Abstract: An electrophysiology catheter assembly having a deflection mechanism rotatably disposed within an inner lumen of the catheter so that deflection of the deflection mechanism within the inner lumen results in a deflection of the distal portion of the catheter. Rotation of the deflection mechanism within the inner lumen of the catheter allows universal deflection of the distal portion of the catheter about its longitudinal axis. The deflection mechanism may be first rotated and then deflected or it may be first deflected and then rotated in a deflected condition. The catheter shaft does not need to be rotated to change the shape of its distal portion.

Abstract: A safety cover, which securably and reliably prevents the readvancement of the tip of a cannula once it has been retracted thereinto, is designed having an elongate body which includes an axial channel having elements which displace and block linear passage of the cannula once it has been retracted. In a first embodiment the displacing elements are inwardly and rearwardly extending bristles which provide for unidirectional motion of the cannula relative to the safety cover, thereby locking the cannula once it has been retracted. In a second embodiment, the displacing element is the axial channel itself which has a curvate bias and distorts into a non-linear path once the cannula is retracted. In a third embodiment, the displacing element is a spring plate which, when compressed permits the cannula to pass through, but once the cannula has been retracted, expands to prevent the tip from being readvanced.

Abstract: The drug delivery stent assembly includes a hollow tubular wire stent which extends in a path defining a generally cylindrical envelope and which has side walls facing outwardly of the cylindrical envelope with holes therein for delivery of liquid to a site in a vessel where the stent is placed.

Abstract: A needle-syringe for inserting a guidewire G in a patient comprises a barrel 10 and a hollow nozzle 15 opening into the interior of the barrel 10. It comprises a plunger 11 slidably mounted in the barrel 10 and a needle holder 14 slidably mounted in the longitudinal cavity of the plunger 11. A hollow guide member is mounted between the proximal ends of the needle holder 14 and the plunger 11 for guiding a guidewire G from the proximal end of the plunger 11 to the proximal end of the needle holder 14. The needle holder 14 includes a valve member for passing a guidewire G through the needle holder 14 while preventing blood from flowing between the interiors of the needle holder 14 and the hollow guide member. The guide member engages and retracts the needle holder 14 in response to relative rotational movement between the barrel 10 and the needle holder 14.

Abstract: A syringe assembly has a hub body which can be inserted into a hub insertion hole and pulled out thereof into inside a sringe body. A chamfer portion is formed at the hub body, being capable of engaging with the hub insertion hole. A needle insertion hole capable of being inserted a needle therein is provided with an end face of the hub body in a direction of an axis center of the hub body. A flow hole is provided with the hub body such that the needle insertion hole and an inside of the syringe body are communicated with each other in the direction of the axis center. A piston engagement hole is provided on end face side of the hub body, so as to engage with the piston. A seal taper is annularly formed at the hub body, such that its outside diameter is made narrower for the end face side, so as to abut on and contact with an inner face of the hub insertion hole.

Abstract: The invention relates to a portable and non-implantable device to enable a patient to self-administer, on demand, successive doses of a liquid while ensuring that the period of time between two successive administrations cannot be less than a reference value. The device has a liquid reservoir formed in a piston which can be pushed in a chamber to expel the contents of the chamber via an injection outlet and which is returned in the opposite direction by a return. The liquid reservoir communicates with the inside of the chamber via a passage formed through the piston and is provided with a flow rate limiter so that the time required to fill the chamber corresponds to a reference value. The invention is suitable for medical applications.

Abstract: A process and apparatus for one-step preparation of fibrinogen adhesive by polyethylene glycol-mediated precipitation from plasma are disclosed. The methods and apparatus of the invention permit preparation of autologous fibrinogen adhesive composition from the patient during surgery, and can be applied generally to provide such compositions. Also disclosed are an apparatus and method for application of sealant comprising this fibrinogen adhesive composition.

Abstract: The present invention relates to a guide catheter system for guiding an angioplasty balloon catheter into a patient's vascular system. The guide catheter system includes a guide catheter and a distal guide catheter extension tube. The guide catheter constitutes an elongated tube, while the guide catheter extension constitutes a distal, smaller diameter extension for the guide catheter. The guide catheter extension is adapted to extend from the guide catheter to an extent possibly sufficient to reach the stenosis in a coronary artery. A fixed wire angioplasty balloon catheter is advanced through the guide catheter and guide catheter extension to the stenosis for treatment thereof. Efficient and easy exchange of the balloon catheter is achieved because the guide catheter extension remains in place when the balloon catheter is withdrawn proximally, so that a path remains to guide another balloon catheter to the stenosis for treatment thereof.

Abstract: An injectable medicament dispenser for use in controllably dispensing fluid medicaments such as insulin, antibiotics, oncolytics and the like from a prefilled container at a uniform rate. The dispenser includes a unique stored energy source in the form of a compressively deformable, polymeric elastomeric member that provides the force necessary to controllably discharge the medicament from the prefilled container which is housed within the body of the device. After having been deformed, the polymeric, elastomeric member will return to its starting configuration in a highly predictable manner.

Abstract: A safety adapter for hypodermic needles and, in particular, double-ended needles of the type used in dental procedures. The adapter comprises two sections coupled together as a unitary device. One section is arranged to receive and house one of the projecting needles and the other section houses and protects the oppositely directed needle.

Abstract: Methods are disclosed for the alleviation of movement disorders via the implantation of static devices which focally release neuroinhibitory compounds to preselected brain areas. Pathological conditions to be treated by these methods include parkinsonian movement disorders, Huntington's chorea, and epileptiform seizure activity. In the treatment of parkinsonism, target areas implantation include the subthalamic nucleus, the globus pallidus internus, and the substantia nigra pars reticulata. In the treatment of epilepsy, implants may be placed in an epileptogenic focus area of neural over-activity. The devices may be polymeric implants that release neuroinhibitory compounds such as GABA, GABA agonists, GABA potentiators, action potential blockers and voltage dependent calcium channel blockers, and glutamate antagonists. Alternatively, the devices may contain living cells which secrete neuroinhibitory compounds.

Abstract: An injection device which includes a container constructed and arranged to contain a medicament, a medicament disposed within the container, a seal constructed and arranged to seal the medicament in the container, and a hypodermic needle. The hypodermic needle has a tubular, elongated, generally cylindrical wall defining an internal longitudinal bore extending longitudinally through the cylindrical wall along a longitudinal axis. The cylindrical wall forms a forward end defining a forward opening of the bore and a rearward end defining a rearward opening of the bore, the cylindrical wall having a laterally facing opening spaced closer to the rearward opening of the longitudinal bore than the forward opening of the longitudinal bore. The longitudinal bore is restricted at a position between the rearward opening and the laterally facing opening.

Abstract: A method and instrument for thermal phacoemulsification includes, in one aspect, a process for introducing high temperature water into the lens capsule of the eye for emulsification purposes. The invention provides a mechanism for heating water to the desired temperature at the point of delivery, whereby the cannula that enters the eye is maintained at a temperature sufficiently low to avoid thermal damage to surrounding eye tissue. The invention provides an isenthalpic device for delivering heated water to the lens capsule for phacoemulsification. The device includes a intraocular cannula for delivering high pressure water, and a throttling mechanism at the point of delivery for converting the energy in the water stream from pressure to heat. The throttling mechanism may comprise a capillary passage, or a porous plug, or a micro-orifice which directs the fluid stream to strike a target in the cannula bore, after which the fluid is discharged from the cannula.

Abstract: An apparatus for securing a medical instrument to a cannula of a trocar assembly includes a first retainer portion. The apparatus also includes a second retainer portion. The apparatus also includes a ball-shaped instrument holder. The ball-shaped instrument holder has a passageway extending therethrough. The instrument is securable within the passageway. A method for securing a medical instrument to a cannula of a trocar assembly is also disclosed.

Abstract: A prefilled syringe capable of separate storage of different substances before use. It includes a tubular body having an injection needle at one end and a plunger at the other end, and a partition axially slidable in the tubular body. The partition includes a front part and a rear part independent of each other, and as a whole divides the interior space of the tubular body into a front compartment and a rear compartment in a sealing manner for storing mutually different substances. A bypass is disposed generally between the front and rear compartments to introduce the substance in the rear compartment into the front compartment when the partition is slid under pressure provided by the plunger to be adjacent to the bypass to thereby mix the substances immediately prior to injection.

Abstract: A syringe apparatus includes a housing having upper and lower end portions and a hollow interior. A rotary cam position inside the hollow interior has a projecting portion for operating a cartridge when the apparatus is used. The housing has a rotary bearing for supporting the cam. A syringe cartridge (single chamber or dual chamber) removably fits the housing interior, the cartridge including a barrel with at least one chamber for containing medicine to be dispensed and a dispensing orifice. The cartridge includes a piston having an upper plunger that engages the cam. The piston slides within the barrel chamber forcing contained medicine through the dispensing orifice (e.g., needle) during use. The upper plunger end of the piston engages the rotary cam during dispensing. The cam is movable between first and second positions, the second position being a dispensing position that positions the projecting portion of the cam at the piston. A spring urges the cam to rotate from the first to the second position.

Abstract: A surgical cannula assembly is provided having a housing defining a channel extending from a proximal end to a distal end of the housing, at least one fluid flow regulator member disposed across the channel, which forms a substantial barrier to the passage of fluids in at least one direction, a cannula extending from the housing distal end in fluid communication with the channel, and a selector valve operatively connected to the cannula assembly housing and movable to at least a first orientation establishing a first fluid pathway from the channel to the environment outside the housing and a second orientation establishing a second fluid pathway from the channel to the outside environment.

Abstract: A syringe assembly specifically designed to dispense high viscosity material. The syringe assembly includes a syringe barrel into which the high viscosity material is placed. A piston assembly is introduced into the syringe barrel. The piston assembly creates a seal against the interior of the syringe barrel that is impervious to the high viscosity material but is not impervious to the passage of air. Consequently, as the piston assembly is advanced into the syringe barrel, any trapped air is permitted to exit the syringe barrel without passing through the high viscosity material. The piston assembly also contains a shaped piston head that stresses the high viscosity material as it is displaced through the syringe barrel. By stressing the high viscosity material in the syringe barrel before it is dispensed, air bubbles and gaps contained within the material can be greatly reduced.

Abstract: An intra-aortic balloon pump catheter includes an inner lumen formed by a thin walled superelastic metal alloy tube, namely of nitinol, with an inside diameter sufficient for a guidewire and a small outside diameter which allows reduction of the outer lumen and related components by at least one size French while providing gas shuttle capacity between the lumens for conventional intra-aortic balloon pump operation. The outer lumen is a tube formed of co-extruded plastics to enhance the size reduction and capacity goals, with an inner nylon portion for strength and a relatively thin polyurethane outer portion for biocompatability, flexibility and compatibility for bonding to a thin polyurethane balloon. The proximal end sleeve of the balloon is stretched and then stress-relieved by heating with an internal heater on a mounting mandrel to effect a desired small diameter sizing.

Abstract: A circuit operator with a push to test arrangement includes a housing. A first switch is mounted in the housing and has a toggle lever pivotably connected thereto so as to place the toggle switch in its on or off state. A second switch is also mounted in the housing and is connected to a push button for initiating tests. A single switch actuator allows a user to actuate the first switch and/or the second switch from an exterior of the housing.