Patents Examined by Robert Gerstl
  • Substituted heteroaryloxyacetanilides and their use as herbicides
    Patent number: 6544931
    Abstract: The invention relates to novel substituted heteroaryloxyacetanilides of the general formula (I), in which n, R, X, and Z are to intermediates for their preparation and to their use as herbicides.
    Type: Grant
    Filed: January 16, 2002
    Date of Patent: April 8, 2003
    Assignee: Bayer Aktiengesellschaft
    Inventors: Klaus-Helmut Müller, Lothar Rohe, Joachim Kluth, Mark Wilhelm Drewes, Peter Dahmen, Dieter Feucht, Rolf Pontzen
  • Crystals of 5-[{6-(2-fluorobenzyl)oxy-2-naphthyl}methyl]-2,4-thiazolidinedione
    Patent number: 6541493
    Abstract: The invention relates to type A crystal of 5-[{6-(2-fluorobenzyl)oxy-2-naphthyl}methyl]-2,4-thiazolidinedione characterized to have characteristic absorption peaks (2&thgr;) at 11.5°±0.3°, 14.5°±0.2°, 16.2°±0.3°, 17.0°±0.3°, 17.7°±0.2°, 18.6°±0.3°, 19.1°±0.2°, 21.3°±0.4°, 22.4°±0.5°, 25.7°±0.5° and 28.3°±0.5° in a powder X-ray diffraction pattern, and also to a method for preparation thereof, and a pharmaceutical composition comprising the same. The crystal is excellent in stability, and has advantages in handling, storage, and pharmaceutical preparation. The invention also relates to type B, C and D crystals of said compound.
    Type: Grant
    Filed: August 20, 2001
    Date of Patent: April 1, 2003
    Assignee: Mitsubishi Chemical Corporation
    Inventors: Takayuki Oe, Hiroaki Ueno, Akira Maruyama, Katsuhiko Masuda
  • Antifungal enediynes
    Patent number: 6541506
    Abstract: The invention features enediynes and methods for their production and use. The enediynes of the invention have the formula: wherein R1 is a hydroxyl group or a moiety that can be replaced by a hydroxyl group in a hydrolysis reaction; each R2 is, independently, H or a monovalent hydrocarbon moiety containing between 1 and 4 carbon atoms, inclusive; R3 is a pyrrole, furan, or thiophene ring; and X is an integer between 4 and 10, inclusive.
    Type: Grant
    Filed: October 5, 2000
    Date of Patent: April 1, 2003
    Assignee: Phytera Incorporated
    Inventors: Baoliang Cui, James Bruce McAlpine, Maureen Kelly Talbot, Shu-Wei Yang, Catherine Heintz, Angela Stafford
  • Hypoglycemic and hypolipidemic compounds
    Patent number: 6541497
    Abstract: This invention provides compounds and their pharmaceutically-acceptable salts, pharmaceutical formulations of said compounds, and methods for treating hyperglycemia associated with non-insulin dependent diabetes and for treating hyperlipidemia.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: April 1, 2003
    Assignee: Eli Lilly and Company
    Inventors: Samuel James Dominianni, Margaret Mary Faul, Russell Dean Stucky, Leonard Larry Winneroski, Jr.
  • 3, 7 or 3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure
    Patent number: 6538018
    Abstract: The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula I; where in A, B, D, X, Y, Z, R1, R3 and R4 are as defined in the specification.
    Type: Grant
    Filed: March 20, 2002
    Date of Patent: March 25, 2003
    Assignee: Allergan, Inc.
    Inventors: Robert M. Burk, Mark Holoboski, Mari F. Posner
  • Sufidomaidocarboxylic acids, method for production thereof, and use therefor
    Patent number: 6534659
    Abstract: Novel sulfidoamidocarboxylic acids (salts), a method for the production thereof, and uses therefor are provided. Sulfidoamidocarboxylic acids (salt) with a thiazolidine residue such as dimethylthiazolidine or methylthiazolidine or thiazolidine residue (residues), or a polycarboxylic acid (salt) residue such as dicarboboxylic acid (salt) or tricarboxylic acid (salt) or tetracarboxylic acid (salt) residue, a method for the production thereof, and uses therefor are also provided.
    Type: Grant
    Filed: April 23, 2001
    Date of Patent: March 18, 2003
    Assignee: Nippon Shokubai Co., Ltd.
    Inventor: Yoshihisa Oda
  • Methods for preventing and treating alopecia induced by chemotherapy or radiotherapy
    Patent number: 6534531
    Abstract: The invention provides a method for preventing or treating alopecia induced by chemotherapy or radiotherapy by administering to a mammalian specie in need thereof a therapeutically effective amount of a compound of formula I or II or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 26, 2001
    Date of Patent: March 18, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: S. David Kimball, Kevin R. Webster, David K. Bol
  • O-aryl dithiazole dioxides
    Patent number: 6531496
    Abstract: The invention relates to new O-aryldithiazole dioxides, to two processes for their preparation, and to their use as pesticides in crop protection and in the protection of materials.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: March 11, 2003
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hermann Uhr, Christiane Boie, Heiko Rieck, Bernd-Wieland Krüger, Ulrich Heinemann, Robert Markert, Martin Vaupel, Martin Kugler, Klaus Stenzel, Ulrike Wachendorff-Neumann, Astrid Mauler-Machnik, Karl-Heinz Kuck, Peter Lösel, Shinichi Narabu
  • Oxazolidinone combinatorial libraries, compositions and methods of preparation
    Patent number: 6531470
    Abstract: Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
    Type: Grant
    Filed: August 30, 2000
    Date of Patent: March 11, 2003
    Assignee: Pharmacia & Upjohn Company
    Inventors: Mikhail F. Gordeev, Gary W. Luehr, Dinesh V. Patel, Zhi-Jie Ni, Eric Gordon
  • Method of prostaglandin synthesis
    Patent number: 6531614
    Abstract: Methods of synthesizing 9-Halo-13,14-dihydroprostaglandins useful in the treatment of glaucoma and ocular hypertension are disclosed. Also disclosed are ophthalmic, pharmaceutical compositions comprising such prostaglandins.
    Type: Grant
    Filed: February 4, 2002
    Date of Patent: March 11, 2003
    Assignee: Alcon Manufacturing, Ltd.
    Inventor: Raymond E. Conrow
  • Prostanoic acid derivatives as agents for lowering intraocular pressure
    Patent number: 6531504
    Abstract: The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula I; wherein hatched lines represent the &agr; configuration, a triangle represents the &bgr; configuration and a dotted line represents the presence or absence of a double bond; A and B are CH2; D represents a covalent bond or CH2, O, S or NH; X is CO2R, CONR2, CH2OR, P(O)(OR)2, CONRSO2R SONR2 or Y is O, OH, OCOR2, halogen or cyano; Z is CH2 or a covalent bond; R is H or R2; R1 is H, R2, phenyl, or COR2; R2 is C1-C5 lower alkyl or alkenyl and R3 is benzothienyl, benzofuranyl, naphthyl or substituted derivatives thereof, wherein the substituents maybe selected from the group consisting of C1-C5 alkyl, halogen, CF3, CN, NO2, NR2, CO2R and OR.
    Type: Grant
    Filed: May 17, 2001
    Date of Patent: March 11, 2003
    Assignee: Allergan, Inc.
    Inventors: Robert M. Burk, Todd S. Gac
  • Phosphated castor oil and derivatives
    Patent number: 6528667
    Abstract: The present invention relates to phosphated derivatives of castor oil and hydrogenated castor oil as well as phosphated esters of ricinoleic acid. The inclusion of the phosphate group results in improved water solubility and a series of dispersants and emulsifiers that provide excellent pigment dispersing properties.
    Type: Grant
    Filed: May 14, 2001
    Date of Patent: March 4, 2003
    Assignee: Phoenix Research Corporation
    Inventors: Anthony J. O'Lenick, Jr., John Imperante
  • Antirheumatic
    Patent number: 6525081
    Abstract: A novel antirheumatic agent comprising as an active ingredient a compound of formula I: or a pharmaceutically acceptable salt or hydrate thereof.
    Type: Grant
    Filed: April 24, 2000
    Date of Patent: February 25, 2003
    Assignee: Shionogi & Co., Ltd.
    Inventors: Saichi Matsumoto, Hirokuni Jyoyama, Shinji Kakudo, Kohji Hanasaki, Kenzo Koizumi, Tsuneaki Sakata, Ryuji Suzuki
  • Heterocyclic aromatic compounds useful as growth hormone secretagogues
    Patent number: 6525203
    Abstract: Heterocyclic aromatic compounds are provided which are useful in stimulating endogenous production or release of growth hormone and in treating obesity, osteoporosis (improving bone density) and in improving muscle mass and muscle strength. The heterocyclic aromatic compounds have the structure including pharmaceutically acceptable salts thereof and all stereoisomers thereof, wherein Xa is heteroaryl, preferably,  and R1, R1a, R6, Y, Xb, A, B, Z, R3, R4, R4a, R5 and R5a are as defined herein.
    Type: Grant
    Filed: September 14, 2000
    Date of Patent: February 25, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventor: Joseph A. Tino
  • 4-amino-2-hydroxy-5-substituted-acylanilide compounds and method of using them
    Patent number: 6525219
    Abstract: Disclosed is a 4-amino-2-hydroxy-5-substituted-acylanilide compound having the structural formula I: wherein R is hydrogen or an alkyl group, and Y is a substituent group linked to the rest of the compound by a hetero atom. Also disclosed is a method of using the compound to prepare an intermediate in a simplified process for making a cyan dye-forming coupler.
    Type: Grant
    Filed: December 3, 2001
    Date of Patent: February 25, 2003
    Assignee: Eastman Kodak Company
    Inventor: Chang-Kyu Kim
  • Thiazoline acid derivatives
    Patent number: 6525080
    Abstract: Phenyl- and pyridyl-substituted thiazoline acid derivatives useful in diagnosing and treating pathological conditions associated with an excess of trivalent metals in humans and animals.
    Type: Grant
    Filed: March 20, 2000
    Date of Patent: February 25, 2003
    Assignee: University of Florida Research Foundation, Inc.
    Inventor: Raymond J. Bergeron
  • Amines as pharmaceutical agents
    Patent number: 6521650
    Abstract: Novel gamma aminobutyric acids of formula (I) are disclosed and are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, inflammation, and gastrointestinal damage. Processes for the preparation and intermediates useful in the preparation are also disclosed.
    Type: Grant
    Filed: April 4, 2000
    Date of Patent: February 18, 2003
    Assignee: Pfizer, Inc.
    Inventors: Thomas Richard Belliotti, Justin Stephen Bryans, Thomas Capiris, David Christopher Horwell, Clare Octavia Kneen, David Juergen Wustrow
  • Thiazoline acid derivatives
    Patent number: 6521652
    Abstract: Phenyl- and pyridyl-substituted thiazoline acid derivatives useful in diagnosing and treating pathological conditions associated with an excess of trivalent metals in humans and animals.
    Type: Grant
    Filed: March 20, 2000
    Date of Patent: February 18, 2003
    Assignee: University of Florida Research Foundation, Inc.
    Inventor: Raymond J. Bergeron
  • Amidophosphate derivatives
    Patent number: 6521605
    Abstract: The present invention provides amidophosphate derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.
    Type: Grant
    Filed: January 23, 2001
    Date of Patent: February 18, 2003
    Assignee: Eli Lilly and Company
    Inventors: Macklin Brian Arnold, Paul Leslie Ornstein, Hamideh Zarrinmayeh, Dennis Michael Zimmerman
  • Aminothiazole inhibitors of cyclin dependent kinases
    Patent number: 6521759
    Abstract: The present invention describes compounds of formula I: and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, m and n are as defined in the specification. The compounds of formula I are protein kinase inhibitors and are useful in the treatment of proliferative diseases, for example, cancer, inflammation and arthritis. They may also be useful in the treatment of Alzheimer's disease, chemotherapy-induced alopecia, and cardiovascular disease.
    Type: Grant
    Filed: April 20, 2001
    Date of Patent: February 18, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: Kyoung S. Kim, S. David Kimball, Zhen-wei Cai, David B. Rawlins, Raj N. Misra, Michael A. Poss, Kevin R. Webster, John T. Hunt, Wen-Ching Han