Abstract: In accordance with the present invention, it has been discovered that various members of the steroid/thyroid superfamily of receptors can interact to form multimeric species comprising a complex of more than one receptor. Accordingly, the interaction of a first receptor species with a second receptor species modulates the ability of the first receptor species to trans-activate transcription of genes maintained under hormone expression control in the presence of the cognate ligand for said first receptor.
Type:
Grant
Filed:
June 5, 1995
Date of Patent:
May 2, 2006
Assignee:
The Salk Institute for Biological Studies
Inventors:
Ronald M. Evans, Steven A. Kliewer, Kazuhiko Umesono
Abstract: A method for identifying agents useful for protection of a human neuron from injury. The method includes the steps of providing a cell which has NMDA receptor; selecting a agent potentially useful for oxidation of the NMDA receptor; treating the cell with the agent; and determining whether the NMDA receptor is oxidized by the agent.
Type:
Grant
Filed:
May 19, 1994
Date of Patent:
February 25, 2003
Assignee:
The Children's Medical Center Corporation
Abstract: The invention in the field of cell biology relates to novel peptides able to interact with intracellular signal transducers, thus interfering with signal transduction pathways leading to cell proliferation and motility.The peptides of the invention may be chemically synthesized from single amino acids and/or preformed peptides of two or more amino acid residues.The peptides of the invention find an useful application in the treatment of a neoplastic disease.
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