Patents Examined by Ryan B Huang
  • Patent number: 11959841
    Abstract: A device and method for isolating extracellular vesicles from biofluids is disclosed. A nanoporous silicon nitride membrane is provided with a tangential flow of biofluid. A pressure gradient through the nanoporous silicon nitride membrane facilitates capture of extracellular vesicles from the tangential flow vector of biofluid. Reversal of the pressure gradient results in the release of the extracellular vesicles for subsequent collection.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: April 16, 2024
    Inventors: James Lionel McGrath, Kilean Scott Lucas, Henry Hung Li Chung
  • Patent number: 11946038
    Abstract: Systems, and their methods of use, for sorting or separating magnetic particles are provided. A system having a magnetic module with features that mate with voids in a flow module exerts a magnetic field on magnetic particles to separate particles.
    Type: Grant
    Filed: May 27, 2021
    Date of Patent: April 2, 2024
    Assignee: 10x Genomics, Inc.
    Inventors: Alireza Salmanzadeh, Dagmar Walter
  • Patent number: 11938417
    Abstract: Methods and systems for removing gases and/or pressure formed during the sterilization, e.g., the gamma irradiation, of prepacked chromatography systems (column plus attached tube and valve set) are described. The methods include purging the gas and/or pressure through specially designed tube and valve sets without breaching the sterility of the prepacked sterile chromatography system. The systems include a sterile or aseptic pre-packed chromatography column including a column having an inlet and an outlet, a tubing and valve set attached to the inlet and the outlet, and a pump configured to pump sterile or aseptic liquid from the fluid source along the tubing and valve set, into the column tube inlet and out of the column tube outlet along a first flow path, thereby removing any entrapped gas and/or pressure from the chamber.
    Type: Grant
    Filed: June 9, 2022
    Date of Patent: March 26, 2024
    Inventors: Alan Kit Ho Chan, James Ronald Peyser
  • Patent number: 11933699
    Abstract: The present disclosure relates to devices and methods for preparing a filtered solution from slurry for lateral flow testing of analytes of interest in agricultural or environmental samples. A porous frit is located adjacent to an outlet of a vessel containing slurry, and positive pressure is applied to the volume enclosed by a vessel body of the vessel to cause the slurry to pass through the porous frit and become a filtered solution that exits the outlet of the vessel. Devices and methods described herein allow more rapid, cleaner, and inexpensive production of filtered samples than conventional methods.
    Type: Grant
    Filed: June 28, 2018
    Date of Patent: March 19, 2024
    Assignee: Waters Technologies Corporation
    Inventors: Lingyun Chen, Chris Borbone
  • Patent number: 11905310
    Abstract: The present invention relates to a process for purification a protein comprising a semi-continuous chromatography step whereby the flow-through is collected and re-loaded onto the chromatography matrix.
    Type: Grant
    Filed: May 24, 2021
    Date of Patent: February 20, 2024
    Inventor: Michael Harry Rose
  • Patent number: 11904259
    Abstract: The present invention relates to a method for isolating extracellular vesicles using cations, and more particularly, to a method for isolating extracellular vesicles from various samples by using the affinity between the extracellular vesicles and cations. A method for isolating extracellular vesicles according to the present invention does not require expensive equipment, can be applied irrespective of sample amount, and has the advantage of being capable of efficiently isolating the extracellular vesicles while preserving the shape or characteristics thereof. Moreover, the method according to the present invention can be combined with existing isolation methods to maximize extracellular vesicle isolation efficiency, and can be applied to disease diagnosis, disease treatment, and multi-omics research using isolated extracellular vesicles, as well as to research on the properties of extracellular vesicles.
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: February 20, 2024
    Inventors: Yong Song Gho, Chang Jin Lee, Ji Hyun Kim, Sung Hyun Song
  • Patent number: 11896933
    Abstract: Embodiments of the present invention provide for the deposition of spacing elements for spiral wound elements that prevent nesting of adjacent spacer layers and occlusion of feed space during element rolling.
    Type: Grant
    Filed: July 6, 2021
    Date of Patent: February 13, 2024
    Assignee: Aqua Membranes Inc.
    Inventors: Kevin Roderick, Rodney Herrington
  • Patent number: 11896934
    Abstract: Porous liquid-filtering membranes are provided having a boundary region substantially surrounding the pore region and having greater tear resistance than the pore region.
    Type: Grant
    Filed: December 8, 2020
    Date of Patent: February 13, 2024
    Assignee: Global Life Sciences Solutions Operations UK Limited
    Inventors: Douglas Albagli, William A. Hennessy
  • Patent number: 11883785
    Abstract: Provided is a reverse osmosis membrane comprising: a support layer comprising a support and a polysulfone layer; and an active layer, wherein a compression modulus is from 20 MPa to 40 MPa, to a method for manufacturing the same, and a water-treatment module.
    Type: Grant
    Filed: May 9, 2019
    Date of Patent: January 30, 2024
    Assignee: LG Chem, Ltd.
    Inventors: Ayoung Lee, Yun Seok Choe, Chong Kyu Shin, Phill Lee
  • Patent number: 11873454
    Abstract: An elongate, horizontally level, pipe includes a circumferential wall. The pipe flows, within the circumferential wall, process fluid that includes a first fluid and a second fluid immiscible with the first fluid. The first fluid and the second fluid are separated by an interfacial layer. Heating coils are disposed within the pipe. Each heating coil passes through an interior region of the pipe between the circumferential wall at a respective height from a bottom of the pipe. The heating coils generate heat. A controller is connected to the heating coils. The controller triggers at least one of the heating coils that is nearest to a location of the interfacial layer within the interior region to apply heat to the interfacial layer. The heat is sufficient to at least partially demulsify the interfacial layer.
    Type: Grant
    Filed: March 22, 2021
    Date of Patent: January 16, 2024
    Assignee: Saudi Arabian Oil Company
    Inventors: Kamarul Ariffin Amminudin, Nagoorpitchai S. Meeranpillai, Sultan H. Owaidhi
  • Patent number: 11866348
    Abstract: Introduced here are systems for treating a wastewater stream to produce an effluent stream. A treatment system can include a sensor for measuring a characteristic of the wastewater stream and/or the effluent stream, a pump for supplying a chemical additive to the wastewater stream, and a controller for varying the flow rate of the chemical additive based on real-time analysis of measurements generated by the sensor. The characteristic could be, for example, turbidity, pH, total suspended solids (TSS), etc. Some embodiments of the treatment system further include a flow meter for measuring flow of the wastewater stream. In such embodiments, the controller may vary the flow rate of the chemical additive based on the measurements generated by the sensor and the flow meter.
    Type: Grant
    Filed: November 11, 2019
    Date of Patent: January 9, 2024
    Inventor: Denny Allen Criswell
  • Patent number: 11839852
    Abstract: Systems and methods for efficient, effective, and safe separation and isolation of multiple isotopes (e.g., Mo, Zr, Ba, Sr, Te, and lanthanide isotopes) from fission products includes use of a plurality of chromatography columns, each containing a chromatographic resin formulated to target one or more particular isotopes. The system is operable in a “series” configuration to load the multiple columns by a single pass of the sample. Then, the system may be transitioned (e.g., using valves) to a “parallel” configuration in which multiple columns of the system may be operated simultaneously to elute targeted isotopes. Additional parallel operations of the columns, using different eluent compositions, may be used to elute different targeted isotopes. The system may be reconditioned in preparation for a subsequent sample.
    Type: Grant
    Filed: January 21, 2021
    Date of Patent: December 12, 2023
    Assignee: Battelle Energy Alliance, LLC
    Inventors: Mathew S. Snow, Jessica L. Ward
  • Patent number: 11840554
    Abstract: In some embodiments, the present invention provides a method of purifying a protein of interest with a reduced level of aggregation formation in cation exchange (CEX) chromatography, comprising: (a) providing a mixture comprising the protein of interest and one or more contaminants; (b) loading the mixture onto a CEX resin coupled with arginine; and (c) eluting the protein of interest from the resin, thereby purifying the protein of interest with a reduced level of aggregation formation in CEX chromatography.
    Type: Grant
    Filed: February 10, 2021
    Date of Patent: December 12, 2023
    Inventors: Zhengjian Li, Xuankuo Xu, Chao Huang, Zhiqiang Chen
  • Patent number: 11833477
    Abstract: A biocompatible polymeric membrane includes pores defined between two material layers, where the first membrane material layer includes strips, and the second membrane material binds to each of the plurality of first membrane material layer strips includes a plurality of windows exposing each of the first membrane material strips. The biocompatible polymeric filtration membrane comprises pores defined by uniform passages defined by the first membrane material layer strips and the second membrane material layer within each window.
    Type: Grant
    Filed: October 9, 2020
    Date of Patent: December 5, 2023
    Inventors: Ralph Stankowski, Douglas Albagli, William A. Hennessy
  • Patent number: 11819822
    Abstract: A silica monolith nested in a polymer sponge may be formed by applying a hydrolyzed mixture of siloxanes to a melamine-formaldehyde sponge, and may be used in methods of solid phase extraction.
    Type: Grant
    Filed: January 31, 2020
    Date of Patent: November 21, 2023
    Assignee: The Governors of the University of Alberta
    Inventors: Xing-Fang Li, Zhongshan Liu
  • Patent number: 11807534
    Abstract: A method for making a membrane includes buffing a first set of graphene platelets onto a surface of a porous substrate to force the graphene platelets into the pores of the substrate, to yield a primed substrate. The method further includes applying a fluid to the primed substrate. The method further includes forcing the fluid through the primed substrate while retaining at least a first portion of the graphene platelets of the first set on the substrate within the pores, to yield a graphene membrane comprising the substrate and a graphene layer platelets lodged within the pores of the substrate.
    Type: Grant
    Filed: October 26, 2021
    Date of Patent: November 7, 2023
    Assignee: 2599218 ONTARIO INC.
    Inventor: Nifemi Oguntuase
  • Patent number: 11795069
    Abstract: A phase separator apparatus includes a fluid flow pathway and a phase separator. The fluid flow pathway includes a fluid inlet and a fluid outlet. The fluid flow pathway is configured to flow multiphase fluid including an oil phase and a water phase from the fluid inlet to the fluid outlet. The phase separator is spatially positioned relative to the fluid flow pathway to receive the multiphase fluid flowing from the fluid outlet. The phase separator includes a mounting substrate and a separation layer attached to the mounting substrate. The separation layer includes a material switchable between oleophilic and hydrophobic under a first condition and oleophobic and hydrophilic under a second condition. The separation layer is configured to separate the oil phase and the water phase when the separation layer is under either the first condition or the second condition.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: October 24, 2023
    Assignee: Saudi Arabian Oil Company
    Inventor: Zeyad Tareq Ahmed
  • Patent number: 11786869
    Abstract: Porous membranes are provided according to the invention having desirable coefficient of thermal expansion and large surface area, for example at least about 4,000 mm2. These porous membranes may be made according to an exemplary process employing lithographic patterning of a photoresist followed by development of the photoresist and etching. In one aspect, the etch barrier layer is chosen from a material that does not react with or incorporate metal or other contaminants into the membrane layer.
    Type: Grant
    Filed: April 7, 2020
    Date of Patent: October 17, 2023
    Inventors: William A Hennessy, Douglas Albagli
  • Patent number: 11786840
    Abstract: A filtering process can comprise providing a dispersion comprising a liquid and a plurality of particles contained in the liquid; moving an object relative to the dispersion; selectively removing at least a portion of the plurality of particles from the dispersion to obtain a plurality of separated particles attached to the object. In a further embodiment, an assembly for separating particles from a dispersion can comprise a chamber including a dispersion, the dispersion comprising a liquid and a plurality of particles; a movable object, the object being adapted for moving through the chamber and adsorbing at least a portion of the plurality of particles during moving; a first construction adapted for moving the object relative to the dispersion at a controlled moving speed, and a second construction adapted for removing and collecting from the object a plurality of separated particles from the dispersion.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: October 17, 2023
    Inventor: Martin Z. Bazant
  • Patent number: 11779860
    Abstract: The present invention relates to Fc binding proteins comprising one or more domains with Cysteine in the C-terminal helical region. The invention further relates to affinity matrices comprising the Fc binding proteins of the invention. The invention also relates to a use of these Fc binding proteins or affinity matrices for affinity purification of immunoglobulins and to methods of affinity purification using the Fc binding proteins of the invention.
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: October 10, 2023
    Assignee: Repligen Corporation
    Inventors: Erik Fiedler, Ulrich Haupts