eye and thus an impairment of the subject.

Abstract: A method for operating a medical probe includes pressing a distal end of the medical probe, which includes one or more arms that extend diagonally outward from a central shaft and have respective position transducers coupled thereto, against an intra-body surface, so as to cause the arms to exert pressure on the surface and bend with respect to the central shaft in response to the pressure. Positions of the respective position transducers coupled to the arms are measured, and the pressure exerted by the arms is estimated responsively to the measured positions.

Abstract: The invention relates to an apparatus for fetal scalp blood sampling, having a shaft, a blade that is mounted removably in the distal end of the shaft and that can be slid by means of a positioning mechanism between a starting position mounted in the shaft and a working position extending beyond the distal end of the shaft, and also having a blood sampling device mounted on the distal end of the shaft. To create an apparatus for fetal scalp blood sampling that is easy to operate and also ensures a high degree of operating safety, it is proposed with the invention that the blade can be fixed by the positioning mechanism in the respective end position.

Abstract: A continuous swallowing movement measuring device includes pressure sensors placed in a line along a direction of an up and down movement of a thyroid cartilage when a food is swallowed, a first one of the pressure sensors placed at a top position of the thyroid cartilage, a second one of the pressure sensors placed along the direction to measure swallows included in a continuous swallowing movement. The device also includes a tool for wearing the pressure sensors and for fixing the pressure sensors to touch an anterior region of a neck of a subject. The tool includes a fixing unit fixes the pressure sensors. The tool also includes a supporter of the pressure sensors supports the fixing unit. Further, the tool includes a holding band holds the supporter of the pressure sensors on the anterior region of the neck of the subject.

Abstract: A system for detecting abnormal tissue in a patient including an introducer cannula having a proximal opening and a distal opening. The system further includes a surgical instrument configured for selective insertion through the cannula. The surgical instrument further includes a tissue cutting opening positioned relative to the distal end of the introducer cannula when fully inserted through the introducer cannula. The system also includes a sensor configured to detect at least one property of the tissue of the patient. The sensor is located at a fixed distance relative to the distal end of the introducer cannula when the surgical instrument is inserted into the introducer cannula.