Abstract: This invention realtes to compounds formula I
and pharmaceutically acceptable salts thereof, which are inhibitors of protein kinase activity, pharmaceutical compositions thereof and provesses for their preparation.
Type:
Grant
Filed:
October 12, 2000
Date of Patent:
October 2, 2001
Assignee:
BASF Aktiengesellschaft
Inventors:
Kevin Doyle, Paul Rafferty, Robert Steele, Allyson Turner, David Wilkins, Lee Arnold
Abstract: Disclosed are compounds that are highly selective partial agonists or antagonists at human CRF.sub.1 receptors that are useful in the diagnosis and treatment of treating stress related disorders such as post traumatic stress disorder (PTSD) as well as depression, headache and anxiety. The compounds have the formula ##STR1## or the pharmaceutically acceptable salts thereof wherein Ar, R.sub.1, R.sub.2, A, and Z are various organic and inorganic substituents.
Abstract: The use of halo-benzotriazoles as corrosion inhibitors in aqueous systems is disclosed. Specific isomers of chloro-methylbenzotriazole were found to be more effective corrosion inhibitors than tolyltriazole in the presence of chlorine.
Type:
Grant
Filed:
June 24, 1998
Date of Patent:
October 19, 1999
Assignee:
BetzDearborn Inc.
Inventors:
Sydia B. Anderson, Longchun Cheng, Michael A. Cady
Abstract: The present invention is directed to the novel intermediate compounds of the formula: ##STR1## wherein, interalia, R.sub.4 is a substituted phenyl or an optionally substituted napthyl derivative.
Type:
Grant
Filed:
May 9, 1997
Date of Patent:
October 19, 1999
Assignee:
SmithKline Beecham Corporation
Inventors:
Jerry Leroy Adams, Peter William Sheldrake, Timothy Francis Gallagher, Ravi Shanker Garigipati, Paul Elliot Bender, Jeffrey Charles Boehm, Joseph Sisko, Zhi-Qiang Peng, John C. Lee
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