Patents Examined by Sally A Merkling
  • Test element analysis system for the analytical examination of a sample
    Patent number: 10809245
    Abstract: A test element analysis system for the analytical examination of a sample comprising: at least one evaluation device with at least one test element holder and at least one measuring device for measuring a change in a measuring zone of a test element; at least one barcode reader comprising at least one circuit board having a front side facing the barcode of the test element positioned in the test element holder and a reverse side facing away from the test element, wherein at least one electronic control element of the barcode reader is disposed on the circuit board and wherein the circuit board comprises at least one cavity penetrating the circuit board; at least one camera carrier element; and at least one camera electrically connected to the camera carrier element, with the camera carrier element and the camera being positioned such that the camera observes the barcode through the cavity.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: October 20, 2020
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Kai Hebestreit, Sylvia Saecker, Klaus Thome, Marina Swan Backhaus
  • Devices and methods for increasing magnetic sensor sensitivity
    Patent number: 10802089
    Abstract: Provided are magnetic sensors, which include a magnetic sensor element having a sensor surface modification and an inter-element area adjacent to the magnetic sensor element and having an inter-element area surface modification, where the sensor surface modification and the inter-element area surface modification provide a binding surface in the inter-element area. Also provided are devices, systems and methods in which the subject magnetic sensors find use.
    Type: Grant
    Filed: May 10, 2016
    Date of Patent: October 13, 2020
    Assignee: MagArray, Inc.
    Inventors: Sebastian J. Osterfeld, Heng Yu
  • Biochemical-immunological hybrid biosensor and sensor system including the same
    Patent number: 10799861
    Abstract: Disclosed is a biochemical-immunological hybrid biosensor. The biochemical-immunological hybrid biosensor includes a reaction strip in the form of a porous membrane through which a sample moves by capillary action. The reaction strip can simultaneously measure heterogeneous multiple biomarkers through both a biochemical analysis and an immunoassay in an independent manner based on membrane chromatography to diagnose a particular disease.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: October 13, 2020
    Assignee: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION, SEJONG CAMPUS
    Inventor: Se-Hwan Paek
  • Apparatus for improved disease detection
    Patent number: 10802014
    Abstract: An apparatus for detecting a disease in a biological subject comprises a delivery system and at least two sub-equipment units which are combined or integrated in the apparatus, wherein the delivery system is capable of delivering the biological subject to at least one of the sub-equipment units and each sub-equipment unit is capable of detecting at least one property of the biological subject. Methods for detecting a disease with the apparatus are also provided.
    Type: Grant
    Filed: January 7, 2014
    Date of Patent: October 13, 2020
    Assignee: AnPac Bio-Medical Science (Shanghai) Co., Ltd.
    Inventors: Chris C. Yu, Xuedong Du
  • Valved cartridge and system
    Patent number: 10767225
    Abstract: This disclosure provides, among other things, a cartridge comprising: (a) a cartridge body comprising a malleable material and having, disposed on a surface of the body, at least one valve body comprising a valve inlet and a valve outlet, each fluidically connected to a fluidic channel; and (b) a layer comprising a deformable material bonded to a surface of the cartridge body and sealing the at least one valve body at points of attachment, thereby forming at least one valve; wherein the at least one valve body is depressed in the cartridge body relative to the points of attachment and wherein the deformable material covering the at least one valve body retains sufficient elasticity after deformation such that in a ground state the valve is open.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: September 8, 2020
    Assignee: IntegenX, Inc.
    Inventors: Philip Justus Wunderle, Chungsoo Charles Park, David King, Dennis Lehto
  • Biochip well, sealed well assembly, cartridge therefor, and apparatus and methods for opening sealed wells
    Patent number: 10751720
    Abstract: A biochip well is disclosed, including a vessel containing a well therewithin, the vessel forming at least base and side walls of the well and defining at least one aperture giving access to the well, and further including retaining means for holding a biochip at a predetermined position within the well, the well including a laterally offset region into which the biochip does not protrude when held at the predetermined position by the retaining means. Also disclosed are sealed well assemblies and apparatus and methods for opening sealed wells.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: August 25, 2020
    Assignee: RANDOX LABORATORIES LTD.
    Inventors: Gareth Wilson, Michael Hooks, Peter Fitzgerald, John Lamont, Ivan McConnell
  • Device for analyzing a biological sample
    Patent number: 10752936
    Abstract: A device for analyzing a biological sample which includes a separation and detection chamber into which an injection channel and a discharge channel open, a filter separating the chamber into two distinct spaces so as to define a first space into which the injection channel opens and a second space into which the discharge channel opens, the filter having a porosity suitable for the separation to be carried out, a rough bearing surface having a surface roughness parameter suitable for carrying out a mechanical lysis of the biological species present in the sample, the bearing surface being arranged in the first space, a flexible membrane arranged opposite the rough bearing surface relative to the filter and blocking an opening made through the housing.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: August 25, 2020
    Assignee: Commissariat a l'energie atomique et aux energies alternatives
    Inventors: David Gosselin, Jean Berthier, Anne-Gaelle Bourdat, Jerome Ventosa
  • Automated system for HTP genomic engineering
    Patent number: 10745694
    Abstract: The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols. This integrative platform utilizes a suite of HTP molecular tool sets to create HTP genetic design libraries, which are derived from, inter alia, scientific insight and iterative pattern recognition. The HTP genomic engineering platform described herein is microbial strain host agnostic and therefore can be implemented across taxa. Furthermore, the disclosed platform can be implemented to modulate or improve any microbial host parameter of interest.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: August 18, 2020
    Assignee: Zymergen Inc.
    Inventors: Zach Serber, Erik Jedediah Dean, Shawn Manchester, Katherine Gora, Michael Flashman, Erin Shellman, Aaron Kimball, Shawn Szyjka, Barbara Frewen, Thomas Treynor, Kenneth S. Bruno
  • Microfluidic device for detecting target gene, method for manufacturing same, and method for detecting using same
    Patent number: 10731208
    Abstract: The present invention provides facile and accurate molecular diagnosis of disease-specific genes capable of the naked eye detection through amplifying the target genes to selectively block the fluid path in a microfluidic device. Specifically, the present invention includes an isothermal amplification of target genes through a rolling circle amplification, a microfluidic device for detecting pathogen genes, and a detection method using the same. Therefore, the present invention can conveniently detect a single target gene, such as a single pathogen, or at the same time, several target genes, such as several pathogens, without complicated mechanical equipment.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: August 4, 2020
    Assignees: EWHA UNIVERSITY—INDUSTRY COLLABORATION FOUNDATION, KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Hyukjin Lee, Haeshin Lee, Ho Yeon Lee, Il Young Jung
  • Sensor clip for stacked sensor dispensing system, and systems, methods and devices for making and using the same
    Patent number: 10712335
    Abstract: Sensor clip assemblies, sensor clips, analyte testing systems, and methods for making and using the same are disclosed. A sensor clip assembly is disclosed for storing and dispensing analyte testing sensors. The sensor clip assembly includes numerous test sensors arranged in a stack. Each test sensor is configured to assist in testing an analyte in a fluid sample. The sensor clip assembly also includes a skeletal frame with a top, a bottom, and numerous sides. The top, bottom and sides are interconnected to define an internal chamber within which is stored the stack of test sensors. At least one of the sides includes one or more elongated rails with structural gaps on opposing sides thereof. For some configurations, multiple sides of the skeletal frame comprise at least one or multiple elongated rails, each of which has structural gaps on opposing sides thereof and may be columnar in nature.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: July 14, 2020
    Assignee: ASCENSIA DIABETES CARE HOLDINGS AG
    Inventors: Jeffery S. Reynolds, Eugene R. Prais
  • Magnetic capturing of rare cells
    Patent number: 10690662
    Abstract: The subject matter discloses systems and methods for magnetic capturing of rare cells from a liquid sample. The system includes a capture chip (104) having a longitudinal channel (208) comprising a first part (304) and a second part (306). The capture chip (104) has a capture well (302) near an end of the second part (306) closer to an interfacing region between the first part (304) and the second part (306). The system includes a first set (126) of multiple rows of magnets for the magnetic capturing of the rare cells in the first part (304) of the longitudinal channel (208), where a first row (132) of the first set (126) of multiple rows has magnets that span a length of the first part (304) of the longitudinal channel (208) and each subsequent row of the first set (126) of multiple rows has one magnet less than a previous row.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: June 23, 2020
    Assignee: INDIAN INSTITUTE OF TECHNOLOGY DELHI
    Inventors: Ravikrishnan Elangovan, Vivekanandan Perumal, Shalini Gupta, Saurabh Singh
  • Measurement device
    Patent number: 10687762
    Abstract: A measurement method includes a first measurement in which a characteristic amount of a specific analyte in a biological fluid with a biosensor having a reagent surface is measured. The method also includes a second measurement in which the tilt angle or rotation angle of the reagent surface from a neutral position, or vibration applied to the reagent surface, as motion information of living activity is measured. Additionally, the method may include recording the motion information, and controlling, based on the motion information, a measurement operation of the first measurement and a recording operation of the recording.
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: June 23, 2020
    Assignee: PHC HOLDINGS CORPORATION
    Inventors: Noriyoshi Terashima, Masataka Nadaoka
  • Mechanochemical platform and sensing methods using DNA origami nanostructures
    Patent number: 10690685
    Abstract: A biosensing platform capable of high throughput mechanochemical biosensing comprising a DNA origami nanostructure having a plurality of slots into which recognition elements are strategically placed and apparatus that senses a change in the origami nanostructure in response to the introduction of a target where the apparatus includes a signal transduction unit and signal sensor which exploits mechanical signals in a recognition element which signal includes one or more mechanical tension or mechanochemical rearrangement event. The nanostructure is preferably a 2-dimensional or 3-dimensional arrangement of tiles linked by locking elements, such as aptamers that will open in response to an event such as exposure to a drug molecule, DNA, RNA or protein target.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: June 23, 2020
    Assignee: KENT STATE UNIVERSITY
    Inventors: Hanbin Mao, Deepak P. Koirala, Hiroshi Sugiyama, Masayuki Endo
  • DNA sequencing with stacked nanopores
    Patent number: 10669579
    Abstract: A sensing device includes a stack of dielectric layers having conductive materials disposed between the dielectric layers. A nanopore is disposed through the stacks of dielectric layers and separates the conductive materials to provide electrodes on opposite sides of the nanopore. Contacts connect to each of the electrodes.
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: June 2, 2020
    Assignee: International Business Machines Corporation
    Inventors: Zhenxing Bi, Kangguo Cheng, Juntao Li, Xin Miao
  • Pipette device
    Patent number: 10661266
    Abstract: A pipette device, including a container having a predetermined space therein, in one end of which a nozzle is formed and the other end of which is opened; a first fixing member whose one end is detachably coupled to the other end of the container; a second fixing member coupled to the other end of the first fixing member; and a pumping member that is inserted into the second fixing member such that an opened end portion faces the other end of the container and delivers internal air into the container by changing shape when it is pressed, wherein the opened end portion of the pumping member is fixed between the first fixing member and the second fixing member by coupling of the first fixing member and the second fixing member.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: May 26, 2020
    Assignee: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Seong Il Kang, Seung Youb Oh, In-Hwan Lee
  • Disposable cartridge system for point-of-care testing
    Patent number: 10661270
    Abstract: Disposable cartridges comprising hinged caps and optical chambers for measuring one or more properties of a blood sample are described. Blood flow in the disposable cartridges may be regulated by either positive or negative pressure. Other embodiments of cartridges comprising a biosensor chamber disposed downstream of the optical chamber are also described. Methods for measuring one or more properties of a blood sample using different cartridge embodiments are provided.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: May 26, 2020
    Assignee: INVIDX CORP.
    Inventor: James Samsoondar
  • Electrophoresis running tank assembly
    Patent number: 10641731
    Abstract: An electrophoresis running tank assembly uses two opposed rows of LEDs to illuminate DNA-containing gel on a transparent tray positioned between the rows. A respective cylindrical lens is positioned horizontally between each row and a respective edge of the tray. The optical axis of the illumination light is midway between a bottom surface of the gel tray and a top surface of the gel.
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: May 5, 2020
    Assignee: C.C. IMEX
    Inventors: Winston Glenn Walker, Richard Chan, Rita M. Wong, Ramey K. Chan, Po Ling Cheng
  • Liquid container, especially a urea solution container, for a motor vehicle
    Patent number: 10641151
    Abstract: A liquid container for a motor vehicle, especially an urea solution container, comprising, as a container component, a tank surrounding an uptake volume, and, as a further container component, a filling line, which, in flow-mechanics terms, connects an admission location placed outside the tank at a distance from it, with the uptake volume, wherein at least a main section of the tank and at least a main section of the filling line are configured to be rigid so that they in essence remain free of deformity when the liquid container is used as directed, wherein on the tank and/or on the filling line at least one auxiliary tank or auxiliary filling line body surrounded by the filling line that expands the intake volume or the filling line volume, is formed, or is able to be formed by increasing the pressure in the interior of the liquid container.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: May 5, 2020
    Assignee: Röchling Automotive SE & Co. KG
    Inventors: Luca Marini, Enrico Merzari, Manuel Pezzi
  • Platelet rich plasma preparation system and devices
    Patent number: 10633631
    Abstract: A platelet rich plasma preparation system and devices having a whole blood centrifuge tube (100) and a plasma centrifuge tube (200) wherein fill tubes (206) and vent tubes (113) are in fixed position and guards are provided to protect the fill tubes and vent tubes during use with a centrifuge. The fixed tubes and guards (114, 210) prevent kinks in the tubes and/or blockages that render the components of the system and the samples contained therein useless.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: April 28, 2020
    Inventor: Gerald R. Harris
  • Aptasensor for detecting female-specific trace of blood and detection apparatus using the same
    Patent number: 10627416
    Abstract: The present invention relates to an aptasensor for detecting a female-specific trace of blood including an aptamer which is used as a biosensor and emits light as the aptamer is bound to the female-specific trace of blood, and a detection apparatus using the same. The aptasensor for detecting a trace of blood to discriminate genders from the trace of blood at a crime scene has a configuration in which the aptasensor emits light as the aptasensor is binding to the female-specific trace of blood, so that genders of a suspect and a victim is distinguished from each other at the crime scene.
    Type: Grant
    Filed: October 2, 2017
    Date of Patent: April 21, 2020
    Assignee: REPUBLIC OF KOREA(NATIONAL FORENSIC SERVICE DIRECTOR MINISTRY OF THE INTERIOR AND SAFETY)
    Inventors: Joo Young Kim, Pil Won Kang, Sang Ok Moon, Man Il Kim, Hye Hyeon Lee, Hye Lim Kim, Ki Won Park, Yang Han Lee, Byung Won Chun