Abstract: The invention comprises a membrane and device and method for removing proteases from fluids, particularly from biological fluids and pharmaceutical solutions, which uses a microporous membrane body, whereby inhibitors that selectively bind proteases are coupled to the membrane body by chemically activated groups.
Type:
Grant
Filed:
June 17, 2003
Date of Patent:
January 1, 2013
Assignee:
Sartorius AG
Inventors:
Wolfgang Demmer, Dietmar Nussbaumer, Hans-Heinrich Hörl
Abstract: The invention comprises a membrane and device and method for removing proteases from fluids, particularly from biological fluids and pharmaceutical solutions, which uses a microporous membrane body, whereby inhibitors that selectively bind proteases are coupled to the membrane body by chemically activated groups.
Type:
Grant
Filed:
May 17, 2006
Date of Patent:
January 1, 2013
Assignee:
Sartorius AG
Inventors:
Wolfgang Demmer, Dietmar Nussbaumer, Hans-Heinrich Hörl
Abstract: Enhancing the effectiveness of therapeutic ionizing radiation and other treatments of disease in which cells are to be destroyed or modified, by subjecting cells in need thereof to low-dose radiation to increase the sensitivity of the cells to subsequent subjection with a lethal dose of high dose radiation (HDR), a chemotherapeutic agent, or other type of therapeutic treatment.
Type:
Grant
Filed:
February 3, 2006
Date of Patent:
September 4, 2012
Assignee:
The Catholic University of America
Inventors:
Theodore A Litovitz, Patrick Mehl, Andrea L Cohen
Abstract: A tissue harvesting method and device for obtaining micrograft tissue particles within the size range of 50-1500 microns, and more preferably 500-1000 microns, and most preferably 600 microns. The particles may be processed after a piece of donor tissue has been excised from the donor site, or processed into the desired size directly at the donor site, and thereafter excised. Cutters having blades or cutting edges spaced in the range of 50-1500 microns are utilized to obtain particles within the desired size range. An elastomer is positioned between the cutting edges to push the excised particles out of the blades for ease of use.
Type:
Grant
Filed:
February 6, 2007
Date of Patent:
February 7, 2012
Assignee:
KCI Licensing, Inc.
Inventors:
Ajit Mishra, Charles Seegert, Makoto Ohira