Patents Examined by S. Treanor
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Patent number: 5145873Abstract: Cyclopropanecarboxyamides of the general formula I ##STR1## Where R.sup.1 is C.sub.1 -C.sub.4 -alkyl, fluorine, chlorine, bromine, C.sub.1 -C.sub.3 -haloalkyl or C.sub.1 -C.sub.3 -haloalkoxy, R.sup.2 is hydrogen, fluorine, chlorine or bromine, with the proviso that R.sup.1 is not fluorine if R.sup.2 is H, and pesticides containing these compounds.Type: GrantFiled: November 14, 1989Date of Patent: September 8, 1992Assignee: BASF AktiengesellschaftInventors: Uwe Kardorff, Hans-Juergen Neubauer, Joachim Leyendecker, Christoph Kuenast, Peter Hofmeister, Wolfgang Krieg, Rainer Buerstinghaus
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Patent number: 5045567Abstract: Propanolamine derivatives of the formula ##STR1## wherein R.sup.1 is hydrogen or a group of formula ##STR2## n is the number 0 or 1; R.sup.2 and R.sup.5 are phenyl, m-halophenyl, m-trifluoromethylphenyl, thienyl or pyridyl;R.sup.3 is hydrogen or methyl;R.sup.4 is hydrogen, --CH.sub.2 COOH, --CH.sub.2 COO--C.sub.1-4 -alkyl, --(CH.sub.2).sub.2 O--C.sub.1-4 -alkyl or --(CH.sub.2).sub.2 O(CH.sub.2).sub.1-4 --C.sub.6 H.sub.5 ;and a physiologically compatible salt thereof.The invention also relates to processes for the preparation of these propanolamine derivatives, pharmaceutical preparations and feedstuffs containing them, and methods of using the propanolamine derivatives.Type: GrantFiled: October 31, 1990Date of Patent: September 3, 1991Assignee: Hoffmann-La Roche Inc.Inventor: Frank Kienzle
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Patent number: 5034408Abstract: Fungicidal cyclopropanoylamino acid amide derivative of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are identical or different and represent hydrogen or alkyl;Q represents an unsubstituted or substituted straight-chain or branched alkylene chain, or together with the radical R.sup.4 and the nitrogen atom forms a pyrrolidine ring;A represents a straight-chain or branched alkylene chain;n represents the number 0 or 1 andAr represents unsubstituted or substituted aryl.Type: GrantFiled: April 25, 1990Date of Patent: July 23, 1991Assignee: Bayer AktiengesellschaftInventors: Detlef Wollweber, Gerd Hanssler
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Patent number: 4985462Abstract: Compounds of the general formula ##STR1## wherein n is from 1 to 6 and each of R.sup.1 and R.sup.2 represents an alkyl group of 1 to 4 carbon atoms and their acid addition salts are useful for thickening mucus, especially gastro-intestinal mucus as an anti-ulceration treatment or cervical mucus in contraception.Type: GrantFiled: December 4, 1989Date of Patent: January 15, 1991Assignee: National Research Development CorporationInventors: James A. Baker, Stuart L. James, Tuncel Ibrahim, Christopher Marriott
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Patent number: 4973761Abstract: Aminomono- or di-[(poly-n-butoxy)-n-butylamino]-(poly-n-butoxy)-n-butylamines of the general formula IH.sub.2 N--[(CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 O).sub.x --(CH.sub.2).sub.4 --NH].sub.y --(CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 O).sub.x --(CH.sub.2).sub.4 --NH.sub.2 (I)where x is from 1 to 150 and y is 1 or 2, are prepared by a process in which a hydroxy-(poly-n-butoxy)-butanol of the formula IIHO--(CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 O).sub.x --(CH.sub.2).sub.4 --OH (II)where x is from 1 to 150, is reacted with from 1.01 to 300 mole equivalents of ammonia per hydroxyl group in the presence of a hydrogenation/dehydrogenation catalyst and hydrogen at from 150.degree. to 300.degree. C. and under from 20 to 400 bar.Type: GrantFiled: July 21, 1989Date of Patent: November 27, 1990Assignee: BASF AktiengesellschaftInventors: Willibald Schoenleben, Herbert Mueller
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Patent number: 4935546Abstract: A process for the production of a primary alkylamine or a dimethylalkylamine in a single stage comprising heating a reaction medium comprising a long chain carboxylic acid ester with ammonia and hydrogen in the presence of a mixed catalyst of the oxide-metal type; said oxide being titanium dioxide and the metal being a combination of copper and cobalt or of copper, chromium, and cobalt; and the mixed oxide-metal catalyst.Type: GrantFiled: October 9, 1987Date of Patent: June 19, 1990Assignee: Ceca, S.A.Inventors: Joel Barrault, Mongi Seffen, Christian Forquy
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Patent number: 4876044Abstract: Novel thiadiazole compounds are produced having the following general formula: ##STR1## wherein X is S or SO.sub.2R.sub.1 is a lower alkyl (cyclic or non-cyclic) radicalR.sub.2 is hydrogen or a lower acyclic hydrocarbon radicalR.sub.3 is a lower acyclic hydrocarbon or cycloalkyl radical or alkoxy radical, andR.sub.4 is hydrogen, a lower acyclic hydrocarbon radical or cycloalkyl radical, provided R.sub.3 and R.sub.4 are not both cycloalkyl, and[B] Tautomers of [A] wherein R.sub.2 is hydrogen.Synthesis of these compounds is disclosed, including synthesis of those compounds which exhibit tautomerism.The compounds show particular utility as agricultural pesticides and most favorably as herbicides.Type: GrantFiled: October 2, 1969Date of Patent: October 24, 1989Inventors: Tony Cebalo, Robert E. Buntrock
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Patent number: 4851031Abstract: The invention relates to the use of quinoline derivatives of formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are each independently hydrogen, halogen, nitro, cyano, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.3 alkoxy,R.sub.4, R.sub.5 and R.sub.6 are each independently hydrogen, halogen or C.sub.1 -C.sub.3 alkyl,A is a group selected from --CH.sub.2 --, --CH.sub.2 --CH.sub.2 -- or --CH(CH.sub.3)-- andZ is (a) cyano or amidoxime which may be acylated at the oxygen atom, or (b) a carboxyl group or a salt thereof, a mercaptocarbonyl group or a salt thereof, an esterified carboxyl group, a thiocarbonyl group, an unsubstituted or a substituted carbamoyl group, a cyclized unsubstituted or substituted derivative of a carbamoyl group, or is a carbonohydrazido group; or A and Z together are an unsubstituted or a substituted tetrafuran-2-one ring.Type: GrantFiled: September 10, 1986Date of Patent: July 25, 1989Assignee: Ciba-Geigy CorporationInventors: Sergio Bellucci, Adolf Hubele, Andreas Nyffeler
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Patent number: 4847412Abstract: The invention relates to a process for racemizing an optically active N-benzylidene amino-acid amide, characterized in that a solution of the N-benzylidene amino-acid amide is mixed in a water-miscible organic solvent with at least 0.05 mole strong base per liter solution.The invention further relates to a process for preparing an L-amino acid by enzymatic separation of the corresponding DL-amino-acid amide with an enzyme preparation from Pseudomonas putida, in which process also unconverted D-amino-acid amide is left behind in solution, characterized in that benzaldehyde is added to the solution, during which addition a precipitate of D-N-benzylidene amino-acid amide is being formed, this precipitate is subsequently, after being separated off, dissolved in an acetone-water mixture, 0.08-0.15 mole KOH/liter solution is subsequently added, the resulting solution is stirred for 1-20 hours at 20.degree.-60.degree. C.Type: GrantFiled: April 10, 1986Date of Patent: July 11, 1989Assignee: Stamicarbon B.V.Inventors: Wilhelmus H. J. Boesten, Hans E. Schoemaker, Bernardus H. N. Dassen
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Patent number: 4827037Abstract: Process for the improvement of the quality of polyalkylene polyamines prepared by the reaction of (i) ammonia and/or an alkyleneamine compound having at least two amino groups and an alkanolamine compound having at least one amino group in the presence of a catalytically effective amount of a metal acid phosphate and at a temperature and pressure sufficient to form the polyalkylene polyamine.Type: GrantFiled: April 4, 1985Date of Patent: May 2, 1989Assignee: Union Carbide CorporationInventor: Arthur R. Doumaux, Jr.
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Patent number: 4814500Abstract: A novel cyanoguanidine derivative represented by the following general formula (I): ##STR1## wherein X stands for a hydrogen atom, a chlorine atom or a bromine atom, and R stands for a lower alkyl group, is an effective precursor for the synthesis of N-cyano-N'-methyl-N"-(2-(5-methyl-4-imidazolylmethylthio(ethyl)-guanidine (Cimetidine) which has an action of controlling secretion of gastric acid and is valuable as an agent for the remedy of a gastric ulcer.This cyanoguanidine derivative is prepared by reacting a methylvinylketone derivative with a mercaptoguanidine derivative or by reacting an amidinoketone derivative with a halogenating agent.Type: GrantFiled: September 1, 1987Date of Patent: March 21, 1989Assignee: Mitsui Petrochemical Industries, Ltd.Inventors: Noriaki Kihara, Teruaki Mukaiyama, Takeshi Ishitoku, Katsuya Takahashi
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Patent number: 4813999Abstract: Herbicidal products comprising a mixture of one or several linear acid esters and one or several branched acid esters of bromoxynil and/or a mixture of one or several linear acid esters and one or several branched acid esters of ioxynil, the proportion of linear acid esters of bromoxynil in the mixture of the latter with the branched acid esters of bromoxynil being from 20-90%, preferably from 30-80% molar and the proportion of linear acid esters of ioxynil in the mixture of the latter with the branched acid esters of ioxynil being from 30-95% and, preferably, from 40-85% molar, with the proportion of branched acid esters representing each time the complement to 100%.Type: GrantFiled: December 9, 1986Date of Patent: March 21, 1989Assignee: Compagnie Francaise de Produits IndustrielsInventors: Joseph Schapira, Jacques Pecheur, Jacques Vincent, Patrick Droniou, Jean-Paul Fournials
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Patent number: 4808207Abstract: Disclosed are compositions and processes for controlling undesirable weeds. These compositions comprise synergistic combinations of microbial herbicides and or plant growth regulators. Use of the synergistic compositions of the subject invention enhances the value of the microbial herbicide by reducing the amount of microbial herbicide needed and by extending the range of environmental conditions in which the microbial herbicide will function.Type: GrantFiled: October 28, 1987Date of Patent: February 28, 1989Assignees: The University of Vermont and State Agricultural College, The Royal Institution for the Advancement of Learning (McGill University)Inventors: Alan R. Gotlieb, Alan K. Watson
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Patent number: 4806564Abstract: The compounds of the following structural formula (I) ##STR1## are 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase inhibitors and useful as antihypercholesterolemic agents for the treatmet of disease in which the inhibition of cholesterol biosynthesis would be useful, such as arteriosclerosis, hyperlipidemia and familial hypercholesterolemia.Type: GrantFiled: May 26, 1987Date of Patent: February 21, 1989Assignee: Merck & Co., Inc.Inventors: John C. Chabala, Yuan-Ching P. Chiang, Michael N. Chang, Donald W. Graham, James V. Heck, Shu S. Yang
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Patent number: 4806566Abstract: The invention relates to the tri-yne carbonate of formula I which has activity against gram positive bacteria. Such compound can be produced by isolating it from the fermentation broth of ATCC-53614, ATCC-53615 or ATCC-53616.Type: GrantFiled: May 26, 1987Date of Patent: February 21, 1989Assignee: Merck & Co., Inc.Inventor: Sheldon B. Zimmerman
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Patent number: 4802905Abstract: Crops, seeds, tissue cultures and cut flowers are protected from stress by application of polyamines and acid salts of such polyamines. The polyamines of this invention are represented by the general formula:H.sub.2 NCHRCHR(--NHCHRCHR--)nNH.sub.2where n represents an integer of from 1 to 3 and R represents either hydrogen or a methyl group.Type: GrantFiled: March 10, 1987Date of Patent: February 7, 1989Assignee: Air Products and Chemicals, Inc.Inventor: Marshall Spector
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Patent number: 4800213Abstract: Novel diethanolaminetriacetic acid triamide compounds such as diethanolaminetriacetic acid tris(N,N-diisobutylamide) (alternatively named 2,2'-[[bis(2-methylpropyl)amino]-2-oxoethyl]nitrilo]bis[2,1-ethanedi yloxy]bis[N,N-bis (2-methylpropyl)acetamide]) are disclosed that are useful for improving feed utilization efficiency of ruminants and for improving lactation of lactating ruminants. Also disclosed are novel intermediates for preparation of the triamide compounds.Type: GrantFiled: August 3, 1987Date of Patent: January 24, 1989Assignee: Eastman Kodak CompanyInventor: Alan W. White
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Patent number: 4760063Abstract: Novel thienooxazines of the formula ##STR1## in which R.sup.1 and R.sup.2, together with the adjacent C atoms, represent an optionally substituted thiophene ring,R.sup.3 represents hydrogen, optionally substituted alkyl, cycloalkyl, alkenyl or aryl, andR.sup.4 represents optionally substituted alkyl, cycloalkyl, alkenyl or aryl, orR.sup.3 and R.sup.4, together with the adjacent nitrogen atom, form a saturated heterocyclic structure which may optionally contain further hetero atoms,promote the yield of animals, e.g. rate of growth, ratio of meat to fat, etc. They are made from new intermediates of the formulas ##STR2## in which R.sup.5 and R.sup.6 may be hydrogen or various organic radicals, or together form a ring.Type: GrantFiled: November 12, 1986Date of Patent: July 26, 1988Assignee: Bayer AktiengsellschaftInventors: Werner Hallenbach, Hans Lindel, Friedrich Berschauer, Martin Scheer, Anno de Jong