Abstract: A process for preparing liquid formulations of dyes of the general formula I
where the variables are as defined in the specification by diazotizing an amine of the formula II
and then coupling the diazonium salt onto a compound of the formula III
and also optionally adding solubilizing additives, which comprises effecting said diazotizing at a pH set to an acidic value using pure methanesulfonic acid or at least 20 mol % mixtures of methanesulfonic acid in monobasic acids.
Type:
Grant
Filed:
April 10, 2003
Date of Patent:
June 1, 2004
Assignee:
BASF Aktiengesellschaft
Inventors:
Michael Schmitt, Roland Merger, Rainer Tresch
Abstract: Substituted imidazolidine derivatives of the formula I,
in which B, E, W, Y, R, R2, R3, R30, e and h have the meanings indicated in the claims. The compounds of the formula I are valuable pharmaceutical active compounds, which are suitable, for example, for the therapy and prophylaxis of inflammatory disorders, for example of rheumatoid arthritis, or of allergic disorders. The compounds of the formula I are inhibitors of the adhesion and migration of leucocytes and/or antagonists of the adhesion receptor VLA-4 belonging to the integrins group. They are generally suitable for the therapy or prophylaxis of illnesses which are caused by an undesired extent of leucocyte adhesion and/or leucocyte migration or are associated therewith, or in which cell-cell or cell-matrix interactions which are based on interactions of VLA-4 receptors with their ligands play a part.
Type:
Grant
Filed:
September 14, 2001
Date of Patent:
February 18, 2003
Assignee:
Aventis Pharma Deutschland GmbH
Inventors:
Volkmar Wehner, Hans Ulrich Stilz, Wolfgang Schmidt, Dirk Seiffge