Abstract: Nitrated hydrocarbons, such as nitroparaffins, are reduced to amines by use of palladium on a carbon catalyst characterized by low ash and low halide.

Abstract: Nonaromatic hydrocarbons are converted to aromatic hydrocarbons by contacting with a molecular chromium trioxide-graphite intercalation catalytic compound under dehydrocyclization conditions of temperature and pressure. In one embodiment, normal hexane is converted to benzene in the presence of a graphite-chromium trioxide interlayered complex with good conversion and high selectivity.

Abstract: The invention provides new compounds of the formula:Ar--SO.sub.Y --Alk--NR.sub.1 R.sub.2in which Ar represents a phenyl group, a phenyl group substituted by one or more C.sub.1 -C.sub.4 alkyl, CF.sub.3 and COOH groups, or a 2-benzimidazolyl group optionally substituted in the 1-position, Y is 0 or 1, Alk is a C.sub.2 -C.sub.5 hydrocarbon radical with a straight or branched chain, and NR.sub.1 R.sub.2 is a secondary, tertiary or N-heterocyclic amino group, and their addition salts which show pharmacological activity, e.g. as analgesics, anti-inflammatory agents, and anorexigenic agents.

Abstract: The present invention is related to new basic enol ethers having the general formula ##STR1## and to the pharmacologically acceptable acid addition salts thereof. The invention is further related to process for the treatment of spasmodic conditions in humans by administering a compound of the above general formula or a pharmacologically acceptable acid addition salt thereof to a human suffering from such conditions.

Abstract: An improved process for the preparation of methylene-bridged polyarylpolyamines by the acid catalyzed condensation reaction of an aromatic primary amine and formaldehyde is disclosed wherein nitrilotriacetic acid is employed as the catalyst system. An aromatic primary amine and formaldehyde are mixed and reacted at an elevated temperature in the presence of a catalytic amount of nitrilotriacetic acid which provides a resulting reaction product that does not have to be subjected to neutralization procedures or filtration for catalyst removal as heretofore required. The reaction product mixtures of methylene-bridged polyarylpolyamines has excellent color and can be employed without further treatment as epoxy curing agents, urethane cross linkers, as precursors for the preparation of corresponding methylene-bridged polyarylpolyisocyanates, and the like. The employment of nitrilotriacetic acid also leads to the completion of the condensation reaction in relatively short periods of time.

Abstract: This invention relates to 2-omega-aminoalkoxydiphenylethers and derivatives thereof which are pharmocologically active as antidepressants.

Abstract: Substituted-iminodimethylene-di-tert-alkylophenones, e.g., 4",4"'-methyliminodimethylene-dipivalophenone, are prepared by treating a corresponding .alpha.-halo-p-tert-alkanoyl toluene with a substituted amine. The phenols are prepared from the corresponding phenones and both the phenones and the phenols are useful as hypolipidemic agents.

Abstract: The instant invention is directed to a novel process for the production of aromatic polyamines. The process of the invention comprisesA. condensing an aromatic amine with formaldehyde in the presence of a hydrophobic solvent and in the absence of an acid catalyst to produce a pre-condensate mixture containing the corresponding N,N'-disubstituted aminals,B. removing substantially all the water from said pre-condensate mixture to produce a first organic phase,C. extracting said first organic phase with an aqueous solution containing an acid catalyst thereby producing a second organic phase and an aqueous pre-condensate phase which contains said aminals,D. subjecting said aqueous pre-condensate phase to a rearrangement reaction thereby producing an aqueous condensation mixture containing said aromatic polyamines,E.

Abstract: 2-Omega-aminoalkoxydiphenyl sulfides are prepared and found useful as pharmaceutical agents, particularly as antidepressants.

Abstract: 2-(3-Alkylaminopropoxy) diphenylmethanes have been produced and have been found to possess antidepressant activity.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, chlorine, hydroxyl, trifluoromethyl, methyl or methoxy, andR.sub.2 is hydrogen, alkyl of 1 to 2 carbon atoms or benzyl;And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as hypertensives.

Abstract: Compounds, pharmaceutical preparations containing same, and method of treating depression in mammals, the compounds being of the formula I ##STR1## or an acid addition salt thereof, particularly a pharmacologically or pharmaceutically acceptable salt thereof, where R and R.sup.1 are the same or different and are each hydrogen or lower alkyl, or R and R.sup.1 taken together are (CH.sub.2).sub.X where X is 4 or 5, or NRR.sup.1 is ##STR2## where Y is 3 or 4 and R.sup.3 is hydrogen or lower alkyl, or NRR.sup.1 is ##STR3## where R.sup.2 is hydrogen or lower alkyl, in the above lower alkyl has 1 to 4 carbons and may be straight or branched and n and m are the same or different and are 1, 2, or 3.

Abstract: Compounds of the formula ##STR1## wherein X, n and B are as defined herein are useful as intermediates in preparing compounds which exhibit antidepressant activity.

Abstract: Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof; processes for their preparation; intermediates useful for their preparation; pharmaceutical preparations containing at least one of these compounds; and the use thereof as a tranquilizing or neuroleptic agent.

Abstract: Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein X and Y are the same or different and each representing a hydrogen atom, a chloro or a methoxy group, n is an integer 0 or 1 and R.sup.1 and R.sup.2 are the same or different and each representing a hydrogen atom or a methyl group; processes for their preparation; pharmaceutical preparations containing at least one of these compounds and the use thereof in the treatment of depressive states.

Abstract: Covers a method of preparing diaminodiphenylmethanes and higher homologues thereof which comprises the step of condensing aniline and formaldehyde in the presence of a barium nitride catalyst. In another embodiment the barium nitride catalyst is used in conjunction with a silicon nitride catalyst.

Abstract: Covers a method of preparing diaminodiphenylmethanes and higher homologues thereof which comprises the step of condensing aniline and formaldehyde in the presence of an aluminum silicide catalyst.

Abstract: Biologically active substances having labile aryl groups can be converted to the corresponding aryl amine derivatives. The biologically active substances are reacted with a diazonium compound which optionally can be linked to a solid, inorganic carrier such as porous glass beads for ease of purification. The diazo reaction product is then reductively cleaved with a chemical reducing agent such as with hydrosulfite to yield the desired amine derivative. A preferred class of biologically active substances used herein is the catecholamines.

Abstract: Benzobicycloalkane amines, their pharmacologically acceptable addition salts, intermediates therefore the processes for their preparation and use. The compounds of the invention exert analgesic and anti-inflammatory activity.

Abstract: The invention relates to novel 1-(4-R.sub.1 O-phenyl)-2-(4-R.sub.2 -phenyl)-6-R.sub.3 -1,2,3,4-tetrahydroquinolines having anti-fertility and hypocholesterolemic activities, to their preparation, and to novel intermediates therefor.