Patents Examined by Ronald Pelley
  • Nucleotide sequences coding for variable regions of the .alpha.chains of human T lymphocyte receptors, corresponding peptide segments and the diagnostic and therapeutic muses
    Patent number: 6114516
    Abstract: The present invention relates to new nucleotide sequences coding for variable regions of the .alpha. chains of human T lymphocyte receptors, corresponding peptide segments and the diagnostic and therapeutic uses.
    Type: Grant
    Filed: March 12, 1998
    Date of Patent: September 5, 2000
    Assignee: Hoechst Marion Roussel
    Inventors: Thierry Hercend, Frederic Triebel, Sergio Roman-Roman, Laurent Ferradini
  • Evaluating the sensitizing/irritant/allergenic potential of a given substrate
    Patent number: 6103482
    Abstract: Methods for determining the sensitizing, irritant and/or allergenic potential of a candidate substrate are provided. These methods involve simultaneously cultivating keratinocytes and Langerhans cell precursors in a nutrient medium in order to effect differentiation of the Langerhans cell precursors, and contacting the candidate substrate with the cultured cells to determine the effect if any on markers associated with sensitizing, irritant or allergenic potential.
    Type: Grant
    Filed: February 11, 1998
    Date of Patent: August 15, 2000
    Assignee: Societe L'Oreal S.A.
    Inventors: Rainer Schmidt, Marcelle Regnier
  • Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens including immunogenic LHRH peptides
    Patent number: 6025468
    Abstract: The present invention is directed to novel peptide immunogens for eliciting antibodies to LHRH comprising artificial T helper cell epitopes (Th epitopes) designed to provide optimum immunogenicity. The artificial Th epitopes are covalently linked to LHRH and optionally an immunostimulatory seqence.
    Type: Grant
    Filed: June 20, 1998
    Date of Patent: February 15, 2000
    Assignee: United Biomedical, Inc.
    Inventor: Chang Yi Wang