Patents Examined by Richard L. Raymond
  • Patent number: 5726308
    Abstract: A process for preparing high purity solutions of highly substituted lithium amide bases by direct reaction of lithium metal with highly substituted amine bases alone or in an ether solvent, a hydrocarbon solvent or in a mixed ether/hydrocarbon solvent mixture, optionally in the presence of a catalyst selected from tin salts and transition metal salts of Groups 4B, 5B, 6B, 7B, and 8 of the Periodic Table.
    Type: Grant
    Filed: March 22, 1996
    Date of Patent: March 10, 1998
    Assignee: FMC Corporation
    Inventors: Randy W. Hall, Robert S. Wedinger, Terry L. Rathman, James A. Schwindeman
  • Patent number: 5723066
    Abstract: An electrooptical system is disclosed in which a PDLC film is positioned between 2 electrode layers. The PDLC film contains a liquid crystal mixture forming microdroplets in an optically isotropic, transparent polymer matrix. The liquid crystal mixture comprises one or more compounds of formula I ##STR1## wherein R, A.sup.1, A.sup.2, Z.sup.1, Z.sup.2, X.sup.1, X.sup.2, Q, Y and n are as herein defined, and one or more reactive liquid crystalline compounds. The PDLC film exhibits improved switching times, especially at low temperatures.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 3, 1998
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: David Coates, Owain Llyr Parri, Simon Greenfield, Martin David Tillin, Mark John Goulding, Patrick Nolan
  • Patent number: 5723489
    Abstract: Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof wherein: R.sup.1 to R.sup.9 are as defined herein and m is the integer 0 or 1.These compounds are beta 3 adrenergic receptor agonists and are useful, therefore for example, in the treatment of diabetes, obesity, gastrointestinal diseases and achalasia.
    Type: Grant
    Filed: May 7, 1996
    Date of Patent: March 3, 1998
    Assignee: Bristol-Myers Squibb Company
    Inventors: Philip M. Sher, William N. Washburn, Kathleen M. Poss
  • Patent number: 5721237
    Abstract: This invention relates to a method for the selective treatment of cell growth and differentiation characterized by activity of the human epidermal growth factor receptor type 2 (HER2). More specifically, this invention relates to the use of substituted or unsubstituted mono- or bi-cyclic aryl, heteroaryl, cycloalkyl or heterocycloalkyl compounds in selectively regulating cell growth. Pharmaceutical compositions useful for the selective treatment of cell growth and differentiation are also described.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 24, 1998
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: Michael R. Myers, Alfred P. Spada, Martin P. Maguire, Paul E. Persons
  • Patent number: 5719150
    Abstract: This invention relates to a 1,2-ethanediol derivative and a salt thereof, a process for producing the same, and a cerebral function-improving agent comprising the same. The cerebral function-improving agent of this invention is useful for treating cerebrovascular dementia, senile dementia, Alzheimer's dementia, sequelae of ischemic encephalopathy and cerebral apoplexy.
    Type: Grant
    Filed: November 14, 1996
    Date of Patent: February 17, 1998
    Assignee: Toyama Chemical Co., Ltd.
    Inventors: Satoshi Ono, Tetsuo Yamafuji, Hisaaki Chaki, Mutsuko Maekawa, Yozo Todo, Hirokazu Narita
  • Patent number: 5719316
    Abstract: The subject-matter of the invention is a process for the preparation of cyclododecanone oxime by photonitrosation of cyclododecane in the presence of hydrochloric acid, characterized in that the nitrosing agent is trichloronitrosomethane.
    Type: Grant
    Filed: March 24, 1997
    Date of Patent: February 17, 1998
    Assignee: Elf Atochem S.A.
    Inventor: Jean Ollivier
  • Patent number: 5719294
    Abstract: The preparation of N-cyclohexylthiophthalimide from cyclohexylsulphenyl chloride and phthalimide can be reproduced more reliably if the cyclohexylsulphenyl chloride is prepared in sire by chlorinating dicyclohexyl disulphide.
    Type: Grant
    Filed: November 13, 1996
    Date of Patent: February 17, 1998
    Assignee: Bayer AG
    Inventors: Adolf Sicheneder, Wilfried Nolte, Harro Schlesmann, Thomas Kleiner
  • Patent number: 5716959
    Abstract: A substituted piperazine zwitterion composition containing, for example, as an active ingredient, HEPES (N-2 Hydroxyethylpiperazine-N'-2 Ethane Sulfonic Acid), and method useful for treatment of cancer, autoimmune, arthritis and other mammalian diseases.
    Type: Grant
    Filed: February 13, 1996
    Date of Patent: February 10, 1998
    Assignee: T. Ronald Theodore
    Inventors: T. Ronald Theodore, Roscoe L. Van Zandt
  • Patent number: 5714617
    Abstract: A method for producing 3-amino-5-mercapto-1,2,4-triazole, useful as an intermediate compound for a medicine or pesticide, or the intermediate thereof, a salt of N-guanidino thiourea from aminoguanidine thiocyanate or a thiocyanate and an aminoguanidine compound in the presence of an acid in a polar solvent, or even from hydrazine and cyanamide is disclosed.
    Type: Grant
    Filed: March 1, 1996
    Date of Patent: February 3, 1998
    Assignee: Nippon Carbide Kogyo Kabushiki Kaisha
    Inventors: Takehiko Yoshie, Masanori Sasaki, Hiroshi Shibafuchi, Yasushi Imai, Masahiro Murotani, Kenichi Ishii, Hajime Mura
  • Patent number: 5714614
    Abstract: The present invention provides a pyridine derivative represented by the following formula A or B, a dye produced by coupling the pyridine derivative A or B with an arbitray coupler and a thermal transfer sheet wherein use is made of the dye. In a thermal transfer process wherein use is made of a sublimable dye, the dye and the thermal transfer sheet according to the present invention can form a clear image having a sufficient density and an excellent light fastness.
    Type: Grant
    Filed: September 10, 1996
    Date of Patent: February 3, 1998
    Assignee: Dai Nippon Printing Co., Ltd.
    Inventors: Ryohei Takiguchi, Koumei Kafuku, Hiroshi Eguchi
  • Patent number: 5712312
    Abstract: The invention relates to a compound selected from these of formula (I): ##STR1## in which R.sub.7, R.sub.8, Y, n and A are as defined in the description, and medicinal product containing the same useful for treating a disorder of the melatoninergic system.
    Type: Grant
    Filed: April 12, 1996
    Date of Patent: January 27, 1998
    Assignee: Adir et Compagnie
    Inventors: Michel Langlois, Monique Mathe-Allainmat, Philippe Delagrange, Pierre Renard, Beatrice Guardiola
  • Patent number: 5712226
    Abstract: Opticalls active enantiomers of the formula I ##STR1## where R is a group of the formulae ##STR2## R.sub.1 and R.sub.2, among others, are halogen or CF.sub.3 and Z is a carboxyl, carboxylate, carboxylic acid ester, thioester, carbonamide, carboxylic acid anilide, carbohydrazide or thioamide group, are interesting herbicides the effect of which is considerably superior to that of the optically inactive racemates.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 27, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Hans Jurgen Nestler, Gerhard Horlein, Reinhard Handte, Hermann Bieringer, Friedhelm Schwerdtle, Peter Langeluddeke, Peter Frisch
  • Patent number: 5710334
    Abstract: This invention relates to a novel thermoplastic and amorphous polyimide which is readily soluble in organic solvent, a novel aromatic diamino compound used for the polyimide, a preparation process thereof, a polyimide-based resin composition comprising the thermoplastic polyimide and a fibrous reinforcement, a process for preparing the resin composition, an injection molded article of the resin composition, a polyimide-based composite obtained by molding the above soluble and thermoplastic polyimide in combination with a fibrous reinforcement, and a fibrous reinforcement having a surface modified with the above polyimide.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: January 20, 1998
    Assignee: Mitsui Toatsu Chemicals, Inc.
    Inventors: Yuko Ishihara, Mitsunori Matsuo, Keizaburo Yamaguchi, Akihiro Yamaguchi
  • Patent number: 5710099
    Abstract: Novel bioactive compounds which when applied to plants in bioregulatory amounts, enhance plant development responses, resulting in enhanced plant properties such as increased total biomass, increased yield, and increased plant quality. Some of the compounds increase the content of taxol and related taxanes in yew plants. One compound, 2-?diethylaminoethyl!-2-methylpropylether causes plants treated with the compound to have resistance to chewing insects. The compound 2-?diethylaminoethyl!-2-methyl-2-phenylpropylether causes plants treated with the compound to have resistance to sucking insects.
    Type: Grant
    Filed: February 27, 1996
    Date of Patent: January 20, 1998
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Henry Yokoyama, Harold W. Gausman
  • Patent number: 5707747
    Abstract: The present invention provides novel amine compounds useful as electron-transporting materials to be incorporated in organic electro-luminescence devices. More particularly, the present invention provides an organic electro-luminescence device (organic EL device) which can find wide application in various display units, requires a low applied voltage and exhibits a high luminance and an excellent stability.
    Type: Grant
    Filed: October 25, 1996
    Date of Patent: January 13, 1998
    Assignees: Hodogaya Chemical Co., Ltd., Matsushita Electric Industrial Co., Ltd.
    Inventors: Hiromitsu Tomiyama, Masahiko Oshino, Ikuko Ihara, Naoko Nakanishi, Mutsumi Suzuki, Masao Fukuyama, Mutsuaki Murakami, Taro Nambu
  • Patent number: 5708024
    Abstract: A salt of 2-?(2,6-dichlorophenyl)amine!phenylacetoxyacetic acid with an organic basic cation of formula (I); Wherein R.sub.1 and R.sub.2 independently are lower alkyl, or if R.sub.1 is hydrogen H--N(R.sub.1)(R.sub.2) has the meaning of arginine or lysine or if R.sub.1 is methyl H--N(R.sub.1)(R.sub.2) has the meaning of N-methylglucamine. This compound pocesses analgesic activity as well as antiinflammatory activity, suitable in the treatment of conditions such as rheumatoid arthritis, ankylosing spondylitis, lumbar pains, luxations and ocular inflammation. The compound further has an improved stability in aqueous solutions in comparison to the alkali metal salts, e.g. sodium and potassium.
    Type: Grant
    Filed: December 17, 1996
    Date of Patent: January 13, 1998
    Assignee: Novartis Corporation
    Inventor: Alfred Sallmann
  • Patent number: 5705602
    Abstract: A star-like or comb-like branched aliphatic polyamino compound for use as a basic catalyst or a curing agent, as an effective thixotropic agent or viscosity adjusting agent for an aqueous medium, as a component for any one of a coating-forming agent, a sealing agent, a molding material and an adhesive resin, or as a substantially solvent-free coating composition, molding material or adhesive resin. The process for the production of the above compound comprises (a) forming an adduct of ammonia or an aliphatic amino compound having an amino group (compound A) with methyl acrylate, adding an alkylenediamine having 2 to 12 carbon atoms to the adduct to carry out an ester-amide exchange reaction (b), thereby obtaining a polyamino compound (B) having a total of 2 to 100 aliphatic primary amino and secondary amino groups per molecule and having a number average molecular weight of 170 to 10,000, and forming an adduct of the polyamino compound (B) with an acrylic acid ester (C) of the formula (1),CH.sub.2 =CHCOO--R.
    Type: Grant
    Filed: February 19, 1997
    Date of Patent: January 6, 1998
    Assignee: Toyo Ink Manufacturing Co., Ltd.
    Inventors: Miki Kawashima, Takeo Yamaguchi, Toru Kurihashi, Norifumi Watanabe
  • Patent number: 5705619
    Abstract: A complex of the formula?L.sub.a Ln.sub.b X.sub.c !.sup.n (A).sub.nwherein Ln is an ion in the oxidation state of 2, 3 or 4 of the lanthanide elements having the atomic numbers 21, 39 and from 57 to 71 in the Periodic Table of the Elements, with the exception of europium and promethium, as central atom, X.sup.(S) are monodentate or multidentate, charged or uncharged ligands bound to the central atom and L is a monocarbene or dicarbene ligand likewise bound to the central atom and which are derived from imidazole and/or pyrazole, A is a singly charged anion or the chemical equivalent of a multiple charged anion, b is an integer from 1 to 4, a is an integer from 1 to 4 . b and c is zero or an integer from 1 to 4.b and n is zero or an integer from 1 to 3.b having catalytic activity.
    Type: Grant
    Filed: December 29, 1995
    Date of Patent: January 6, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventor: Wolfgang A. Herrmann
  • Patent number: 5705672
    Abstract: Tertiary amines having carbonate and urethane groups and optionally hydroxyl groups are produced by reacting a) a polyhydric alcohol and b) a primary-tertiary diamine with c) a carbonic acid derivative selected from the group consisting of optionally cyclic carbonates, urea, phosgene and bis-chlorocarbonates of alcohols of the same type as those used as component a). This reaction may be carried out in one or two steps. The tertiary amines produced by this process are useful as catalysts, which may optionally be incorporated into an isocyanate-reactive material, in the isocyanate addition reaction for the production of polyurethane plastics. These tertiary amines are particularly useful for the production of foam backed plastic films.
    Type: Grant
    Filed: August 3, 1995
    Date of Patent: January 6, 1998
    Assignee: Bayer Aktiengesellschaft
    Inventors: Klaus Konig, Ulrich Liman, Josef Sanders
  • Patent number: 5705698
    Abstract: A process is provided for the preparation of isometrically pure pendimethalin and iso-pendimethalin as well as mixtures thereof.
    Type: Grant
    Filed: March 25, 1996
    Date of Patent: January 6, 1998
    Assignee: SRM Chemical, Ltd. Co.
    Inventors: Lowell J. Lawrence, Stefan Kwiatkowski, Krzysztof Pupek, Miroslaw J. Golinski