Patents Examined by Roberto Fabian, Jr.
  • Patent number: 11898959
    Abstract: Raman systems and methods use advantages offered by increased laser mobility/path length and photon migration to analyze diffusively scattering solids, including pharmaceuticals. A collimated laser excitation beam having a first diameter induces from a sample a backscattered collimated Raman collection beam with a second diameter. The collimated laser excitation beam and the collimated Raman collection beam form a counter-propagating collimated optical path, and the collimated laser excitation beam is preferably smaller in diameter than the diameter of the backscattered collimated Raman beam. The collection beam to a spectrograph for Raman analysis of the sample. A Raman calibration standard may be placed in the collimated optical path, and/or the sample may be supported in a reflective holder that may be at least partially spherical and/or may form part of a multi-well plate. The counter-propagating collimated optical path may be contained within a Raman microscope.
    Type: Grant
    Filed: December 6, 2021
    Date of Patent: February 13, 2024
    Inventor: Harry Owen
  • Patent number: 11892406
    Abstract: A method of assaying the interaction of a molecule and a lipid bilayer is described. The method employs a microfluidic device comprising a substrate having at least one concave microcavity with a metallic surface defining an aperture and a liquid disposed within the microcavity, a lipid bilayer suspended across the aperture, and a microfluidic channel containing a liquid disposed on top of the substrate in fluid communication with the lipid bilayer. The method comprises the steps of passing a liquid containing a test molecule across the microfluidic channel, and monitoring lipid bilayer molecule interactions by plasmonically enhanced Raman or fluorescence spectroscopy configured for plasmonic enhancement of a detection signal evolving from the test molecule or lipid bilayer. Also described in a microfluidic device configured to perform the method of the invention.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: February 6, 2024
    Inventors: Tia Keyes, Rokas Sakalys, Kiang Wei Kho, Agata Steplewska, Aurelien Gimenez, Nirod Kumar Sarangi
  • Patent number: 11885609
    Abstract: The invention describes a metrology system allowing for the reduction of the errors caused by vibration of the production floor and allowing for measurements of the thickness of wafers in motion. This is accomplished by performing simultaneous measurements of spectra containing interference signals containing distance information using a plurality of probes positioned on both sides of the measured wafer on the same detector at the same time or by means of plurality of synchronized detectors. System is also able to measure thickness of the individual optically accessible layers present in the sample.
    Type: Grant
    Filed: November 22, 2021
    Date of Patent: January 30, 2024
    Inventor: Wojciech Jan Walecki
  • Patent number: 11874229
    Abstract: An optical metrology device performs multi-wavelength polarized confocal Raman spectroscopy. The optical metrology device uses a first light source to produce a first light beam with a first wavelength and a second light source to produce a second light beam with a second wavelength. A dichroic beam splitter partially reflects the first light beam and transmits the second light beam to combine the light beams along a same optical axis that is incident on a sample. The dichroic beam splitter directs the Raman response emitted from the sample in response to the first light beam and the second light beam together towards at least one spectrometer and directs the first light beam away from the at least one spectrometer. A chopper may be used to isolate the Raman response to the first and second light beams that is received and spectrally measured by the at least one spectrometer.
    Type: Grant
    Filed: April 7, 2022
    Date of Patent: January 16, 2024
    Assignee: Onto Innovation Inc.
    Inventor: George Andrew Antonelli
  • Patent number: 11841325
    Abstract: There are provided a substrate including a three-dimensional (3D) nanoplasmonic composite structure, a method of fabricating the same, and a rapid analysis method using the same. More specifically, there are provided a substrate including a 3D plasmonic-nanostructure/target-molecule composite thin film composed of an analyte and a plasmonic nanostructure and formed by applying a voltage to a plasmonic electrode in an electrochemical cell including an analyte and a metal precursor to induce an analyte molecule on the electrode and performing electrochemical deposition (or electrodeposition), a method of fabricating the same, and a rapid analysis method using the same.
    Type: Grant
    Filed: April 28, 2021
    Date of Patent: December 12, 2023
    Inventors: Sung-gyu Park, Dong-ho Kim, Ho-sang Jung, Mijeong Kang, Iris Baffour Ansah
  • Patent number: 11841316
    Abstract: The present disclosure discloses a mechanism for aligning and orienting a probe in an optical system. The mechanism includes a sensor head, which are defined with one or more provisions. Further, the mechanism includes at least one block member, which is movably disposed within the one or more provisions in the sensor head. The at least one block member is defined with a cavity to accommodate a probe. During contact of the probe with a surface of the subject, a torque is generated, which facilitates in aligning the probe on the surface of the subject. The block member is configured to tilt corresponding to movement of the probe, for aligning the probe at an angle on the surface of the subject.
    Type: Grant
    Filed: September 17, 2019
    Date of Patent: December 12, 2023
    Inventors: Anupam Lavania, Shilpa Malik
  • Patent number: 11841317
    Abstract: A gas detection device and process detect a target gas for monitoring an area for the target gas. A radiation source emits electromagnetic radiation (50) that penetrates the area and impinges on an array of filters (15, 25) that distributes the impinging radiation (50) onto a first gas photosensor (35), a second gas photosensor (37) and a reference photosensor (36). The first gas photosensor (35) is only sensitive to radiation in a first wavelength range, the second gas photosensor (37) is only sensitive to radiation in a second wavelength range and the reference photosensor (36) is only sensitive to radiation in a reference wavelength range. The wavelength ranges are spaced apart from one another. An analysis unit (10) analyzes signals [Sig(35), Sig(36), Sig(37)] from the three photosensors (35, 36, 37) and carries out three pair comparisons to determine whether or not the target gas is present.
    Type: Grant
    Filed: November 4, 2021
    Date of Patent: December 12, 2023
    Assignee: Dräger Safety AG & Co. KGaA
    Inventor: Andreas Flammiger
  • Patent number: 11828747
    Abstract: An optical multimodal detection system for targeted detection of cancer biomarkers in blood serum. The system comprises of a nano-biosensor, a chamber for receiving the nano-biosensor, a localized surface plasmon resonance (LSPR) based detector, a plasmon enhanced fluorescence (PEF) based detector and a surface-enhanced Raman scattering (SERS) based detector. The nano-biosensor comprises of a glass substrate provided with an active site for receiving a sample of blood serum, and is dimensioned to define a flow channel for introducing the sample of blood serum into the nano-biosensor. The nano-biosensor is provided with a layer of amino-silane compound coating over the glass substrate and a plurality of gold nano-urchins (GNU) bound to the layer of silicone compound.
    Type: Grant
    Filed: November 27, 2021
    Date of Patent: November 28, 2023
    Assignee: M.I.S. ELECTRONICS INC.
    Inventors: Mohammad E Khosroshahi, Yesha Patel
  • Patent number: 11821841
    Abstract: A method and system for classifying a tissue specimen is provided. The method includes: a) interrogating a tissue specimen with a first interrogation light; b) detecting first light from the tissue specimen resulting from the interrogation, wherein the first light includes a first scattered light component and a first fluorescence light component, and producing first signals; c) interrogating the tissue specimen with a second interrogation light at a second excitation wavelength, wherein the first and second excitation wavelengths are within about 2 nm of each other; d) detecting second light from the tissue specimen resulting from the interrogation, wherein the second light includes a second scattered light component and a second fluorescence light component, and producing second signals; e) determining a difference between the first and second lights; f) determining a fluorescence spectrum produced by the interrogation of the tissue specimen; and g) classifying the tissue specimen.
    Type: Grant
    Filed: March 7, 2022
    Date of Patent: November 21, 2023
    Assignee: CytoVeris, Inc.
    Inventors: Rishikesh Pandey, Alan Kersey
  • Patent number: 11821912
    Abstract: Methods of producing augmented probe system images and associated probe systems. A method of producing an augmented probe system image includes recording a base probe system image, generating the augmented probe system image at least partially based on the base probe system image, and presenting the augmented probe system image. The augmented probe system image includes a representation of at least a portion of the probe system that is obscured in the base probe system image. In some examples, a probe system includes a chuck, a probe assembly, an imaging device, and a controller programmed to perform methods disclosed herein.
    Type: Grant
    Filed: May 6, 2021
    Date of Patent: November 21, 2023
    Assignee: FormFactor, Inc.
    Inventors: Anthony James Lord, Gavin Neil Fisher, David Randle Hess
  • Patent number: 11815450
    Abstract: Disclosed are a system and method for active stabilization of parasitic fringes in optical spectrometers, wherein the spectrometer obtains the transmission spectrum, and a signal processor extracts the etalon drift from the spectral signatures of parasitic fringes. The disclosed approach improves spectrometer accuracy, minimizes drift, and increases time between calibrations.
    Type: Grant
    Filed: March 8, 2022
    Date of Patent: November 14, 2023
    Inventors: Chu C. Teng, Gerard Wysocki
  • Patent number: 11808913
    Abstract: An optical probe and method for analysing a soil located in an underground area are provided. The optical probe includes a probe head insertable into the underground area, the probe head including a transparent wall defining a hollow chamber within the probe head; a light source mounted in the hollow chamber, configured to generate an illumination beam towards the soil, the illumination beam passing through the transparent wall to irradiate the soil, thereby producing a resulting light emanating from the soil, a portion of the resulting light returning towards the probe head and being guided in the transparent wall by total internal reflection along the optical path; a detector configured to receive the portion of the resulting light and outputting an output signal representative of characteristic(s) of the soil; and an optical element guiding the portion of the resulting light from the transparent wall to the detector.
    Type: Grant
    Filed: September 18, 2019
    Date of Patent: November 7, 2023
    Assignee: 9371-0184 QUÉBEC INC.
    Inventors: Gabriel Mangeat, Benjamin De Leener
  • Patent number: 11781977
    Abstract: An optically thin sample of a sample material is analyzed by propagating probe electromagnetic radiation from a beam source along a plurality of different ray paths, directing each ray so that each ray path intersects upon the sample at a plurality of different locations where the rays interact with the sample material to cause a modification of the ray. The rays received at each of a plurality of detection spatial region are measured separately and the measurements analyzed to provide information about at least one property of the sample material at each interaction location. An analysis is carried out to trace the path of probe radiation from a location at the probe beam source to the detection spatial region on the detection surface so as to identify the interaction locations so as to provide information about the presence of target material at each interaction location.
    Type: Grant
    Filed: November 24, 2021
    Date of Patent: October 10, 2023
    Assignee: 12535505 Canada Ltd.
    Inventors: David Allan Prystupa, John Stephen Pacak
  • Patent number: 11774367
    Abstract: A Raman detection system has a Raman spectrometer and a fixing light shielding stand. One end of the fixing light shielding stand is fixedly connected to the Raman spectrometer, and the other end is disposed with an entrance groove for a needle-like SERS probe to enter. A slot for fixing the needle-like SERS probe is formed at an end of the entrance groove, and the slot and the needle-like SERS probe match in shape and size. The Raman detection system has a fixing light shielding device with a dark color groove and a focal length. The groove can be used for limiting the rolling of the curved surface structure of the needle-like SERS probe. A laser can be focused on the curved surface more accurately by adjusting the distance from the instrument detector to the SERS probe.
    Type: Grant
    Filed: September 29, 2022
    Date of Patent: October 3, 2023
    Assignee: City University of Hong Kong Shenzhen Futian Research Institute
    Inventors: Jian Lu, Binbin Zhou, Junda Shen, Zebiao Li, Yangyang Li
  • Patent number: 11768152
    Abstract: An information processing system includes a storage, an interface device, and a computing circuit. The storage stores a database, in which spectrum data concerning light from a light source and a measurement condition data at a time of measurement of the light are associated with a plant status data concerning growth of a plant and/or a harvest data concerning a harvest of the plant. The interface device receives an input of a user measurement condition which is to be applied at a time of measurement of the plant by a user and which includes data concerning angles at the time of measurement and data concerning a plant status and/or a harvest to be predicted. The computing circuit determines at least two wavelengths contained in the light from the light source to be measured under the user measurement condition by referring to the database based on the user measurement condition.
    Type: Grant
    Filed: March 3, 2022
    Date of Patent: September 26, 2023
    Inventors: Yukihiro Takahashi, Tatsuharu Ono, Nobuyasu Naruse, Yurino Ishida
  • Patent number: 11768153
    Abstract: Disclosed is a structure (e.g., a lab-on-chip structure) including a substrate, an insulator layer on the substrate, and at least one optical ring resonator. Each ring resonator includes cladding material on the insulator layer and, embedded within the cladding material, a first waveguide core with an input and an output, and second waveguide core(s) (e.g., ring waveguide core(s)) positioned laterally adjacent to the first waveguide core. A reservoir is below the ring resonator within the insulator layer and substrate such that surfaces of the waveguide cores are exposed within the reservoir. During a sensing operation, the waveguide core surfaces contact with fluid within the reservoir and a light signal at the output of the first waveguide core is monitored (e.g., by a sensing circuit, which in some embodiments is also coupled to a reference optical ring resonator) and used, for example, for spectrum-based target identification and, optionally, characterization.
    Type: Grant
    Filed: March 8, 2022
    Date of Patent: September 26, 2023
    Assignee: GlobalFoundries U.S. Inc.
    Inventors: Bartlomiej J. Pawlak, Michal Rakowski
  • Patent number: 11768420
    Abstract: Recent remarkable progress in wave-front shaping has enabled control of light propagation inside linear media to focus and image through scattering objects. In particular, light propagation in multimode fibers comprises complex intermodal interactions and rich spatiotemporal dynamics. Control of physical phenomena in multimode fibers and its applications is in its infancy, opening opportunities to take advantage of complex mode interactions. Various embodiments of the present technology provide wave-front shaping for controlling nonlinear phenomena in multimode fibers. Using a spatial light modulator at the fiber's input and a genetic algorithm optimization, some embodiments control a highly nonlinear stimulated Raman scattering cascade and its interplay with four wave mixing via a flexible implicit control on the superposition of modes that are coupled into the fiber.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: September 26, 2023
    Assignee: The Regents of the University of Colorado
    Inventors: Omer Tzang, Rafael Piestun, Antonio Miguel Caravaca-Aguirre, Kelvin Wagner
  • Patent number: 11768108
    Abstract: The disclosure provides an optical filter element including a plurality of nano-columns separated from each other in a horizontal direction and extended in a vertical direction, and each of the plurality of nano-columns includes a first material layer having an first extinction coefficient and second material layers having second extinction coefficients different from the first extinction coefficient of the first material layer and a spectrometer including the same.
    Type: Grant
    Filed: November 19, 2020
    Date of Patent: September 26, 2023
    Inventors: Jaesoong Lee, Yeonsang Park, Hyochul Kim
  • Patent number: 11754501
    Abstract: The present invention relates to a surface-enhanced Raman scattering substrate and a method of fabricating the same. More particularly, the surface-enhanced Raman scattering substrate according to an embodiment includes a substrate; a lower plasmonic layer formed on the substrate and based on a first metal nanostructure; an oxide layer formed on the lower plasmonic layer; and an upper plasmonic layer formed on the oxide layer and based on a second metal nanostructure.
    Type: Grant
    Filed: January 21, 2022
    Date of Patent: September 12, 2023
    Assignee: PICO FOUNDRY INC.
    Inventors: Hyung Joon Park, Hee Jin Gil, Si Jin Kim, Yong Won Choi
  • Patent number: 11747281
    Abstract: Disclosed is a spectroscopic apparatus includes a laser irradiation device that receives an orthogonal code including a series of bits each having a first value or a second value, generates a control signal having a pulse that has a width shorter than a width of a bit section in the bit section corresponding to a bit having the first value, generates a pulsed laser beam having a pulse width shorter than the bit section using the pulse as a trigger, and irradiates an incident beam including the generated pulsed laser beam to a sample, and a detector that receives a detection signal generated from the sample and the orthogonal code, generates an orthogonal code signal of the same waveform as that of the incident beam, based on the orthogonal code, and demodulates a Raman signal, based on a correlation between the generated orthogonal code signal and the Raman signal.
    Type: Grant
    Filed: July 14, 2020
    Date of Patent: September 5, 2023
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Won Kyoung Lee, Hong-Seok Seo