Patents Examined by Robert Shiao
  • Arylindenopyridines and related therapeutic and prophylactic methods
    Patent number: 6958328
    Abstract: This invention provides novel arylindenopyridines of the formula: , and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by reducing PDE activity in appropriate cells. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.
    Type: Grant
    Filed: April 16, 2002
    Date of Patent: October 25, 2005
    Assignee: Ortho-McNeil Pharmaceutical, Inc
    Inventors: Geoffrey R. Heintzelman, Kristin M. Averill, John H. Dodd
  • Polyisoprenylbenzophenone derivatives, processes for their preparation and use thereof
    Patent number: 6956061
    Abstract: The present invention relates to compounds of the formula (I): which are produced by the plant Garcinia punctata, chemical derivatives derived therefrom, a process for their preparation, and their use as pharmaceuticals, in particular for the treatment and/or prophylaxis of bacterial infectious diseases.
    Type: Grant
    Filed: July 31, 2003
    Date of Patent: October 18, 2005
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Matthias Schiell, Michael Kurz, Sabine Haag-Richter
  • Aryl and heteroaryl compounds as antibacterial and antifungal agents
    Patent number: 6951880
    Abstract: This invention provides novel compounds possessing antibacterial and/or antifungal and/or antitumor activity. Pharmaceutical compositions containing these compounds, methods of making and methods for using these compounds are also provided.
    Type: Grant
    Filed: May 15, 2003
    Date of Patent: October 4, 2005
    Assignee: Genelabs Technologies, Inc.
    Inventors: Christoher Don Roberts, Jesse Daniel Keicher, Mikail Hakan Gezginci, Mark Douglas Velligan
  • Labeled peptides, proteins and antibodies and processes and intermediates useful for their preparation
    Patent number: 6951947
    Abstract: The invention provides peptide synthons having protected functional groups for attachment of desired moieties (e.g. functional molecules or probes). Also provided are peptide conjugates prepared from such synthons, and synthon and conjugate preparation methods including procedures for identifying the optimum probe attachment site. Biosensors are provided having environmentally sensitive dyes that can locate specific biomolecules within living cells and detect chemical and physiological changes in those biomolecules as the living cell is moving, metabolizing and reacting to its environment. Methods are included for detecting GTP activation of a Rho GTPase protein using polypeptide biosensors. When the biosensor binds GTP-activated Rho GTPase protein, the environmentally sensitive dye emits a signal of a different lifetime, intensity or wavelength than when not bound.
    Type: Grant
    Filed: April 20, 2001
    Date of Patent: October 4, 2005
    Assignee: The Scripps Research Institute
    Inventors: Klaus M. Hahn, Alexei Toutchkine
  • Triamide-substituted heterobicyclic compounds
    Patent number: 6949572
    Abstract: The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.
    Type: Grant
    Filed: August 13, 2003
    Date of Patent: September 27, 2005
    Assignee: Pfizer Inc.
    Inventors: Peter Bertinato, Brian S. Bronk, Alan E. Blize, Hengmiao Cheng, Jin Li, Hiep Huatan, Clive Mason
  • Insecticidal 3-(2,6-disubstituted phenyl)-5-[5-arylthien-3-yl]-1,2,4-triazoles
    Patent number: 6949576
    Abstract: Triazole compounds having a 2,6-disubstituted-phenyl group in the 3-position, 5?-arylthien-3-yl group in the 5-position and an alkyl group in the 1-position are effective in controlling lepidoptera, coleoptera, mites and other sucking pests.
    Type: Grant
    Filed: September 17, 2003
    Date of Patent: September 27, 2005
    Assignee: Dow AgroSciences LLC
    Inventors: Vidyadhar Babu Hegde, Scott Jerome Bis, Maurice Chee Hoong Yap, Denise Marie Perreault, Francis Eugene Tisdell, Leonard Paul Dintenfass, James Edwin Dripps, James Michael Gifford, Katherine Anne Guenthenspberger, Laura Lee Karr, Joe Raymond Schoonover
  • 3-substituted-3-(substitutedsulfonyl or sulfanyl) pyrrolidine-2,5-diones useful for inhibition of farnesyl-protein transferase
    Patent number: 6949661
    Abstract: The invention relates to compounds of Formula (I), to processes for their preparation and pharmaceutical compositions thereof, that inhibit the Ras farnesyl-protein transferase enzyme (FPTase), and may be used as an alternative to, or in conjunction with, traditional cancer therapy for the treatment of ras oncogene-dependent tumors, such as cancers of the pancreas, colon, bladder, and thyroid.
    Type: Grant
    Filed: September 26, 2003
    Date of Patent: September 27, 2005
    Assignee: Wyeth Holdings Corporation
    Inventors: Joseph William Epstein, Semiramis Ayral-Kaloustian
  • Synthesis of peptoid substituted azole compounds
    Patent number: 6946562
    Abstract: Disclosed is a process for the preparation of a peptoid substituted azole compound comprising reacting an amino functionalized azole compound with a resin bound peptoid oligomer bearing a terminal halogen substituent followed by cleavage of the resultant product from the resin surface using a fluorinated organic acid in an inert solvent.
    Type: Grant
    Filed: December 12, 2001
    Date of Patent: September 20, 2005
    Assignee: Eastman Kodak Company
    Inventors: Donald R. Diehl, Robert J. Niger, Hans F. Schmitthenner, William J. Sonnefeld, Richard P. Dunlap
  • Process for the isolation and purification of epothilones
    Patent number: 6946561
    Abstract: The invention relates to a desorption process for epothilones, especially epothilone A and/or epothilone B, from resins and new production, work-up or purification processes or manufacturing methods for epothilones comprising said desorption process, as well as the use of certain solvents for the desorption of epothilones from resins.
    Type: Grant
    Filed: December 5, 2001
    Date of Patent: September 20, 2005
    Assignee: Novartis AG
    Inventors: Ernst Küsters, Heinz Unternährer
  • Quarternary ammonium compounds
    Patent number: 6939889
    Abstract: Novel compounds and pharmaceutical compositions containing such compounds and possessing anti-tussive activity, and a method of administering the same to warm-blooded animals, including humans.
    Type: Grant
    Filed: December 23, 2003
    Date of Patent: September 6, 2005
    Assignee: UCB Farchim SA
    Inventors: Gregory N. Beatch, Lewis S. L. Choi, Clive P. Page, Bertrand M. C. Plouvier, Yuzhong Liu
  • Hydroxy substituted fused naphthyl-azoles and fused indeno-azoles and their use for the treatment of glaucoma
    Patent number: 6933392
    Abstract: Hydroxy substituted fused naphthyl-azoles and fused indeno-azoles are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions containing one or more of the compounds of the present invention.
    Type: Grant
    Filed: May 28, 2003
    Date of Patent: August 23, 2005
    Assignee: Alcon, Inc.
    Inventors: Jesse A. May, Paul W. Zinke
  • sPLA2 inhibitors
    Patent number: 6930123
    Abstract: A novel class of benz[f]indole compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: August 16, 2005
    Assignee: Eli Lilly and Company
    Inventors: Douglas Wade Beight, Michael Dean Kinnick, Ho-Shen Lin, John Michael Morin, Michael Enrico Richett, Daniel Jon Sall, Jason Scott Sawyer, Edward C R Smith
  • Biaromatic compound activators of PPAR?-type receptors
    Patent number: 6927228
    Abstract: The invention relates to novel biaromatic compounds which correspond to the general formula (I) below: and also to the method for preparing them and their use in pharmaceutical compositions intended for use in human or veterinary medicine (in dermatology, and also in the field of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or alternatively in cosmetic compositions.
    Type: Grant
    Filed: February 10, 2003
    Date of Patent: August 9, 2005
    Assignee: Galderma Research & Development, S.N.C.
    Inventors: Jean-Michael Bernardon, Laurence Clary
  • Reduction of monomer content and stabilization of polyaziridines
    Patent number: 6927297
    Abstract: The invention relates to a process for reducing the monomeric aziridine content in a polyaziridine forming reaction mixture by adding to the polyaziridine forming reaction mixture an excess of an organic carbonate scavenger wherein the excess is based on the equivalent ratio of scavenger to monomeric aziridine, and to a product obtained by this process and to a coating composition containing the product obtained by the process.
    Type: Grant
    Filed: October 31, 2002
    Date of Patent: August 9, 2005
    Assignee: Bayer MaterialScience LLC
    Inventors: Lanny D. Venham, Douglas A. Wicks, Karsten Danielmeier, Joseph P. Mandara
  • Substituted triazole diamine derivatives as kinase inhibitors
    Patent number: 6924302
    Abstract: The present invention provides substituted triazole diamine derivatives as selective kinase or dual-kinase inhibitors and a method for treating or ameliorating a selective kinase or dual-kinase mediated disorder.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: August 2, 2005
    Assignee: Ortho McNeil Pharmaceutical, Inc.
    Inventors: Ronghui Lin, Peter J. Connolly, Steven K. Wetter, Shenlin Huang, Stuart L. Emanuel, Robert H. Gruninger, Steven A. Middleton
  • Aralkyl and aralkylidene heterocyclic lactams and imides
    Patent number: 6921760
    Abstract: The present invention relates to compounds of the formula Orosco wherein R1, R2, R3, X, Y and the dashed line are defined as in the specification, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. These compounds are useful as psychotherapeutic agents.
    Type: Grant
    Filed: November 6, 2001
    Date of Patent: July 26, 2005
    Assignee: Pfizer Inc.
    Inventor: Harry Ralph Howard
  • Five-membered-ring compound
    Patent number: 6919361
    Abstract: A 5-membered cyclic compound of the formula: wherein X is oxygen or sulfur, R1 is hydrogen, substituted or unsubstituted alkyl, etc., R2 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, etc., Y1 is a direct bond, substituted or unsubstituted alkylene, —CO(CH2)n—, etc., the wavy line means (E)-configuration or (Z)-configuration, R3 is substituted or unsubstituted aryl, etc., Y2 is substituted or unsubstituted alkylene, etc., R4 is hydrogen, substituted or unsubstituted alkanoyl, substituted or unsubstituted alkyl, etc., R5 is hydrogen, etc., or a salt thereof, these compound being able to inhibit infiltration of leukocytes such as eosinophils and lymphocytes, by which being useful for the treatment of various kinds of inflammation.
    Type: Grant
    Filed: June 28, 2001
    Date of Patent: July 19, 2005
    Assignee: Sumitomo Pharmaceuticals Company, Limited
    Inventors: Norio Fujiwara, Hitoshi Fujita, Fujio Antoku, Toshinari Sugasawa, Hajime Kawakami
  • Losartan potassium synthesis
    Patent number: 6916935
    Abstract: A process for the synthesis of Losartan Potassium by reacting Trityl Losartan in a primary alcohol with potassium tertiary alkoxide.
    Type: Grant
    Filed: May 7, 2003
    Date of Patent: July 12, 2005
    Assignee: Ipca Laboratories
    Inventors: Ashok Kumar, Rajeshkumar Singh, Nalinakshya Panda, Abhay Upare, Manmohan Nimbalkar, Satish Soudagar
  • Cystine derivative and agent for suppressing activation of inflammatory factors
    Patent number: 6914075
    Abstract: The present invention provides cystine derivatives, which may be in a free form, a salt form, a solvate form. The cystine derivatives of the present invention may be used to suppress activation of inflammatory factors. Accordingly, the present invention provides: compositions containing the cystine derivatives; a method for suppressing the activation of inflammatory factors by administering the composition; a method for preventing, ameliorating and/or therapeutically treating diseases, skin injuries or disorders involved in the activation of inflammatory factors by administering the composition; a method for preventing, delaying, ameliorating and/or therapeutically treating skin change via aging or aesthetically unfavorable skin change as induced or promoted by inflammatory factors by administering the composition; and pharmaceutical agents containing the cystine derivatives.
    Type: Grant
    Filed: August 4, 2003
    Date of Patent: July 5, 2005
    Assignee: Ajinomoto Co., Inc.
    Inventors: Takashi Nakano, Manabu Kitazawa, Keiji Iwasaki, Kazutami Sakamoto
  • 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
    Patent number: 6911461
    Abstract: The invention concerns 2-oxo-1-pyrrolidine derivatives of formula I, wherein the substituents are as defined in the specification, as well as their use as pharmaceuticals. The compounds of the invention are particularly suited for treating neurological disorders such as epilepsy.
    Type: Grant
    Filed: October 28, 2003
    Date of Patent: June 28, 2005
    Assignee: UCB, S.A.
    Inventors: Edmond Differding, Benoît Kenda, Bénédicte Lallemand, Alain Matagne, Philippe Michel, Patrick Pasau, Patrice Talaga