Abstract: A novel process for the preparation of (R)-3-(4-Bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl-1-H-imidazo[1,2-&agr;]imidazol-2-one (1):
This compound is useful as an intermediate in the preparation of certain small molecules that are useful in the treatment or prevention of inflammatory and immune cell-mediated diseases. The present invention also relates to certain intermediates used in this novel process.
Type:
Grant
Filed:
February 15, 2002
Date of Patent:
October 1, 2002
Assignee:
Boehringer Ingelheim Pharmaceuticals, Inc.
Inventors:
Rogelio P. Frutos, Michael Dale Johnson
Abstract: A process for preparation of isoflavone compounds, comprising separating isoflavone compounds from a starting material containing isoflavone compounds and/or their precursors by means of extraction, wherein the starting material is subjected to removal of fat prior to the separation of isoflavone compounds by means of extraction.