Patents Examined by Robert A. Wax
  • Stable liquid pharmaceutical preparation
    Patent number: 11730698
    Abstract: A stable liquid pharmaceutical formulation according to the present invention includes an antibody or antigen-binding fragment thereof, a surfactant, a sugar or a sugar derivative, a buffer, and a stabilizer. The stable liquid pharmaceutical formulation according to the present invention has low viscosity not only when antibody content is low but also when antibody content is high, and exhibits superior long-term storage stability based on superior stability observed under accelerated conditions and harsh conditions.
    Type: Grant
    Filed: July 18, 2019
    Date of Patent: August 22, 2023
    Assignee: CELLTRION INC.
    Inventors: So Young Kim, Yeon Kyeong Shin, Hye Young Kang, Kwang Woo Kim, Jun Seok Oh, Su Jung Kim, Joon Won Lee, Won Yong Han, Jae Bin Lee, Ji Won Roh, Ji Min Kwak
  • Antimicrobial-antibiofilm compositions and methods of use thereof for personal care products
    Patent number: 11723852
    Abstract: Compositions comprising one or more chelating agents and optionally zinc ion salts are used to inhibit the growth or biofilm formation in bacteria associated with personal care products such as ophthalmic, pedicure, manicure or podiatric solutions. The compositions of the present application can also comprise gelling agents, antimicrobials, antibiotic or a pH adjuster. The compositions may be in the form of a solution, a gel, a cream, a jelly, a powder, a paste, a lotion, soap and a cleaner.
    Type: Grant
    Filed: August 3, 2021
    Date of Patent: August 15, 2023
    Assignee: KANE BIOTECH INC.
    Inventors: Purushottam V. Gawande, Karen Lovetri, Nandadeva Yakandawala, Gord Froehlich, Srinivasa Madhyastha
  • Pharmaceutical solution of amlodipine
    Patent number: 11723866
    Abstract: Disclosed herein is a liquid pharmaceutical formulation substantially free of water, comprising: (i) amlodipine or a pharmaceutically acceptable salt thereof, (ii) at least one pharmaceutically acceptable excipient, and (iii) a sufficient amount of a vehicle comprising glycerin. Also disclosed herein is a liquid pharmaceutical formulation substantially free of water and ethanol, comprising: (i) amlodipine or a pharmaceutically acceptable salt thereof, (ii) at least one pharmaceutically acceptable excipient, and (iii) a sufficient amount of a vehicle comprising glycerin.
    Type: Grant
    Filed: June 15, 2022
    Date of Patent: August 15, 2023
    Assignee: LIQMEDS WORLDWIDE LIMITED
    Inventors: Jayanta Kumar Mandal, Malay Patel, Swati Nagar, Michael Paul DeHart
  • Poly(meth)acrylic acid popcorn polymerizates as disintegrants for tablets
    Patent number: 11723871
    Abstract: The use of powder-form, crosslinked, water-insoluble, low-swelling polyacrylates as disintegrants for solid pharmaceutical dosage forms.
    Type: Grant
    Filed: May 15, 2019
    Date of Patent: August 15, 2023
    Assignee: BASF SE
    Inventors: Theo Smit, Matthias Karl, Felicitas Guth, Maximilian Angel, Karl Kolter, Frank Schmidt, Maximilian Blochberger-Claus
  • Solid nanoparticle with inorganic coating
    Patent number: 11717491
    Abstract: A nanoparticle having a solid core comprising a biologically active substance, said core being enclosed by an inorganic coating, a method for preparing the nanoparticle, and the use of the nanoparticle in therapy. A kit comprising the nanoparticle and a pharmaceutical composition comprising the nanoparticle.
    Type: Grant
    Filed: November 12, 2020
    Date of Patent: August 8, 2023
    Assignee: NANEXA AB
    Inventors: Jan-Otto Carlsson, Anders Johansson, Marten Rooth
  • Reduction of flake-like aggregation in nanoparticulate active agent compositions
    Patent number: 11717481
    Abstract: This invention is directed to reduction of flake-like aggregation in nanoparticulate compositions. Also encompassed by the invention are compositions comprising a nanoparticulate active agent, at least one surface stabilizer and a flake-like aggregation reducing agent, such as a buffer and a sugar. The nanoparticulate active agent compositions comprise particles of the active agent having an effective average particle size of less than about 2000 nm.
    Type: Grant
    Filed: December 3, 2021
    Date of Patent: August 8, 2023
    Assignee: ALKERMES PHARMA IRELAND LIMITED
    Inventors: Niels P. Ryde, Peter Snyder, Wei Liu, David M. Slifer
  • Therapeutic nanocarrier system and methods of use
    Patent number: 11717490
    Abstract: A nanoparticle for treatment of cancer is provided comprising a poloxamer surfactant, a Vitamin E TPGS and an anticancer compound.
    Type: Grant
    Filed: June 4, 2021
    Date of Patent: August 8, 2023
    Assignee: UNIVERSITY OF CYPRUS
    Inventors: Yiota Gregoriou, Gregoria Gregoriou, Andreas I. Constantinou
  • Formulated cannabis oil powder by nanoemulsification, methods of producing and uses thereof
    Patent number: 11712430
    Abstract: The invention discloses particular water-dispersible solid formulation of a cannabinoid or a cannabis extract, wherein they are present in the form of a nanoemulsion, and upon dispersion in water said formulation produces nanoparticles (droplets of a submicron size) with an average size of up to about 500 nm. The present disclosure further relates to methods of making thereof, as well as therapeutic applications in humans for treating disorders and broader application for a range of medical conditions.
    Type: Grant
    Filed: March 11, 2019
    Date of Patent: August 1, 2023
    Assignee: Karnak Technologies, LLC
    Inventors: Shlomo Magdassi, Liraz Larush, Rafael Ezra
  • Fast dispersing suspending composition, method of preparation and application thereof
    Patent number: 11712417
    Abstract: Disclosed herein is a fast-dispersing suspending composition which promotes the formation of a suspension for pharmaceutical, food and veterinary products. The composition includes a suspending agent, a diluent, and a glidant, wherein the amounts of these agents are selected to enable the dispersion of the composition and the formation of the suspension. Also disclosed are a method of forming a suspension of a solid dosage form and a method of administering the resulting suspension to a subject.
    Type: Grant
    Filed: June 8, 2022
    Date of Patent: August 1, 2023
    Assignee: AUSON PHARMACEUTICALS INC.
    Inventors: Enxian Lu, Peng Hou, Longlong Feng, Long Wang
  • Kit for locating a vein
    Patent number: 11712527
    Abstract: The kit for locating a vein is configured for use in inserting an intravenous (IV) catheter into a targeted vein of a patient. The kit for locating a vein is a transparent structure. The kit for locating a vein: a) removably attaches to the skin of the patient; b) numbs the skin of the patient; c) generates a vasomotor response; d) provides the ability to insert the IV catheter into the targeted vein while the kit for locating a vein remains attached to the patient; and, e) forms a dressing that captures bodily fluids. The kit for locating a vein comprises a parchment sheeting, a working media, a transparent pocket, and a plurality of apertures. The parchment sheeting, the working media, and the transparent pocket form a transparent composite textile structure. The plurality of apertures are apertures that are formed through the composite textile structure.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: August 1, 2023
    Inventor: Tanya Hamilton
  • Inorganic sunscreen agents with higher UV radiation protection
    Patent number: 11707422
    Abstract: Ultraviolet radiation sun protective compositions are reported which feature micronized metal oxide inorganic particles selected from zinc oxide, titanium oxide and mixtures thereof, the inorganic particles being coated with poly[C8-C20 hydroxycarboxylic acid], the coated particles measured at a 10% loading in dodecane and 1 minute elapsed time having a Zeta Potential ranging from 2 to 10 mv, amounts of the poly[C8-C20 hydroxycarboxylic acid] to the inorganic particles being in a relative weight ratio of 1:100 to 1:10.
    Type: Grant
    Filed: January 10, 2022
    Date of Patent: July 25, 2023
    Assignee: VIZOR, LLC
    Inventors: Yannick Rigg, Richard Rigg
  • Methods of killing nematodes
    Patent number: 11707064
    Abstract: Provided herein are methods for killing nematodes, said method comprising contacting said nematodes with an effective nematodes killing amount of a fatty-ammonium salt polysaccharide inclusion complex, and optionally a carrier. The fatty-ammonium salt starch inclusion complexes comprise one or more of a variety of fatty amines.
    Type: Grant
    Filed: April 7, 2020
    Date of Patent: July 25, 2023
    Assignee: The United States of America, as represented by the Secretary of Agriculture
    Inventors: Gordon W. Selling, William T. Hay, George F. Fanta, Susan L. Meyer, Inga A. Zasada
  • Composition comprising highly-concentrated ?1 proteinase inhibitor and method for obtaining thereof
    Patent number: 11701412
    Abstract: Compositions include highly-concentrated Alpha-1 Proteinase Inhibitor (A1PI) in a concentration greater than or equal to 100 mg/ml. Pharmaceutical compositions can be prepared from these compositions. The pharmaceutical compositions can be suitable for subcutaneous administration. The highly-concentrated A1PI solutions can be obtained by single-pass tangential flow filtration (SPTFF).
    Type: Grant
    Filed: September 22, 2021
    Date of Patent: July 18, 2023
    Assignee: GRIFOLS WORLDWIDE OPERATIONS LIMITED
    Inventors: James Rebbeor, Charles Miller, Anthony Klos, Eric Allgaier, Thomas P. Zimmerman, Kevin Wee, Michelle StPeter, Kelly Glancy
  • Plant health compositions comprising a water-soluble pesticide and a water-insoluble agrochemical
    Patent number: 11700853
    Abstract: Compositions for improving plant health, the compositions comprising at least one water-soluble pesticide and at least one non-herbicidal water-insoluble agrochemical, are described. Also described are processes for preparing the compositions and methods of improving agronomic crop plant health using the compositions.
    Type: Grant
    Filed: June 9, 2020
    Date of Patent: July 18, 2023
    Assignee: Monsanto Technology LLC
    Inventors: William Abraham, Andrew Dyszlewski, John W. Hemminghaus, Frank C. Kohn, Daniel R. Wright, Junhua Zhang
  • Amlodipine formulations
    Patent number: 11701326
    Abstract: Provided herein are stable amlodipine liquid formulations. Also provided herein are methods of using amlodipine liquid formulations for the treatment of certain diseases including hypertension and Coronary Artery Disease (CAD).
    Type: Grant
    Filed: August 22, 2022
    Date of Patent: July 18, 2023
    Assignee: AZURITY PHARMACEUTICALS, INC.
    Inventors: Scott Brauer, Gerold L. Mosher
  • Process for preparing aripiprazole oral soluble film
    Patent number: 11701352
    Abstract: The present invention is directed to an aripiprazole oral soluble film and a preparation method thereof. The aripiprazole oral soluble film comprises 10-60% w/w of aripiprazole in a crystalline state and 30-95% w/w of one or more film-forming materials, wherein 90% of the aripiprazole particles have a size of ?14.3 ?m and are uniformly blended in the film without visible undispersed particles. The aripiprazole oral soluble film has excellent bioavailability, uniformity, stability, and palatability. The oral soluble film preparation is prepared by first grinding aripiprazole particles to have desired small particle sizes, then blending the aripiprazole particles with film forming materials in an aqueous solution to a uniform suspension, defoaming the suspension, and coating the suspension on a substrate and drying it to form a film.
    Type: Grant
    Filed: December 15, 2021
    Date of Patent: July 18, 2023
    Assignee: XIAMEN LP PHARMACEUTICAL CO., LTD.
    Inventors: Rongbin Ling, Lingyu Cai, Fuxiang Lin, Yong Yu, Xiaojin Xiao
  • Core-shell microneedle devices and uses thereof
    Patent number: 11697007
    Abstract: The present disclosure relates to microneedle devices and methods for treating a disease (for example, diabetes) using a degradable cross-linked gel for self-regulated delivery of a therapeutic agent (for example, insulin).
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: July 11, 2023
    Assignee: NORTH CAROLINA STATE UNIVERSITY
    Inventors: Zhen Gu, Jinqiang Wang, Yanqi Ye
  • Preparation comprising vonoprazan
    Patent number: 11696893
    Abstract: The present invention aims to provide a preparation expected to improve the bitter taste of an organic acid salt of vonoprazan and permit rapid dissolution of the organic acid salt of vonoprazan after administration. The present invention provides a preparation containing fine granules or granules containing (1) a core granule containing an organic acid salt of vonoprazan, (2) an intermediate layer containing the same organic acid as the organic acid forming the salt of vonoprazan in (1), or a salt thereof, and (3) a coating layer containing a water-insoluble polymer.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: July 11, 2023
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Hiroyuki Fujii, Akira Suzuki
  • Curcumin nanoparticle and preparation and application thereof
    Patent number: 11696901
    Abstract: Disclosed is a curcumin nanoparticle, including curcumin as core material and a wall material, where a weight ratio of the curcumin to the wall material is (5.5-7.5):100, and the wall material includes gum arabic and zein in a weight ratio of (1-5):5. The disclosure further provides a method of making the curcumin nanoparticle and a curcumin beverage containing the curcumin nanoparticle.
    Type: Grant
    Filed: February 25, 2021
    Date of Patent: July 11, 2023
    Assignee: SHAOGUAN UNIVERSITY
    Inventors: Siqun Jing, Ruimin Zhong, Junyan Zhang
  • Antimicrobial compositions comprising minocycline and degradation products of oxidized cellulose
    Patent number: 11690937
    Abstract: Provided is an antimicrobial composition comprised of at least one degradation product of oxidized cellulose (OC), such as oxidized regenerate cellulose (ORC), and minocycline, methods of preparation thereof and uses thereof.
    Type: Grant
    Filed: June 11, 2021
    Date of Patent: July 4, 2023
    Assignees: Omrix Biopharmaceuticals Ltd., Ethicon, Inc.
    Inventors: Eve Montia, Dwayne Looney, Theresa Scheuble, Ronen Eavri, Roi Mashiach