Patents Examined by Robert W. Ramsuer
  • Fused pyrazolyl compounds
    Patent number: 6518294
    Abstract: A fused pyrazolyl compound of the following formula: wherein each of Ar1, Ar2, and Ar3, independently, is phenyl, thienyl, pyrrolyl, or furyl, optionally substituted with halo, alkyl, carboxyl, alkoxycarbonyl, thiocarbonyl, aminocarbonyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl, or thioalkyl; each of X and Y, independently, is O, S, or NH; m is 1, 2, or 3; and n is 0, 1, 2, 3, or 4. Also disclosed is a pharmaceutical composition containing a pharmaceutically effective amount of the compound described above.
    Type: Grant
    Filed: January 24, 2002
    Date of Patent: February 11, 2003
    Assignee: Yung Shin Pharmaceutical Ind. Co.
    Inventors: Che-Ming Teng, Sheng-Chu Kuo, Fang Yu Lee
  • Acetal compound, polymer, resist composition and patterning response
    Patent number: 6515149
    Abstract: Acetal compounds in which a 5- or 6-membered ring acetal structure is connected to a norbornene structure through a linker represented by —(CH2)m— in which one hydrogen atom may be substituted with a hydroxyl or acetoxy group, and m is from 1 to 8 are novel. Using the acetal compounds as a monomer, polymers are obtained. A resist composition comprising the polymer as a base resin is sensitive to high-energy radiation and has excellent sensitivity, resolution, and etching resistance.
    Type: Grant
    Filed: August 7, 2001
    Date of Patent: February 4, 2003
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Takeru Watanabe, Takeshi Kinsho, Koji Hasegawa, Tsunehiro Nishi, Mutsuo Nakashima, Seiichiro Tachibana, Jun Hatakeyama
  • Method for producing N-substituted 2-pyrazoline-5-one
    Patent number: 6515139
    Abstract: The present invention relates to a process for preparing N-substituted 2-pyrazolin-5-ones of the formula I where R has the meaning given in claim 1, which comprises reacting a compound of the formula II where R, X and Y have the meanings given in claim 1, at elevated temperature with a molar excess of alkali metal hydroxide in an aqueous reaction medium and then adjusting the pH to pH≦6 by adding an acid.
    Type: Grant
    Filed: May 13, 2002
    Date of Patent: February 4, 2003
    Assignee: BASF Aktiengesellschaft
    Inventors: Hans Rupert Merkle, Erich Fretschner, Knut Koob
  • Urotensin-II receptor antagonists
    Patent number: 6514970
    Abstract: The present invention relates to pyrrolidiones, pharmaceutical compostions containing them and their use as antagonist of urotensin II.
    Type: Grant
    Filed: June 13, 2002
    Date of Patent: February 4, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Dashyant Dhanak, Steven David Knight, Gregory Lee Warren, Jian Jin, Katherine L. Widdowson, Richard McCulloch Keenan
  • Bisphenol aryl fluoride AB2 monomer and the hyperbranched polymer therefrom
    Patent number: 6512124
    Abstract: A self-polymerizable AB2 monomer of the formula The resulting AB2 monomer can be polymerized to afford high molecular, low viscosity hyperbranched ether-ketone-imide polymer having repeating units with hydroxyl endgroups.
    Type: Grant
    Filed: February 27, 2002
    Date of Patent: January 28, 2003
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: Jong-Beom Baek, Loon-Seng Tan
  • Process using a titanium-containing silicon oxide catalyst
    Patent number: 6512128
    Abstract: A titanium-containing silicon oxide catalyst satisfying all of the following conditions (1) to (4): (1): an average pore size of 10 Å or more, (2): a pore size of 90% or more of the total pore volume of 5 to 200 Å, (3): a specific pore volume of 0.2 cm3/g or more, and (4): a quarternary ammonium ion represented by the following general formula (I) is used as a template and then said template is removed by solvent extraction operation; [NR1R2R3R4]+  (I) wherein, R1 represents a linear or branched hydrocarbon chain having 2 to 36 carbon atoms, and R2 to R4 represent an alkyl group having 1 to 6 carbon atoms, a method for producing said catalyst, and a method for producing propylene oxide by reacting propylene with a hydroperoxide, except for ethylbenzene hydroperoxide, in the presence of said catalyst.
    Type: Grant
    Filed: October 2, 2001
    Date of Patent: January 28, 2003
    Assignee: Sumitomo Chemical Company Limited
    Inventors: Jun Yamamoto, Junpei Tsuji
  • Energetic triazolium salts
    Patent number: 6509473
    Abstract: New energetic salts of 1,2,4-triazole; 3,4,5-triamino-1,2,4-triazole and of 4-amino 1,2,4-triazole were synthesized, characterized and their thermal and safety properties evaluated as possible new propellant ingredients. Energetic anions, including the nitrate anion, NO3, the perchlorate anion, ClO4, & the dinitramide anion, N(NO2)2, were paired with the protonated heterocycles through facile, high yield synthetic routes to give crystalline, energetic salts. Using such a heterocycle system, either 1,2,4-triazole; 3,4,5-triamino-1,2,4-triazole or 4-amino 1,2,4-triazole, a new family of salts were synthesized through the direct reaction of the heterocycle with the corresponding acid form of the desired anion. These reactions were carried out in commonly available polar solvents, and at ambient temperatures, to give high purity, high yield products.
    Type: Grant
    Filed: October 16, 2000
    Date of Patent: January 21, 2003
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventor: Greg W. Drake
  • Aromatic heterocyclic compounds as antiinflammatory agents
    Patent number: 6506748
    Abstract: Disclosed are novel aromatic heterocyclic compounds of the formula(I) wherein Ar1,Ar2,L,Q and X are described herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are processes of making such compounds.
    Type: Grant
    Filed: June 26, 2001
    Date of Patent: January 14, 2003
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Eugene R. Hickey, John R. Regan
  • Use of 1,3-substituted pyrazol-5-yl sulfonates as pesticides
    Patent number: 6506784
    Abstract: The present invention is directed to inhibiting pest GABA receptors by contacting said receptors with a compound of Formula I: The invention is also directed to methods of controlling pests, especially insects and arachnids such as fleas and ticks, and to novel compounds within the scope of Formula I.
    Type: Grant
    Filed: June 29, 2000
    Date of Patent: January 14, 2003
    Assignees: 3-Dimensional Pharmaceuticals, Inc., Heska Corporation
    Inventors: Daljit S. Dhanoa, Dario Doller, Sanath Meegalla, Richard M. Soll, Dimitris Agrafiotis, Nancy Wisnewski, Gary M. Silver, Dan T. Stinchcomb, R. Lee Seward
  • 3-(heterocyclyl)-benzoylpyrazole-derivatives
    Patent number: 6506708
    Abstract: 3-(Heterocyclyl)benzoylpyrazole derivatives of the formula I where: X is O, NH or N-alkyl; R1 is nitro, halogen, alkoxy, haloalkoxy, alkylthio, haloalkylthio, alkylsulfonyl or haloalkylsulfonyl; R2,R3,R4,R5 are hydrogen, alkyl or haloalkyl; R6 is halogen, nitro, haloalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, alkylsulfonyl or haloalkylsulfonyl; R7 is hydroxyl, alkoxy, alkenyloxy, alkylsulfonyloxy, alkylcarbonyloxy, (alkylthio)carbonyloxy, phenylsulfonyloxy or phenylcarbonyloxy, where the phenyl radical may be substituted; R8,R9 are alkyl; R10 is hydrogen or alkyl; R11 is hydrogen or alkyl; and their agriculturally useful salts, compounds for their preparation, and the use of these compounds or of compositions comprising them for controlling undesirable plants are described.
    Type: Grant
    Filed: May 1, 2001
    Date of Patent: January 14, 2003
    Assignee: BASF Aktiengesellschaft
    Inventors: Ulf Neidlein, Norbert Götz, Ulf Misslitz, Roland Götz, Ernst Baumann, Wolfgang von Deyn, Steffen Kudis, Klaus Langemann, Guido Mayer, Matthias Witschel, Martina Otten, Karl-Otto Westphalen, Helmut Walter
  • Indole and dihydroindole derivatives
    Patent number: 6503907
    Abstract: The present invention relates to indole derivatives, dihydroindole derivatives and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
    Type: Grant
    Filed: November 20, 2001
    Date of Patent: January 7, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean Ackermann, Johannes Aebi, Henrietta Dehmlow, Olivier Morand, Narendra Panday, Thomas Weller
  • Pesticidal 1-arylpyrazoles
    Patent number: 6500850
    Abstract: The invention relates to novel 1-arylpyrazole oxime derivatives, of general formula (I) or (I bis) These compounds are found to be generally safe systemic insecticides for control of arthropod, nematode, helminth or protozoan pests including compositions and derivatives thereof.
    Type: Grant
    Filed: October 5, 2001
    Date of Patent: December 31, 2002
    Assignee: Rhone-Poulenc Inc.
    Inventors: Tai-Teh Wu, Alain Chene, David Treadway Manning, Peter Wyatt Newsome, Nicholas Charles Ray, Jennifer Lantz Phillips, Patrick Doyle Lowder
  • Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation
    Patent number: 6492411
    Abstract: A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders.
    Type: Grant
    Filed: April 17, 2002
    Date of Patent: December 10, 2002
    Assignee: G. D. Searle & Co.
    Inventors: John J Talley, Thomas D Penning, Paul W Collins, Donald J Rogier, Jr., James W Malecha, Julie M Miyashiro, Stephen R Bertenshaw, Ish K Khanna, Matthew J Graneto, Roland S Rogers, Jeffery S Carter, Stephen H. Docter, Stella S Yu
  • Bis pyrazole-1H-pyrazole intermediates and their synthesis
    Patent number: 6492529
    Abstract: Disclosed are aromatic heterocyclic compounds of the formula (I) wherein Ar1, Ar2, L, Q and X are described herein, and intermediate compounds useful for making such compounds. The compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are processes of making compounds of the formula (I), their intermediates and processes of making such intermediates, including bis pyrazole-1H-pyrazole intermediates of the formula: wherein Alk, Rx and Rz are described herein.
    Type: Grant
    Filed: February 5, 2002
    Date of Patent: December 10, 2002
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Suresh R. Kapadia, Jinhua J. Song, Nathan K. Yee
  • Process to produce oxazolidinones
    Patent number: 6492555
    Abstract: The present invention includes a number of novel intermediates such as the (S)-secondary alcohol of formula (VIIIA) X2—CH2—C*H(OH)—CH2—NH—CO—RN  (VIIIA) and processes for production of pharmacologically useful oxazolidinones.
    Type: Grant
    Filed: January 15, 2002
    Date of Patent: December 10, 2002
    Assignee: Pharmacia & Upjohn Company
    Inventor: Bruce Allen Pearlman
  • Highly selective herbicidal phenoxypropionic acid alkoxycarbonyl anilid compounds and method of preparing the same
    Patent number: 6489268
    Abstract: The present invention relates to high selective herbicidal phenoxypropionic acid alkoxycarbonyl anilid compounds represented in formula 1, method of preparing thereof, their use to control barnyard grass produced from rice, and a composition as suitable herbicides, wherein R is a hydrogen atom, methyl or ethyl group; R1 is a hydrogen atom, C1-C6 alkyl, C1-C6 alkyl substituted with 1 to 3 of the group consisting of hydroxy, carboxyl, and a halogen atom, C3-C6 cycloalkyl, C3-C4 alkenyl, C3-C4 alkinyl, or C2-C4 alkoxyalkyl group; n is an integer of 1 or 2 and when n is 2, R1 can be a combination of other substituents.
    Type: Grant
    Filed: January 29, 2002
    Date of Patent: December 3, 2002
    Assignee: Dongbu Hannong Chemical Co., Ltd.
    Inventors: Dae Whang Kim, Hae Sung Chang, Young Kwan Ko, Jae Wook Ryu, Jae Chun Woo, Dong Wan Koo, Tae-Joon Kim
  • C3A receptor ligands
    Patent number: 6489339
    Abstract: A compound according to Formula (I): wherein: A represents C1-4 alkylene, unsubstituted or optionally substituted by C1-4 alkyl or aryl; or A forms a 5-8 membered fused aliphatic ring with the adjacent phenyl ring; m is an integer from 1 to 3; each R1 is independently selected form the group consisting of halo, C1-4 alkyl, methanesulfonyl, alkoxy, nitrile, dimethylamine, methylenedioxy and CF3; and R2 is hydrogen or methyl is provided.
    Type: Grant
    Filed: February 7, 2001
    Date of Patent: December 3, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Dennis Lee, William E. Bondinell, Anthony J. Jurewicz
  • Prodrugs for antimicrobial amidines
    Patent number: 6486200
    Abstract: A methods of treating an infection comprises administering a therapeutically effective amount of a compound described by the Formula (I): wherein: X may be O, S, or NR′ wherein R′ is H or loweralkyl; R1 and R2 may be independently selected from the group consisting of H, loweralkyl, oxyalkyl, alkoxyalkyl, cycloalkyl, aryl, hydroxyalkyl, aminoalkyl, and alkylaminoalkyl; R3 and R4 are each independently selected from the group consisting of H, loweralkyl, halogen, oxyalkyl, oxyaryl, and oxyarylalkyl; R5 is represented by a formula selected from the group consisting of:  wherein: X1, X2, and X3 are independently selected from O and S; and R6 and R7 are independently selected from the group consisting of loweralkyl, aryl, alkylaryl, oxyaryl, an ester-containing substituent, and oxyalkyl; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: July 7, 2000
    Date of Patent: November 26, 2002
    Assignees: The University of North Carolina at Chapel Hill, Georgia State University Research Foundation, Inc.
    Inventors: David W. Boykin, M. Syed Rahmathullah, Richard R. Tidwell, James E. Hall
  • 3-aminopyrazole inhibitors of cyclin dependent kinases
    Patent number: 6482842
    Abstract: The present invention describes compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds are protein kinase inhibitors and are useful in the treatment of proliferative diseases, for example, cancer, inflammation and arthritis. They may also be useful in the treatment of Alzheimer's disease, and cardiovascular disease.
    Type: Grant
    Filed: February 6, 2001
    Date of Patent: November 19, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Mark E. Salvati, S. David Kimball
  • Pesticidal 1-polyarylpyrazoles
    Patent number: RE37936
    Abstract: A compound of formula (I): compositions containing them and methods of use to control pests.
    Type: Grant
    Filed: July 13, 2001
    Date of Patent: December 10, 2002
    Assignee: Aventis CropScience USA Inc.
    Inventors: Jamin Huang, Scot Kevin Huber