Patents Examined by Samuel Liu
  • Patent number: 9988652
    Abstract: The present invention is directed to cellulytic host cells. The host cells of the invention expressing heterologous cellulases and are able to produce ethanol from cellulose. According to the invention, host cells expressing a combination of heterologous cellulases can be used to produce ethanol from cellulose. In addition, multiple host cells expressing different heterologous cellulases can be co-cultured together and used to produce ethanol from cellulose. Furthermore, the invention demonstrates for the first time the ability of Kluveryomyces to produce ethanol from cellulose. The yeast strains and co-cultures of yeast strains of the invention can be used to produce ethanol on their own, or can also be used in combination with externally added cellulases to increase the efficiency of saccharification and fermentation processes.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: June 5, 2018
    Assignees: Lallemand Hungary Liquidity Management LLC, Stellenbosch University
    Inventors: John McBride, Elena Brevnova, Mark Mellon, Allan Froehlich, Kristen Deleault, Vineet Rajgarhia, Riaan Den Haan, Merja Penttila, Marja Ilmen, Matti Siika-Aho, Jaana Uusitalo, Emily A. Stonehouse, Alan Gilbert, Haowen Xu, Deidre Willes, John Bardsley, Anu Koivula, Sanni Voutilainen
  • Patent number: 9982242
    Abstract: Provided are: a protein complex capable of selectively and asymmetrically oxidizing an enantiomer of a secondary alcohol without adding a coenzyme and having an asymmetric oxidation activity in a water-soluble solvent system in the presence of oxygen; a method for producing the same; and a method for coating the protein complex with a high molecular weight compound. The method for producing the protein complex includes: (1) enclosing a crude water-soluble protein in a gel, air-oxidizing the gel, and eluting the protein complex into an aqueous solution; and (2) applying gravity to concentrate and precipitate the protein complex, redissolving the precipitate in an aqueous glycine sodium hydroxide solution of about 0.5 mM and allowing the same to homogeneously coexist with a high molecular weight compound, and re-precipitating the solution and dehydrating and drying the same to yield a protein complex coated with a high molecular weight compound.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: May 29, 2018
    Assignee: SANYO FOODS CO., LTD.
    Inventor: Hiroyuki Nagaoka
  • Patent number: 9890401
    Abstract: Methods and compositions, including nucleotide sequences, amino acid sequences, and host cells, for producing fatty alcohols are described.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: February 13, 2018
    Assignee: REG LIFE SCIENCES, LLC
    Inventors: Zhihao Hu, Vikranth Arlagadda
  • Patent number: 9868941
    Abstract: A novel luciferase that is distinct from conventional luciferase has been desired. A luciferase mutant comprising an amino acid sequence in which glutamic acid at position 4, arginine at position 11, leucine at position 18 and valine at position 27 are substituted with other amino acids, in the amino acid sequence of SEQ ID NO: 2.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: January 16, 2018
    Assignee: JNC CORPORATION
    Inventors: Satoshi Inouye, Yuiko Miura, Junichi Sato
  • Patent number: 9861609
    Abstract: The present invention provides methods for producing cannabinoids and cannabinoid analogs as well as a system for producing these compounds. The inventive method is directed to contacting a compound according to Formula I or Formula II with a cannabinoid synthase. Also described is a system for producing cannabinoids and cannabinoid analogs by contacting a THCA synthase with a cannabinoid precursor and modifying at least one property of the reaction mixture to influence the quantity formed of a first cannabinoid relative to the quantity formed of a second cannabinoid.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: January 9, 2018
    Assignee: FULL SPECTRUM LABORATORIES LIMITED
    Inventors: Robert Winnicki, Marc Donsky, Mingyang Sun, Richard Peet
  • Patent number: 9822335
    Abstract: This invention provides an Amycolatopsis sp. strain (zhp06), and a method of using the whole cell preparation of the strain for vanillin production. The strain was deposited in China Center for Type Culture Collection on Jul. 26, 2011 with the number of CCTCC NO: M 2011265. Under high concentrations of ferulic acid substrate, the vanillin production by this method can reach more than 10 g/L. The molar conversion rate of ferulic acid is more than 50% and the purity of vanillin is from 80% to 95%. The advantage of this invention includes: repeated use of biocatalyst cells, mild biotransformation condition, low environmental pollution, short production cycle, high product purity and simple purification procedure. It has a great potential for industrial applications.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: November 21, 2017
    Assignee: BGN TECH LLC
    Inventors: Pu Zheng, Hui Li, Xinglin Wang, Jianhai Zhou, Shibiao Chu
  • Patent number: 9816127
    Abstract: The present invention provides an assay for detection of oxidized glutathione (GSSG).
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: November 14, 2017
    Assignee: PROMEGA CORPORATION
    Inventors: Fen Huang, Dieter Klaubert, John Shultz, Wenhui Zhou
  • Patent number: 9796763
    Abstract: An isolated polynucleotide is provided. The isolated polynucleotide comprising a nucleic acid sequence encoding a polypeptide of a Type II reaction center of a photosynthetic organism, the nucleic acid sequence being capable of imparting the type II reaction center with an activity under a temperature range different than that of the type II reaction center endogenous to the photosynthetic organism. Also provided are methods of using the sequences for generating photosynthetic organisms or tailor-made thermotolerance.
    Type: Grant
    Filed: December 2, 2013
    Date of Patent: October 24, 2017
    Inventors: Avigdor Scherz, Oksana Shlyk-Kerner, Ilan Samish, David Kaftan, Jorge Dinamarca
  • Patent number: 9790522
    Abstract: The invention relates to the fields of bacterial metabolism and the utilization or consumption of short-chain carboxylic acids to reduced products. Specifically, it relates to syngas fermentations using monocultures of syngas-utilizing homoacetogenic bacteria for the production of alcohols using native alcohol dehydrogenase.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: October 17, 2017
    Assignee: Synata Bio
    Inventors: Andrew Reeves, Richard Tobey, Mike Enzien
  • Patent number: 9782458
    Abstract: The composition for tissue/cell repair facilitates healing of damaged tissues, promoting tissue and cell growth, protecting cells and tissues, and reducing scar tissue. The composition includes hydrolyzed collagen, and may include high molecular weight hydrolyzed collagen. The hydrolyzed collagen may be combined with native collagen and/or at least one other therapeutic agent. For example, the therapeutic agent may be a polysulfated glycosaminoglycan, a glucosamine salt, or mixtures thereof. The collagen may be derived from two or more different sources, and may be combined with hydrolyzed whey and/or elastin.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: October 10, 2017
    Inventor: George D. Petito
  • Patent number: 9777298
    Abstract: The present invention provides tools and methods for producing organic acids using strains of Monascus which are tolerant to high organic acid concentrations at low pH.
    Type: Grant
    Filed: October 28, 2011
    Date of Patent: October 3, 2017
    Assignee: TOTAL RESEARCH & TECHNOLOGY FELUY
    Inventors: Alexander Ruud Weusthuis, Emil Johan Harald Wolbert, Jan Springer, John Van Der Oost, Gerrit Eggink
  • Patent number: 9777295
    Abstract: The document provides methods for biosynthesizing isobutene using one or more isolated enzymes such as one or more of an enoyl-CoA dehydratase, a 2-hydroxyacyl-CoA dehydratase, an isovaleryl-CoA/acyl-CoA dehydrogenase and a mevalonate diphosphate decarboxylase, or using recombinant host cells expressing one or more such enzymes.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: October 3, 2017
    Assignee: INVISTA NORTH AMERICA S.A.R.L.
    Inventors: Adriana Leonora Botes, Alex Van Eck Conradie
  • Patent number: 9765378
    Abstract: The invention provides a method of preparing a new recombinant antibacterial polypeptide medicine, which primarily relates to liquid culture medium formula suitable for large-scale production of the antibacterial polypeptide, as well as optimization of the enlarged culture parameters.
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: September 19, 2017
    Assignee: Creative Trio Biotech (Beijing) Co., Ltd.
    Inventors: Xiaoqing Qiu, Rongqi Li, Xiangli Zhang, Xiaofeng Zhang
  • Patent number: 9758759
    Abstract: This invention provides an Amycolatopsis sp. strain (zhp06), and a method of using the whole cell preparation of the strain for vanillin production. The strain was deposited in China Center for Type Culture Collection on Jul. 26, 2011 with the number of CCTCC NO: M 2011265. Under high concentrations of ferulic acid substrate, the vanillin production by this method can reach more than 10 g/L. The molar conversion rate of ferulic acid is more than 50% and the purity of vanillin is from 80% to 95%. The advantage of this invention includes: repeated use of biocatalyst cells, mild biotransformation condition, low environmental pollution, short production cycle, high product purity and simple purification procedure. It has a great potential for industrial applications.
    Type: Grant
    Filed: July 15, 2015
    Date of Patent: September 12, 2017
    Assignee: BGN TECH LLC
    Inventors: Pu Zheng, Hui Li, Xinglin Wang, Jianhai Zhou, Shibiao Chu
  • Patent number: 9738879
    Abstract: Disclosed herein are transcription activator-like effector nuclease (TALEN)-related compositions and methods of using said TALENs for correcting mutant genes.
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: August 22, 2017
    Assignee: Duke University
    Inventors: Charles Gersbach, David Ousterout
  • Patent number: 9731052
    Abstract: The invention provides a method for the controlled assembly of layered silk fibroin coatings using aqueous silk fibroin material. The methods described herein can be used to coat substrates of any material, shape, or size. Importantly, the described methods enable control of the biomaterial surface chemistry, thickness, morphology and structure using layered thin film coatings, or bulk coatings. Furthermore, the methods can be performed in all water and do not require intensive chemical processing enabling controlled entrapment of labile molecules such as, drugs, cytokines, and even cells or viruses to generate functional coatings that can be used in a variety of applications.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: August 15, 2017
    Assignee: Trustees of Tufts College
    Inventors: David L. Kaplan, Xianyan Wang
  • Patent number: 9725498
    Abstract: The present disclosure provides synthetic collagen and methods of making and using synthetic collagen that include a synthetic collagen that facilitates wound closure comprising an isolated and purified triple helical backbone protein that facilitates wound closure comprising one or more alteration in a triple helical backbone protein sequence, that stabilize the isolated and purified triple helical backbone protein and does not disrupt an additional collagen ligand interaction; and one or more integrin binding motifs, wherein the isolated and purified triple helical backbone protein facilitates wound closure.
    Type: Grant
    Filed: December 3, 2013
    Date of Patent: August 8, 2017
    Assignee: THE TEXAS A&M UNIVERSITY SYSTEM
    Inventors: Brooke H. Russell, Magnus Hook, Mariah S. Hahn, Elizabeth M. Cosgriff-Hernandez, Neungseon Seo, Marvin Xuejun Xu, Jose J. Rivera, Mary Beth Browning
  • Patent number: 9701948
    Abstract: The present disclosure provides recombinant E. coli and other bacteria with reduced alcohol dehydrogenase and/or aldehyde reductase activity. The present disclosure further provides recombinant E. coli and other bacteria with reduced isobutyraldehyde reductase activity. Methods for the production and the uses of the recombinant bacteria are also provided. Specifically, recombinant bacteria further expressing 2-keto-acid decarboxylase can be used for producing higher aldehydes or other non-alcohol chemicals derived from aldehydes.
    Type: Grant
    Filed: June 18, 2013
    Date of Patent: July 11, 2017
    Assignee: The Regents Of The University Of California
    Inventors: Shota Atsumi, Gabriel Rodriguez
  • Patent number: 9670436
    Abstract: The present invention relates to cleaning compositions comprising variants of an alpha-amylase and methods of treating surfaces such as textiles with aqueous liquor comprising such compositions, especially at low temperatures.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: June 6, 2017
    Assignee: The Procter & Gamble Company
    Inventors: Michelle Jackson, Philip Frank Souter, Lindsay Suzanne Bewick, Svend Kaasgaard, Jens Oebro, Signe Eskildsen Larsen, Allan Svendsen, Annette Helle Johansen, Michael Skjoet, Carsten Andersen, Lars Beier, Esben Peter Friis, Miguel Duarte Guilherme Pereira Toscano, Mads Bjoernvad, Frank Winther Rasmussen, Liv Spaangner Christiansen
  • Patent number: 9663658
    Abstract: Provided are compositions and methods for making a variety of products. The methods involve mixing sucker ring teeth (SRT) protein and a plasticizer or a solvent to obtain a mixture of the SRT protein and the plasticizer. When the SRT is mixed with a plasticizer it is heated to between 32° C. and 195° C. to obtain an SRT protein melt. The melt is used to form a wide variety of products. When the SRT is mixed with a solvent, such as an organic solvent or an aqueous solvent, a solution of the SRT protein is formed, and is subsequently used to forming a product from the solution, wherein the product contains SRT protein.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: May 30, 2017
    Assignee: The Penn State Research Foundation
    Inventors: Melik Demirel, Abdon Pena-Francesch