Abstract: Systems tune, control, or remediate the intrinsic Circadian clock. A light controller sets spectral distribution, intensity of a bioactive spectral band to shift or entrain circadian response to enhance performance and/or synchronize with local or expected conditions. The systems enhance performance under conditions that might be changing, disrupted, or otherwise present an irregular phase or unnatural change in the subject's circadian status, for example, due to geographically discontinuous activity or spectrally deficient workplace illumination, or due to divergent individual sleep/wake behaviors of subjects in a structured group activity. An illumination recipe that compensates for the deficiency of lighting or of participant sleep or behavior patterns, or age- or disease-related changes, to evoke, shift, or align circadian response and improve behaviors such as classroom alertness, relaxation, excitability, attention, or focus.

Abstract: Systems and methods of the present disclosure are directed to systems and methods for treating cognitive dysfunction in a subject in need thereof. The system can include a neural stimulation system that receives an indication of an ambient audio signal detected by a microphone. The system selects, from a profile, an audio signal including a fixed parameter and a variable parameter. The system sets the variable parameter to a first value. The system generates an output signal based on the fixed parameter and the first value, and provides the output signal to the speaker. The system measures a physiological condition of the subject, adjusts the variable parameter to a second value, generates a second output signal based on the fixed parameter and the second value of the variable parameter, and provides the output signal to the speaker to cause the speaker to provide modified sound to the subject.

Abstract: A radiation suite includes a room having a floor, a ceiling, and one or more walls, a radiation system including a gantry enclosing a radiation source and a couch, and an image projection system operable to project an image on a projection surface on at least a portion of the gantry and/or the couch, providing a calming environment for a patient to relax. The image projection system comprises a computer and one or more projectors operably controlled by the computer. The computer comprises a mapping software operable to map an image file to the projection surface. The one or more projectors are operable to project the mapped image file on the projection surface.

Abstract: Combined methods for treating a patient using time-varying magnetic field are described. The treatment methods combine various approaches for aesthetic treatment. The methods are focused on enhancing a visual appearance of the patient.

Abstract: A database stores pre-calculated solutions each of which defines a radiation therapy treatment plan for a treatment volume associated with at least one target and at least one organ-at-risk. The pre-calculated solutions are divided into at least two groups each of which includes at least one pre-calculated solution. The pre-calculated solutions in a given group represent radiation therapy treatment plans which share a common beam configuration. A radiation therapy treatment plan (sc) is established based on the pre-calculated solutions as follows. A first user interface receives operator commands specifying criteria for selecting radiation therapy treatment plans from the database, the criteria defining a set of parameters for the treatment volume. In particular, the operator commands jointly specify criteria for selecting radiation therapy treatment plans from more than one of the at least two groups.

Abstract: This invention will allow men suffering from full and periodic erectile dysfunction to achieve, or at least assist in the process of achieving a firm and lasting erection. And, for all men, this device will be able to measure blood-flow to the penis, as well as increase sexual pleasure through micro-electronic stimulation to the penis (induce erection). Blood-flow data captured from devices' internal sensors will be processed by software and presented to users via a smart-phone app to provide useful, actionable, and customizable tasks to improve penile and overall sexual performance, health, and wellness.

Abstract: An apparatus includes a plurality of beads and a plurality of links joining the beads together. Each bead includes a housing, a passageway extending through the housing, and at least one annular magnet. The passageway defines an axis. The at least one annular magnet is coaxially positioned about the passageway. The housing defines a gap adjacent to the at least one annular magnet. The gap is sized and configured to allow at least one annular magnet to rotate relative to the housing about a rotation axis. The rotation axis is offset from the axis of the passageway. Portions of the links are slidably disposed in corresponding passageways of the beads.

Abstract: Method and system for treating a patient using a compressible, pressure-attenuating device. According to one embodiment, the system is used to treat urinary tract disorders and comprises an access device, a delivery device, a pressure-attenuating device, and a removal device. The access device may be used to create a passageway to an anatomical structure, such as the patient's bladder. The delivery device may be inserted through the passageway created by the access device and may be used to deliver the pressure-attenuating device to the anatomical structure. The removal device may be inserted through the passageway created by the access device and may be used to view the bladder and/or to capture, to deflate and to remove the pressure-attenuating device.

Abstract: A sexual aid device, system and method that provide a chassis with a distal end; a proximal end with at least one penile port; at least one penile support between the distal end and proximal end; at least one penile channel between the distal end and proximal end; wherein the chassis is configured to have an opening along the top toward the proximal end and an upper chassis plate is securable in a closed position. When used with a sleeve and chassis cover the system provides additional support so that the combined device substantially surrounds the donning penis and enables new methods of intimate sexual intercourse without an erection and without substantially obstructing blood flow to and from the penis. In an optional saddled embodiment the inner and outer scrotal support of the chassis and sheath help to hold the device in place while providing a comfortable scrotal opening an enabling gentle massage of the scrotum and perineum through use of a perineum bump.

Abstract: Stimulation devices and methods of use are described herein. An example stimulation device configured to stimulate a portion of a body of a user comprises a housing that includes a casing and a covering. The casing includes a nozzle, a motor disposed within the casing configured to generate stimulation patterns, a drive shaft connected to the motor, a sensor configured to detect changes in the rotation of the draft shaft, a controller, and a battery. The covering covers a portion of the casing.

Abstract: Systems and methods for generating a radiation therapy treatment plan by using ultrasound images are disclosed. The method includes obtaining a first set of image data representing a first image of an anatomical region that includes a treatment applicator inserted into the anatomical region. The method further includes receiving tracking information indicating a position of the treatment applicator as represented in the first set of image data, obtaining a second set of image data representing a second image of the anatomical region, and combining at least a portion of the first set of image data with the second set of image data. One of the first set and the second set of image data is used to identify a target tissue portion in the anatomical region. The method further includes generating, based on the combined image data, treatment plan information for treating the target tissue portion in the anatomical region.

Abstract: A compressible and resilient sexual aid device has a module. The module has a rim, a neck, a base, and an aperture. The neck has a first end and a second end. The rim is connected to the first end. The base is connected to the second end. The aperture extends from the rim through the neck and through the base. The rim has a first diameter. The neck has a second diameter. The base has a third diameter. The first diameter is greater than the second diameter. The third diameter is greater than the first diameter and the second diameter. The module is compressible and resilient. Additional modules may be added to the device according to a user's preference.

Abstract: The invention refers to a needle for follicular aspiration, having a base with a through-hole, inside of which a needle cannula is coupled, the needle cannula having a front aspiration end which protrudes from a front end of the base, and a rear end which freely protrudes from the rear end of the base, the through-hole of the base having a frustro- conical segment tapering from the rear end towards the front end of the base, forming a gap between the inner surface of the base and the outer surface of the needle cannula for coupling a biological sample collecting line.

Abstract: The system may include a chamber structure having a substantially oval or “egg” shaped outer shell. The system may also include an interior formed within the outer shell. A user area may be provided in the chamber structure substantially centered front to back and side to side within the outer shell. The system may also include at least one sound emitting device positioned to provide at least one person in the user area with a prescribed sound therapy. The system may also include at least one light emitting device selected to provide the person in the user area with a prescribed light therapy.

Abstract: A method and system are provided for converting clinical criteria constraints for a target structure of radiation therapy into a second set of constraints. The method includes selecting, by a hardware processor, a plurality of clusters of voxels in the target structure based on pre-specified criteria. The method further includes assigning, by the hardware processor, each of the plurality of clusters of voxels a respective constraint that specifies one or more bounds on a radiation dose applied to each voxel in a corresponding one of the plurality of clusters of voxels. The method also includes storing, in a memory device, the respective constraint for each of the plurality of clusters of voxels.

Abstract: The present application is generally directed to an expandable sleeve component of an implantable penile prosthesis, to a prosthesis containing the sleeve, and to related methods of preparation and use. More specifically, the present application is directed to an implantable penile prosthesis having a cylindrical polymeric (e.g., extruded, molded, etc.) sleeve for controlling cylinder expansion upon placement of the prosthesis within a corpus cavemosum and expansion during use.

Abstract: Devices, system and methods for deforming body channels are disclosed herein. At least some embodiments described may be used to deform a body channel so as to decrease or prevent the normal intrachannel flow of material within the body channel. Such deformation may be used to treat such maladies as Gastroesophageal Reflux Disease.

Abstract: Methods of preparing calcification-resistant bioprosthetic tissue include providing fresh biological tissue, cross-linking the tissue, treating the cross-linked tissue with an alcohol for a time sufficient to allow the alcohol to be diffused into the tissue, and treating the alcohol-treated fixed tissue with a polyol for a time sufficient to allow fluid in the tissue to be replaced by the polyol. The methods may include sterilizing the cross-linked tissue in a solution including propylene oxide or peracetic acid either before or after the alcohol treatment step; or drying the alcohol/polyol-treated, cross-linked tissue, sterilizing the dried tissue by exposure to ethylene oxide or peracetic acid, and storing the sterilized tissue in a dry, ambient environment. The treated tissue may be a tissue component for a bioprosthetic valve, a valve assembly for a bioprosthetic valve or a fully assembled bioprosthetic valve incorporating the tissue.

Abstract: The present invention relates to a method for increasing the embryo implantation rate in a mammalian uterus, by administering to the uterus of a mammal an effective amount of an extracellular matrix remodeling enzyme, as well as to a product comprising an extracellular remodeling enzyme.

Abstract: An adjustable compression device (10) including an elongate rigid band (12) provided to extend around a portion of the circumference of a penis (16) is described. The band (12) includes first and second side portions (18, 20) connecting by an intermediate portion (22). An engagement member (14) is secured between the first and second side portions (18, 20) such that the engagement member (14) is rotatable about a rotational axis (24) extending between the side portions (18, 20). The engagement member (14) is off-centred relative to said rotational axis (24) such that an area defined between the engagement member (14) and the band (12) can be increased or decreased by rotation of the engagement member (14) thereby adjusting pressure applied to the penis (16).