Abstract: A prophylactic spermicidal lubricant composition and method for its use in safe sexual relations, including prevention of infection by HIV and other viruses. The composition contains: a) a cosmetically acceptable lubricant effective to reduce friction, thereby reducing the rupture of blood vessels during sexual relations; b) an effective amount of chlorhexidine salt active against HIV and other, viruses, the chlorhexidine salt immobilizing sperm and reacting with vaginal mucosa to form a barrier to the penetration of sperm calls into the uterus, but also destroying natural flora in the vagina and thereby permitting growth of fungi which causes ulceration; and c) an effective amount of a cosmetically acceptable fungicide to prevent the growth of fungi in the vagina in the absence of natural bacterial flora, destroyed by the chlorhexidine salt.

Abstract: Disclosed herein are agents for enhancing the contrast in an ultrasound image. These agents are extremely small bubbles, or “microbubbles,” comprised of specially selected gases. The microbubbles described herein exhibit long life spans in solution and may be produced at a size small enough to traverse the lungs, thus enabling improved ultrasound imaging of the cardiovascular system and other vital organs. Also disclosed herein is a method for selecting gases from which contrast agents may be produced. The method is based on calculations using inherent physical properties of gases and describes a means to associate the properties of a gas with the time for dissolution of microbubbles comprised of the gas.

Abstract: A method of treating premenstrual syndrome and menopausal symptoms in a patient, the method comprising: administering to the patient an 1H-indole-3-methanol compound (e.g., 1H-indole-3-methanol; ascorbigen) in a medically acceptable manner in a pharmaceutically effective amount. It has been found that the administration of such indoles, particularly, 1H-indole-3-methanol, greatly relieves the symptoms of PMS. Patients with PMS have reported decreased menstrual cramping, decreased menstrual flow, shorter duration of menses, decreased fatigue, less frequent headaches, improved mood, and decreased bloating resulting from the oral administration each day or during specific portions of the menstrual cycle of pharmaceutically effective amounts of dietary indoles derived from 1H-indole-3-methanol. It has also been found that the administration of such indoles, particularly, 1H-indole-3-methanol, greatly relieves the symptoms of menopause.

Abstract: The method of the present invention provides a novel use of the iron binding protein lactoferrin to prevent or treat the insult-induced metabolic imbalance in humans and other animals. More particularly, the present invention is the use of lactoferrin for the manufacture of a medicament for the treatment of the metabolic hypo- or hyperactivity in the gut.

Abstract: Disclosed are attractants and lures for attracting and controlling the adult form of Diabrotica species, in particular northern corn rootworm, useful individually or in mixtures and in combination with insecticides and compulsive feeding stimulants, such as cucurbitacins.

Abstract: A method is disclosed for the treatment of non-rheumatoid arthritis by administering to a mammal in need thereof a therapeutically effective amount of an sPLA2 inhibitor.

Abstract: A powder-based solid cosmetic composition is provided having a hardness not greater than 75 as measured by an Asker hardness tester type C1L, a porosity of at least 0.4 and an impact resistance of at least 5. A process is also provided for making the powder-based solid cosmetic composition. The composition according to the present invention has excellent skin feel upon use and is not easily broken.

Abstract: Retinoids with retinoid receptor antagonistic activity, pharmaceutically acceptable salts and pharmaceutically acceptable hydrolyzable esters thereof, have been found efficacious in treating T-helper cell type 2 (Th2)-mediated immune diseases, such as immunoglobulin E (IgE)-mediated allergic diseases.

Abstract: Provided is a method comprising administering (+) -Z- bisdehydrodoisynolic acid to a patient for treating, inhibiting or delaying the onset of prostatic conditions including prostatitis, benign prostatic hypertrophy and prostate cancer without accompanying feminizing effects.

Abstract: A blood collection system and method are disclosed in which taurolidine, a neutralizing agent for pathogens is added to the blood collected in standard blood bags. The taurolidine agent may be prepositioned in the collection bag prior to the collection of blood or alternatively the taurolidine may be added after the collection of blood has been completed.

Abstract: The invention provides a use of a metalloproteinase inhibitor for the preparation of a pharmaceutical composition for treating human pulmonary emphysema which comprises admixing the metalloproteinase inhibitor in an amount effective to treat human pulmonary emphysema and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition which comprises a metalloproteinase inhibitor in an amount effective to treat human pulmonary emphysema and a pharmaceutically acceptable carrier.

Abstract: A multiple pulsed dose drug delivery system for pharmaceutically active amphetamine salts, comprising an immediate-release component and an enteric delayed-release component wherein (1) the enteric release coating has a defined minimum thickness and/or (2) there is a protective layer between the pharmaceutically active amphetamine salt and the enteric release coating and/or (3) there is a protective layer over the enteric release coating. The product can be composed of either one or a number of beads in a dosage form, including either capsule, tablet, or sachet method for administering the beads.

Abstract: Methods for producing coronary vasospasms and for inhibiting coronary vasospasms are disclosed. Both in vivo and in vitro methods are disclosed. The methods are useful as tests for determining the ability of a chemical compound to inhibit or reduce coronary vasospasms.

Abstract: This invention relates to homogeneous, anhydrous formulations which contain glycerophospholipids and polar or lipophilic substances (eg, physiologically active ingredients) in a molar ratio of 1:0.001 to 1:2, and maybe anhydrous formulation aids, eg, in the form of glycerol, in a molar ratio of 1:0.001 to 1:1, expressed in terms of the glycerophospholipids, the components forming such stable aggregates with one another as to render the formulations ideal for the preparation of dispersions, emulsions and/or suspensions in many fields of application, these including the food-processing sector, biotechnology, and the pharmaceuticals industry. The formulations are produced in an extraction column using compressed hydrocarbons, and are obtained from the column as a melt.

Abstract: A test system for characterizing the compatibility of bioactive substances with polyvinylpyrrolidones in a solid dispersion consisting of one or more bioactive substances and 1,3-bis(1-pyrrolidonyl)butane.

Abstract: The present invention is directed to a complex comprising a redox-active metal cluster in a chemically inert shell. The inventive complex has the formula M8(&mgr;4-E)4(&mgr;-L)12X, where M is chosen from a transition metal, a lanthanide, an actinide and mixtures thereof; E is a chalcogenide; L is a bridging ligand; and X is a terminal ligand. The chemically inert shell enables the complex to exhibit structural stability over several oxidation states, and to exhibit reversible electrochemical reduction properties. A single reactor method of making this complex from simple starting materials is also disclosed. The active center further allows the octanuclear complex to be used in making supercluster assemblies that have electron transfer properties or in making contrasting agents for MRI applications, for example.

Abstract: An anti-stress agent and functional food containing the anti-stress agent and having an anti-stress effect, which contain as an effective ingredient fermented sour milk prepared by, for example, fermenting animal milk starting material with lactic acid bacteria of the genus Lactobacillus, which can be taken repeatedly and daily without any problems with safety, and which can mitigate and prevent mental and physical symptoms caused by stress.

Abstract: The present invention relates to the use of sterols derived from a plant or algae extract as the active principle of a cosmetic composition for combating adiposity. Said sterols are, for example, at least one of the three following sterols: campesterol, beta-sitosterol or stigmasterol.

Abstract: The present invention teaches the composition of terminally modified, amino, polyether, siloxanes, known hereforth as amino siloxane alkokylates, and their use as adjuvants. The amino siloxane alkoxylates of the present invention enhance the efficacy of agrichemicals on plants as compared to conventional TSE's alone. The amino siloxane alkoxylates have at one end, an amine functionality and at the other end, a polyalkyleneoxide functionality.

Abstract: The present invention relates to a composition for suppressing or ameliorating a symptom accompanying diminished homeostasis, comprising theanine; and a mineral composition comprising theanine and a mineral. According to the present invention, there can be provided a composition for suppressing or ameliorating the above symptoms; and a mineral composition having a reduced peculiar metal taste, of which administration is made easily.