Patents Examined by Samantha L Shterengarts
  • Thermally sensitive protecting groups for cysteine, and manufacture and use thereof
    Patent number: 11560387
    Abstract: In a preferred embodiment, there is provided a protecting group for protecting the thiol side chain of a cysteine residue, the protecting group comprising a Diels-Alder cycloadduct of a furan and a maleimide, and optionally, a linker interposed between the thiol side chain and the Diels-Alder cycloadduct.
    Type: Grant
    Filed: September 7, 2021
    Date of Patent: January 24, 2023
    Inventors: John Frederick Trant, Daniel Meister, Sarah Nasri, Anthony Emanuel Chifor, John James Hayward, Seyedeh Maryamdokht Taimoory, Mohadeseh Dashti-Pour
  • Combinations of artemisinins, BCL-2 inhibitors, and kinase inhibitors for cancer treatment
    Patent number: 11554105
    Abstract: Methods of treating cancer, such as leukemia, via administration of therapeutically effective amounts of artemisinins and one or more additional therapeutic agents are detailed herein. The artemisinins include artesunate, dihydroartemisinin, artemether, arteether, artelinate, ART-631, and ART-838. The one or more additional therapeutic agents include BCL-2 inhibitors such as ABT-199, ABT-263, and ABT-737; kinase inhibitors such as lestaurtinib, midostaurin, and sorafenib; and anti-neoplastic agents such as cytarabine, doxorubicin, etoposide, cyclophosphamide, triplotide, vinorelbine, cisplatin, and rituximab.
    Type: Grant
    Filed: October 31, 2019
    Date of Patent: January 17, 2023
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Curt I. Civin, Blake S. Moses
  • Phosphonate linkers and their use to facilitate cellular retention of compounds
    Patent number: 11554172
    Abstract: Phosphonate linkers and their use for delivering compounds with passive cell permeability into a cell wherein the phosphonate group facilitates cellular retention of the compound are described.
    Type: Grant
    Filed: September 24, 2020
    Date of Patent: January 17, 2023
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Robert M. Garbaccio, Jeffrey C. Kern, James J. Mulhearn, Philip E. Brandish
  • Heterocyclic compounds, compositions comprising heterocyclic compound, and methods of use thereof
    Patent number: 11548868
    Abstract: Disclosed herein are compounds of formula I and/or a stereoisomer, stable isotopologue, and/or pharmaceutically acceptable salts thereof; and therapeutic uses of these compounds, which are inhibitors of tryptophan 2, 3-dioxygenase 2 (TDO2) and/or indoleamine 2, 3-dioxygenase 1 (IDO1), potentially useful in the treatment of diseases treatable, such as cancers.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: January 10, 2023
    Assignee: JS Innopharm (Shanghai) Ltd.
    Inventors: Jintao Zhang, Wen Xu, Shanzhong Jian, Ao Li, Qun Li
  • Sulfonyldiazoles and N-(fluorosulfonyl)azoles, and methods of making the same
    Patent number: 11542236
    Abstract: The present disclosure provides methods for producing N-(fluorosulfonyl)azoles, sulfonyldiazoles, or related derivatives thereof, and the related products including N-(fluorosulfonyl)azoles, sulfonyldiazoles, and related derivatives thereof. For example, an N-(fluorosulfonyl)azole is obtained by reaction of sulfuryl fluoride with an azoles, an azolate salt, an N-silylazole, or a combination thereof. Symmetric and asymmetric sulfonyldiazoles are obtained by further reaction of such an N-(fluorosulfonyl)azole with azoles, azolate salts, or N-silylazoles. A sulfonyldiazole can be also produced by reacting sulfuryl fluoride with an azole, an N-silylazole, or a combination thereof in one pot.
    Type: Grant
    Filed: September 30, 2020
    Date of Patent: January 3, 2023
    Assignee: Trinapco, Inc.
    Inventor: Martin Reid Johnson
  • Substituted imidazolidin-2-one derivatives as PRMT5 inhibitors
    Patent number: 11542275
    Abstract: The present invention relates to substituted imidazolidin-2-one derivatives of formula (I) or pharmaceutically acceptable salts thereof. The present invention further provides the methods of preparation of compound of formula (I) and utility as PRMT5 inhibitors. The compounds are useful as medicaments in the treatment of conditions and disorders mediated by PRMT5, such as cancer, metabolic disorders, inflammation, autoimmune disease and hemoglobinopathies.
    Type: Grant
    Filed: March 20, 2019
    Date of Patent: January 3, 2023
    Assignee: AURIGENE DISCOVERY TECHNOLOGIES LIMITED
    Inventors: Dinesh Chikkanna, Sunil Kumar Panigrahi, Srinivasa Raju Sammeta
  • Trehalose analogues
    Patent number: 11535642
    Abstract: Described herein are trehalose analogues. Also described herein are methods of making the trehalose analogues and uses of the analogues. For example, the disclosed trehalose analogues may be useful in the detection of bacteria.
    Type: Grant
    Filed: May 3, 2021
    Date of Patent: December 27, 2022
    Assignee: Central Michigan University
    Inventor: Benjamin M. Swarts
  • Fused pyrrolines which act as ubiquitin-specific protease 30 (USP30) inhibitors
    Patent number: 11535618
    Abstract: The disclosure relates to USP30 Inhibitor Compounds I, pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising same, and medical uses involving same.
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: December 27, 2022
    Assignee: FORMA Therapeutics, Inc.
    Inventors: Alex J. Buckmelter, Justin Andrew Caravella, Hongbin Li, Matthew W. Martin, Steven Mischke, David James Richard, Angela V. West
  • Heterocyclic compound and organic light-emitting device including the same
    Patent number: 11538999
    Abstract: A heterocyclic compound and an organic light-emitting device including the same are provided. The heterocyclic compound is represented by Formula 1: Details of R1, R2, R3, X1, L1, and a1 and b1 are provided in the disclosure.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: December 27, 2022
    Assignee: SAMSUNG DISPLAY CO., LTD.
    Inventors: Soobyung Ko, Haejin Kim, Mieun Jun, Youngkook Kim, Seokhwan Hwang
  • Tetracarboxylic acid dianhydride and method for preparing the same
    Patent number: 11530228
    Abstract: Provided are a novel tetracarboxylic acid dianhydride and a method for preparing the same. According to an exemplary embodiment of the present invention, a novel tetracarboxylic acid dianhydride appropriate for providing a polyimide film having high transparency and thermal resistance and having excellent thermal dimensional stability due to a substrate of which the stress is not increased even with a heat treatment at a high temperature and a method for preparing the same may be provided.
    Type: Grant
    Filed: July 9, 2021
    Date of Patent: December 20, 2022
    Assignees: SK Innovation Co., Ltd., SK ie technology Co., Ltd.
    Inventors: So Young Lee, Jong Chan Kim
  • Pyrazole compounds as LSD1 inhibitors and applications thereof
    Patent number: 11524941
    Abstract: Disclosed are a class of pyrazole compounds and applications thereof in the preparation of a medicament for treating related diseases. Specifically, related are a compound represented by formula (II) and a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: August 30, 2021
    Date of Patent: December 13, 2022
    Assignee: MEDSHINE DISCOVERY INC.
    Inventors: Lingyun Wu, Lele Zhao, Jianjun Sun, Zhen Zhan, Shuhui Chen
  • Arginine methyltransferase inhibitors and uses thereof
    Patent number: 11512053
    Abstract: Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting arginine methyltransferase activity. Methods of using the compounds for treating arginine methyltransferase-mediated disorders are also described.
    Type: Grant
    Filed: August 27, 2020
    Date of Patent: November 29, 2022
    Assignee: Epizyme, Inc.
    Inventors: Richard Chesworth, Lorna Helen Mitchell, Gideon Shapiro, Kerren Kalai Swinger
  • Hydrophilic antibody-drug conjugates
    Patent number: 11510959
    Abstract: Hydrophilic Linkers, Drug-Linker compounds, Drug-Ligand Conjugate compounds and Ligand-Linkers and methods of making and using the same are provided.
    Type: Grant
    Filed: January 27, 2021
    Date of Patent: November 29, 2022
    Assignee: Seagen Inc.
    Inventors: Svetlana Doronina, Robert Lyon, Peter Senter
  • GLP-1 receptor agonists and uses thereof
    Patent number: 11512070
    Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.
    Type: Grant
    Filed: October 30, 2020
    Date of Patent: November 29, 2022
    Assignee: Pfizer Inc.
    Inventors: Gary Erik Aspnes, Scott W. Bagley, John M. Curto, Matthew S. Dowling, David Edmonds, Mark E. Flanagan, Kentaro Futatsugi, David A. Griffith, Kim Huard, Gajendra Ingle, Wenhua Jiao, Chris Limberakis, Alan M. Mathiowetz, David W. Piotrowski, Roger B. Ruggeri
  • Salts of a Pim kinase inhibitor
    Patent number: 11505540
    Abstract: The present invention relates to salt forms of the Pim kinase inhibitor N-{(7R)-4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide, including methods of preparation thereof, and intermediates in the preparation thereof, where the compound is useful in the treatment of Pim kinase-related diseases such as cancer.
    Type: Grant
    Filed: January 13, 2021
    Date of Patent: November 22, 2022
    Assignee: Incyte Corporation
    Inventors: Zhongjiang Jia, Ganfeng Cao, Qiyan Lin, Yongchun Pan, Lei Qiao, Vaqar Sharief, Chongsheng Eric Shi, Michael Xia, Changsheng Zheng, Qun Li
  • Crystalline epinephrine malonate salt
    Patent number: 11505521
    Abstract: Described herein are epinephrine salts, specifically the epinephrine malonate salt; the epinephrine malonate salt in crystalline form; a pharmaceutical composition comprising epinephrine malonate; a sublingual or buccal pharmaceutical composition comprising epinephrine malonate in crystalline form; and a method for treating a patient comprising administering a pharmaceutical composition of epinephrine malonate in crystalline form.
    Type: Grant
    Filed: March 29, 2021
    Date of Patent: November 22, 2022
    Assignee: Biothea Pharma, Inc.
    Inventors: Jean-Pierre Sommadossi, Adel Moussa
  • Redox-activated pro-chelators
    Patent number: 11504346
    Abstract: Compositions of pro-chelator compounds are described herein. The pro-chelators may be activated in reducing conditions, such as in the intracellular space, so as to sequester metals such as iron. The pro-chelators may be used to target malignant cells or in the treatment in a condition associated with metal ion disregulation.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: November 22, 2022
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventors: Elisa Tomat, Tsuhen Chang, Eman A. Akam
  • Silanol based therapeutic payloads
    Patent number: 11497757
    Abstract: Described herein in part are silanol based therapeutic payloads comprising a silanol terminus, a divalent spacer moiety, and a drug moiety capable of effecting a target cell or tissue.
    Type: Grant
    Filed: June 29, 2020
    Date of Patent: November 15, 2022
    Assignee: BlinkBio, Inc.
    Inventors: Hanh N. Nguyen, Leslie O. Ofori, Jutta Wanner, Douglas S. Werner
  • Furan surfactant compositions and methods
    Patent number: 11492338
    Abstract: Chemical compositions, and related methods for synthesizing furan, such as oleo-furan, surfactants, include calcium, magnesium, ammonium and/or lithium cations and one of a number of furan derivatives. Methods for synthesizing such furan surfactants containing calcium, magnesium, ammonium and/or lithium cations can include chemical reagents and purification procedures to prepare furan surfactants containing calcium, magnesium, ammonium and/or lithium cations. These furan surfactant compositions can be free of dioxane and ethoxylate.
    Type: Grant
    Filed: May 3, 2021
    Date of Patent: November 8, 2022
    Assignee: SIRONIX RENEWABLES, INC.
    Inventors: Shawn Eady, Sabrina Conrad, Trenton Wilke, Christoph Krumm
  • Redox substrates for leukocyte esterase
    Patent number: 11492331
    Abstract: Certain embodiments are directed hydrophilic redox substrates for leukocyte esterase (LE). In certain aspects a hydrophilic redox leukocyte esterase substrate or a small molecule enzyme substrate for use in methods and/or devices to electrochemically detect and/or measure LE activity in a sample.
    Type: Grant
    Filed: November 8, 2018
    Date of Patent: November 8, 2022
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Waldemar Gorski, Stanton McHardy, Douglas Hanson, Travis Menard, Andrew Fleischman