Patents Examined by Richard Sharpe
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Patent number: 4952234Abstract: A new compound, named Substance No. 51262, may be produced by cultivating a suitable microorganism of the genus Streptomyces, especially the new strain SANK 63584 (FERM BP-958). Said compound has herbicidal and growth retardant properties.Type: GrantFiled: July 29, 1988Date of Patent: August 28, 1990Assignee: Sankyo Company LimitedInventors: Tatsuo Haneishi, Mutsuo Nakajima, Akio Torikata, Takao Okazaki, Manbu Tohjigamori, Katsuhiko Kawakubo
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Patent number: 4948798Abstract: Novel substituted pyridylmethyl-cyanoiminoimidazolidines and pyridylmethyl-cyanoiminotetrahydropyrimidines of the formula ##STR1## in which R.sub.3 is hydrogen or C.sub.1 -C.sub.4 alkyl; A is a --(CH.sub.2).sub.2 -- or --(CH.sub.2).sub.3 -- radical; X is halogen; and n is an integer 0, 1, 2 or 3; and the salts of compounds of formula I. Also described is a process for the preparation of these compounds, the corresponding starting materials and intermediates, and the use of the novel compounds in pest control, especially for controlling insects and representatives of the order Ararina, particularly insect pests in rice crops.Type: GrantFiled: August 21, 1989Date of Patent: August 14, 1990Assignee: Ciba-Geigy CorporationInventor: Laurenz Gsell
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Patent number: 4944790Abstract: 1,5-diphenylpyrazole-3-carboxylic acid derivatives of the formula ##STR1## in which each of R.sub.a and R.sub.b, independently of the other represents halogen, C.sub.1 -C.sub.5 -alkyl, C.sub.1 -C.sub.5 -haloalkyl, C.sub.2 -C.sub.5 -alkenyl, C.sub.2 -C.sub.5 -alkynyl or cyano, n represents zero or an integer from 1 to 3, and OR.sub.1 represents hydroxy, a plant-physiologically tolerable salt radical or any desired ester radical, are capable of antagonizing specifically the phytotoxic action of phenoxypropionic acid ester herbicides of the formula II ##STR2## in which G represents ##STR3## in which Hal.sub.1 represents fluorine, chlorine, bromine, iodine or trifluoromethyl, Hal.sub.2 represents hydrogen, fluorine, chlorine, bromine or trifluoromethyl, Z represents nitrogen or methine (--CH.dbd.), X represents an oxygen or sulphur atom, R.sub.1 ' represents halogen, trifluoromethyl, nitro, cyano, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.Type: GrantFiled: March 20, 1989Date of Patent: July 31, 1990Assignee: Ciba-Geigy CorporationInventors: Hans Moser, Beat Bohner, Werner Fory
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Patent number: 4940800Abstract: The compounds of formula ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, and R.sub.4 have the meanings given in the specification, are described.The compounds of formula I are active as inhibitors of the enzyme HMG-CoA reductase and can be used in therapy as anti-hypercholesterolemics.Type: GrantFiled: July 27, 1989Date of Patent: July 10, 1990Assignee: Zambon Group S.p.A.Inventors: Giorgio Bertolini, Cesare Casagrande, Francesco Santangelo
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Patent number: 4940742Abstract: Benzimidazolecarboxanilides of the formula (I) ##STR1## where R.sup.1 and R.sup.2 independently of one another are each hydrogen, chlorine, bromine, alkyl, alkoxy, unsubstituted or alkyl-substituted or alkoxy-substituted phenyl or phenylalkyl, R.sup.3 and R.sup.4 independently of one another are each hydrogen, alkyl, alkyl which is interrupted by one or more oxygen atoms, alkoxy, alkoxy which is interrupted by one or more oxygen atoms, unsubstituted or alkyl-substituted or alkoxy-substituted phenyl, phenylalkoxy, alkanoylamino, benzoylamino, alkanoyloxy or benzoyloxy, n is 0, 1, 2, 3, 4 or 5, X is oxygen, ##STR2## R.sup.5 is hydrogen, alkyl, phenylalkyl, cyanomethyl, aminoethyl, hydroxyethyl, alkylcarbonyl or benzoyl, R.sup.6 is hydrogen, alkyl, phenylalkyl or phennyl and m is from 2 to 8, and the acid addition salts and hydrates of these compounds are stabilizers for organic material, in particular for plastics, such as polyethylene, polypropylene and polyamide.Type: GrantFiled: August 11, 1989Date of Patent: July 10, 1990Assignee: BASF AktiengesellschaftInventors: Alexander Aumueller, Peter Spang, Peter Neumann, Hubert Trauth
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Patent number: 4937258Abstract: This invention relates to novel pyrrolo[1,2-c]imidazolones and their pharmaceutically acceptable salts. The compounds of the invention are PDE inhibitors with primarily cardiovascular effects especially cardiotonic effects.Type: GrantFiled: September 12, 1989Date of Patent: June 26, 1990Assignee: Berlex Laboratories, Inc.Inventor: Kenneth J. Shaw
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Patent number: 4933350Abstract: Pyrrolo[2,1-a]isoquinoline derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2 each represent cycloalkyl or alkyl, alkenyl or alkynyl which may be halogen-substituted, or optionally substituted aryl or heteroaryl, X represents ethylene or vinylene, R.sup.3 represents a group of the formula:--Y--CH.sub.2 --CH(OH)--CH.sub.2 --COOR.sup.5 IIwherein Y represents carbonyl or hydroxymethylene and R.sup.5 represents hydrogen or optionally substituted alkyl, or R.sup.3 represents a lactone ring, and the symbols R.sup.4 represent hydrogen, halogen, optionally substituted alkyl, alkenyl or alkynyl, optionally substituted aryl or heteroaryl, or a group of the formula R.sup.6 O--, wherein R.sup.6 represents alkyl, aryl or arylalkyl and pharmaceutical properties.Type: GrantFiled: August 9, 1988Date of Patent: June 12, 1990Assignee: May & Baker LimitedInventors: Michael J. Ashton, Donald I. Dron, Garry Fenton, David J. Lythgoe, Christopher G. Newton, David Riddell
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Patent number: 4933455Abstract: The invention relates to nitrogen-containing bidentate compound immobilized on a solid carrier having the formula ##STR1## wherein the symbols have specified meanings intermediate thereto and to processes for the preparation.Type: GrantFiled: March 27, 1989Date of Patent: June 12, 1990Assignee: Shell Oil CompanyInventor: Johan Stapersma
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Patent number: 4929618Abstract: Disclosed is a compound represented by Formula (I): ##STR1## wherein Ar.sup.1, Ar.sup.2, n, A, B and Z are as defined in claims. Disclosed are also a process for preparing the compound and pharmaceutical compositions containing the compound.The compound has an antihistamic and antiallergic effect.Type: GrantFiled: March 16, 1989Date of Patent: May 29, 1990Assignee: Ube Industries, Ltd.Inventors: Akihide Koda, Jun'ichiro Kita, Yoshiaki Kuroki, Hiroshi Fujiwara, Shinji Takamura, Kayoko Yamano
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Patent number: 4929726Abstract: A method of preparation of substituted halogenodiazines which are useful as intermediates in the synthesis of novel unfused heterobicyclic compounds, and the products thereof.The reaction consists of the addition of an organolithium reagent with subsequent dehydrogenation of the addition product. The reaction takes place in one reaction vessel, without isolation of the substituted halogenodihydrodiazine intermediate. The reactions proceed at moderate temperature and in a short amount of time, which decreases the probability of side reactions and increases yield. Furthermore, the workup step is conducted under two-phase conditions to prevent hydrolysis of the substituted halogenodiazine to a substituted hydroxydiazine. The method is easy, efficient and results in a high yield of product.Type: GrantFiled: February 9, 1988Date of Patent: May 29, 1990Assignee: Georgia State University Foundation, Inc.Inventors: Lucjan Strekowski, Maria Mokrosz, Donald B. Harden
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Patent number: 4927826Abstract: The invention relates to compounds of the formula ##STR1## Y is O or S, *A is paraphenylene or *--(CH.sub.2).sub.n --(X).sub.m --(CH.sub.2).sub.r --, X is O, S or --CH.dbd.CH--, n or r, independently, are integers from 0 to 3, s is an integer from 0 to 1, m is an integer from 0 to 1, provided that when m is 1, n+s must be at least 2, R.sub.1 and R.sub.2, independently, are hydrogen, lower alkyl, cycloalkyl, lower alkenyl. Het or aryl, *E is ##STR2## or --(CH.sub.2).sub.k -- wherein k is an integer fro 0 to 4. R.sub.3, R.sub.4 and R.sub.8 are independently hydrogen or lower alkyl, R.sub.5 and R.sub.6, independently are hydrogen or lower alkyl, R.sub.Type: GrantFiled: August 30, 1988Date of Patent: May 22, 1990Assignee: Hoffman-La Roche Inc.Inventors: Robert W. Guthrie, Richard W. Kierstead, Jefferson W. Tilley
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Patent number: 4923504Abstract: There are provided novel 2-(2-imidazolin-2-yl)pyridine and quinoline compounds, a process and intermediate compounds for the preparation thereof, and a method for controlling a wide variety of annual and perennial plant species therewith.Type: GrantFiled: December 9, 1988Date of Patent: May 8, 1990Assignee: American Cyanamid CompanyInventor: Marinus Los
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Patent number: 4924010Abstract: Certain specific substituted 9-N-(1-azabicycolo-[2.2.2.]octan-3-yl)carboxamido-2,3,4,5-tetrahydro-1-ben zoxepins and their valuable use as 5-HT.sub.3 antagonists having CNS and gastric prokinetic activity and void of any significant D.sub.2 receptor binding properties are disclosed. Methods for their preparation also are described.Type: GrantFiled: July 31, 1989Date of Patent: May 8, 1990Assignee: Rorer Pharmaceutical CorporationInventors: Raymond Youssefyeh, Scott I. Klein, Henry F. Campbell, Donald E. Kuhla
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Patent number: 4920231Abstract: A process for the preparation of trifluoromethylvinyl compounds in all their possible streoisomeric forms and mixtures thereof comprising reacting a salt of trifluoroacetic acid with a halovinyl compound in the presence of a cuprous salt to obtain the same stereo-specific compound and all possible stereo-isomeric forms and mixtures thereof of 1R, trans compounds of the formula ##STR1## wherein R is an alcohol residue used in pyrethrinoid series, or an alcohol residue capable of blocking the acid function, and Z is aryl or haloaryl and the double bond has Z geometry having pesticide activity.Type: GrantFiled: March 30, 1989Date of Patent: April 24, 1990Assignee: Roussel UclafInventors: Werner Bonin, Jean-Pierre Demoute, Jean Tessier
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Patent number: 4918202Abstract: The present invention provides new compound, 10-substituted-5,9-dioxatricyclo[6.4.0.0.sup.2,6 ]dodecane-4-one, which is very useful as an intermediate for prostaglandin synthesis.Type: GrantFiled: July 28, 1989Date of Patent: April 17, 1990Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo KenkyujoInventors: Ryuzo Ueno, Ryuji Ueno, Tomio Oda
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Patent number: 4916129Abstract: Imidazole compounds such as ##STR1## which have angiotensin II antagonizing properties as well as .beta.-adrenoceptor antagonizing properties are useful as antihypertensives and for treatment of congestive heart failure.Type: GrantFiled: January 19, 1989Date of Patent: April 10, 1990Assignee: E. I. Du Pont de Nemours and CompanyInventors: David J. Carini, John J. V. Duncia
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Patent number: 4910314Abstract: There is provided a fluorescent adduct which is amenable to detection by fluorometric and electrochemical techniques. The adduct is of the formula: ##STR1## wherein X is a radical derived from a primary amine of the formula X--NH.sub.2 and where R.sub.1 --R.sub.6 are selected from various organic or inorganic substituents.Type: GrantFiled: January 26, 1989Date of Patent: March 20, 1990Assignee: Oread Laboratories, Inc.Inventors: Pierre M. R. de Montigny, Larry A. Sternson, Arnold J. Repta, John F. Stabaugh, Takeru Higuchi, deceased, by Martin B. Dickinson, Jr., co-executor, by Kenji W. Higuchi, co-executor
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Patent number: 4909832Abstract: 5-Dichloracetamido-4-nitro-1-aryl-pyrazoles of the formula ##STR1## in which R.sup.1 represents hydrogen, fluorine, chlorine or bromine,R.sup.2 represents hydrogen, fluorine or chlorine,R.sup.3 represents halogen, halogenoalkyl, halogenoalkoxy, halogenoalkythio or halogenoalkylsulphonyl,R.sup.4 represents hydrogen, fluorine, or chlorine, andR.sup.5 represents fluorine, chlorine or bromine, but in the case in which R.sup.1 and R.sup.5 simultaneously represent chlorine and in addition R.sup.2 and R.sup.4 simultaneously represent hydrogen, R.sup.3 does not represent chlorine or trifluoromethyl,exhibit herbicidal and plant growth-regulating properties. Novel intermediates therefor are also shown.Type: GrantFiled: April 2, 1988Date of Patent: March 20, 1990Assignee: Bayer AktiengesellschaftInventors: Reinhold Gehring, Otto Schallner, Jorg Stetter, Albercht Marhold, Hans-Joachim Santel, Robert R. Schmidt, Klaus Lurssen
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Patent number: 4908368Abstract: Novel heterocyclic compounds shown by the general formula ##STR1## or the pharmaceutically acceptable salts thereof useful as medicament in particular as antagonist of slow reacting substance of anaphylaxis(SRS-A).Type: GrantFiled: June 7, 1989Date of Patent: March 13, 1990Inventors: Kiyoshi Murase, Toshiyasu Mase, Hiromu Hara, Kenichi Tomioka
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Patent number: 4908371Abstract: 3-Substituted 4(1H)-pyridone compounds of formula ##STR1## wherein R.sub.1 is an unsubstituted or substituted hydrocarbon radical, X is a bond or a group of formula --O-- or --N(R.sub.3)--, wherein R.sub.3 is hydrogen or an unsubstituted or substituted hydrocarbon radical, and R.sub.2 is an unsubstituted or substituted hydrocarbon radical, or wherein R.sub.2 and R.sub.3, when taken together, are an unsubstituted or substituted divalent hydrocarbon radical, and wherein the other ring carbon atoms of the 4(1H)-pyridinone ring, independently of one another, are unsubstituted or substituted by an unsubstituted or substituted hydrocarbon radical or by etherified or esterified hydroxy, and salts of compounds of formula I with salt-forming properties, form chelate-type metal complexes, especially with trivalent metal ions, and can be used, for example, as pharmacologically active compounds.Type: GrantFiled: November 1, 1988Date of Patent: March 13, 1990Assignee: Ciba-Geigy CorporationInventors: Theophile Moerker, Heinrich Peter