Patents Examined by Russell S. Negin
  • Patent number: 10892040
    Abstract: A method is provided for evaluating a set of measurement data from an oral glucose tolerance test. The method may include calculating a similarity measure that quantifies the similarity between a time profile of the series of measured data of the glucose concentration and a corresponding glucose reference profile. The method may include calculating a further similarity measure that quantifies the similarity between the profile of the series of measured values of the further analyte concentration and the corresponding analyte sample profile, wherein the data set is represented by a point in a vector space that comprises coordinate axes that are formed by the similarity measures, whereby the coordinates of said point contain the calculated values of the similarity measures.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: January 12, 2021
    Assignee: ROCHE DIABETES CARE, INC.
    Inventors: Arnulf Staib, Ortrud Quarder, Gerhard Werner
  • Patent number: 10892036
    Abstract: The present invention relates to systems and methods for determining the identity of alleles from genomic sequencing data via pseudoalignments. Particularly, aspects of the present invention are directed to a computer implemented method that includes obtaining a paired-end fragment from a genomic sample, determining a first nucleotide substring from a first end of the paired-end fragment matches a nucleotide substring within an index of nucleotide substrings and alleles, determining a second nucleotide substring from a second end of the paired-end fragment matches another nucleotide substring within the index, determining an intersection between the nucleotide substring and the another nucleotide substring exists, when an allele that contains the nucleotide substring is the same allele that contains the another nucleotide substring; and determining a probability that the paired end fragment is an observation of the allele based on the existence of the intersection.
    Type: Grant
    Filed: August 2, 2017
    Date of Patent: January 12, 2021
    Assignee: Verily Life Sciences LLC
    Inventors: Mauricio Carneiro, Mark DePristo, Ryan Poplin
  • Patent number: 10892033
    Abstract: A method of monitoring bioprocesses, wherein a course of a bioprocess is predicted using a process model and values for process parameters are estimated during the bioprocess, where at least one process parameter is selected (step a), for which current measured values are determined during the bioprocess, the respective current measured value of the selected process parameter is compared with the corresponding estimated value for this process parameter estimated by the process model (step b), a variance is then compared with a predetermined threshold value (step c), in a step d), at least one model parameter is then changed when the threshold value is exceeded by the variance, where steps b) to d) are executed until the variance fails to meet the threshold value, and in the case that the threshold value is not met after a predetermined number of repetitions, the method is discontinued and a warning is output.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: January 12, 2021
    Assignee: Siemens Aktiengesellschaft
    Inventors: Martin Joksch, Johannes Scheiblauer
  • Patent number: 10890588
    Abstract: This invention is directed to methods for the facile and accurate identification of cancer cells in a tissue sample, such as a surgical field. In particular, the compositions and methods employ conjugates comprising pro-fluorescent fluorescein based moieties bound to folic or pteroic acid targeting moiety optionally through a linker. The pro-fluorescent fluorescein based moieties are non-fluorescent but capable of being rendered fluorescent by intracellular processes. The conjugates are employed to detect cancer cells that overexpress folic acid receptors thereby providing for differential accumulation of these conjugates in these cells.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: January 12, 2021
    Assignee: ISI Life Sciences, Inc.
    Inventors: John Fante, Theodore Hessler, III, Robert M. Moriarty, Richard Pariza, Gerald F. Swiss, David White, Craig Keshishian
  • Patent number: 10872682
    Abstract: A computer assisted method of designing a designed alloy composition comprising a plurality of elements, the method comprising the steps of: populating a multi-dimensional alloy space with a plurality of candidate alloy compositions, the plurality of candidate alloy compositions including for each of the plurality of elements at least three candidate alloy compositions with different amounts of the respective element to each other; performing at least one test on each individual one of the plurality of candidate alloy compositions until each of the individual ones of the plurality of candidate alloy compositions fails a test or has passed all tests; outputting the designed alloy composition based on one or more of the individual ones of the plurality of candidate alloy compositions which have passed all tests, wherein the at least one test includes at least: a phase equilibrium test in which predicted phase equilibrium is determined as a function of elemental composition of the individual one of the plurality
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: December 22, 2020
    Assignee: Oxford University Innovation Limited
    Inventors: Roger Reed, Zailing Zhu, David Crudden
  • Patent number: 10854314
    Abstract: A representation of a nucleic acid sequence encodes a particular gene having at least one intron. An intron signature value corresponding to the at least one intron is determined based on a first computational function applied to at least one portion of the representation of the nucleic acid sequence corresponding to the at least one intron. A protein signature value is determined, being based on a second computational function applied to a representation of a protein. In a database, an association is formed between the intron and protein signature values. This process is repeated for each of a plurality of nucleic acid sequences. Nucleic acid sequences in the database are ordered based on a sort of corresponding intron signature values. An ordering determined by the sort is used to determine or confirm a role or function of a portion of a given nucleic acid sequence.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: December 1, 2020
    Assignee: CODONDEX LLC
    Inventors: Kevin Bermeister, Xinghao Yu
  • Patent number: 10847250
    Abstract: This invention relates to a binomial calculation of copy number of data obtained from a mixed sample having a first source and a second source.
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: November 24, 2020
    Assignee: Ariosa Diagnostics, Inc.
    Inventors: Craig Struble, John Stuelpnagel
  • Patent number: 10844429
    Abstract: The disclosed embodiments concern methods, apparatus, systems and computer program products for determining sequences of interest using unique molecular index sequences that are uniquely associable with individual polynucleotide fragments, including sequences with low allele frequencies and long sequence length. In some implementations, the unique molecular index sequences include variable-length nonrandom sequences. In some implementations, the unique molecular index sequences are associated with the individual polynucleotide fragments based on alignment scores indicating similarity between the unique molecular index sequences and subsequences of sequence reads obtained from the individual polynucleotide fragments. System, apparatus, and computer program products are also provided for determining a sequence of interest implementing the methods disclosed.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: November 24, 2020
    Assignee: Illumina, Inc.
    Inventors: Kevin Wu, Chen Zhao, Han-Yu Chuang, Alex So, Stephen Tanner, Stephen M. Gross
  • Patent number: 10844424
    Abstract: Methods are provided for detecting and quantitating molecules using fluidics. In some embodiments, the methods comprise minimizing or eliminating biases caused by label density, or minimizing or eliminated biases caused by factors other than label density. In some embodiments, the methods comprise automated identification of genetic structural variation. In some embodiments, the methods comprise analyzing blood to detect the presence of circulating DNA or cells from a fetus or tumor.
    Type: Grant
    Filed: February 24, 2015
    Date of Patent: November 24, 2020
    Assignee: Bionano Genomics, Inc.
    Inventor: {hacek over (Z)}eljko D{hacek over (z)}akula
  • Patent number: 10842444
    Abstract: Systems and methods are provided for assessing perturbation of a target biological tissue caused by exposure to an agent. A set of scores indicative of a perturbation of the target biological tissue is determined based on a set of contrast data and a computational causal network model of xenobiotic metabolism in the target biological tissue and a surrogate biological tissue. The contrast data includes differences between activity measures of measurable nodes obtained from the surrogate biological tissue while exposed to the agent, and while exposed to a control. To determine the set of scores, a set of values is computed that indicates a perturbation of the surrogate biological tissue caused by the agent. A correlation is identified between the set of values for the backbone nodes obtained from the surrogate biological tissue and the set of scores that is indicative of a perturbation of the target biological tissue.
    Type: Grant
    Filed: September 4, 2014
    Date of Patent: November 24, 2020
    Assignee: Philip Morris Products S.A.
    Inventors: Julia Hoeng, Manuel Claude Peitsch
  • Patent number: 10839938
    Abstract: Roughly described, a computer-implemented evolutionary data mining system implements a genetic algorithm. The Genetic algorithm includes a requirements checkpoint, which selects individuals for discarding from the pool of candidate genomes which do not meet a predetermined minimum behavioral requirement for operating in production. The requirements checkpoint enforces an absolute minimum threshold for a behavioral characteristic of the individual, and is different from a competition step in which individuals are selected for removal on the basis of comparisons with each other. A requirements checkpoint may be inserted at various points within the genetic algorithm flow or at reasonable intervals during the training cycle. If at any of these checkpoints the minimum requirement is not met, the candidate individual may be removed from the candidate pool.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: November 17, 2020
    Assignee: Cognizant Technology Solutions U.S. Corporation
    Inventors: Babak Hodjat, Hormoz Shahrzad
  • Patent number: 10835131
    Abstract: Methods for detecting a seizure, by use of a wavelet transform maximum modulus (WTMM) algorithm applied to body data. A non-transitive, computer-readable storage device for storing data that when executed by a processor, perform such a method.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: November 17, 2020
    Assignee: FLINT HILLS SCIENTIFIC, LLC.
    Inventors: Ivan Osorio, Alexey Lyubushin, Didier Sornette
  • Patent number: 10839945
    Abstract: The present invention provides improved methods for maintaining the physical separation and identity integrity of a biological cellular sample from a patient during processing. The invention enables parallel processing of biological cellular samples, such as patient samples, in a space and time efficient fashion. The methods of the invention find particular utility in processing patient samples for use in cell therapy.
    Type: Grant
    Filed: July 6, 2015
    Date of Patent: November 17, 2020
    Assignee: Global Life Sciences Solutions USA LLC
    Inventors: Mohan Mark Amaratunga, Nicholas Thomas, Philip Vanek
  • Patent number: 10839948
    Abstract: Embodiments herein relate to data storage and retrieval using information-encoding polymers encapsulated in droplets stored in a microfluidic droplet storage array. In various embodiments, a data storage apparatus may include a microfluidic droplet storage array to store one or more droplets containing one or more information-encoding polymer molecules in one or more droplet storage locations, and an interface coupled with the microfluidic droplet storage array to receive the one or more droplets from a data writer that writes the one or more droplets into the microfluidic droplet storage array. Other embodiments may be described and/or claimed.
    Type: Grant
    Filed: December 29, 2016
    Date of Patent: November 17, 2020
    Assignee: Intel Corporation
    Inventors: Brian W. Bramlett, Amar S. Basu
  • Patent number: 10822654
    Abstract: The invention relates to a method and a corresponding arrangement for sequencing at least two biopolymers (6), wherein for each biopolymer (6) a sequence signal is picked up by a respective measured variable pickup on the basis of the sequence of the biopolymer (6), the sequence signals are transferred to a shift register (16) and buffer-stored therein, the buffer-stored sequence signals are transferred from the shift register (16) sequentially to an evaluation device (26) and evaluated therein. Each sequence signal is preferably produced here by means of a nanopore arrangement (10). A corresponding sequencing arrangement (11) has the measured variable pickups and the shift register (16) integrated in it, preferably in an electrical circuit, that is to say on a sensor array, for example. Each sequence signal can be amplified here by a preamplifier (14) prior to transfer to the shift register (16).
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: November 3, 2020
    Assignee: SIEMENS AKTIENGESELLSCHAFT
    Inventors: Walter Gumbrecht, Oliver Hayden, Meinrad Schienle
  • Patent number: 10818485
    Abstract: For a sample whose components are separated from each other, an MS2 analysis is repeatedly performed by an MS/MS unit to obtain MS2 spectra. Peak information is collected from the MS2 spectrum acquired for each micro area on a two-dimensional chromatogram. A principal component analysis processor performs a principal component analysis on the collected peak information to determine a principal component score reflecting an overall tendency of the peak pattern of the MS2 spectra. A factor loading calculator computes a factor loading for each m/z from the principal component score. A correlation information calculator computes the coefficient of correlation between each MS2 spectrum and the factor loadings. Since the MS2 spectra reflect the chemical structure of a contained component, a two-dimensional image created based on the coefficient of correlation shows the distribution of a component having a similar chemical structure to a component which is characteristically contained in the sample.
    Type: Grant
    Filed: December 8, 2014
    Date of Patent: October 27, 2020
    Assignee: SHIMADZU CORPORATION
    Inventor: Shinichi Yamaguchi
  • Patent number: 10815518
    Abstract: A sampler and a method of parameterization by calibration of digital circuits and non-invasive determination of the concentration of several biomarkers simultaneously and in real time. The method makes use of equipment which, from a set of luminous signatures—spectrum—provided by a spectrophotometer (E5) (E6), applies a digital filter that breaks down the spectrum into sub-spectra that shows the digital signatures of relevant markers and, through a digital decoder, the concentration of a set of several biomarkers is obtained simultaneously and in real time.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: October 27, 2020
    Inventors: José António Martins, Marcelo Adorni Pereira, Vanderlei Pereira Ferreira
  • Patent number: 10808280
    Abstract: Systems and a method for computationally analyzing genetic base pairs are provided. In one or more aspects, a system includes a memory and a processor coupled to the memory. The processor is configured to receive a number of genetic sequences from a genetic sequencer device. The processor can generate, for each genetic sequence, a binary sequence. Each binary sequence is partitioned into a set of binary strings. Each binary string includes multiple binary base pairs. A set of entropy values are determined, each entropy value is associated with a binary string, and an entropy distribution function (EDF) is generated based on the set of entropy values.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: October 20, 2020
    Assignee: Colossio, Inc.
    Inventor: Joseph A. Jaroch
  • Patent number: 10790045
    Abstract: Techniques for screening homopolymers, copolymers or blends for fabrication are disclosed. A data repository stores data points. Each data point comprises a structural repeating unit (SRU) and at least one material property value for the SRU. Each SRU is a homopolymer SRU, a copolymer component SRU or a blend component SRU. A machine determines a fingerprint for at least a subset of the SRUs in the data repository. The machine stores, in the data repository, each determined fingerprint in conjunction with a corresponding SRU. The machine generates a quantitative modeling engine to predict material property values, based on SRUs, for homopolymers, copolymers or blends. The quantitative modeling engine is based, at least in part, on the fingerprints. The machine identifies, using the quantitative modeling engine, at least one homopolymer SRU, copolymer SRU set or blend SRU set that has a material property value within a given range.
    Type: Grant
    Filed: October 15, 2019
    Date of Patent: September 29, 2020
    Assignee: Corning Incorporated
    Inventors: Sushmit Sunil Kumar Goyal, Franklin Langlang Lee, Adama Tandia, Mardochee Reveil
  • Patent number: 10782224
    Abstract: Provided is a spectrum analysis apparatus including a processing unit configured to generate analysis data using an analysis function in which a linear function and a logarithmic function are included as function elements and an intensity value is set as a variable from measurement data including the intensity value of light acquired by detecting the light from a measurement target object using a plurality of light-receiving elements having different detection wavelength bands.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: September 22, 2020
    Assignee: Sony Corporation
    Inventor: Nao Nitta