Patents Examined by Robert Havlin
  • Patent number: 10053444
    Abstract: Biologically active cannabinergic nitrate esters and related analogs, process of preparation, pharmaceutical compositions and their methods of use as medicaments, pharmacological tools or biomarkers. Pharmaceutical compositions may include one or more of the nitrate ester compounds. Medicaments include one or more of the cannabinergic nitrate ester compounds and are useful in treating a variety of diseases. A method of treating, preventing or reducing the severity of a condition includes administering at least one of the disclosed nitrate ester compounds to an individual or animal in need thereof.
    Type: Grant
    Filed: October 6, 2014
    Date of Patent: August 21, 2018
    Assignee: University of Connecticut
    Inventors: Alexandros Makriyannis, Kiran Vemuri
  • Patent number: 10047061
    Abstract: Water-soluble triazabutadiene molecules and methods for producing and using such compounds. The triazabutadiene molecules may be more labile at pH levels below physiological pH, such as pH 7, pH 6, pH 5, etc. The triazabutadiene molecules and compounds may be used for depositing diazonium salt and/or cargo in a pH-sensitive manner. The triazabutadiene molecules may alternatively be cleaved in reducing conditions or as a light-catalyzed reaction. The compounds herein may be used for delivery of drugs, as part of detection systems, or for other applications such as underwater adhesive applications.
    Type: Grant
    Filed: June 10, 2015
    Date of Patent: August 14, 2018
    Assignee: Arizona Board of Regents on Behalf of The University of Arizona
    Inventors: John C. Jewett, Flora W. Kimani
  • Patent number: 10047084
    Abstract: This application relates to imidazolone compounds, pharmaceutically acceptable salts, solvents, polymorphs or prodrugs thereof, and further relates to pharmaceutical combinations comprising the foregoing substances and uses for preventing and treating protein kinase related diseases such as cancer, metabolic diseases, and cardiovascular diseases.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: August 14, 2018
    Inventors: Xingmin Zhang, Qi Ji, Lei Wang, Congmin Gao, Ensi Wang, Zhenjian Du, Longlong Gong, Bo Chen
  • Patent number: 10016444
    Abstract: The invention relates to compounds of general formula (I) and pharmaceutically acceptable salts thereof: (I) wherein Ri is selected from an SCN— group or is an RCONH— group; in particular, where Ri=RCONH, R is selected from an aromatic benzene ring substituted with an SCN— group in the ortho, meta or para position, according to the following formula: SCN— or R is a C1-C4 alkyl chain, substituted with an SCN— group; n can be equal to 0 or else 1. The invention also relates to the use of such compounds for the treatment of osteoporosis and in general of bone pathologies characterized by a progressive loss of bone mass, for example rheumatoid arthritis, hyperparathyroidism or bone tumor metastases.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: July 10, 2018
    Inventors: Gina Lisignoli, Francesco Grassi, Vincenzo Calderone, Simona Rapposelli
  • Patent number: 10017478
    Abstract: Described are cancer therapies and anti-cancer compounds. In particular, disclosed are inhibitors of Ack1 tyrosine kinase and their use in the treatment of cancer. Methods of screening for new Ack1 tyrosine kinase inhibitors are also disclosed. In specific example, compound having Formula I through IV are disclosed.
    Type: Grant
    Filed: November 9, 2017
    Date of Patent: July 10, 2018
    Assignee: H. Lee Moffitt Cancer Center and Research Institute, Inc.
    Inventors: Nupam P. Mahajan, Kiran N. Mahajan, Nicholas J. Lawrence, Harshani R. Lawrence
  • Patent number: 10005730
    Abstract: The present invention relates to novel benzoyl derivatives of 3-aminocarbazole, to a pharmaceutical composition containing them, to a method for preparing them and to the use of such compounds for the production of a drug that is useful in the treatment or prevention of disturbances associated with the production of prostaglandin E2 (PGE2), for instance inflammatory processes, pain, fever, tumours, Alzheimer's disease and atherosclerosis.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: June 26, 2018
    Inventors: Maria Alessandra Alisi, Nicola Cazzolla, Isabella Coletta, Patrizia Dragone, Guido Furlotti, Barbara Garofalo, Angelo Guglielmotti, Giorgina Mangano, Caterina Maugeri
  • Patent number: 10000451
    Abstract: The invention provides mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) inhibitors, and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant diminution of tumor cell growth, cancer or metastasis.
    Type: Grant
    Filed: July 15, 2017
    Date of Patent: June 19, 2018
    Assignee: SRI International
    Inventors: Ling Jong, Chih-Tsung Chang, Jaehyeon Park
  • Patent number: 9994601
    Abstract: Provided is a process for depolymerizing lignin, the process comprising exposing a liquid feed comprising lignin and a solvent to a metal-incorporated solid mesoporous silicate catalyst under conditions sufficient to depolymerize the lignin to produce one or more aromatic monomers.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: June 12, 2018
    Assignee: University of Kansas
    Inventors: Bala Subramaniam, Anand Ramanathan, Kakasaheb Y. Nandiwale, Andrew M. Danby, Raghunath V. Chaudhari
  • Patent number: 9994591
    Abstract: The present invention relates to compounds of general formula I, wherein the groups R1, R2 and n are defined as in claim 1, which have valuable pharmacological properties, in particular bind to ghrelin O-acyl transferase (GOAT) and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular obesity.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: June 12, 2018
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Cédrickx Godbout, Thomas Trieselmann, Viktor Vintonyak
  • Patent number: 9987257
    Abstract: The invention is directed to a pediatric oral suspension composition containing amoxicillin and clavulanate potassium where the clavulanate potassium is present in an amount equal to or less than about 21.5 mg/5 mL, and a method of treating bacterial infections by providing between about one to about fourteen dosage days of the composition.
    Type: Grant
    Filed: January 10, 2013
    Date of Patent: June 5, 2018
    Inventors: Michael Spector, Alejandro Hoberman
  • Patent number: 9988364
    Abstract: The present invention relates to a process for synthesis of Eliglustat and intermediate compounds thereof. In particular, the present invention relates to a process for synthesis of Eliglustat and pharmaceutically acceptable salts thereof, and relates to the intermediate compounds in the process and a process for preparation of the intermediate compounds.
    Type: Grant
    Filed: August 21, 2017
    Date of Patent: June 5, 2018
    Inventors: Yu Liu, Guanneng Yu, Zhiguo Zheng
  • Patent number: 9981956
    Abstract: Described herein are compounds and compositions for the treatment of a fibrotic disease.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: May 29, 2018
    Assignees: The Scripps Research Institute, The California Institute for Biomedical Research
    Inventors: Luke Lairson, Michael Bollong, Peter G. Schultz, Arnab K. Chatterjee, Baiyuan Yang, Puneet Kumar, Kaveri Urkalan
  • Patent number: 9969739
    Abstract: The present invention relates to a compound of general Formula (VIII), the compound having a bowl-shaped conformation, its formation and its use in asymmetric catalysis. In Formula (VIII), M is a metal selected from the group consisting of Group 1 to Group 14 metals, lanthanides and actinides; R is one of —COOR3, —R4COOR3, —R4CHO, —R4COR3, —R4CONR5R6, —R4COX, —R4OP(?O)(OH)2, —R4P(?O)(OH)2), —R4C(O)C(R3)CR5R6 and R4CO2C(R3)O, wherein R1, R2, R3, R4, R5 and R6 are as defined herein.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: May 15, 2018
    Assignee: Nanyang Technological University
    Inventors: Teck Peng Loh, Jian Xiao
  • Patent number: 9962368
    Abstract: This technology relates generally to compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or protecting neuronal cell from cell death. Various compounds are disclosed herein. In vivo activity tests suggest that these compounds may have therapeutic benefits in neuropsychiatric and/or neurodegenerative diseases such as schizophrenia, major depression, bipolar disorder, normal aging, epilepsy, traumatic brain injury, post-traumatic stress disorder, Parkinson's disease, Alzheimer's disease, Down syndrome, spinocerebellar ataxia, amyotrophic lateral sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of a neuro-active drug, retinal degeneration, spinal cord injury, peripheral nerve injury, physiological weight loss associated with various conditions, as well as cognitive decline associated with normal aging, chemotherapy, and the like.
    Type: Grant
    Filed: August 24, 2012
    Date of Patent: May 8, 2018
    Assignee: Board of Regents of the University of Texas System
    Inventors: Steven L. McKnight, Andrew A. Pieper, Joseph M. Ready, Jef K. De Brabander
  • Patent number: 9951007
    Abstract: Compounds of Formula (I) are disclosed herein and their use in inhibiting quorum sensing in bacteria.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: April 24, 2018
    Inventors: Venkata L. Malladi, Adam J. Sobczak, Lisa Schneper, Kalai Mathee, Stanislaw F. Wnuk
  • Patent number: 9947967
    Abstract: The present invention provides a method for producing a fluorisulfonylimide salt, which enables reducing the impurity content and continuous operation for a long time, and a fluorosulfonyl imide salt. The fluorosulfonyl imide salt of the present invention has a K content of 10,000 ppm or less. The method for producing a fluorosulfonyl imide salt of the present invention is that after a fluorination reaction of chlorosulfonyl imde or a salt thereof, the reaction solution is brought into contact with an aqueous alkaline solution so as to remove impurities. The fluorosulfonyl imide salt of the present invention, in which various impirities are reduced to extremely low levels, is useful as an electrolyte used in a lithium secondary battery, a capacitor or the like, an ionic liquid, or an intermediate for a sulfonyl imide salt, and the like. It is expected that use of the fluorosulfonyl imide salt of the present invention as an electrolyte leads to a high-performance electrochemical device.
    Type: Grant
    Filed: November 26, 2010
    Date of Patent: April 17, 2018
    Assignee: Nippon Shokubai Co., Ltd.
    Inventors: Shimpei Sato, Yasunori Okumura, Yuichi Sato, Yasuyuki Miyoshi
  • Patent number: 9943816
    Abstract: Disclosed are a variety of amphoteric ester sulfonates, including 3-(N,N-dimethyl-cocoylpropylammonio-1-yl)-2-hydroxypropanesulfonate. These amphoteric ester sulfonates can be advantageously prepared in high yield and purity by a two-step chemoenzymatic process, and have excellent surfactant properties.
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: April 17, 2018
    Assignee: Eastman Chemical Company
    Inventors: Neil Warren Boaz, Matthew Allen Boone, Jennifer Michelle Lloyd
  • Patent number: 9938412
    Abstract: This invention relates to bis-azo colorants for use as bluing agents, laundry care compositions comprising bis-azo colorants that may serve as bluing agents, processes for making such bluing agents and laundry care compositions and methods of using the same. The bluing agents are generally comprised of at least two components: at least one chromophore component and at least one polymeric component. These bluing agents are advantageous in providing a whitening effect to fabrics, while not building up over time and causing undesirable blue discoloration to the treated fabrics.
    Type: Grant
    Filed: January 8, 2015
    Date of Patent: April 10, 2018
    Assignee: Milliken & Company
    Inventors: Robert L Mahaffey, Jr., Xiaoyong Michael Hong, Eduardo Torres, Dominick J Valenti, Gregory Scot Miracle
  • Patent number: 9937133
    Abstract: The present invention relates an aldehyde dehydrogenase inhibitor for use in the treatment or prevention of fibrosis.
    Type: Grant
    Filed: May 1, 2015
    Date of Patent: April 10, 2018
    Assignee: UCL Business PLC
    Inventors: David Abraham, Virginia Calder, Sarah Dale
  • Patent number: 9908849
    Abstract: Imidamide (amidine) analogs that can inhibit the activity of sphingosine kinase 1 and sphingosine kinase 2 (SphK1 & SphK2) are provided. The compounds can prevent angiogenesis in tumors.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: March 6, 2018
    Assignee: University of Virginia Patent Foundation
    Inventors: Kevin R. Lynch, Timothy L. Macdonald, Thomas P. Mathews, Andrew Kennedy, Yugesh Kharel