Abstract: Described are cancer therapies and anti-cancer compounds. In particular, disclosed are inhibitors of Ack1 tyrosine kinase and their use in the treatment of cancer. Methods of screening for new Ack1 tyrosine kinase inhibitors are also disclosed. In specific example, compound having Formula I through IV are disclosed.
Type:
Grant
Filed:
August 6, 2014
Date of Patent:
December 26, 2017
Assignee:
H. Lee Moffitt Cancer Center and Research Institute, Inc.
Inventors:
Nupam P. Mahajan, Kiran N. Mahajan, Nicholas J. Lawrence, Harshani R. Lawrence