Patents Examined by Robert W. Ramsuen
  • Synthesis and biological evaluation of analogs of the antimitotic marine natural product curacin A
    Patent number: 6392055
    Abstract: The present invention provides an efficient synthetic strategy for the preparation of analogs that incorporate important structural elements of the marine natural product curacin A, the compositions and various uses of the compositions. The most active of these compounds at nanomolar concentrations inhibit tubulin polymerization, show growth inhibition activity, inhibited colchicines binding to tubulin and block mitotic progression. The compounds of the present invention represent some of the most potent synthetic curacin A analogs synthesized, with an activity profile rivaling that of the natural product despite the simplified structure, greater water solubility, and increased chemical stability.
    Type: Grant
    Filed: July 19, 2001
    Date of Patent: May 21, 2002
    Assignee: The University of Pittsburgh
    Inventors: Peter Wipf, Jonathan T. Reeves, Billy W. Day, Raghavan Balachandran
  • Enantiomer of carbazole derivative as 5-HT1-like agonists
    Patent number: 5962501
    Abstract: A (+) or (-) enantiomer of a compound of formula (I) wherein R.sup.4 is methyl or ethyl, or a salt, solvate, or hydtrate thereof, processes for preparing said compounds and pharmaceutical compostions containing them. Compounds of formula (+) are 5-HT.sub.1 -like agonists.
    Type: Grant
    Filed: December 23, 1996
    Date of Patent: October 5, 1999
    Assignee: SmithKline Beecham, p.l.c.
    Inventors: Gary Thomas Borrett, John Kitteringham, Roderick Alan Porter, Mark Ralph Shipton, Mythily Vimal, Rodney Christopher Young
  • 3, 5-disubstituted and 3, 4, 5-trisubstituted 2-isoxazolines and isoxazoles, process for their preparation and their use as pharmaceuticals
    Patent number: 5814627
    Abstract: A compound having the formula (I), a physiologically tolerable salt of the compound having the formula (I) and/or a steroisomeric form of the compound having the formula (I), in which one residue R.sup.1 or R.sup.2 stands for the formula (II), are suitable for preparing medicaments for the therapy of inflammations, asthma, rheumatoid diseases and auto-immune diseases.
    Type: Grant
    Filed: November 19, 1996
    Date of Patent: September 29, 1998
    Assignee: Hoechst Aktienegesellschaft
    Inventors: Wilfried Schwab, Hiristo Anagnostopulos, Robert Ryder Bartlett, Rudolf Schleyerbach, Klaus Ulrich Weithmann