Abstract: This invention relates to processes for the production of purified, partially esterified polyol fatty acid polyesters and the compositions derived from those processes. The purified, partially esterified polyol fatty acid polyesters of the present invention are particularly well suited for use in a variety of food, beverage, pharmaceutical, and cosmetic applications and comprise less than about 5% polyol; less than about 5 ppm of residual solvent; less than about 700 ppm of lower alky esters; less than about 5% of a soap and free fatty acid mixture; less than about 3% of ash; and have an acid value of less than about 6.

Abstract: Microspheres for controlled release of a bioactive agent are disclosed, and in particular, blend, cross-linkable poly(propylene fumarate) for immobilization and controlled drug delivery. The microsphere includes poly(propylene fumarate), a polymeric material other than poly(propylene fumarate) (e.g., poly(lactic-co-glycolic acid)), and a bioactive agent. The bioactive agent is selected depending on the physiological effect desired. For example, in bone regeneration applications, the bioactive agent may be selected from osteoinductive agents, peptides, growth hormones, osteoconductive agents, cytokines and mixtures thereof. The bioactive agent is dispersed in the microsphere, the microsphere has a diameter in the range of 1 to 300 micrometers, the poly(propylene fumarate) and poly(lactic-co-glycolic acid) are distributed in the microsphere, and the microsphere releases the bioactive agent in a sustained manner after an initial burst release.

Abstract: The present invention discloses apparatus and methods of inducing bubble nucleation to overcome problems commonly associated with preservation by foam formation. Specifically, the invention relates to methods of using bubble nucleation in foam formation to preserve sensitive biological materials. Preferred methods of inducing bubble nucleation include, mixing, chamber rotation, crystals, and ultrasound.

Abstract: A process for the preparation of nanoparticles for the encapsulation of active constituents, the nanocapsules prepared being dispersible in aqueous phase in colloidal form, non-toxic, biocompatible, stable in colloidal suspension and economical. In the process, two non-oily solvents as used, together with a third, oily solvent.

Abstract: Method and apparatus for preparing microparticles using liquid-liquid extraction. A first phase and a second phase are combined to form an emulsion. A portion of the second phase is separated from the emulsion (solvent rich), and the solvent is extracted from the separated second phase, which is then returned (solvent poor) to the emulsion. This process of separation of a solvent rich phase, extraction of solvent, and return of a solvent poor phase, is carried out until a selected level of solvent in the emulsion is achieved. Alternatively, the separated solvent rich phase is not returned to the emulsion, but replaced with another solution, such as an aqueous solution, that is free from solvent. The solvent is preferably extracted into an extraction liquid that functions as a “solvent sink” for the solvent.

Abstract: Methods of making microcapsules and microcapsules comprising a core material and a shell material with substantially different dielectric constants and dissipation factors. Exposure to appropriate electromagnetic energy selectively (a) heats the core material with the higher dielectric constant and dissipation factor, directly or indirectly fusing the shell material and forming microcapsules, or (b) hardens polymerized shell material, which has a high dielectric constant and dissipation factor.

Abstract: An aqueous dispersion based on an amorphous unsaturated polyester resin obtained by polycondensing a mixture of Dicidol isomers and one or more saturated and/or unsaturated dicarboxylic acids.

Abstract: A polymer comprising recurring units represented by formula (I): wherein X is selected from the group consisting of C(O)OR1, C(O)SR1, C(O)NR1R2, and VZ, where R1 and R2 are each individually selected from the group consisting of hydrogen, C1 to C10 alkyl, and C6 to C10 aryl, where V is a labile linker group, and where Z is selected from the group consisting of poly(ethyleneimine), poly(propyleneimine), poly(lysine), PAMAM dendrimer, octaamine dendrimer, and hexadecaamine dendrimer; and wherein Y is selected from the group consisting of —(CH2)2—, —(CH2)2—O—(CH2)2—, —(CH2)2—O—(CH2)2—, and —(CH2)3—NHC(O)—(CH2)6—C(O)NH—(CH2)3— is useful in nucleic acid delivery applications. Polyacetals of the formula (I) are preferably made by reacting appropriate diols and divinyl ethers. In preferred embodiments, complexes formed between polyacetals of the formula (I) and polynucleotides are useful as transfection reagents.

Abstract: A resin composition is prepared by reacting components comprising dibasic acid, diamine, polyol and monoalcohol, wherein (a) at least 50 equivalent percent of the dibasic acid comprises polymerized fatty acid; (b) at least 50 equivalent percent of the diamine comprises ethylene diamine; (c) 10-60 equivalent percent of the total of the hydroxyl and amine equivalents provided by diamine, polyol and monoalcohol are provided by monoalcohol; and (d) no more than 50 equivalent percent of the total of the hydroxyl and amine equivalents provided by diamine, polyol and monoalcohol are provided by polyol. This resin composition may be formulated into, for example, personal care products, fragrance releasing products and candles.

Abstract: Chlorinated olefin polymers prepared from olefin polymer base resins having I10 values of 0.05-0.8 dg/minute act as impact modifiers for vinyl chloride polymers under low to ambient temperature conditions. When vinyl chloride polymers are mixed with a preferred class of the chlorinated polymers, having chlorine contents of 20-30 percent by weight, compositions that exhibit short fusion times and low fusion temperatures are produced.

Abstract: A method is provided which biosynthesizes a PHA having an epoxy group on a side chain with improved physicochemical properties. Specifically, a method of producing a polyester containing an epoxy group in a side chain thereof using alkene as a raw material is provided which comprises the steps of bringing alkene into contact with a microorganism having an ability to uptake alkene and convert it to a polyester and allowing the microorganism to convert the alkene into a polyester containing an epoxy group in a side chain thereof. Further, a method of producing a crosslinked polymer is provided which comprises reacting the polyester obtained by the above mentioned method with a diamine compound.

Abstract: The present invention is directed to medical devices or pharmaceutical composition, each containing a synthetic, biodegradable, biocompatible polymer that is the reaction product of a polybasic acid or derivative thereof, a monoglyceride, and a cationic polyol.

Abstract: A method of spherifying a sustained release ionic conjugate which contains a free carboxyl group-containing polymer and a free amino group-containing drug which are ionically bonded to each other.

Abstract: The present invention describes the incorporation of several types of soft-block materials into resorcinol phthalate-co-polycarbonate polymers. In preferred embodiments, the soft-block materials contain aliphatic moieties or silicones as flexibilizing units. Several methods of incorporation into the copolymer structure are described including co-reaction of diols with iso/terephthaloyl chloride, replacement of the normal chainstopper with a p-alkylphenol, replacement of a portion of the bisphenol A with an aliphatic ester-bisphenol, and co-reaction of aliphatic diacid chlorides. The polymers of the present invention have good flow characteristics at temperatures generally used for coating, and have good thermostability and weatherability.

Abstract: A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.

Abstract: This invention relates to micro-encapsulated particles of solid matter and a quasi-continuous method for producing the same, especially those having water-insoluble characteristics or a hydrophobic form, taking into careful consideration ecologically and economically favorable ways of recycling the media used, and the resulting smallest possible amount of waste products such as waste water and polymer residues, while simultaneously ensuring that even exposed parts of the solid bodies are coated, such as crystal tips and grooves, which are insufficiently coated using standard methods due to the hydrodynamic conditions on these areas.

Abstract: The present invention provides a method of making a fluoropolymer comprising repeating units derived from one or more gaseous fluorinated monomers. The method comprises an aqueous emulsion polymerization of gaseous fluorinated monomers in the presence of an ether selected from the group consisting of dimethyl ether (DME), methyl tertiary butyl ether (MTBE) and mixtures thereof.

Abstract: The invention relates to polymer beads comprising an anisotropic polymer material with helically twisted structure, to their use in reflective films, spraying or printing inks or as pigments, for optical or electrooptical, decorative or security applications, to a reflective film comprising one or more polymer beads in a transmissive binder, and to a security marking or security device comprising one or more polymer beads or comprising a reflective film.

Abstract: The invention is directed to polyester processes that utilizes a pipe reactor in the esterification, polycondensation, or both esterification and polycondensation processes. Pipe reactor processes of the present invention have a multitude of advantages over prior art processes including improved heat transfer, volume control, agitation and disengagement functions. The pipe reactor processes and apparatus of the present invention are built and operated at a much lower cost than conventional polyester processes.

Abstract: The present invention relates to specific glyceryl alkoxylated citrate esters and their use in lipsticks. These polymers not only do not have a mal taste, but also have a very pleasant taste. This coupled with their use to prevent syneresis in lipsticks, make these products very desirable in lipstick applications.