Abstract: The invention provides a pyridazinone derivative having a high insecticidal and miticidal activity against agricultural noxious insects. The pyridazinone derivative of the invention is represented by the formula (1) ##STR1## wherein R is a hydrogen atom, an alkyl group, an alkoxyalkyl group, or a phenyl group which may have 1 or 2 substituents in an optional position.

Abstract: Diastereomeric intermediate salts of formulae (IIIa) or (IIIb) ##STR1## are prepared.

Abstract: 10-hydroxy 7-ethyl camptothecin (HECPT), an active metabolite of the camptothecin analog CPT-11, is poorly soluble in water. Because of its poor water solubility, HECPT has not been directly administered by parenteral or oral routes in human patients for the purpose of inhibiting the growth of cancer cells. There is also unpredictable interpatient variability in the metabolic production of HECPT from CPT-11 which limits the utility of CPT-11. This invention overcomes these limitations by teaching novel pharmaceutically acceptable lactone stable HECPT formulations for the direct administration of HECPT. The claimed invention also describes novel dosages, schedules, and routes of administration of the lactone stable HECPT formulations to patients with various forms of cancer.

Abstract: The present invention is directed to a novel process for the production of folic acid in high yield utilizing a novel diimine as an intermediate. This diimine is formed by reacting 2-substituted malondialdehyde with p-aminobenzoyl-L-glutamic acid. This diimine may be converted into folic acid by reacting said diimine with triaminopyrimidinone in the presence of sulphite.

Abstract: Herbicidal new 2-(2-benzoxazolyloxy)-acetamides of the formula ##STR1## in which R represents hydrogen, halogen, alkyl or halogenoalkyl andAr represents optionally substituted aryl,but with the exception of the compounds N-isopropyl-2-(2-benzoxazolyl-oxy)-acetanilide and N-isopropyl-2-(6-chlorobenzoxazol-2-yl-oxy)-acetanilide.