Patents Examined by Robert Xu
  • Patent number: 9890325
    Abstract: A method of monitoring a location of a nanoparticle within a material is described herein. The method includes the steps of providing at least one nanoclay particle, attaching a fluorescent tag to the at least one nanoclay particle, and determining a fluorescence of the fluorescent-labeled nanoclay particle. The method also includes forming the material including the at least one fluorescent-labeled nanoclay particle, depositing the material in an aqueous solution, and detecting a movement of the fluorescent-labeled nanoclay particle from the material to the aqueous solution.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: February 13, 2018
    Assignee: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
    Inventors: Maria I. Rubino, Rafael A. Auras, Krishnamurthy Jayaraman, Yining Xia, Carlos Diaz, Joe Hotchkiss
  • Patent number: 9845499
    Abstract: A microfluidic device can have a plurality of microchambers connected to a microchannel via siphon apertures. The microfluidic device may be formed from a thermoplastic and capped by a thermoplastic thin film. The microfluidic device may be used for digital polymerase chain reactions by forcing reagent into the microchambers at low pressure via an inlet, forcing any gas trapped in the microfluidic device to outgas through the thin film by applying high pressure to the microfluidic device via inlets and outlets of the microfluidic device, and applying air at low pressure to the inlets in order to digitize the chambers such that the reagent in each chamber is isolated from the reagent in other chambers by an air gap. After digitization, the device may be used to run a digital polymerase chain reaction process.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: December 19, 2017
    Assignee: COMBINATI INCORPORATED
    Inventors: Ju-Sung Hung, Andrew Zayac, Megan Dueck
  • Patent number: 9846168
    Abstract: The present invention provides fluorogenic compounds for the detection of target metal ions wherein the compounds exhibit a Stokes shift greater than 50 nm and the detectable signal is modulated by photoinduced electron transfer (PET). The present compounds consist of three functional elements, the ion sensing moiety (chelating moiety), the reporter moiety (fluorophore or fluorescent protein) and spacer or linker between the sensing and reporter moieties of the present compound that allows for PET upon binding of a metal ion and excitation by an appropriate wavelength.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: December 19, 2017
    Assignee: Life Technologies Corporation
    Inventors: Kyle Gee, Vladimir Martin
  • Patent number: 9829436
    Abstract: The present invention relates to enhancement of detectable emissions from carbon nanodots or variants thereof by using the techniques of MEF to further enhance carbon nanodot brightness, photostability, and thus, potentially detectability in biological imaging applications by using plasmon supporting materials, such as silver island films and positioning of the carbon nanodots an optimal distance from the plasmon supporting materials.
    Type: Grant
    Filed: March 19, 2012
    Date of Patent: November 28, 2017
    Inventor: Chris D. Geddes
  • Patent number: 9824182
    Abstract: A process of determining whether a patient with a disease or disorder will be responsive to a drug, used to treat the disease or disorder, including obtaining a test spectrum produced by a mass spectrometer from a serum produced from the patient. The test spectrum may be processed to determine a relation to a group of class labeled spectra produced from respective serum from other patients having the or similar clinical stage same disease or disorder and known to have responded or not responded to the drug. Based on the relation of the test spectrum to the group of class labeled spectra, a determination may be made as to whether the patient will be responsive to the drug.
    Type: Grant
    Filed: August 6, 2010
    Date of Patent: November 21, 2017
    Assignee: Biodesix, Inc.
    Inventors: Heinrich Röder, Maxim Tsypin, Julia Grigorieva
  • Patent number: 9810638
    Abstract: A system and method for the detection of one or more analytes in a collected sample employs capillary action in a sample card containing a sample substrate, at least one test capsule and an absorbent pad. The absorbent pad absorbs the contents of the test capsule and delivers the same to the sample substrate, with the contents of the test capsule chemically reacting with at least one detection reagent to establish an optical indicator for the analyte(s). The sample card can be automatically tested within a reader device, which records and processes an optical signal produced by the chemical reaction and outputs a test result. The collected sample can then be further analyzed using a second device. Additionally, an adhesive component can be provided so that a sample can be collected thereon. Furthermore, the at least one detection reagent can include a surfactant.
    Type: Grant
    Filed: June 6, 2014
    Date of Patent: November 7, 2017
    Assignee: REDXDEFENSE, LLC
    Inventors: Arman Ghodousi, Sarah Josepha Toal, Gregory Scott Ericksen, Daniel Douglas Montgomery, Thomas Emory McVeigh, Jacek Kotowicz, Sean Conte
  • Patent number: 9810681
    Abstract: The invention includes compositions, devices, and methods for analyzing a polymer and/or polymer unit. The polymer may be a homo or hetero-polymer such as DNA, RNA, a polysaccharide, or a peptide. The device includes electrodes that form a tunnel gap through which the polymer can pass. The electrodes are functionalized with a reagent attached thereto, and the reagent is capable of forming a transient bond to a polymer unit. When the transient bond forms between the reagent and the unit, a detectable signal is generated and used to analyze the polymer.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: November 7, 2017
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Stuart Lindsay, Shuai Chang, Jin He, Peiming Zhang, Shuo Huang
  • Patent number: 9805165
    Abstract: A handheld diagnostic test device includes a port to removably receive a test cartridge, an element connected with an electronic device, and sensors for detection of test data from a biological or environment sample after reaction with reagents onboard the cartridge. The test device also includes memory storing algorithms for upload to the electronic device to enable a processor thereof: to await elapse of a pre-determined time following reaction of the sample with the reagents; to thereafter instruct the sensors to detect the test data; to generate presentation data based on the test data; and to present the presentation data from a presentation element of the electronic device to a user. A related method includes a connecting step, an uploading step, a presentation step, a cartridge inserting step, a waiting step, a sensing step, and an electronic device processing step.
    Type: Grant
    Filed: January 13, 2010
    Date of Patent: October 31, 2017
    Assignee: Fio Corporation
    Inventors: Qing Xiang, Jill Lindsey Osborne, Ryan Davey, Francois Dupoteau
  • Patent number: 9802177
    Abstract: A metal adsorption acrylic fiber wherein the strontium adsorption rate is 85% or more when the strontium adsorption rate is measured using the following measurement method. A strontium adsorption rate measurement method (strontium 0.1 ppm measurement method) involves immersing a metal adsorption acrylic fiber into an immersion fluid, collecting the immersion fluid as a testing solution 24 hours after beginning the immersion, analyzing the quantity of strontium in the testing solution, obtaining the concentration (C1) (ppm) of strontium in the testing solution, creating a contrast solution, analyzing the quantity of strontium in the contrast solution as in the case with the testing solution, obtaining the concentration (C2) (ppm) of strontium in the contrast solution, and calculating the strontium adsorption rate of the metal adsorption acrylic fiber by using the following equation: strontium adsorption rate (%)={(C2?C1)/C2}×100.
    Type: Grant
    Filed: January 25, 2013
    Date of Patent: October 31, 2017
    Assignee: Mitsubishi Chemical Corporation
    Inventors: Yukio Onohara, Tatsuhiko Inagaki, Yasuyuki Fujii, Masahiro Ootsubo, Hideaki Kobayashi
  • Patent number: 9797914
    Abstract: The invention features a method of monitoring a clotting process by measuring a signal characteristic of the NMR relaxation of water in a sample undergoing clotting to produce NMR relaxation data and determining from the NMR relaxation data a magnetic resonance parameter of water in the sample characteristic of the clots being formed.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: October 24, 2017
    Assignee: T2 Biosystems, Inc.
    Inventors: Thomas Jay Lowery, Jr., Vyacheslav Papkov, Walter W. Massefski, Jr., Rahul K. Dhanda, Edward Chris Thayer
  • Patent number: 9783497
    Abstract: The present invention relates to methods of determining the purity of a sample of 3,4-diaminopyridine comprising determining the presence, absence, or amount of a dimer of 3,4-diaminopyridine or a dimer of 3,4-diaminopyridine in the form of a salt, solvate or complex or a combination thereof. The invention also relates to methods of detecting and quantitating degradation in a sample of 3,4-diaminopyridine. Dimers of 3,4-diaminopyridine and methods of making and isolating the same are also provided.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: October 10, 2017
    Assignee: Jacobus Pharmaceuticals, Inc.
    Inventors: Guy Alan Schiehser, Rajendra Shah, Wenyi Zhao
  • Patent number: 9784664
    Abstract: Systems, including apparatus and methods, for the microfluidic manipulation, dispensing, and/or sorting of particles, such as cells and/or beads. The systems may include a shaped focusing chamber and/or a branched diverting mechanism.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: October 10, 2017
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Amir M. Sadri, Tal Rosenzweig, Nenad Kircanski
  • Patent number: 9778181
    Abstract: The present invention provides a system for analyzing a sample liquid comprising a test tape having a plurality of test elements, a tape transport device which successively transports the test elements to a sample application site while advancing the tape, and a measuring device which scans the test elements loaded with sample liquid at a measuring site. The measuring site is located at a distance from the sample application site in the direction of tape movement. The tape transport is interrupted in order to exactly position a wetted area of the test elements carrying a sample liquid at the measuring site by means of a positioning device that responds to the presence of sample liquid on the test element.
    Type: Grant
    Filed: September 11, 2013
    Date of Patent: October 3, 2017
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Uwe Krämer, Hans List
  • Patent number: 9778243
    Abstract: The present invention relates to improved methods for measuring the renewable bio-source carbon content and renewable bio-content in renewable bioplastic resins produced in manufacturing plants. In particular, the present invention relates to measuring the renewable bio-source carbon content in renewable bioplastic resins produced during a production run by correlating measured ?13C values are measured by iTOC-CRDS and CM-CRDS with actual renewable bio-source carbon content measurements (AMS or LSC 14C) via a linear regression.
    Type: Grant
    Filed: September 16, 2011
    Date of Patent: October 3, 2017
    Assignee: The Coca-Cola Company
    Inventors: Robert Kriegel, Sheng Sheng Yang, Hsiao Hua Liu, Christopher Mubarak
  • Patent number: 9778200
    Abstract: A method is provided for a portable computing device to read a reaction area on a test strip, which is located in a peripheral device placed over an image sensor and a light source of the portable computing device. Light is provided with the light source, which the peripheral device directs to the reaction area. An image including the reaction area is captured with the image sensor. An analyte characteristic is determined based on a color of the captured reaction area in the image.
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: October 3, 2017
    Assignee: IXENSOR CO., LTD.
    Inventors: Tungmeng Tsai, Yenyu Chen, Chieh Hsiao Chen
  • Patent number: 9779204
    Abstract: A programmed computer functioning as a classifier operates on mass spectral data obtained from a blood-based patient sample to predict indolence or aggressiveness of prostate cancer. Methods of generating the classifier and conducting a test on a blood-based sample from a prostate cancer patient using the classifier are described.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: October 3, 2017
    Assignee: Biodesix, Inc.
    Inventors: Joanna Röder, Heinrich Röder, Carlos Oliveira
  • Patent number: 9771380
    Abstract: Disclosed herein are embodiments of gold nanoparticles and methods of making and using the gold nanoparticles. The disclosed gold nanoparticles have core sizes and polydispersities controlled by the methods of making the gold nanoparticles. In some embodiments, the methods of making the gold nanoparticles can concern using flow reactors and reaction conditions controlled to make gold nanoparticles having a desired core size. The gold nanoparticles disclosed herein also comprise various ligands that can be used to facilitate the use of the gold nanoparticles in a variety of applications.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: September 26, 2017
    Assignee: University of Oregon
    Inventors: James E. Hutchison, Edward W. Elliott, III, Zachary Kennedy, Patrick Haben
  • Patent number: 9766231
    Abstract: A biosensor device controls actuation of label particles e.g., using frustrated total internal reflection. By applying a predetermined actuation force on the label particles and determining the effect of the applied actuation force in a binding volume or surface of a sensor cartridge of the biosensor device, a feedback control of the actuation force is applied.
    Type: Grant
    Filed: August 6, 2014
    Date of Patent: September 19, 2017
    Assignee: KONINKLIJKE PHIIPS N.V.
    Inventor: Josephus Arnoldus Henricus Maria Kahlman
  • Patent number: 9761426
    Abstract: The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: September 12, 2017
    Assignee: PURDUE RESEARCH FOUNDATION
    Inventors: Robert Graham Cooks, Jason Duncan, Guangming Huang, Guangtao Li, Xin Yan, Ewa Sokol, Xin Li
  • Patent number: 9759729
    Abstract: Necrotizing Enterocolitis (NEC) biomarkers, NEC biomarker panels, and methods for obtaining a NEC signature for a sample are provided. Also provided are methods, compositions, and kits for making a Necrotizing Enterocolitis (NEC) assessment of an individual, e.g. for diagnosing NEC in a patient, prognosing NEC in a patient, treating an NEC patient, etc. These methods find use in a number of applications, such as diagnosing and treating infants who are suspected of having NEC, intestinal perforation (IP), or sepsis.
    Type: Grant
    Filed: June 10, 2013
    Date of Patent: September 12, 2017
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl G. Sylvester, Guozhong Tao