Patents Examined by S L Chen
  • Methods of using cytochrome P450 reductase for the enhancement of P450-based anti-cancer gene therapy
    Patent number: 6207648
    Abstract: Methods of killing neoplastic cells are provided. The invention relates to the use of NADPH-cytochrome P450 reductase (RED) gene transfer in combination with cytochrome P450 gene transfer to enhance the sensitivity of tumor cells to anti-cancer drugs that are activated by P450 enzymes. The use of bioreductive drugs that are activated by RED and/or cytochrome P450, in this paradigm, is also provided.
    Type: Grant
    Filed: July 17, 1998
    Date of Patent: March 27, 2001
    Assignee: Trustees of Boston University
    Inventors: David J. Waxman, Ling Chen