Abstract: This invention provides a composition comprising an amount of a purified protein selected from a group consisting of bone morphogenetic protein 4, bone morphogenetic protein, bone morphogenetic protein 7, dorsalin-1 and combinations thereof effective to stimulate neural crest cell differentiation and an acceptable carrier. This invention provides different uses of this composition.
Type:
Grant
Filed:
September 20, 1996
Date of Patent:
April 30, 2002
Assignee:
The Trustees of Columbia University in the City of New
York
Inventors:
Thomas M. Jessell, Karel F. Liem, Jr., Gabi Tremml