Abstract: Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering derivatives of 2-methoxyestradiol of the general formula: wherein the variables are defined in the specification.
Type:
Grant
Filed:
February 8, 2001
Date of Patent:
February 7, 2006
Assignee:
Entre Med, Inc.
Inventors:
Gregory E. Agoston, Victor Pribluda, Anthony M. Treston, Shawn J. Green
Abstract: The invention is the novel androgen (7?,17?)-7-methyl-17-[(1-oxoundecyl)oxy]estr-4en-3one (MENT undecanoate). This compound distinguishes favourably from other testosterone derivatives in that it has a good solubility in oily media. It particularly exhibits a good dissolved potency relative to testosterone. The compound is particularly suitable for administration by means of injection.
Type:
Grant
Filed:
October 13, 2004
Date of Patent:
January 24, 2006
Assignee:
Akzo Nobel N.V.
Inventors:
Dirk Leysen, Hendrikus Adrianus Antonius Van Der Voort
Abstract: The present invention relates to a process for effectively preparing prostaglanin derivatives and to a stereospecific alkyl halide containing 15S-alcohol group as a starting material.
Type:
Grant
Filed:
December 22, 2004
Date of Patent:
January 24, 2006
Assignee:
Yonsung Fine Chemical Co.
Inventors:
Won-Hun Ham, Chang-Young Oh, Yong-Hyun Kim, Yiu-Suk Lee, Kee-Young Lee
Abstract: The present invention provides novel 16-ene-C25-oxime and 16-ene-C-25-oxime ether analogs of 1?,25-dihydroxy vitamin D3, compositions comprising these compounds and methods of using these compounds as inhibitors of CYP24. In particular, the compound of Formula I are useful for treating diseases which benefit from a modulation of the levels of 1?,25-dihydroxy vitamin D3, for example, cell-proliferative disorders.
Type:
Grant
Filed:
October 15, 2002
Date of Patent:
January 3, 2006
Assignees:
Cytochroma Inc., Johns Hopkins University
Inventors:
Gary Posner, Mehmet Kahraman, Heung Bae Jeon, Jay A. White, Glenville Jones, Bethany Halford
Abstract: Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.
Type:
Grant
Filed:
November 2, 2001
Date of Patent:
November 8, 2005
Assignee:
Genaera Corporation
Inventors:
Michael Zasloff, Ann Shinnar, William Kinney, Steven Jones
Abstract: Compounds expressed by the following general formula (1), [wherein, R01 and R02 are each independently a hydrogen atom or a protecting group for a hydroxyl group; Z is one out of the following formulae (1-1), (1-2), (1-3), (1-4) and (1-5)]. The compounds can be used as active ingredients of treating agents for inflammatory respiratory diseases, malignant tumors, rheumatoid arthritis, osteoporosis, diabetes mellitus, hypertension, alopecia, acne, psoriasis, dermatitis, hypercalcemia, hypoparathyroidism and metabolic disorder of cartilage.
Abstract: Herbicidal compositions comprising at least one herbicidally active compound of the formula (I) and at least one crop-plant-protecting compound of the formula (II) as safener are described.
Type:
Grant
Filed:
September 11, 2002
Date of Patent:
July 5, 2005
Assignee:
Bayer CropScience GmbH
Inventors:
Frank Ziemer, Lothar Willms, Christopher Rosinger, Hermann Bieringer, Erwin Hacker
Abstract: Cyclohexenone derivatives of benzazolones of the formula I where the variables R1, R2, R3, A and Hex are as defined in claim 1, and their salts, and their use for controlling harmful plants, are described.
Type:
Grant
Filed:
December 10, 2001
Date of Patent:
June 21, 2005
Assignee:
BASF Aktiengesellschaft
Inventors:
Guido Mayer, Ulf Misslitz, Ernst Baumann, Wolfgang von Deyn, Steffen Kudis, Michael Hofmann, Thorsten Volk, Matthias Witschel, Cyrill Zagar, Andreas Landes, Klaus Langemann
Abstract: The present invention relates to the field of chemistry and more particularly to that of therapeutic chemistry. The invention relates more particularly to novel contraceptive compositions formed from a progestative agent and an oestrogen. The invention relates specifically to novel pharmaceutical contraceptive compositions, characterized in that they contain, as active ingredients, a nomegestrol ester and oestradiol, in combination or admixture with an inert, non-toxic, pharmaceutically-acceptable vehicle or diluent which is suitable for oral administration.
Abstract: The invention relates to a cosmetic or pharmaceutical formulation comprising at least one compound of formula (I). The cosmetics or pharmaceutical products are particularly suitable for the care of the skin in protecting against oxidative stress and ageing phenomena.
Type:
Grant
Filed:
January 22, 2001
Date of Patent:
June 7, 2005
Assignee:
Merck Patent GmbH
Inventors:
Frank Pflücker, Herwig Buchholz, Ralf Rosskopf, Joachim Bünger
Abstract: The invention provides fungicidal compounds of formula (I) and salts thereof wherein: R1 is alkyl, alkenyl, alkynyl, carbocyclyl or heterocyclyl, each of which may be substituted, or hydrogen; R2 and R3, which may be the same or different, are any group defined for R1; cyano; acyl; —ORa or —SRa, where Ra is alkyl, alkenyl, alkynyl, carbocyclyl or heterocyclyl, each of which may be substituted; or R2 and R3, or R2 and R1, together with their interconnecting atoms may form a ring, which may be substituted; R4 is alkyl, alkenyl, alkynyl, carbocyclyl or heterocyclyl, each of which may be substituted; hydroxy; mercapto; azido; nitro; halogen; cyano; acyl; optionally substituted amino; cyanato; thiocyanato; —SF5; —ORa; —SRa or —Si(Ra)3; m is 0 to 3; when present R5, which may be the same or different to any other R5, is any group defined for R4; R6 is optionally substituted carbo- or heterocylclyl; and A is a defined linking group, or —A—R6 and R5 together with benzene ring M form an optionally substituted fused ri
Type:
Grant
Filed:
February 4, 2000
Date of Patent:
May 17, 2005
Assignee:
Bayer Cropscience GmbH
Inventors:
Mark David Charles, Wilfried Franke, David Eric Green, Thomas Lawley Hough, Dale Robert Mitchell, Donald James Simpson, John Frederick Atherall
Abstract: This invention relates to a group of novel sapogenins, their use in anti-cancer applications, and to a process for their production. More particularly, this invention pertains to a novel group of dammarane sapogenins, PAM-120, PBM-110 and PBM-100 (the dammarance sapogenine structure is specifically clean of any sugar moieties (glycons) at any position and hydroxyl at C-20) and PAN-20 and PAN-30 (the dammarance sapogenin structure has sugar moieties but is free of hydroxyl at C-20), obtained by chemical cleavage of dammarane saponins. The invention also includes a novel application of the said sapogenins for anti-cancer treatment by using them separately or together, and/or jointly with other drugs, as well as to the process of producing these novel sapogenins. Said novel dammarane sapogenins show surprising anti-cancer effect when applied, particularly against multi-drug resistant cancers.
Abstract: An antifungal composition comprising 3-iodo-2-propynyl butylcarbamate, 4,5-dichloro-2-octyl-isothiazolin-3-one and methyl 2-benzimidazolylcarbamate is useful as industrial antifungal composition, particularly for wood protection.
Abstract: The invention provides a method of using pregnadienones and pregnadienols represented by the structural formula (I) as shown herein below Wherein X?OH or O or combination thereof and positioning of olefinic bonds are at 4(5); 5(6); 16(17); 17(20) or various combinations and said compounds containing at least one olefinic bond in or on their D-ring for the treatment of hyperlipidemic and hyperglycemic conditions in mammals, said method comprising administering an effective amount of the said compounds to the recipient mammals.
Type:
Grant
Filed:
March 14, 2003
Date of Patent:
April 5, 2005
Assignee:
Council of Scientific & Industrial Research
Abstract: Saponins of formula (I), a stereoisomeric form thereof or a pharmaceutically acceptable addition salt thereof, wherein R1 to R12 have the meaning given in the description, can be isolated from plants of the family Myrsinaceae and used, to decrease the infectiousness of and reduce the mortality associated with protozoan parasites of the genus Leishmania which are responsible for a group of conditions known as leishmaniases.
Type:
Grant
Filed:
December 15, 1999
Date of Patent:
March 29, 2005
Assignee:
Janssen Pharmaceutica N.V.
Inventors:
Louis Jules Roger Marie Maes, Nils Albert Gilbert Germonprez, Luc Emiel Mathilde Van Puyvelde, Norbert G. M. De Kimpe, Tran Ngoc Ninh
Abstract: What is described are herbicidal compositions comprising herbicidal compounds of the formula I and a compound which acts as safener. In the formula I, the symbols R1 to R4 denote hydrogen, halogen, alkyl and haloalkyl.
Type:
Grant
Filed:
November 20, 2002
Date of Patent:
March 29, 2005
Assignee:
Bayer CropScience GmbH
Inventors:
Monika H. Schmitt, Lothar Willms, Frank Ziemer, Christopher Rosinger, Hermann Bieringer, Philipp Huff, Erwin Hacker
Abstract: Compounds expressed by the following general formula (1), [wherein, R01 and R02 are each independently a hydrogen atom or a protecting group for a hydroxyl group; Z is one out of the following formulae (1-1) to (1-5)]. The compounds can be used as active ingredients of treating agents for inflammatory respiratory diseases, malignant tumors, rheumatoid arthritis, osteoporosis, diabetes mellitus, hypertension, alopecia, acne, psoriasis, dermatitis, hypercalcemia, hypoparathyroidism and metabolic disorder of cartilage.
Abstract: The present invention relates to a process for effectively preparing prostaglandin derivatives and to a stereospecific alkyl halide containing 15S-alcohol group as a starting material.
Type:
Grant
Filed:
May 7, 2002
Date of Patent:
February 8, 2005
Assignee:
Yonsung Fine Chemical Co.
Inventors:
Won-Hun Ham, Chang-Young Oh, Kee-Young Lee, Yong-Hyun Kim, Yiu-Suk Lee
Abstract: The subject invention provides methods for producing homogenous organic base fertilizer for plant nutrition and soil fertility. Also provided by the subject invention are value added fertilizer products for plant nutrition and soil fertility and concentrated liquid formulations/nutrient supplements that provide the value added nutrients to fertilizer products. Methods according to the invention involve the application of concentrated liquid(s) and/or dry formulation(s) comprising a mixture of one or more plant nutrient(s), one or more additional organic compound(s), one or more penetrate(s), and one or more optional supplement(s) into one or more organic base material(s). These organic base materials include, and are not limited to, biosolids, activated sludge, municipal compost, animal manures (e.g., horse, cow, chicken, pig, and sheep), and composted organic byproducts.
Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
Type:
Grant
Filed:
June 29, 2001
Date of Patent:
January 25, 2005
Assignees:
Paratek Pharmaceuticals, Inc., Trustees of Tufts College
Inventors:
Mark L. Nelson, Roger Frechette, Peter Viski, Beena Bhatia