Patents Examined by S. Marshall
  • Antimicrobial peptides
    Patent number: 5798336
    Abstract: Peptides which exhibit antimicrobial activity comparable to certain known antibiotics are provided. These peptides are related in sequence to amino acid sequences within Cathepsin G. A broad spectrum bactericidal peptide disclosed herein is RPGTLCTVAGWGRVSMRRGT (SEQ ID NO:22). It is active against Pseudomonas aeruginosa, Neisseria gonorrhoeae and Staphylococcus aureus. RRENTQQHITARRAIRHPQY (SEQ ID NO:19) and GKSSGVPPEVFTRFVSSFLPWIRTTMR (SEQ ID NO:26) also exhibited potent activity against P. aeruginosa strains, including clinical isolates. IIGGR (SEQ ID NO:1) and IVGGR (SEQ ID NO:2) act against both gram-negative and gram-positive bacterial strains. HPQYNQR (SEQ ID NO:3) and certain related peptides are also active against both gram-negative and gram-positive bacteria, including, but not limited to, strains of Escherichia coli, Neisseria gonorrhoeae, Staphylococcus aureus, Capnocytophage sputigena and Pseudomonas aeruginosa.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: August 25, 1998
    Assignees: Emory University, University of Georgia Research Foundation Inc.
    Inventors: James Travis, William M. Shafer, Neelesh Bangalore, Jan Pohl
  • C-reactive protein fragment with immunomodulatory activity
    Patent number: 5783179
    Abstract: Compounds having immunomodulatory activity comprising the optionally modified dodecapeptide fragment A-(SEQ ID No: 1)-B corresponding to residues 174 to 185 of C-reactive protein (CRP), pharmaceutical compositions thereof, and methods of treating cancer with the compositions. Liposomal formulations containing the CRP-peptide fragment are particularly efficacious when administered in conjunction with interleukin-2.
    Type: Grant
    Filed: August 9, 1991
    Date of Patent: July 21, 1998
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: John J. Nestor, Jr., Teresa H. Ho, Deborah A. Eppstein, Philip L. Felgner, Barbara P. Barna, Sharad D. Deodhar
  • Laminin a chain polypeptides from the amino terminal golbular domain
    Patent number: 5703205
    Abstract: Polypeptides derived from domain VI of the amino terminal globule of the A chain of laminin and having sequences of at least about 5 amino acids, and which exhibit cell adhesion and cell spreading capacity are described.Medical devices such as prosthetic implants, per-cutaneous devices and cell culture substrates coated with a composition including the described polypeptides are also provided.
    Type: Grant
    Filed: June 7, 1993
    Date of Patent: December 30, 1997
    Assignee: Regents of the University of Minnesota
    Inventors: Amy P. N. Skubitz, Leo T. Furcht
  • Endothelin antagonistic substance
    Patent number: 5614498
    Abstract: Peptides having the formula: ##STR1## inhibit the binding of endothelin to its ET.sub.B receptor and are useful in treating diseases associated with excess production or secretion of endothelin.
    Type: Grant
    Filed: September 16, 1992
    Date of Patent: March 25, 1997
    Assignee: Banyu Pharmaceutical Co., Ltd.
    Inventors: Kiyofumi Ishikawa, Takehiro Fukami, Takeshi Hayama, Kenji Niiyama, Toshio Nagase, Toshiaki Mase, Kagari Fujita, Masaki Ihara, Fumihiko Ikemoto, Mitsuo Yano, Masaru Nishikibe
  • Method and composition for increasing body weight and stimulating immune systems
    Patent number: 5478559
    Abstract: A method and composition for increasing body weight and stimulating the immune systems of domestic animals, poultry and fish are disclosed. In the method of the present invention, bacterial and yeast cells from which capsules have been removed are given to the domestic animals, poultry or fish.
    Type: Grant
    Filed: January 15, 1991
    Date of Patent: December 26, 1995
    Assignee: National Federation of Agricultural Cooperative Associations
    Inventors: Terutake Yabiki, Atsushi Hamano, Sunao Fukami, Katsuyoshi Kitajima, Fumio Tachibana
  • Endothelin antagonistic peptide derivatives
    Patent number: 5470833
    Abstract: Peptides having the formula: ##STR1## inhibit the binding of endothelin to its receptor and are useful in treating diseases associated with excess production or secretion of endothelin.
    Type: Grant
    Filed: March 14, 1994
    Date of Patent: November 28, 1995
    Assignee: Banyu Pharmaceutical Co., Ltd.
    Inventors: Kiyofumi Ishikawa, Takehiro Fukami, Takashi Hayama, Kenji Niiyama, Toshio Nagase, Toshiaki Mase, Kagari Fujita, Masaki Ihara, Fumihiko Ikemoto, Mitsuo Yano