Patents Examined by Robert Whittenbaugh
  • N6-substituted 9-methyladenines: a new class of adenosine receptor antagonists
    Patent number: 5066655
    Abstract: A series of 15 N.sup.6 -substituted 9-methyladenines have been assessed as antagonists of A.sub.2 -adenoisine receptor-mediated stimulation of adenylate cyclase in membranes of hman platelets and rat PC12 cells and of A.sub.1 -adenosine receptor-mediated inhibition of adenylate cyclases in membranes of rat fat cells and as inhibitors of binding of N.sup.6 -R-[.sup.3 H]-phenylisopropyladenosine to A.sub.1 adenosine receptors in rat brain membranes.
    Type: Grant
    Filed: October 6, 1989
    Date of Patent: November 19, 1991
    Assignee: Whitby Research, Inc.
    Inventor: Ray A. Olsson
  • Novel separation process
    Patent number: 5066806
    Abstract: A process for the recovery of isomeric pure 7-chloro-quinaldine from isomeric mixtures of chloro-quinaldines comprising dissolving the isomeric mixture of chloro-quinaldines in an organic solvent, adding an aqueous tartaric acid solution to the organic solution to form the tartrate of 7-chloro-quinaldine in crystalline form, recovering the crystals and treating the same with a base to obtain 7-chloro-quinaldine.
    Type: Grant
    Filed: August 13, 1990
    Date of Patent: November 19, 1991
    Assignee: Rutgerswerke AG
    Inventors: Emmerich Pastorek, Winfried Orth, Wolfgang Weiss, Hans W. Kleffner