Abstract: The omega-hydroxylase activity in the yeast Candida tropicalis is increased by amplification of the P450ALK and P450RED genes. The specific productivity (grams of dicarboxylic acid/liter/hr) of substantially pure alpha, omega-dicarboxylic acids is increased by culturing C. tropicalis strains having amplified P450ALK and P450RED genes.
Type:
Grant
Filed:
April 19, 1995
Date of Patent:
July 15, 1997
Assignee:
Henkel Corporation
Inventors:
Stephen Picataggio, Tracy Rohrer, L. Dudley Eirich