Patents Examined by Richard L. Huff
  • Patent number: 3957989
    Abstract: Novel bis-basic ketones of xanthene and xanthen-9-one have antiviral activity when administered orally and parenterally. The compounds are represented by the following formula: ##SPC1##Wherein Z is oxygen or H.sub.2 ; each A is a straight or branched alkylene chain having from 1 to about 6 carbon atoms; and each Y isA. the group ##EQU1## wherein R.sup.1 and R.sup.2 are individually hydrogen, lower alkyl having from 1 to about 6 carbon atoms, cycloalkyl having from 3 to 6 carbon atoms, alkenyl of from 3 to 6 carbon atoms and having the vinyl unsaturation in other than the 1-position of the alkenyl group; orB. the group ##EQU2## WHEREIN N IS A WHOLE INTEGER FROM 4 TO 6, AND R.sup.3 is hydrogen, lower alkyl of from 1 to about 4 carbon atoms and can be linked to any one of the carbon atoms of the heterocyclic group; orC. the group ##EQU3## wherein X is oxygen or NR.sup.4, and R.sup.4 is hydrogen or lower alkyl of from 1 to about 4 carbon atoms;Or a pharmaceutically acceptable acid addition salt thereof.
    Type: Grant
    Filed: February 20, 1973
    Date of Patent: May 18, 1976
    Assignee: Richardson-Merrell Inc.
    Inventors: Robert W. Fleming, Arthur D. Sill, Francis W. Sweet
  • Patent number: 3957968
    Abstract: Dentifrices containing flat flakes of alpha-alumina.
    Type: Grant
    Filed: March 25, 1975
    Date of Patent: May 18, 1976
    Assignee: Colgate-Palmolive Company
    Inventor: Martin Cordon
  • Patent number: 3957986
    Abstract: Novel bis-basic esters and amides of xanthene and xanthone of the formula ##SPC1##Wherein:Z is oxygen or H.sub.2 ; each of R.sup.1 and R.sup.2 is hydrogen, (lower)-alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 ring carbon atoms, alkenyl of 3 to 6 carbon atoms having the vinyl unsaturation in other than the 1-position of the alkenyl group, or each set of R.sup.1 and R.sup.2 taken together with the nitrogen atom to which they are attached is pyrrolidino, piperidino, N-(lower)alkylpiperazino, or morpholino;Each A is alkylene of 2 to about 8 carbon atoms and separates its adjacent Y and amino nitrogen by an alkylene chain of at least 2 carbon atoms; and each Y is oxygen, or >N--R wherein R is hydrogen or (lower)-alkyl of 1 to 4 carbon atoms;Or a pharmaceutically acceptable acid addition salt thereof. These compounds can be used as pharmaceuticals for preventing or inhibiting a viral infection.
    Type: Grant
    Filed: July 2, 1973
    Date of Patent: May 18, 1976
    Assignee: Richardson-Merrell Inc.
    Inventors: Albert A. Carr, Robert W. Fleming, Arthur D. Sill
  • Patent number: 3957988
    Abstract: The novel bis-basic ketones of thioxanthene have antiviral activity when administered orally and parenterally. These compounds are represented by the following formula: ##SPC1##Wherein A is a straight or branched alkylene chain having from 1 to about 6 carbon atoms; and each Y isA. the group ##EQU1## wherein R.sup.1 and R.sup.2 are individually hydrogen or lower alkyl having from 1 to about 4 carbon atoms; orB. the group ##EQU2## WHEREIN N IS A WHOLE INTEGER OF 4 OR 5, AND R.sup.3 is hydrogen or lower alkyl having from 1 to about 4 carbon atoms and can be linked to any one of the carbon atoms of the heterocyclic group; orC. the group ##EQU3## wherein X is oxygen or NR.sup.4, and R.sup.4 is hydrogen or lower alkyl of from 1 to about 4 carbon atoms; or pharmaceutically acceptable acid addition salts of said base.These new compounds can be prepared by several different methods which are described.
    Type: Grant
    Filed: February 20, 1973
    Date of Patent: May 18, 1976
    Assignee: Richardson-Merrell Inc.
    Inventors: Robert W. Fleming, Arthur D. Sill
  • Patent number: 3954962
    Abstract: An essentially non-aqueous oral hygiene product is disclosed comprising an alcohol base, a combination of viscosity adjusters, e.g., polyvinylpyrrolidone and glycerin; a detergent such as sodium lauryl sulfate; a sweetening agent such as saccharin, and a flavor additive. The combination of viscosity adjusters imparts a suitable viscosity and body to the product to enable it to adhere to a toothbrush and be readily dispersible in water to be used as a mouthwash.
    Type: Grant
    Filed: April 1, 1974
    Date of Patent: May 4, 1976
    Assignees: Alan R. Tripp, Samuel Grubstein, Eugene F. Whelan, E. R. Finnis, Samuel Prussin
    Inventor: Samuel B. Prussin
  • Patent number: 3954961
    Abstract: A dental cream comprising a dental vehicle a small portion of flat flakes of alpha-alumina and a small proportion of iridescent flakes. The vehicle preferably has dispersed therein amorphous silica or aluminosilicate as a dental abrasive.
    Type: Grant
    Filed: April 30, 1973
    Date of Patent: May 4, 1976
    Assignee: Colgate-Palmolive Company
    Inventors: Daniel Colodney, Martin Cordon
  • Patent number: 3953592
    Abstract: Stable H.sub.3 N.sub.2 influenza virus strains completely resistant to serum inhibitors are obtained by passaging at least one time in the allantoic cavity of embryonated eggs in the presence of serum a recombinant strain previously obtained from an H.sub.3 N.sub.2 influenza strain and the A/PR.sub.8 influenza virus strain and isolating the so-obtained serum inhibitors resistant strains. The obtained strains are useful for vaccine production.
    Type: Grant
    Filed: September 27, 1973
    Date of Patent: April 27, 1976
    Assignee: Recherche et Industrie Therapeutiques (R.I.T.)
    Inventor: Julien Peetermans
  • Patent number: 3952092
    Abstract: The present invention provides a composition which comprises at least one agglutinin which is a site-directed homing agent attached to a biologically active molecule which is effective in modifying the nature of a target site. There is also provided a process for the production of a composition which comprises attaching at least one agglutinin which is a site-directed homing agent to a biologically active molecule which is effective in modifying the nature of a target site.
    Type: Grant
    Filed: June 7, 1973
    Date of Patent: April 20, 1976
    Inventors: William Henry Bowen, Sidney Alan Barker
  • Patent number: 3950513
    Abstract: Plasmin compositions containing a concentration of plasmin sufficiently great for therapeutic administration are stabilized by the addition thereto of a physiologically nontoxic amino acid.
    Type: Grant
    Filed: September 19, 1969
    Date of Patent: April 13, 1976
    Assignee: Novo Terapeutisk Laboratorium A/S
    Inventor: Villy Johannes Jensen
  • Patent number: 3947567
    Abstract: Cleaning compositions exhibiting effervescence comprise a cleaning agent and a liquefied gas distributed therethrough. The liquefied gas is present in the compositions at pressure and temperature conditions at which it would normally exist only in the gaseous state. As vapors of the liquefied gas separate from the compositions, effervescence occurs.
    Type: Grant
    Filed: January 4, 1974
    Date of Patent: March 30, 1976
    Assignee: Phoenix Research Inc.
    Inventors: Robert C. Berg, Jr., Norman H. Ishler, Joseph Jellema
  • Patent number: 3944664
    Abstract: A synergistic acaricidal composition comprises as a first ingredient the .beta.-exotoxin of Bacillus thuringiensis or a metal salt thereof and has a second ingredient of one or more of the following chemical acaricides:1,1-bis-(p-chlorophenyl) ethanol,Bis-(p-chlorophenyl) sulfide,Bis-(p-chlorophenoxy) methane.The first and second ingredients are used generally in a ratio of about 0.5:1 to 10:1 and may be dispersed in a major portion of an agronomically acceptable carrier.
    Type: Grant
    Filed: December 13, 1971
    Date of Patent: March 16, 1976
    Assignee: Sandoz, Inc.
    Inventors: Tadaharu Kitagaki, Yoshio Takahashi, Kiyoshi Takita
  • Patent number: 3944661
    Abstract: A dentifrice containing small proportions of mother of pearl flakes or other iridescent flakes.
    Type: Grant
    Filed: August 5, 1974
    Date of Patent: March 16, 1976
    Assignee: Colgate-Palmolive Company
    Inventors: Daniel Colodney, John J. Steinke, Robert Mitchell
  • Patent number: 3942512
    Abstract: A mouthwash solution and method for treating both the lower and upper throat. The aqueous solution contains dioctyl sodium sulfosuccinate as the active ingredient. The treatment of the lower throat involves holding a small amount of the solution in the mouth for a short period of time. The treatment for the upper throat area is to hold a small amount of the solution in the mouth, lie down with the head back, swallow several times, and hold the head in position for a short period of time.
    Type: Grant
    Filed: February 12, 1975
    Date of Patent: March 9, 1976
    Inventor: Edgar R. Hargett
  • Patent number: 3942527
    Abstract: A process for oxygenating blood which comprises, contacting an emulsion, the exterior phase of which comprises an oxygen saturated fluorinated organic compound surrounding aqueous droplets containing a carbon dioxide absorbent or reactant, with mammalian blood. The oxygen permeates rapidly from the fluorocarbon into the blood, while the CO.sub.2 within the blood permeates through the fluorocarbon into the aqueous interior phase wherein it is absorbed or converted by a reactant to a nonpermeable form. In this manner the blood is oxygenated and CO.sub.2 is simultaneously removed.
    Type: Grant
    Filed: January 15, 1974
    Date of Patent: March 9, 1976
    Assignee: Exxon Research & Engineering Co.
    Inventor: Norman N. Li
  • Patent number: 3943241
    Abstract: A cariostatic composition is disclosed which contains an alkali metal amino acid phosphate or an alkaline earth metal amino acid phosphate. The amino acid phosphate serves as a cariostatic agent and may be used for topical application or as a dentifrice.
    Type: Grant
    Filed: August 30, 1971
    Date of Patent: March 9, 1976
    Assignee: General Mills, Inc.
    Inventors: Ray H. Anderson, Albert L. Saari
  • Patent number: 3941877
    Abstract: Dentifrice composition containing a monofluorophosphate and polishing agent containing calcium carbonate and insoluble alkali metal metaphosphate, alumina or mixture therof. The ratio of calcium carbonate to insoluble alkali metal metaphosphate and to alumina is about 3:1 to about 1000:1. This dentifrice retains a desirable level of soluble fluoride upon aging and when insoluble alkali metal metaphosphate is present, does not cause substantial corrosion of unlined aluminum containers.
    Type: Grant
    Filed: May 20, 1974
    Date of Patent: March 2, 1976
    Assignee: Colgate-Palmolive Company
    Inventors: William James King, Leo Thomas Murray, Gerhard Martin Salzman
  • Patent number: 3940476
    Abstract: This invention relates to a method inhibiting the formation of dental plaque. This invention has identified a number of compounds (e.g. allyl isothiocyanate, uranine, obtusastyrene, citral, citronellol, nerol and geraniol) which are effective as antimicrobial agents against cariogenic streptococci and which when topically applied to the teeth would be effective for use in oral preparations as a means to reduce dental plaque.
    Type: Grant
    Filed: September 24, 1973
    Date of Patent: February 24, 1976
    Assignee: General Foods Corporation
    Inventor: Gerhard J. Haas
  • Patent number: 3937806
    Abstract: Anticariogenic oral compositions such as dentifrices and mouthwashes comprising a water-soluble fluoride salt and an indium (III)-malic acid water-soluble complex as a stable and dental enamel reactive source of indium.
    Type: Grant
    Filed: May 7, 1974
    Date of Patent: February 10, 1976
    Assignee: The Procter & Gamble Company
    Inventor: William Edward Cooley
  • Patent number: 3937805
    Abstract: Preparation of a dentifrice composition containing an insolubilized salt of 1,6-di-(p-chlorophenyl biguanido) hexane antimicrobial agent such as the disarcosinate monomeric salt or monofluorophosphate polymeric salt. The insolubilized salt may be pre-formed or formed in situ in the dentifrice composition. The insolubilized material is antimicrobially effective and provides desirable cosmetic effect.
    Type: Grant
    Filed: December 13, 1973
    Date of Patent: February 10, 1976
    Assignee: Colgate-Palmolive Company
    Inventor: Michael Harrison
  • Patent number: 3935307
    Abstract: A liquid or pasty dentifrice comprising, uniformly incorporated therein, a polysaccharide as a thickening and suspending agent, said polysaccharide having a number average molecular weight (Mn) of not less than 100,000 and the molecule of said polysaccharide containing D-glucose, D-mannose, D-galactose and succinic acid in the approximate molar ratio of 1 : 0.03 : 0.1 : 0.2. The polysaccharide is obtained by cultivating Alcaligenes faecalis var. myxogenes in a culture medium containing at least one member selected from the group consisting of lactic acid, pyruvic acid, succinic acid, fumaric acid, malic acid and esters thereof and saccharide.
    Type: Grant
    Filed: May 30, 1974
    Date of Patent: January 27, 1976
    Assignees: Teijin Limited, Sunstor Dentrificy Co. Ltd.
    Inventors: Kenji Aimoto, Shigeru Hashimoto, Toyoaki Yoneda