Patents Examined by Robert H Havlin
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Patent number: 11602518Abstract: Provided herein are lipidic furan, pyrrole, and thiophene compounds, compositions, and methods using such compounds and compositions for the treatment of atrophic vaginitis. Specifically, the invention includes administering an effective amount of a compound of Formula I, I?, or I?, or a pharmaceutically acceptable composition, salt, isotopic analog, prodrug, or combination thereof, to a subject suffering from atrophic vaginitis.Type: GrantFiled: December 17, 2020Date of Patent: March 14, 2023Assignee: Avoscience, LLCInventor: Samuel Richard Huber
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Patent number: 11597968Abstract: The invention relates to a method for analysing ribonucleic acid (RNA) interactions comprising: a) cross-linking base-paired nucleotides of at least one RNA molecule and/or at least one pair of RNA molecules using a tagged, reversible cross-linking agent (preferably tagged-psoralen) under ultraviolet irradiation; b) fragmenting the said cross-linked RNA molecule(s); c) using said tag to extract said cross-linked RNA fragment(s); d) ligating the said cross-linked RNA fragment(s) to produce cross-linked ligated RNA chimera(s); e) reversing the cross-linking of the said agent to the said RNA molecule(s); f) preparing a sequence library by sequencing the ligated RNA chimera molecule(s) or pair(s); and g) analysing the sequence library to determine RNA interactions. Also disclosed is a method of studying a subject by analysing RNA interactions and attributing them to a clinical picture, or a drug discovery method by attributing an efficacy score to the drug based upon determined RNA interactions.Type: GrantFiled: May 12, 2017Date of Patent: March 7, 2023Assignee: Agency for Science, Technology and ResearchInventors: Yue Wan, Jong Ghut Ashley Aw, Niranjan Nagarajan, Andreas Wilm, Miao Sun
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Patent number: 11572368Abstract: The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U, J, V, X, R2a, R2b, R2c, R5 and t are as described herein. The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. These compounds are useful for promoting cognitive function and enhancing learning and memory formation. In addition, these compounds are useful for treating, alleviating, and/or preventing various conditions, including for example, neurological disorders, memory and cognitive function disorders/impairments, extinction learning disorders, fungal diseases and infections, inflammatory diseases, hematological diseases, and neoplastic diseases in humans and animals.Type: GrantFiled: August 11, 2016Date of Patent: February 7, 2023Assignees: The General Hospital Corporation, The Broad Institute, Inc., Massachusetts Institute of TechnologyInventors: Edward Holson, Florence Fevrier Wagner, Michel Weiwer, Li-Huei Tsai, Stephen J. Haggarty, Yan-Ling Zhang
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Patent number: 11560585Abstract: The invention provides methods, compositions, kits and devices for the detection of target molecules. In some embodiments, the invention allows for multiplexed target molecule detection.Type: GrantFiled: March 3, 2020Date of Patent: January 24, 2023Assignee: ROCHE SEQUENCING SOLUTIONS, INC.Inventor: Garry P. Nolan
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Patent number: 11535882Abstract: The present disclosure provide compositions, methods and kits for generating a set of combinatorial barcodes, and uses thereof for barcoding samples such as single cells or genomic DNA fragments. Some embodiments disclosed herein provide compositions comprising a set of component barcodes for producing a set of combinatorial barcodes. The set of component barcodes can comprise, for example, n×m unique component barcodes, wherein n and m are integers, each of the component barcodes comprises: one of n unique barcode subunit sequences; and one or two linker sequences or the complements thereof, wherein the component barcodes are configured to connect to each other through the one or two linker sequences or the complements thereof to produce a set of combinatorial barcodes.Type: GrantFiled: March 29, 2016Date of Patent: December 27, 2022Assignee: Becton, Dickinson and CompanyInventors: Glenn Fu, Stephen P. A. Fodor
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Patent number: 11535599Abstract: The present invention relates to a medicament for treating various nervous system diseases or psychiatric diseases, comprising a compound of formula (1) or a pharmaceutically acceptable salt thereof as an active ingredient, wherein R1 is hydrogen, etc., R2 is halogen, etc., R3, R4, R5, and R6 are hydrogen, etc.Type: GrantFiled: March 22, 2022Date of Patent: December 27, 2022Assignee: Sumitomo Pharma Co., Ltd.Inventors: Tomoyuki Tanaka, Yoshiaki Isobe, Hiroyuki Kitano, Hiroaki Tanaka, Shun Narai
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Patent number: 11530295Abstract: A hydrophilic polymer derivative having a cyclic benzylidene acetal linker represented by the following formula (1): wherein R1 and R6 are each independently a hydrogen atom or a hydrocarbon group; R2, R3, R4 and R5 are each independently an electron-withdrawing or electron-donating substituent or a hydrogen atom; X1 is a chemically reactive functional group; P is a hydrophilic polymer; s is 1 or 2, t is 0 or 1, and s+t is 1 or 2; w is an integer of 1 to 8; and Z1 and Z2 are each independently a selected divalent spacer.Type: GrantFiled: May 29, 2020Date of Patent: December 20, 2022Assignee: NOF CORPORATIONInventors: Takuma Tsubusaki, Yuji Yamamoto
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Patent number: 11529423Abstract: A biodegradable polyethylene glycol derivative in which a polyethylene glycol chain is linked by an acetal linker capable of accurately controlling the hydrolysis rate under different pH environments in the living body, and whose division rate into a polyethylene glycol chain of low molecular weight in the living body can be accurately controlled. The biodegradable polyethylene glycol derivative is represented by formula (1) or formula (2) as described.Type: GrantFiled: May 28, 2020Date of Patent: December 20, 2022Assignee: NOF CORPORATIONInventors: Takuma Tsubusaki, Yuji Yamamoto
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Patent number: 11474111Abstract: Characterization of the binding dynamics at the interface between any two proteins that specifically interact plays a role in myriad biomedical applications. The methods disclosed herein provide for the high-throughput characterization of the specific interaction at the interface between two protein binding partners and the identification of functionally significant mutations of one or both protein binding partners. For example, the methods disclosed herein may be useful for epitope and paratope mapping of an antibody-antigen pair, which is useful for the discovery and development of novel therapies, vaccines, diagnostics, among other biomedical applications.Type: GrantFiled: December 16, 2021Date of Patent: October 18, 2022Assignee: A-Alpha Bio, Inc. et alInventors: David Younger, David Colby, Randolph Lopez, Michael Wittekind
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Patent number: 11458139Abstract: The present technology relates to compositions comprising BRAF inhibitors and uses thereof for treating and/or preventing a MEK inhibitor-associated cutaneous condition in a subject. Kits for use in practicing the methods are also provided.Type: GrantFiled: August 8, 2018Date of Patent: October 4, 2022Assignee: MEMORIAL SLOAN KETTERING CANCER CENTERInventors: Neal Rosen, Noa Shelach
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Patent number: 11458119Abstract: The hemitartrate salt of a compound represented by the following structural formula: (Formula I Hemitartrate), which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of the Formula (I) Hemitartrate are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline Formula (I) Hemitartrate, and using it to inhibit glucosylceramide synthase or lowering glycosphingolipid concentrations in subjects to treat a number of diseases, are also discussed. Pharmaceutical compositions are also described.Type: GrantFiled: November 24, 2010Date of Patent: October 4, 2022Assignee: GENZYME CORPORATIONInventors: Hanlan Liu, Chris Willis, Renu Bhardwaj, Jianmei Kochling, Craig Siegel
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Patent number: 11459336Abstract: Pyridine carbamates, pharmaceutical compositions containing pyridine carbamates, and uses of the pyridine carbamates and pharmaceutical compositions for modulating GluN2B receptors and for treating diseases, disorders, and medical conditions mediated by GluN2B receptor activity.Type: GrantFiled: June 12, 2020Date of Patent: October 4, 2022Assignee: JANSSEN PHARMACEUTICA NVInventor: Christine Gelin
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Patent number: 11447503Abstract: Pyridine carbamates, pharmaceutical compositions containing pyridine carbamates, and uses of the pyridine carbamates and pharmaceutical compositions for modulating GluN2B receptors and for treating diseases, disorders, and medical conditions mediated by GluN2B receptor activity.Type: GrantFiled: June 12, 2020Date of Patent: September 20, 2022Assignee: JANSSEN PHARMACEUTICA NVInventors: Christine Gelin, Heather Coate, Brice Stenne, Curt Dvorak
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Patent number: 11420961Abstract: The invention provides new heterocyclic compounds having the general formula (IA) wherein A, L, X, Y, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.Type: GrantFiled: May 27, 2020Date of Patent: August 23, 2022Assignee: Hoffmann-La Roche Inc.Inventors: Joerg Benz, Uwe Grether, Benoit Hornsperger, Buelent Kocer, Bernd Kuhn, Hans Richter, Satoshi Tsuchiya, Charles Bell, Xiang Wu, Xiaofei Yan, Luca Gobbi
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Patent number: 11419946Abstract: A heterobifunctional monodispersed polyethylene glycol represented by formula (1) which has two adjacent monodispersed polyethylene glycol side chains and does not have a chiral center in the molecular structure: wherein X1 and Y1 are each an atomic group containing a functional group capable of forming a covalent bond upon a reaction with a functional group present in a biofunctional molecule. R1 is a hydrocarbon group or the like. n is an integer of 3 to 72. A1 represents -L1-(CH2)m1— or the like, L1 and L2 represent each an ether bond or the like, and m1 and m2 each independently represent an integer of 1 to 5. B1 represents -L3-(CH2)m3— or the like, L3 and L4 represent an amide bond or the like, and m3 and m4 each independently represent an integer of 1 to 5. Also disclosed is an antibody-drug conjugate including the heterobifunctional monodispersed polyethylene glycol.Type: GrantFiled: March 23, 2018Date of Patent: August 23, 2022Assignee: NOF CORPORATIONInventors: Takuma Tsubusaki, Kohei Yoshimura, Mika Hamura
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Patent number: 11414686Abstract: This disclosure describes a method of purifying several full-length oligonucleotide targets from corresponding synthesis truncation products, in a way that ensures roughly stoichiometric equality among the targets.Type: GrantFiled: May 5, 2017Date of Patent: August 16, 2022Assignee: William Marsh Rice UniversityInventors: David Zhang, Alessandro Pinto
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Patent number: 11414696Abstract: The present disclosure provides a microarray comprising a plurality of probes. Each probe comprises a first oligonucleotide and a second oligonucleotide. The location of each probe on the microarray can be determined by the length of the first oligonucleotide and the length of the second oligonucleotide, thus providing a spatially barcoded microarray. Also provided are the methods of producing such spatially barcoded microarray. Also provided are the method of using such spatially barcoded microarray.Type: GrantFiled: September 9, 2021Date of Patent: August 16, 2022Assignee: WELLSIM BIOMEDICAL TECHNOLOGIES, INC.Inventor: Yuchao Chen
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Patent number: 11396650Abstract: The invention provides compositions comprising nucleic acid complexes for use in screening compounds based on their ability to modulate binding interactions, wherein the compounds are barcoded.Type: GrantFiled: June 2, 2016Date of Patent: July 26, 2022Assignee: Children's Medical Center CorporationInventors: Wesley Philip Wong, Clinton H. Hansen
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Patent number: 11395822Abstract: The present description relates to a method or use of a compound for treating or ameliorating HD (Huntington's Disease) in a subject in need thereof comprising administering to the subject an effective amount of a compound of Formula (I): or a form thereof, wherein R1, R2, Ra, Rb and Rc are as defined herein. In particular, the present description relates to a method of use of a compound of Formula (I) or a form or composition thereof for treating or ameliorating HD in a subject in need thereof comprising, administering an effective amount of the compound or a form or composition thereof to the subject.Type: GrantFiled: June 27, 2018Date of Patent: July 26, 2022Assignee: PTC THERAPEUTICS, INC.Inventors: Anuradha Bhattacharyya, Minakshi B. Jani
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Patent number: 11364246Abstract: Compounds of general formula (I): wherein R1, R2, R3, R4, R5a, R* X1, X2, Z and Y are as defined herein are positive modulators of the calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases and conditions affected by modulation of TMEM16A, particularly respiratory diseases and conditions.Type: GrantFiled: November 22, 2019Date of Patent: June 21, 2022Assignee: TMEM16A LIMITEDInventors: Stephen Collingwood, Clive Mccarthy, Jonathan David Hargrave, Duncan Alexander Hay, Thomas Beauregard Schofield, Sarah Ellam, Craig Stephen Buxton, Matthew Habgood, Peter Neville Ingram, Chun Yan Ma, Spencer Charles Robert Napier, Abdul Kadar Shaikh, Matthew Raymond Smith, Christopher Charles Stimson, Edward Richard Walker