Abstract: The present invention is a material having excellent performance as an n-type semiconductor material, in particular for organic thin-film solar cells. The present invention provides an n-type semiconductor consisting of a fullerene derivative having a purity of 99% or more, the fullerene derivative being represented by formula (1): wherein ring A represents C60 fullerene; R1 represents a hydrogen atom, alkyl optionally having at least one substituent, or aryl optionally having at least one substituent; and Ar represents aryl optionally substituted with at least one alkyl group.
Type:
Grant
Filed:
May 16, 2014
Date of Patent:
August 20, 2019
Assignees:
DAIKIN INDUSTRIES, LTD., OSAKA UNIVERSITY
Abstract: Gold(III) complexes containing mixed ligands. A method of treating cancer with these complexes is disclosed. The complexes are cytotoxic to prostate, breast, ovarian, and Hodgkin lymphoma cancer cell lines. These complexes were either more potent than cisplatin or had similar potency to cisplatin.
Type:
Grant
Filed:
July 20, 2017
Date of Patent:
August 20, 2019
Assignee:
King Fahd University of Petroleum and Minerals
Inventors:
Anvar Husain Abdul Kadir Isab, Muhammad Altaf
Abstract: Provided herein are quinolines, e.g., a compound of Formula I, pharmaceutical compositions thereof, and methods of their use for treating, preventing, or ameliorating one or more symptoms of an endoplasmic reticulum stress-caused disease. Also provided herein are methods of their use for reducing endoplasmic reticulum stress and modulating the activity of a sarcoplasmic/endoplasmic reticulum Ca2+ ATPase.
Abstract: The present invention relates to an organic electronic device, comprising a first electrode, a second electrode, and a substantially organic layer comprising a compound according to formula (I) between the first and the second electrode: wherein A1 is a C6-C20 arylene and each of A2-A3 is independently selected from a C6-C20 aryl, wherein the aryl or arylene may be unsubstituted or substituted with groups comprising C and H or with a further LiO group, provided that the given C count in an aryl or arylene group includes also all substituents present on the said group.
Abstract: Novel crystalline forms of lesinurad and its sodium salt, processes for their preparation, pharmaceutical compositions comprising these new forms, and use of them for treating or delaying progression or onset of diseases or disorders related to activity of uric acid transporter 1 (URAT1) proteins are disclosed. These novel forms were characterized by X-ray powder diffraction, differential scanning calorimetry, and other techniques. They can be readily prepared and are suitable for preparation of solid dosage forms owing to their ease of handling and superior pharmacological properties.
Abstract: The present invention provides compounds of the general formula (I), their salts and N-oxides, and solvates and prodrugs thereof (wherein the substituents are as defined in the description). The compounds of the general formula (I) are inhibitors of factor XIa, and are useful in the prevention of and/or therapy for thromboembolic diseases.
Type:
Grant
Filed:
January 23, 2017
Date of Patent:
July 2, 2019
Assignee:
ONO PHARMACEUTICAL CO., LTD.
Inventors:
Akira Imagawa, Takashi Kondo, Taihei Nishiyama, Steve Courtney, Chris Yarnold, Osamu Ichihara, Stuart Flanagan
Abstract: The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids comprising at least one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA.
Abstract: New compounds of formula I are described. The compounds have potentially valuable pharmaceutical properties in the treatment of some central and peripheral nervous system disorders.
Type:
Grant
Filed:
January 10, 2017
Date of Patent:
July 2, 2019
Assignee:
BIAL—PORTELA & CA, S.A.
Inventors:
David Alexander Learmonth, Laszlo Erno Kiss, Pedro Nuno Leal Palma, Humberto dos Santos Ferreira, Patricio Manuel V. A. Soares Da Silva
Abstract: The present invention provide a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of autoimmune diseases and/or inflammatory diseases, graft versus host disease, cancers, central nervous diseases including neurodegenerative diseases, Charcot-Marie-Tooth disease and the like, and a pharmaceutical composition comprising the compound. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
Abstract: The present invention relates to compounds of general formula I, wherein the groups R1, R2 and n are defined as in claim 1, which have valuable pharmacological properties, in particular bind to ghrelin O-acyl transferase (GOAT) and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular obesity.
Type:
Grant
Filed:
May 9, 2018
Date of Patent:
June 4, 2019
Assignee:
Boehringer Ingelheim International GmbH
Inventors:
Cédrickx Godbout, Thomas Trieselmann, Viktor Vintonyak
Abstract: In an embodiment of the present disclosure, there is provided a composition for dissolving calcium oxalate crystals thereby inhibiting/preventing further growth of crystals. In some embodiments, such a composition comprises at least one stereoisomer of hydroxycitrate, a derivative of the organic acid citrate. Such a method comprises administering to the subject an effective amount of the aforementioned composition. In another embodiment, the present disclosure pertains to a method of treating kidney stone disorder. Such a method comprises administering to a subject in need thereof a therapeutically effective amount of the aforementioned composition. In yet another embodiment, the present disclosure relates to a method of treating calcium oxalate stone disease. In an embodiment, the method comprises administering to a subject in need thereof a therapeutically effective amount of the aforementioned composition.
Type:
Grant
Filed:
April 27, 2015
Date of Patent:
May 14, 2019
Assignee:
University of Houston System
Inventors:
Jeffrey D. Rimer, Jihae Chung, John Asplin
Abstract: The invention comprises, inter alia, pyrazolylheteroarylamides of the general formula (I) in which the A1-A4, T, W, Q, R1 and Z1-Z3 radicals are each as defined in the description. Also described are processes for preparing the compounds of the formula (I). The inventive compounds are especially suitable for controlling insects, arachnids and nematodes in agriculture and ectoparasites in veterinary medicine.
Type:
Grant
Filed:
December 30, 2014
Date of Patent:
April 30, 2019
Assignee:
BAYER ANIMAL HEALTH GMBH
Inventors:
Hans-Georg Schwarz, Michael Maue, Kerstin Ilg, Ulrich Görgens, Andreas Turberg, Sebastian Horstmann, Johannes Köbberling, Niels Lindner
Abstract: Provided are a repellent having a superior repellent activity for Rodentia animal and a repellent method for Rodentia animal. A Rodentia animal repellent containing, as an active ingredient, a compound represented by the formula (1) wherein Z1 is a C1-C4 hydrocarbon group, Z2 is a hydrogen atom, or Z1 and Z2 are joined to form a bond, R1 is a C1-C4 hydrocarbon group optionally having fluorine atom(s), R2 is a halogen atom or a C1-C4 hydrocarbon group, and n is an integer of 0 to 4.
Abstract: The present invention provides a novel crystalline form of [R—(R*,R*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-heptanoic acid hemi-calcium salt (atorvastatin hemi-calcium salt) of the following formula 1, which is known to be useful as a drug, a hydrate thereof and a preparation method thereof:
Type:
Grant
Filed:
February 24, 2017
Date of Patent:
April 9, 2019
Assignee:
KYONGBO PHARM
Inventors:
Kyung Ju Lee, Hoe Joo Son, Doo Seong Choi, Sun Ho Chang, Do Yeon Oh
Abstract: The invention relates to hydrosoluble hydroxybisphosphonic derivatives of doxorubicin of formula (I) and the pharmaceutically acceptable salts thereof. The invention also relates to the use of said compounds as a drug, especially in the treatment of a bone tumour. The invention further relates to the pharmaceutical compositions comprising such compounds, the methods for the synthesis thereof and synthesis intermediates.
Type:
Grant
Filed:
November 20, 2015
Date of Patent:
March 26, 2019
Assignee:
Atlanthera
Inventors:
Maxim Egorov, Jean-Yves Goujon, Ronan Le Bot, Emmanuelle David
Abstract: The present invention relates to the cosmetic use, as an agent for treating greasy skin and/or preventing greasy or greasy-prone skin and/or the associated aesthetic skin defects, of an essential oil of Origanum majorana and/or of origanum hybrids. The invention also relates to a cosmetic composition comprising same, to a non-therapeutic cosmetic care and/or cleansing treatment process for greasy skin, and also to said essential oil as a dermatological agent.
Type:
Grant
Filed:
April 18, 2014
Date of Patent:
March 19, 2019
Assignee:
L'OREAL
Inventors:
Géraldine Lerebour, Pierre Lartaud, Agnes Pegeon
Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of HIF pathway activity for the treatment or prevention of cancer and other hypoxia-mediated diseases.
Type:
Grant
Filed:
October 4, 2016
Date of Patent:
February 19, 2019
Assignee:
Board of Regents, The University of Texas System
Inventors:
Philip Jones, Maria Emilia Di Francesco, Alessia Petrocchi, Christopher L. Carroll, Joe Marszalek, Barbara Czako, Ryan Johnson, Jay Theroff