Abstract: Dentifrices containing flat flakes of alpha-alumina.

Abstract: Novel bis-basic esters and amides of xanthene and xanthone of the formula ##SPC1##Wherein:Z is oxygen or H.sub.2 ; each of R.sup.1 and R.sup.2 is hydrogen, (lower)-alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 ring carbon atoms, alkenyl of 3 to 6 carbon atoms having the vinyl unsaturation in other than the 1-position of the alkenyl group, or each set of R.sup.1 and R.sup.2 taken together with the nitrogen atom to which they are attached is pyrrolidino, piperidino, N-(lower)alkylpiperazino, or morpholino;Each A is alkylene of 2 to about 8 carbon atoms and separates its adjacent Y and amino nitrogen by an alkylene chain of at least 2 carbon atoms; and each Y is oxygen, or >N--R wherein R is hydrogen or (lower)-alkyl of 1 to 4 carbon atoms;Or a pharmaceutically acceptable acid addition salt thereof. These compounds can be used as pharmaceuticals for preventing or inhibiting a viral infection.

Abstract: The novel bis-basic ketones of thioxanthene have antiviral activity when administered orally and parenterally. These compounds are represented by the following formula: ##SPC1##Wherein A is a straight or branched alkylene chain having from 1 to about 6 carbon atoms; and each Y isA. the group ##EQU1## wherein R.sup.1 and R.sup.2 are individually hydrogen or lower alkyl having from 1 to about 4 carbon atoms; orB. the group ##EQU2## WHEREIN N IS A WHOLE INTEGER OF 4 OR 5, AND R.sup.3 is hydrogen or lower alkyl having from 1 to about 4 carbon atoms and can be linked to any one of the carbon atoms of the heterocyclic group; orC. the group ##EQU3## wherein X is oxygen or NR.sup.4, and R.sup.4 is hydrogen or lower alkyl of from 1 to about 4 carbon atoms; or pharmaceutically acceptable acid addition salts of said base.These new compounds can be prepared by several different methods which are described.

Abstract: Novel bis-basic ketones of xanthene and xanthen-9-one have antiviral activity when administered orally and parenterally. The compounds are represented by the following formula: ##SPC1##Wherein Z is oxygen or H.sub.2 ; each A is a straight or branched alkylene chain having from 1 to about 6 carbon atoms; and each Y isA. the group ##EQU1## wherein R.sup.1 and R.sup.2 are individually hydrogen, lower alkyl having from 1 to about 6 carbon atoms, cycloalkyl having from 3 to 6 carbon atoms, alkenyl of from 3 to 6 carbon atoms and having the vinyl unsaturation in other than the 1-position of the alkenyl group; orB. the group ##EQU2## WHEREIN N IS A WHOLE INTEGER FROM 4 TO 6, AND R.sup.3 is hydrogen, lower alkyl of from 1 to about 4 carbon atoms and can be linked to any one of the carbon atoms of the heterocyclic group; orC. the group ##EQU3## wherein X is oxygen or NR.sup.4, and R.sup.4 is hydrogen or lower alkyl of from 1 to about 4 carbon atoms;Or a pharmaceutically acceptable acid addition salt thereof.

Abstract: An essentially non-aqueous oral hygiene product is disclosed comprising an alcohol base, a combination of viscosity adjusters, e.g., polyvinylpyrrolidone and glycerin; a detergent such as sodium lauryl sulfate; a sweetening agent such as saccharin, and a flavor additive. The combination of viscosity adjusters imparts a suitable viscosity and body to the product to enable it to adhere to a toothbrush and be readily dispersible in water to be used as a mouthwash.

Abstract: A dental cream comprising a dental vehicle a small portion of flat flakes of alpha-alumina and a small proportion of iridescent flakes. The vehicle preferably has dispersed therein amorphous silica or aluminosilicate as a dental abrasive.

Abstract: Stable H.sub.3 N.sub.2 influenza virus strains completely resistant to serum inhibitors are obtained by passaging at least one time in the allantoic cavity of embryonated eggs in the presence of serum a recombinant strain previously obtained from an H.sub.3 N.sub.2 influenza strain and the A/PR.sub.8 influenza virus strain and isolating the so-obtained serum inhibitors resistant strains. The obtained strains are useful for vaccine production.

Abstract: The present invention provides a composition which comprises at least one agglutinin which is a site-directed homing agent attached to a biologically active molecule which is effective in modifying the nature of a target site. There is also provided a process for the production of a composition which comprises attaching at least one agglutinin which is a site-directed homing agent to a biologically active molecule which is effective in modifying the nature of a target site.

Abstract: Plasmin compositions containing a concentration of plasmin sufficiently great for therapeutic administration are stabilized by the addition thereto of a physiologically nontoxic amino acid.

Abstract: Cleaning compositions exhibiting effervescence comprise a cleaning agent and a liquefied gas distributed therethrough. The liquefied gas is present in the compositions at pressure and temperature conditions at which it would normally exist only in the gaseous state. As vapors of the liquefied gas separate from the compositions, effervescence occurs.

Abstract: A synergistic acaricidal composition comprises as a first ingredient the .beta.-exotoxin of Bacillus thuringiensis or a metal salt thereof and has a second ingredient of one or more of the following chemical acaricides:1,1-bis-(p-chlorophenyl) ethanol,Bis-(p-chlorophenyl) sulfide,Bis-(p-chlorophenoxy) methane.The first and second ingredients are used generally in a ratio of about 0.5:1 to 10:1 and may be dispersed in a major portion of an agronomically acceptable carrier.

Abstract: A dentifrice containing small proportions of mother of pearl flakes or other iridescent flakes.

Abstract: A process for oxygenating blood which comprises, contacting an emulsion, the exterior phase of which comprises an oxygen saturated fluorinated organic compound surrounding aqueous droplets containing a carbon dioxide absorbent or reactant, with mammalian blood. The oxygen permeates rapidly from the fluorocarbon into the blood, while the CO.sub.2 within the blood permeates through the fluorocarbon into the aqueous interior phase wherein it is absorbed or converted by a reactant to a nonpermeable form. In this manner the blood is oxygenated and CO.sub.2 is simultaneously removed.

Abstract: A mouthwash solution and method for treating both the lower and upper throat. The aqueous solution contains dioctyl sodium sulfosuccinate as the active ingredient. The treatment of the lower throat involves holding a small amount of the solution in the mouth for a short period of time. The treatment for the upper throat area is to hold a small amount of the solution in the mouth, lie down with the head back, swallow several times, and hold the head in position for a short period of time.

Abstract: A cariostatic composition is disclosed which contains an alkali metal amino acid phosphate or an alkaline earth metal amino acid phosphate. The amino acid phosphate serves as a cariostatic agent and may be used for topical application or as a dentifrice.

Abstract: Dentifrice composition containing a monofluorophosphate and polishing agent containing calcium carbonate and insoluble alkali metal metaphosphate, alumina or mixture therof. The ratio of calcium carbonate to insoluble alkali metal metaphosphate and to alumina is about 3:1 to about 1000:1. This dentifrice retains a desirable level of soluble fluoride upon aging and when insoluble alkali metal metaphosphate is present, does not cause substantial corrosion of unlined aluminum containers.

Abstract: This invention relates to a method inhibiting the formation of dental plaque. This invention has identified a number of compounds (e.g. allyl isothiocyanate, uranine, obtusastyrene, citral, citronellol, nerol and geraniol) which are effective as antimicrobial agents against cariogenic streptococci and which when topically applied to the teeth would be effective for use in oral preparations as a means to reduce dental plaque.

Abstract: Anticariogenic oral compositions such as dentifrices and mouthwashes comprising a water-soluble fluoride salt and an indium (III)-malic acid water-soluble complex as a stable and dental enamel reactive source of indium.

Abstract: Preparation of a dentifrice composition containing an insolubilized salt of 1,6-di-(p-chlorophenyl biguanido) hexane antimicrobial agent such as the disarcosinate monomeric salt or monofluorophosphate polymeric salt. The insolubilized salt may be pre-formed or formed in situ in the dentifrice composition. The insolubilized material is antimicrobially effective and provides desirable cosmetic effect.

Abstract: A human epithelial heterploid liver cell line, such as line WRL 68 which forms individually separated islands or discrete clumps when cultured in a growth medium, has a morphology closely resembling that of hepatocytes of the human liver and a generation time not more than 24 hours, manifests increased production of glycogen in the presence of 1% glucose in the medium, and is capable of supporting viruses.Such cells may be advantageously used to provide cell cultures for supporting viruses for the preparation of viral vaccines.