Patents Examined by San Ming R. Hui
  • Methods and compounds to inhibit enveloped virus release
    Patent number: 11369622
    Abstract: A compound having an antiviral activity for inhibiting release of an enveloped virus from a cell is disclosed, including methods of inhibiting release of an enveloped virus from a cell. The antiviral activity of the compound includes inhibiting formation of an associative complex or disrupting formation of an associative complex. The associative complex comprises an L-domain motif of the enveloped virus and at least one cellular polypeptide, or fragment thereof, capable of binding the L-domain motif of the enveloped virus.
    Type: Grant
    Filed: August 5, 2020
    Date of Patent: June 28, 2022
    Assignees: Northwestern University, THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Jonathan Leis, Carol Carter
  • Prophylactic or therapeutic agent for pulmonary hypertension comprising mebendazole and/or itraconazole or salt thereof
    Patent number: 11369601
    Abstract: An object to be achieved by the present invention is to provide a novel preventive or therapeutic agent for pulmonary hypertension containing as an active ingredient a compound that has not been known for a therapeutic effect on pulmonary hypertension heretofore. The present invention provides a preventive or therapeutic agent for pulmonary hypertension, including at least one kind selected from the group consisting of mebendazole and itraconazole or a salt thereof.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: June 28, 2022
    Assignee: TOHOKU UNIVERSITY
    Inventors: Hiroaki Shimokawa, Kimio Satoh, Junichi Omura, Nobuhiro Kikuchi, Ryo Kurosawa
  • Prostacyclin analogue formulations
    Patent number: 11369617
    Abstract: The present invention relates to an injectable pre-formulation comprising: a) at least one of a mono-, di-, or tri-acyl lipid and/or a tocopherol; b) optionally at least one phospholipid; c) at least one biocompatible, organic solvent; and d) at least one prostacyclin analogue or a salt thereof; wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with excess aqueous fluid. Such compositions may additionally comprise polar co-solvents. Methods of treatment, particularly for management of pulmonary artery hypertension (PAH), severe PAH, Raynard's disease, ischemia and related conditions are provided, as well as corresponding uses of the compositions. Administration devices comprising the formulations and kits comprising the devices are also provided.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: June 28, 2022
    Assignee: CAMURUS AB
    Inventors: Fredrik Tiberg, Justas Barauskas, Catalin Nistor, Markus Johnsson
  • Compounds, compositions and methods for prevention and/or treatment of cancer
    Patent number: 11369618
    Abstract: The present invention includes compounds, compositions and methods that are useful for preventing or treating melanoma or any other cancer in a subject, such as a GPCR-expressing cancer. In certain embodiments, the compounds comprise estrogen (including estrogen derivatives or analogues), a selective GPER agonist and/or another G-protein coupled receptor (GPCR) agonist that increases cancer cell differentiation.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: June 28, 2022
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Todd Ridky, Christopher Natale, Jeffrey Winkler
  • Compositions for the treatment of gastrointestinal inflammation
    Patent number: 11357859
    Abstract: Provided herein are methods for treating, preventing or alleviating the symptoms of and inflammation associated with inflammatory diseases and conditions of the gastrointestinal tract, for example, those involving the esophagus. Also provided herein are pharmaceutical compositions useful for the methods of the present invention.
    Type: Grant
    Filed: April 2, 2019
    Date of Patent: June 14, 2022
    Assignee: ViroPharma Biologics LLC
    Inventors: Elaine Phillips, Malcolm Hill
  • Pharmaceutical composition
    Patent number: 11351127
    Abstract: A pharmaceutical composition in the form of an emulsion, in particular an oil-in-water emulsion, comprising certain polyunsaturated long-chain ketones and polysorbate. The composition may be used to treat or prevent certain inflammatory or proliferative conditions.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: June 7, 2022
    Assignee: Avexxin AS
    Inventors: Philip Hansen, Anders Ljungqvist
  • Anti-methanogenic compositions and uses thereof
    Patent number: 11344501
    Abstract: The present invention relates to, in part, methods and compositions for the treatment of methanogen-associated disorders such as, for example, Irritable Bowel Syndrome (IBS). Particularly, modified-release formulations comprising at least one antimethanogenic statin are provided which release the antimethanogenic statin in the intestines.
    Type: Grant
    Filed: April 27, 2020
    Date of Patent: May 31, 2022
    Assignee: Cedars-Sinai Medical Center
    Inventors: Mark Pimentel, Ruchi Mathur, Steve Kanzer, Vince Wacher
  • Compositions and methods for treating central nervous system disorders
    Patent number: 11337987
    Abstract: The present disclosure is drawn to compositions and methods for treating CNS disorders. In one embodiment, an oral pharmaceutical composition can comprise a therapeutically effective amount of pregn-4-ene-3,20-dione; and a pharmaceutically acceptable carrier that provides formation of either 3?-OH-5?-pregnan-20-one, or 3?-OH-5?-pregnan-20-one, or both in an amount sufficient to treat a CNS disorder when orally administered to a subject. In another embodiment, a method of treating a CNS disorder can comprise orally administering to a subject, a therapeutically effective amount of pregn-4-ene-3,20-dione that provides an amount of GABA receptor binding pregn-4-ene-3,20-dione metabolites that is sufficient to treat the CNS disorder.
    Type: Grant
    Filed: May 7, 2021
    Date of Patent: May 24, 2022
    Inventors: Mahesh V. Patel, Nachiappan Chidambaram, Kilyoung Kim, Kongnara Papangkorn, Benjamin J. Bruno, Kiran Kumar Vangara
  • Method for treatment of Parkinson's disease
    Patent number: 11331293
    Abstract: Disclosed is a method for the treatment of a neurological or movement disorder, e.g., Parkinson's disease, in an individual in need thereof, by parenteral administration of levodopa and a dopa decarboxylase inhibitor (DDCI), such as carbidopa, benserazide or any combination thereof, concomitantly with oral administration of levodopa, a DDCI, such as carbidopa, benserazide, or any combination thereof.
    Type: Grant
    Filed: January 3, 2022
    Date of Patent: May 17, 2022
    Assignee: NeuroDerm, Ltd.
    Inventors: Tal Birnberg, Liat Adar, Itay Perlstein
  • Methods for treating B cell proliferative disorders
    Patent number: 11318138
    Abstract: Described herein are methods for treating B cell proliferative disorders, in an individual in need thereof. The methods include administering to an individual in need thereof a Btk inhibitor (e.g., ibrutinib), in combination with a CDK4 inhibitor (e.g., palbociclib).
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: May 3, 2022
    Assignee: Cornell University
    Inventors: Selina Chen-Kiang, Maurizio Di Liberto
  • Compositions for improving sexual function
    Patent number: 11304920
    Abstract: The present invention relates to compositions comprising L-arginine and L-citrulline in specific ratios. In particular, the present invention relates to the use of such compositions for improving sexual function in a healthy human subject.
    Type: Grant
    Filed: December 6, 2019
    Date of Patent: April 19, 2022
    Assignee: INXO A/S
    Inventors: Djamaluddin Zaferan, Jahangir Khan
  • Use of isoxazoline derivatives for the treatment or prevention of arthropod infestations in poultry
    Patent number: 11304934
    Abstract: The present invention relates to methods of treating or preventing arthropod infestations of poultry animals and methods of controlling arthropod infestations in poultry animal's environment by administering an isoxazoline compound of formula (I) via drinking water.
    Type: Grant
    Filed: April 15, 2020
    Date of Patent: April 19, 2022
    Assignee: Intervet Inc.
    Inventors: Anja Regina Heckeroth, Hartmut Zoller, Annie Flochlay-Sigognault, Bruno Huyghe
  • Pharmaceutical compositions comprising a hydroxyethylquercetin glucuronide
    Patent number: 11304968
    Abstract: Disclosed herein are hydroxyethylquercetin glycosides, including compounds of Structural Formulas I, II, III and IV. The compounds disclosed are useful for inhibiting norepinephrine metabolism and treating antenatal and postnatal depression in subjects in need thereof.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: April 19, 2022
    Assignee: Janssen Pharmaceutica NV
    Inventor: Thomas M. DiMauro
  • Crystalline compounds
    Patent number: 11299458
    Abstract: The present invention relates to crystalline forms of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride and compositions comprising the same and methods of making and using the same.
    Type: Grant
    Filed: August 14, 2020
    Date of Patent: April 12, 2022
    Assignee: OTSUKA AMERICA PHARMACEUTICAL, INC.
    Inventors: Anthony Alexander McKinney, Franklin Bymaster, Walter Piskorski, Fred J. Fleitz, Yonglai Yang, David A. Engers, Valeriya Smolenskaya, Venkat Kusukuntla
  • Tannin formulations for agricultural use in plants
    Patent number: 11266148
    Abstract: The preparation, composition, and method of use of an antibacterial formulation utilizing tannins, acceptable for agriculture and for use against bacterial and fungicidal diseases in plants. The composition is based on an organic matrix and may be balanced with dispersants, flocculants and humectants, and may be used against a wide range of agricultural bacterial diseases.
    Type: Grant
    Filed: June 5, 2020
    Date of Patent: March 8, 2022
    Assignee: QUÍMICA AGRONÓMICA DE MÉXICO S. DE R.L. DE C.V.
    Inventor: Miguel Enrique Alvarado Licon
  • Oral pharmaceutical composition of lurasidone and preparation thereof
    Patent number: 11260055
    Abstract: The present invention relates to an oral pharmaceutical composition, particularly a tablet, comprising an active ingredient lurasidone or its pharmaceutically acceptable salt(s) or solvate(s) thereof and one or more pharmaceutical excipient(s); and a process for its preparation.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: March 1, 2022
    Assignee: PIRAMAL ENTERPRISES LIMITED
    Inventors: Tejas Shah, Milan B. Agrawal, Narendra Patel, Devesh Bhatt, Umesh Barabde, Vipan Dhall
  • On site generated performic acid compositions for teat treatment
    Patent number: 11260040
    Abstract: The present disclosure relates generally to peroxyformic acid forming compositions and methods for forming peroxyformic acid, preferably in situ, and peroxyformic acid formed by said compositions and methods for the purpose of treating an animal tissue and providing an antimicrobial function thereon. present disclosure in particular relates to a residue-free teat treatment composition for the treatment of an animal tissue, especially bovine teats, which provides antimicrobial efficacy and does not leave a non-food ingredient residue on treated teats.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: March 1, 2022
    Assignee: ECOLAB USA INC.
    Inventors: Junzhong Li, Alexander Thomas, Allison Prideaux, David D. McSherry, Joseph Morelli, Richard Staub
  • Arimoclomol for treating glucocerebrosidase associated disorders
    Patent number: 11253505
    Abstract: The present invention relates to an active pharmaceutical ingredient selected from N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboximidoyl chloride, its stereoisomers and the acid addition salts thereof (arimoclomol), for use in a method of treating glucocerebrosidase associated disorders.
    Type: Grant
    Filed: May 20, 2020
    Date of Patent: February 22, 2022
    Assignee: Orphazyme A/S
    Inventors: Anders Mørkeberg Hinsby, Thomas Kirkegaard Jensen, Catherine Kolster Fog-Tonnesen, Nikolaj Havnsøe Torp Petersen, Claus Bornæs
  • Uses of salt-inducible kinase (SIK) inhibitors for treating osteoporosis
    Patent number: 11241435
    Abstract: The present disclosure provides methods of treating and/or preventing osteoporosis using salt-inducible kinase (SIK) inhibitors. Also provided are methods of using SIK inhibitors for increasing the function of osteocytes, increasing the number of osteoblasts, increasing the activity of osteoblasts, inhibiting the resorption of a bone, decreasing the number of osteoclasts, inhibiting the activity of osteoclasts, increasing the mass of a bone, down-regulating the expression of the gene SOST, and/or inhibiting the activity of sclerostin. The SIK inhibitors may be combined with Src inhibitors or CSF I R inhibitors. Exemplary SIK inhibitors include the compounds of the formula: (I), (II), (III), (IV), (V) or (VI).
    Type: Grant
    Filed: September 16, 2017
    Date of Patent: February 8, 2022
    Assignees: The General Hospital Corporation, The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Marc Wein, Henry Kronenberg, Thomas Sundberg, Ramnik Xavier, Nathanael S. Gray, Yanke Liang, Hwan Geun Choi, Alykhan Shamji
  • Method for treatment of parkinson's disease
    Patent number: 11213502
    Abstract: Disclosed is a method for the treatment of a neurological or movement disorder, e.g., Parkinson's disease, in an individual in need thereof, by parenteral administration of levodopa and a dopa decarboxylase inhibitor (DDCI), such as carbidopa, benserazide or any combination thereof, concomitantly with oral administration of levodopa, a DDCI, such as carbidopa, benserazide, or any combination thereof.
    Type: Grant
    Filed: May 28, 2021
    Date of Patent: January 4, 2022
    Assignee: NeuroDerm, Ltd.
    Inventors: Tal Birnberg, Liat Adar, Itay Perlstein