Patents Examined by Rosalynd Williams
  • Patent number: 5905169
    Abstract: A process is disclosed for preparing polyhaloacyl fluorides such as trifluoroacetyl fluoride and difluoroacetyl fluoride by oxidizing 1-chloro-1,2,2,2-trifluoroethanes and 1,1-dichloro-2,2-difluoroethane, respectively with oxygen.
    Type: Grant
    Filed: March 20, 1995
    Date of Patent: May 18, 1999
    Assignee: E. I. Du Pont De Nemours and Company
    Inventor: Stephen Ernest Jacobson
  • Patent number: 5834442
    Abstract: A method for the treatment of cancer in mammals. A subject afflicted with cancer receives by oral administration a pH modified citrus pectin which inhibits metastasis of primary tumors.
    Type: Grant
    Filed: July 7, 1994
    Date of Patent: November 10, 1998
    Assignees: Barbara Ann Karmanos Cancer Institute, Wayne State University
    Inventors: Avraham Raz, Kenneth J. Pienta
  • Patent number: 5696128
    Abstract: Disclosed are methods for rectifying or ameliorating abnormal responses of mammalian immune systems. Also disclosed are methods for modifying normal responses of the mammalian immune system. Further disclosed are methods for accomplishing the foregoing by administering to a mammal a prolactin reducer and/or enhancer at a pre-determined time or times during a 24-hour period that results in modification of the mammal's abnormal prolactin profile so that it approaches or conforms to the prolactin profile of a young, healthy mammal of the same species (or to a standard profile generated from such individuals). Additionally, methods of upregulating or augmenting an immune response in a mammal are disclosed.
    Type: Grant
    Filed: July 7, 1994
    Date of Patent: December 9, 1997
    Assignees: The Board of Supervisors of Louisiana University and Agricultural and Mechanical College, The General Hospital Corporation
    Inventors: Anthony H. Cincotta, Albert H. Meier
  • Patent number: 5696295
    Abstract: The invention relates to a method for the purification by distillation of p,p-bisphenol A from the melt.The p,p-bisphenol A melt thus obtained is highly heat-stable, stable in storage and colour-stable, is free from high-boiling components and no longer contains any surface-active or non-distillable metal, salt, acid or polymer components and no sulphur-containing components; o,p-BPA and phenol are removed and the low-boiling components are scarcely detectable.
    Type: Grant
    Filed: April 6, 1995
    Date of Patent: December 9, 1997
    Assignee: Bayer AG
    Inventors: Claus Wulff, Kaspar Hallenberger, Heinrich Steude, Kurt-Peter Meurer, Tony van Osselaer, Jurgen Hinz, Frank Quaeyhaegens, Johan Vaes, Ignace Hooftman
  • Patent number: 5684179
    Abstract: An improved method for recovering purified diesters of polytetramethylene ethers involving the polymerization of tetrahydrofuran (THF) optionally with one or more comonomers (e.g., 3-methyl THF, ethylene oxide, propylene oxide, or the like) utilizing a solid acid catalyst (e.g., Nafion.RTM.) and a carboxylic acid with carboxylic acid anhydride (e.g., acetic acid with acetic anhydride) as molecular weight control agents wherein after polymerization product recovery involves bulk flashing of unreacted THF and stripping of remaining THF, carboxylic acid and carboxylic acid anhydride (e.g., acetic acid and acetic anhydride) by use of superheated THF. Such a process is useful in producing high purity commercial grade PTMEA that advantageously avoids problems associated with the presence of high boilers when converting to PTMEG.
    Type: Grant
    Filed: December 14, 1995
    Date of Patent: November 4, 1997
    Assignee: E. I. du Pont de Nemours and Company
    Inventor: Suriyanarayan Dorai
  • Patent number: 5684178
    Abstract: Lysine derivatives, the salts of the derivatives, their optical isomers of D or L configuration, or their mixtures, the derivatives containing an N.sup..epsilon. -alkoxy or N.sup..epsilon. -alkenoxycarbonyl group of formula: ##STR1## in which: R represents a linear or branched C.sub.13 -C.sub.24 alkyl radical, the C.sub.16 radical being branched, or a linear or branched C.sub.8 -C.sub.24 alkenyl radical. The lysine derivatives are used in cosmetic, pharmaceutical hygiene or food compositions.
    Type: Grant
    Filed: November 2, 1994
    Date of Patent: November 4, 1997
    Assignee: L'Oreal
    Inventors: Michel Philippe, Thierry Bordier
  • Patent number: 5679830
    Abstract: A pivaloylacetic acid ester is prepared at a high yield by decarbonylating a pivaloylpyruvic acid ester in gas or liquid phase in the presence of an inorganic oxide catalyst which comprises aluminum in an amount of 10% by weight or more in terms of aluminum oxide, and preferably is substantially free from heavy metals, for example, Fe, Cu, Ni, Mn, Cr, Mo and Co, and exhibits a high catalytic activity and chemical stability.
    Type: Grant
    Filed: July 12, 1995
    Date of Patent: October 21, 1997
    Assignee: Ube Industries, Ltd.
    Inventors: Katsuhiko Mizutare, Masayoshi Oku, Tsuyoshi Ueyama
  • Patent number: 5672744
    Abstract: By employing a process for the preparation of acetic acid which comprises carbonylating methanol with carbon monoxide in a first reactor in the presence of a reaction fluid comprising a rhodium catalyst, methyl iodide, an iodide salt, methyl acetate and water, while continuously withdrawing the reaction fluid from the first reactor and introducing it into a flash zone to separate it into an evaporated part and an unevaporated part, characterized in that second reactor is provided between the first reactor and the flash zone and methanol is carbonylated with the carbon monoxide contained in the reaction fluid in a state in which it is dissolved therein in the second reactor with a residence time of 7 to 60 seconds at 150.degree. to 220.degree. C.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: September 30, 1997
    Assignee: Daicel Chemical Industries, Ltd.
    Inventors: Masahiro Kagotani, Yasuteru Kajikawa
  • Patent number: 5672743
    Abstract: A process for the production of acetic acid by carbonylation of methanol or a reactive derivative thereof by contacting the methanol or derivative with carbon monoxide in a liquid reaction composition comprising (a) acetic acid, (b) an iridium catalyst, (c) methyl iodide, (d) at least a finite quantity of water and (e) methyl acetate is improved by the use as promoter of at least one of ruthenium and osmium.
    Type: Grant
    Filed: August 1, 1994
    Date of Patent: September 30, 1997
    Assignee: BP Chemicals Limited
    Inventors: Carl Sherman Garland, Martin Francis Giles, John Glenn Sunley
  • Patent number: 5672735
    Abstract: The present invention refers to a Process for the preparation of S-(-)-5-??2-(acetyloxy)-1-oxopropyl!amino!-2,4,6-triiodo-1,3-benzenedicarb oxylic acid dichloride of formula (I) comprising the reaction between S-(-)-?2-(acetyloxy)!propionic acid chloride and 5-amino-2,4,6-triiodo-, 1,3-benzenedicarboxylic acid dichloride, in an aprotic dipolar solvent and in presence of a halogenhydric acid.
    Type: Grant
    Filed: May 21, 1996
    Date of Patent: September 30, 1997
    Assignee: Fructamine S.p.A.
    Inventors: Marina Mauro, Carlo Felice Viscardi, Massimo Gatti, Nicola Desantis
  • Patent number: 5665757
    Abstract: A method of treating anxiety in a warm blooded animal by administering an anti-anxiety effective amount of a nitric oxide synthase inhibitor, and compositions containing the same.
    Type: Grant
    Filed: July 13, 1994
    Date of Patent: September 9, 1997
    Assignee: Robert W. Dunn
    Inventors: Robert W. Dunn, Suzanne La Marca
  • Patent number: 5663430
    Abstract: In a process for purifying a carboxylic acid fraction obtained by liquid phase carbonylation of an alkyl alcohol and/or its reactive derivative in which volatile iridium- and/or volatile co-promoter contaminants are converted to involatile forms by contacting with an iodide in the absence of carbon monoxide or at a partial pressure less than that of the carbonylation reaction. The involatile contaminants are then separated from the carboxylic acid.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: September 2, 1997
    Assignee: BP Chemicals Limited
    Inventors: George Ernest Morris, Stephen James Smith, John Glenn Sunley, Robert John Watt, Bruce Leo Williams
  • Patent number: 5663460
    Abstract: A liquid l-n-menthol composition containing 30 to 80% by weight of (-)-n-isopulegol and a process for preparing a liquid l-n-menthol composition comprising mixing 20 to 70 parts by weight of liquid menthol at a temperature of not lower than 42.degree. C. as obtained in the production of l-n-menthol with 30 to 80 parts by weight of (-)-n-isopulegol are disclosed. Further, the liquid l-n-menthol composition in which part of the (-)-n-isopulegol is replaced with 3-l-n-menthoxypropane-1,2-diol and the process for preparing the same are also disclosed. The liquid l-n-menthol composition of the present invention is less expensive than conventionally available menthol and yet has an improved feeling of coolness (particularly, the bitterness is reduced) and can be used in place of conventional menthol. Besides, the liquid menthol composition of the present invention is excellent in workability and hygiene on use.
    Type: Grant
    Filed: July 28, 1995
    Date of Patent: September 2, 1997
    Assignee: Takasago International Corporation
    Inventors: Takeshi Yamamoto, Hideaki Ohta
  • Patent number: 5661184
    Abstract: The present invention provides a method of treating substance dependence disorders using an agonist which acts at negatively coupled cAMP-linked metabotropic glutamate receptors.
    Type: Grant
    Filed: June 29, 1995
    Date of Patent: August 26, 1997
    Assignee: Eli Lilly and Company
    Inventors: David R. Helton, Mary Jeanne Kallman, James A. Monn, Darryle D. Schoepp, Joseph P. Tizzano
  • Patent number: 5659076
    Abstract: A process for the transesterification of dimethyl succinylsuccinate with one or more aliphatic alcohols which in each case have at least 2 C atoms, in the presence of an acidic catalyst and in the presence or absence of a diluent which is inert under the reaction conditions, with exclusion of oxygen and under pressure, at least one of the two methoxy groups being replaced by the oxy group corresponding to the alcohol used and use of the process in a process for the preparation of terephthalic acids and of quinacridones.
    Type: Grant
    Filed: August 25, 1995
    Date of Patent: August 19, 1997
    Assignee: DSM Chemie Linz GmbH
    Inventors: Franz Thomas Schwarz, Johann Altreiter, Franz Mostl
  • Patent number: 5659073
    Abstract: Disclosed is a method of making a glycol ether acetate. Acetic acid is reacted with a glycol ether at a molar ratio of about 1.1 to about 2, in a mixture with a catalyst and an azeotropic agent which can be either butyl acetate or dibutyl ether. The mixture is heated to a temperature and pressure sufficient to vaporize an azeotrope of water and the azeotropic agent. In another embodiment of the invention, a glycol ether acetate is made by preparing a reaction mixture of acetic acid and a glycol ether in a molar ratio of about 1.1 to about 1.2, about 5 to about 25 wt % n-butanol, an additional amount of acetic acid stoichiometric with the amount of n-butanol, and a catalyst. The reaction mixture is heated to form a glycol ether acetate, water, and butyl acetate. The azeotrope, excess acetic acid, butyl acetate, and glycol ether are successively removed by distillation.
    Type: Grant
    Filed: July 7, 1995
    Date of Patent: August 19, 1997
    Inventor: Jian Steven Qi
  • Patent number: 5656588
    Abstract: The present invention provides a composition that stimulates and improves wound healing in a patient in need of same. To this end, a method for stimulating wound healing comprising the step of administering to a patient a composition including a therapeutically effective amount of a source of carnosine is provided. In an embodiment, the composition also meets the nutrient requirements of a patient that are generated due to tissue repair and healing requirements.
    Type: Grant
    Filed: July 19, 1994
    Date of Patent: August 12, 1997
    Assignee: Wake Forest University
    Inventors: Gary P. Zaloga, Pamela Roberts
  • Patent number: 5654473
    Abstract: Novel trifluoromethylated intermediates are provided which are useful in synthesizing trifluoromethylated organic compounds. Specifically, compounds of the formula CF.sub.3 CCl.dbd.CHCH.sub.2 X are provided, which compounds are versatile intermediates for the synthesis of a wide variety of trifluoromethylated organic compounds.
    Type: Grant
    Filed: March 16, 1995
    Date of Patent: August 5, 1997
    Assignee: AlliedSignal Inc.
    Inventor: Michael Van Der Puy
  • Patent number: 5650390
    Abstract: Pharmaceutical compositions containing FSH, LH or hCG stabilized by means of a combination of sucrose and glycine. The formulation is particularly suitable for stabilizing a lyophilisate of recombinant gonadotropins.
    Type: Grant
    Filed: July 28, 1994
    Date of Patent: July 22, 1997
    Assignee: Applied Research Systems ARS Holding N. V.
    Inventors: Fabrizio Samaritani, Patrizia Natale
  • Patent number: RE35615
    Abstract: In a process for removing iodide compounds from a liquid composition comprising carboxylic acids having 2 to 6 carbon atoms or anhydrides thereof, by passing the liquid composition through a silver, mercury, palladium and/or rhodium-exchanged strong acid cation exchange resin, prior to contacting with the metal-exchanged resin the composition is contacted with a cation exchanger in the acid form to remove at least a portion of the metal ion contaminants in the liquid composition which have been found to displace the silver, mercury, palladium and/or rhodium from the metal-exchanged resin.
    Type: Grant
    Filed: June 19, 1995
    Date of Patent: September 23, 1997
    Assignees: BP Chemicals Limited, The British Petroleum Company, P.L.C.
    Inventors: Michael David Jones, Derrick John Watson, Bruce Leo Williams