Abstract: An operation control system for an engine using alcohol fuel or mixed fuel of alcohol and hydrocarbon, or for an engine supplying cooling liquid such as alcohol, water or the like as fuel. Vapor concentration in exhaust gas and an air excess ratio of air-fuel mixture are detected, and a supply rate of alcohol, a water absorption ratio of alcohol or an amount of the cooling liquid is computed on the basis of the vapor concentration and the air excess ratio. Ignition timing, temperature of the coolant, a compression ratio and an air excess ratio are controlled on the basis of the supply rate of alcohol or the water absorption ratio of alcohol. Further, the cooling liquid is supplied which has its amount computed at a heavy load. Thus, operational performance of the engine is improved.