Abstract: Induced Pluripotent Stem Cell (Ipsc) technology enables the generation and study of living brain tissue relevant to Parkinson's disease (PD) ex vivo. Utilizing cell lines from PD patients presents a powerful discovery system that links cellular phenotypes observed in vitro with real clinical data. Differentiating patient-derived iPSCs towards a dopaminergic (DA) neural fate revealed that these cells exhibit molecular and functional properties of DA neurons in vitro that are observed to significantly degenerate in the substantia nigra of PD patients. Clinical symptoms that drive the generation of other relevant cell types may also yield novel PD-specific phenotypes in vitro that have the potential to lead to new therapeutic avenues for patients with PD.

Abstract: This invention provides a method of securing the tube ends of a plurality of explosively expandable metal tubes to a tube plate in which the tubes are inserted utilizing explosive cartridges equipped with a heat sensitive means. The heat sensitive means is in operative proximity to the explosive charges. There are also provided heating means capable of effectively heating the heat sensitive means. Expansion of the tubes located at multiple positions is effected by successively exploding the charges by the application of heat energy to the heat sensitive means.

Abstract: A puching press with a very strong main swanneck frame having an upper arm carrying a punching head equipped with an actuating slide, and a lower arm provided with an anvil. A rotary turret is provided with a plurality of punches engageable selectively with the actuating slide by rotation of the turret, and the turret is also provided with a plurality of punching dies each corresponding to a punch and locatable over the anvil by synchronous rotation with the punches. The turret is mounted on a second swanneck frame disposed outside of the slot of the first swanneck frame.

Abstract: A manipulator system for automatically feeding blanks into a gap press and for collecting finished articles therefrom has two major parts. The first part is a revolver table and the second part is an automatic handling device, or robot. The revolver table should be located between the press and the robot. It is stepwise rotatable around a vertical axis and has a number of arms each carrying a set of tools. The robot has at least two arms swingable around a vertical axis between positions for collecting blanks, for temporary holding of semiprocessed articles, as well as for placement of blanks and semifinished articles between selected tool sets on the arms of the revolver table and for sequential working in the press and for delivery of finished articles.

Abstract: By predetermined selection of tin coating weight in the manufacture of electrolytically tinplated continuous steel strip, cup formation of sheet metal blanks cut from such tinplated flat rolled steel with the selected tin coating weight disposed internally, selective reduction of sidewall gage and coating weight, maintenance of tin coating weight on the interior surface of the bottom wall, and selective organic coating, the present invention enables production of special container packs, previously limited to three-piece containers, from unitary seamless can bodies. Selected tin coating weight on the interior surface of the bottom wall of the can body is maintained throughout the manufacturing process and this surface is exposed to container contents. The sidewall interior surface of the can body is protected from exposure to container contents by an organic coating.

Abstract: Methods of and apparatus for the production of wire are presented. Previously, the most economic and popular process was drawing. In each pass, a small reduction was obtained and normally several dies in tandem were mounted on a single wire drawing machine. The process was continuous and precision wire was made. Also in the prior art, traditional rolling was a continuous process, but was limited to heavy and medium gauge, to small reductions per pass, and to poor dimensional and surface control. In comparison, traditional extrusion and hydrostatic extrusion are capable of large reductions, good dimensional control and surface finish, but are limited to finite wire or rod length. The more recent concepts of: continuous extrusion with viscous drag, continuous chamber extrusion, continuous extrusion forming, combined hydrostatic extrusion and drawing for fine wire and helical extrusion are compared and their advantages and shortcomings are discussed.

Abstract: A dual purpose spring coiling machine adapted for two point and single point coiling and particularly adapted for convenient and rapid convertibility from one form of coiling to the other. The machine comprises a coiling tool slide assembly mounted on a frame generally opposite a wire feed and guide means and adjacent a coiling station. The tool slide assembly comprises a coiling tool slide and a guide mountable selectively on the frame in three discrete positions. Right and left-hand two point coiling positions respectively employ mounting of the guide in first and second positions inclined upwardly and downwardly 221/2.degree. from the horizontal. Single point coiling is achieved with the guide mounted horizontally. Coiling tool holders mounted on the slide may be selectively moved from one position to another for right and left-hand coiling with a first holder mounted on and movable with the slide.