Abstract: The invention provides a pharmaceutical compositions comprising a compound of formula I:R.sub.2.sup.2 N--CH.sub.2 COCH.sub.2 --CH.sub.2 CO--OR.sup.1(I)wherein, R.sup.1 and R.sup.2 have any of the values defined in the specification; or a salt thereof; and a pharmaceutically acceptable carrier or excipient. The invention also provides a method for the diagnosis or photochemotherapeutic treatment of disorders or abnormalities of external or internal surfaces of the body using such compounds or salts.
Type:
Grant
Filed:
December 5, 1997
Date of Patent:
March 7, 2000
Assignee:
PhotoCure AS
Inventors:
Karl E. Gierskcky, Johan Moan, Qian Peng, Harald Steen, Trond Warloe, Alf Bjorseth
Abstract: The present invention relates to methods for preparing 3-amino-4,4,4-trihalocrotonates and their derivatives from a 4,4,4-trihaloacetoacetate derivative and an amine or ammonium salt.
Type:
Grant
Filed:
April 29, 1998
Date of Patent:
June 8, 1999
Assignee:
Rohm and Haas Company
Inventors:
Joshua Anthony Chong, Fereydon Abdesken, Peter Osei-Gyimah