Patents Examined by Ruth A. Davis
  • Patent number: 11926816
    Abstract: The disclosure provides a culture plate comprising medium which supports microbial growth and comprises a dextrin comprising four or more glucose units linked by ?(1?4) glycosidic bonds as a sole carbon source. The culture plate comprises a first zone inoculated with a sta? S. cerevisiae strain which produces a pigment upon sugar fermentation, and a second zone adjacent to the first zone and which is not inoculated with a microbe. The disclosure further provides a method of using the culture plate to characterize microbial diastatic activity.
    Type: Grant
    Filed: January 19, 2021
    Date of Patent: March 12, 2024
    Assignee: OMEGA YEAST LABS, LLC
    Inventors: Lance Shaner, Laura Burns
  • Patent number: 11891620
    Abstract: Platelet lysate compositions and cell culture media compositions for maintaining and/or growing mammalian cells, such as mammalian endothelial cells (ECs) and mammalian endothelial progenitor cells (EPCs), in particular human ECs (huECs) and human EPCs (huEPCs), such as primary huECs and primary huEPCs, are provided. The cell culture media compositions contain a basal medium, a platelet lysate and, optionally, one or more exogenously added growth factors. Also provided are methods for making and using such cell culture media compositions to grow and/or maintain ECs and EPCs, including huECs and huEPCs, as well as cell culture vessels, dishes, plates, and/or flasks pretreated with the cell culture media compositions.
    Type: Grant
    Filed: May 14, 2015
    Date of Patent: February 6, 2024
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Allan B. Dietz, Gaylord Knutson
  • Patent number: 11877578
    Abstract: A composition for biologically controlling phytopathogenic fungi that pertains to the agricultural biotechnology area, more particularly a composition of bacteria and fungi with different complementary mechanisms of action in the mitigation of phytopathogenic fungi in crops. The composition is a formulation containing Bacillus amyloliquefaciens and Trichoderma harzianum mixed with additives and excipients. Micro-organism Clonostachys rosea can also be added.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: January 23, 2024
    Assignee: AGRIVALLE BRASIL INDÚSTRIA E COMÉRCIO DE PRODUTOS AGRÍCOLAS LTDA.
    Inventors: Eduardo Roberto de Almeida Bernardo, Tiago Domingues Zucchi
  • Patent number: 11879122
    Abstract: A method of producing natto includes inoculating a mutant strain of Bacillus subtilis var. natto onto steamed or boiled soybeans, and fermenting the soybeans inoculated with the mutant strain by maintaining a temperature of the soybeans at 40° C. to 53° C. The number of the mutant strain spores after fermenting the soybeans is 5×105 or less spores per gram of the fermented soybeans. A single colony of the mutant strain cultured in a selective solid medium supplemented with biotin at a gas phase temperature of 49° C. for 48 hours has a region having a hue of yellow (Y), a value of 9 or more, and a chroma of 2 or less, as defined by the Munsell Color System, and a surface area of the region is 20% or less of the total surface area of the single colony.
    Type: Grant
    Filed: August 28, 2019
    Date of Patent: January 23, 2024
    Assignee: Mizkan Holdings Co., Ltd.
    Inventor: Atsushi Ishikawa
  • Patent number: 11871767
    Abstract: The disclosure relates to isolated microorganisms—including novel strains of the microorganisms—microbial ensembles, and compositions comprising the same. Furthermore, the disclosure teaches methods of utilizing the described microorganisms, microbial compositions, and compositions comprising the same, in methods for modulating the agricultural production of ruminants. In particular aspects, the disclosure provides methods of increasing feed efficiency, and methods of decreasing acidosis.
    Type: Grant
    Filed: June 22, 2021
    Date of Patent: January 16, 2024
    Assignee: Native Microbials, Inc.
    Inventors: Mallory Embree, Cameron Martino, Norman Pitt, Jordan Embree, Corey Dodge
  • Patent number: 11866691
    Abstract: The present invention provides an improved method of utilizing agricultural waste and fungal mycelium in order to create mycelium-based biocomposite materials capable of serving in structural, load-bearing capacities. The dramatic reduction in the embodied carbon of a part grown with the method of the present invention over prior art creates benefit for the use of mycelium-based biocomposites in a new, regenerative economy. The present invention creates parts of superior strength over prior art using far less embodied carbon in the process of manufacture.
    Type: Grant
    Filed: June 10, 2021
    Date of Patent: January 9, 2024
    Assignee: okom wrks labs, PBC
    Inventor: Joshua Aaron English
  • Patent number: 11859170
    Abstract: Animal feed or animal feed additives comprising one or more polypeptides having lysozyme activity. Polypeptides having lysozyme activity, polynucleotides encoding the polypeptides nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: January 2, 2024
    Assignee: Novozymes A/S
    Inventors: Ye Liu, Ming Li, Kirk Matthew Schnorr, Peter Bjarke Olsen
  • Patent number: 11845971
    Abstract: Methods for producing methane from algae, and particularly methods for producing methane from brown algae. The present methods can use a biomass of brown algae such as Hormophysa cuneiformis subjected to bacterial treatment to produce methane. The bacteria can comprise Aeromonas sobria and Staphylococcus haemolyticus. The brown algae and bacteria can all be obtained from the Arabian Gulf.
    Type: Grant
    Filed: May 4, 2023
    Date of Patent: December 19, 2023
    Assignee: KING FAISAL UNIVERSITY
    Inventor: Nermin Adel El Semary
  • Patent number: 11820974
    Abstract: A pomegranate molasses medium for culturing microbes includes a mixture of pomegranate molasses, soil extract, and water. The pomegranate molasses medium for culturing microbes may optionally include at least one of potassium dihydrogen phosphate and iron ammonium EDTA. At least one beneficial microbe may be cultured on the pomegranate molasses medium. The at least one beneficial microbe may include, e.g., Cyanothece and/or beneficial fungus.
    Type: Grant
    Filed: August 31, 2022
    Date of Patent: November 21, 2023
    Assignee: KING FAISAL UNIVERSITY
    Inventor: Nermin Adel Hussein El Semary
  • Patent number: 11812751
    Abstract: The biocontrol agent for use against soil and air-borne pathogens includes a mixture of isolates from at least three Trichoderma species, including Trichoderma harzianum, Trichoderma longibrachiatum, and Trichoderma asperellum. The mixture of Trichoderma isolates may be effective in controlling plant pathogens. The biocontrol agent for use against soil and air-borne fungal pathogens may be formulated as a wettable powder. The biocontrol agent may be used in the treatment or prevention of infection of date palms with Thielaviopsis punctulata. In a further embodiment, the biocontrol agent may be used in the treatment or prevention of infection of cucumbers with Rhizoctonia solanii.
    Type: Grant
    Filed: October 3, 2022
    Date of Patent: November 14, 2023
    Assignee: KING FAISAL UNIVERSITY
    Inventors: Khalid A. Alhudaib, Sherif Mohamed El-Ganainy, Muhammad Naeem Sattar, Mustafa Ibrahim Al-Maghaslah
  • Patent number: 11814617
    Abstract: The present invention relates to methods of producing ensiled plant materials using the anaerobic bacterium Megasphaera elsdenii and ensiled plant materials thereof.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: November 14, 2023
    Assignees: Kansas State University Research Foundation, Axiota U.S., Inc.
    Inventors: James Scott Drouillard, Kevin Alan Miller, Celine Caroline Aperce, Taylor Marie Horne, Tara Jo Ellerman, Gina Rae Herren
  • Patent number: 11771722
    Abstract: Methods of inhibiting or reducing tumor metabolism and growth are disclosed. A composition containing oxygen scavenging membrane fragments and anaerobe bacteria is injected into a tumor to interfere with tumor growth and metabolism, leading to tumor necrosis. The composition may also contain a cryoprotectant, which permits the composition to be stored at sub-zero temperatures without freezing.
    Type: Grant
    Filed: July 27, 2020
    Date of Patent: October 3, 2023
    Assignee: Oxyrase, Inc.
    Inventor: James C. Copeland
  • Patent number: 11752201
    Abstract: Herein disclosed are improved methods for treating stress disorders, such as Post-Traumatic Stress Disorder and perceived stress, by administration of acetylcholine release inhibitors, such as neurotoxic proteins (e.g., a botulinum toxin), to a patient at specific locations and amounts.
    Type: Grant
    Filed: January 7, 2020
    Date of Patent: September 12, 2023
    Inventor: Babak Azizzadeh
  • Patent number: 11724004
    Abstract: The present application relates to use of transglutaminases to treat various products, including medical devices such as tissue grafts, tissue matrices or other tissue-derived materials, and synthetics. The transglutaminases can be applied to the medical devices to provide advantages such as adhesion resistance or abrasion resistance.
    Type: Grant
    Filed: October 6, 2020
    Date of Patent: August 15, 2023
    Assignee: LifeCell Corporation
    Inventors: Yi Chen, Sean Collins, Li Ting Huang, Eric Stec, Hui Xu
  • Patent number: 11725199
    Abstract: The invention is directed to a lactose-positive, galactose-negative, Streptococcus thermophilus strain releasing glucose during milk fermentation. This Streptococcus thermophilus strain carries mutation in the glcK gene, in the ccpA gene, in the lacZ gene and/or in the ptsH gene, and optionally in one or more genes, in particular one gene, encoding a protein of the mannose-glucose-specific PTS. The invention also concerns a composition comprising at least one, lactose-positive, galactose-negative, Streptococcus thermophilus strain of the invention, and the use of this strain or composition to manufacture a fermented dairy product.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: August 15, 2023
    Assignee: DUPONT NUTRITION BIOSCIENCES APS
    Inventors: Armelle Cochu-Blachere, Christophe Fremaux, Thomas Desfougeres
  • Patent number: 11707493
    Abstract: Disclosed herein are methods and compositions that can be used to improve motor deficits and neuroinflammation in subjects in need, for example subjects suffering from neurodegenerative disorders (e.g., Parkinson's disease). Also disclosed are methods and compositions that can be used to diagnose neurodegenerative disorders, such as Parkinson's disease.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: July 25, 2023
    Assignee: California Institute of Technology
    Inventors: Sarkis K. Mazmanian, Timothy R. Sampson
  • Patent number: 11696584
    Abstract: The present disclosure discloses a Streptomyces antioxidans strain Sa-21, namely, strain Sa-21 with an accession number of CCTCC NO: M 2020423. The present disclosure also discloses the use of the aforementioned Strepiomyces antioxidans strain Sa-21 in inhibition of Alternaria solani (A. solani). The Streptomyces antioxidans strain also has an inhibiting effect on both plant pathogenic fungi and plant pathogenic bacteria.
    Type: Grant
    Filed: December 7, 2021
    Date of Patent: July 11, 2023
    Assignee: Zhejiang Normal University
    Inventors: Donghua Jiang, Xin Guo, Jingjing Ma, Jingjing Zhang, Zhipeng He
  • Patent number: 11666640
    Abstract: Neonatal seizure is different from adult seizure, and many anti epileptic drugs that are effective in adults often fail to treat neonatal seizure. Gluconic acid, a natural organic acid enriched in fruits and honey, and the glucose oxidase enzyme, is shown herein to potently inhibit neonatal epilepsy both in vitro and in vivo. Sodium gluconate is shown to inhibit epileptiform burst activity in cell cultures and protect neurons from kainic acid-induced cell death. Sodium gluconate also inhibited epileptiform burst activity in brain slices in a manner that was much more potent in neonatal animals than in older animals. Consistently, in vivo EEC recordings also revealed that sodium gluconate inhibited the epileptic seizure activity in a manner that was much more potent in neonates than in adult animals. Mechanistically, sodium gluconate inhibits voltage-dependent CLC-3 C1? channels both in neuronal cultures and in hippocampal slices.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: June 6, 2023
    Assignee: PENN STATE RESEARCH FOUNDATION
    Inventors: Gong Chen, Zheng Wu
  • Patent number: 11660376
    Abstract: The growth factor profile, connective tissue matrix constituents, and immunoprivileged status of urodele extracellular matrix (ECM) and accompanying cutaneous tissue, plus the presence of antimicrobial peptides there, render urodele-derived tissue an ideal source for biological scaffolds for xenotransplantation. In particular, a biological scaffold biomaterial can be obtained by a process that entails (A) obtaining a tissue sample from a urodele, where the tissue comprises ECM, inclusive of the basement membrane, and (B) subjecting the tissue sample to a decellularization process that maintains the structural and functional integrity of the extracellular matrix, by virtue of retaining its fibrous and on-fibrous proteins, glycoaminoglycans (GAGs) and proteoglycans, while removing sufficient cellular components of the sample to reduce or eliminate antigenicity and immunogenicity for xenograft purposes.
    Type: Grant
    Filed: February 26, 2020
    Date of Patent: May 30, 2023
    Assignee: NeXtGen Biologies, Inc.
    Inventor: Ryanne Early
  • Patent number: 11655446
    Abstract: A method for cultivating micro-algae cultures using bivalve waste comprising usable nitrogen and phosphorus as a nutrient source. The micro-algae cultures may be used in turn as a nutrient source for oysters.
    Type: Grant
    Filed: September 27, 2021
    Date of Patent: May 23, 2023
    Assignee: MORGAN STATE UNIVERSITY
    Inventors: Thomas F. Ihde, Rebekah Borgert