Patents Examined by Sandra Saucier
  • Patent number: 9095818
    Abstract: The present invention relates to methods for removing antiplatelet agents and anticoagulants from a platelet preparation. In one embodiment, the method includes the step of flowing the platelet preparation through a filtering tube comprising a filtering membrane and separating the antiplatelet agents and anticoagulants from the platelet preparation by tangential flow filtration. In another embodiment, the method includes the step of passing the platelet preparation through porous material that specifically binds to the antiplatelet agents and anticoagulants.
    Type: Grant
    Filed: June 2, 2010
    Date of Patent: August 4, 2015
    Inventor: Lakshman R. Sehgal
  • Patent number: 9078428
    Abstract: The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ.
    Type: Grant
    Filed: October 7, 2005
    Date of Patent: July 14, 2015
    Assignee: TransMedics, Inc.
    Inventors: Waleed Hassanein, Paul Lezberg, Tamer Khayal
  • Patent number: 9012221
    Abstract: The present invention relates to a method for producing platelets from mature megakaryocytes. More particularly, the invention relates to an ex vivo method for producing platelets, from mature megakaryocytes, said method comprising a step of subjecting a suspension of mature megakaryocytes to a flow having a minimal shear rate of 600 s?1 on a solid phase coated with Von Willebrand factor.
    Type: Grant
    Filed: December 4, 2009
    Date of Patent: April 21, 2015
    Assignees: INSERM (Institut National de la Sante et de la Recherche Medicale), Universite Paris Descartes, Assistance Publique Hopitaux de Paris, Universite de Versailles Saint-Quentin-en-Yvelines
    Inventors: Dominique Baruch, Elisabeth Cramer-Borde, Claire Dunois
  • Patent number: 9012137
    Abstract: The present invention refers to a method of processing a biological fluid which comprises cellular components by a freezing/thawing treatment. The method is particularly useful for preparing biological samples for analyte detection.
    Type: Grant
    Filed: July 23, 2009
    Date of Patent: April 21, 2015
    Assignee: Thermo Finnigan LLC
    Inventor: Dietrich Seidel
  • Patent number: 8980542
    Abstract: Blood storage and/or rejuvenating compositions that include D-ribose and an arginine (e.g. L-arginine, D-arginine, or a combination thereof) are disclosed herein. Such compositions can be useful in methods for treating (e.g., storing and/or rejuvenating) red blood cells.
    Type: Grant
    Filed: February 16, 2011
    Date of Patent: March 17, 2015
    Assignee: Viacell, LLC
    Inventors: Daniel G. Ericson, Jeffrey A. Thompson
  • Patent number: 8980301
    Abstract: A blood product (10), a method for preparing the blood product, a blood product obtainable by the method and a blood product preparing container means. The blood product comprises components from whole blood, especially fibrin, thrombocytes and leukocytes. The blood product (10) comprises a first layer (21), a second layer (22) and a third layer (23). The second layer (22) is adjacent to the first layer (21) and the third layer (23). The first layer (21) defines a first outer surface (24) of the blood product (10) and the third layer (23) defining a second outer surface (25) of the blood product (10). The first layer (21) comprises a majority of fibrin, the second layer (22) comprises a majority of thrombocytes and the third layer (23) comprises a majority of leukocytes.
    Type: Grant
    Filed: August 24, 2009
    Date of Patent: March 17, 2015
    Assignee: Reapplix APS
    Inventors: Rasmus Lundquist, Niels Erik Holm
  • Patent number: 8945823
    Abstract: Methods and compositions for resuscitating, storing, and preserving functional integrity of organs and tissues. Metabolic function is maintained by sustaining ATP levels, mitochondrial function, cardiomyocyte contractility, prevention of acidosis, inhibition of induction of apoptosis, maintaining ionontrophy and lusiotrophy by regulating calcium, sodium, potassium and chloride ions.
    Type: Grant
    Filed: July 18, 2012
    Date of Patent: February 3, 2015
    Assignee: The United States of America as Represented by the Department of Veterans Affairs
    Inventors: Hemant Thatte, Patrick Treanor, Laki Rousou, Randa Khuri
  • Patent number: 8927202
    Abstract: Disclosed are compositions and methods for the preservation, storage, and transport of living biological tissues, organs, and populations of isolated cells. In particular, the disclosed compositions and processes permit mammalian cells, tissues, and organs to be harvested from suitable donor animals, stored for prolonged periods, and transported to the site of recipient implantation, all without significant loss of cell viability, biological activity, and/or tissue integrity.
    Type: Grant
    Filed: November 19, 2010
    Date of Patent: January 6, 2015
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Daniel Andrew Shimko, Scott P. Noel, Susan J. Drapeau, Josee Roy
  • Patent number: 8927203
    Abstract: The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally, the composition may also contain an ultra-short acting broad spectrum anti-microbial agents. The preservative composition may be used to store platelets in a liquid state, a frozen state, or a freeze-dried state.
    Type: Grant
    Filed: October 21, 2011
    Date of Patent: January 6, 2015
    Assignee: Biovec Transfusion, LLC
    Inventor: Lakshman R. Sehgal
  • Patent number: 8921063
    Abstract: Provided herein are methods for detecting endotoxin or Gram negative bacteria in a sample. Kits for detecting endotoxin or Gram negative bacteria in a sample are provided.
    Type: Grant
    Filed: February 28, 2012
    Date of Patent: December 30, 2014
    Assignee: BioDtech, Inc.
    Inventors: Michael G. Pepe, Milton Keith Champion
  • Patent number: 8900804
    Abstract: Described herein are compositions and methods particularly useful in the medical arts. The compositions and methods may be used in connection with the preservation of a portion of a mammal, for example, tissues, organs, appendages, limbs, extremities, stem cells, myocytes, bone marrow, skeletal muscle as well as an array of other medical procedures, such as cardiac surgery, transplantation and/or preservation. In various embodiments, the inventive composition may be hyperoxygenated and be formulated to resemble the biochemistries of natural intracellular fluids. The inventive composition includes active ingredients to reduce ischemic, hypothermic and reperfusion injury during transplantation, thereby resulting in improved post-transplant graft function and quality, when used in connection with organ transplantation and storage procedures, for example cardiac transplantation.
    Type: Grant
    Filed: November 15, 2005
    Date of Patent: December 2, 2014
    Assignee: Cedars-Sinai Medical Center
    Inventors: Andreas Kamlot, Alfredo Trento, Lawrence Czer, Jennifer Pass
  • Patent number: 8895236
    Abstract: A red blood cell storage composition includes a composition of red blood cells and biochemistry altering reagents, the biochemistry altering reagents being present at a concentration so as to reduce the percent hemolysis of the red blood cells during the freeze-thaw cycle below that of the percent hemolysis of the red blood cells in the absence the biochemistry altering reagents. The red blood cell storage composition preferably includes reagents selected from: modifiers of glycolytic/metabolic components, modifiers of antioxidant potential, effectors of intracellular ionic distribution, modifiers of membrane fluidity, modifiers of cytoskeletal structure, effectors of the cyclooxygenase second messenger pathway, effectors of the lipoxygenase second messenger pathway, effectors of the hexose monophosphate second messenger pathway, effectors of the phosphorylation second messenger pathway, modifiers of specific messenger molecules, and combinations thereof.
    Type: Grant
    Filed: February 8, 2012
    Date of Patent: November 25, 2014
    Inventors: Stephen A. Livesey, Michael Brian Burnett, Jerome Connor, Christopher Todd Wagner
  • Patent number: 8889624
    Abstract: A virally safe, thrombin-free factor-XIa concentrate or a coagulation factor concentrate which contains factor XIa as an active pharmaceutical ingredient and which is obtained by fractionation of plasma or serum or by genetic engineering and is suitable for the treatment of coagulation disorders attributable to diminished and/or delayed thrombin formation.
    Type: Grant
    Filed: September 16, 2010
    Date of Patent: November 18, 2014
    Assignee: Bio & Bio Licensing SA
    Inventor: Johann Eibl
  • Patent number: 8883409
    Abstract: Disclosed are methods for pathogen reduction in blood by illuminating with UV light while taking steps for preservation of blood components and reducing oxidative damage from reactive oxygen species generated during UV light exposure. Fresh whole donor blood or products derived therefrom may be submitted to UV light treatment while in a low oxygenation state defined by a partial oxygen pressure below a normal level. Such low oxygenation state occurs naturally shortly after blood collection or may be induced by exposure to low-oxygen environment, reducing temperature or by other disclosed steps.
    Type: Grant
    Filed: December 8, 2013
    Date of Patent: November 11, 2014
    Assignee: Hemalux LLC
    Inventor: Ehud Ben-Hur
  • Patent number: 8846306
    Abstract: The invention relates to the use of at least one globin and/or at least one globin protomer and/or at least one naturally extracellular native hemoglobin for the preservation of organs, tissues, organ and tissue cells and cell cultures.
    Type: Grant
    Filed: July 25, 2008
    Date of Patent: September 30, 2014
    Assignees: Hemarina SA, Centre National de la Recherche Scientifique, Universite Pierre et Marie Curie (Paris 6)
    Inventors: Franck Zal, Morgane Rousselot, Delphine Dutheil
  • Patent number: 8835104
    Abstract: Synthetic storage media are disclosed for use in the processing and the storing of platelets. The storage media includes a platelet storage solution and less than 20 percent plasma to preserve platelet function after at least 7 days of storage.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: September 16, 2014
    Assignee: Fenwal, Inc.
    Inventors: VĂ©ronique Mayaudon, Jean-Marc Payrat
  • Patent number: 8802083
    Abstract: The present invention relates to compositions comprising complexes of human cells and polymer fibers and methods of their use for therapeutic purposes. Methods of making such compositions are also provided. The present invention encompasses compositions comprising poly-?-1?4-N-acetylglucosamine polymers and stored platelets and their use for promoting wound healing and achieving hemostasis.
    Type: Grant
    Filed: May 18, 2012
    Date of Patent: August 12, 2014
    Assignee: Marine Polymer Technologies, Inc.
    Inventors: John N. Vournakis, Sergio Finkielsztein
  • Patent number: 8802385
    Abstract: The present invention relates to a new suspension medium or diluent solution for red blood cells for use in haematological methods. The suspension medium or diluent solution for red blood cells may comprise a combination of two or more amino acids of any group, and preserves the red blood cells in the sample for at least 8 weeks.
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: August 12, 2014
    Assignee: Grifols, S.A.
    Inventors: Daniel Martorell Pena, Ma del Carmen Traves Polo, Jordi Farre Leon, Josefina Castells Parera
  • Patent number: 8795956
    Abstract: The invention relates to a method for protecting transplants, as well as organs and individual blood vessels, against inflammatory reactions that are caused by the operative procedure linked to the explantation and storage until transplantation. This can be achieved by treating the transplant via intra arterial application of flavonol compounds, in particular with quercetin glucuronide and/or kaempferol glucuronide.
    Type: Grant
    Filed: March 3, 2009
    Date of Patent: August 5, 2014
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Anke Esperester, Stephan Nees
  • Patent number: 8741282
    Abstract: Methods are disclosed to promote vascularization of tissue in mammals using an autologous platelet-rich plasma composition. In particular, a method of treating a cardiac tissue lesion is disclosed.
    Type: Grant
    Filed: June 17, 2008
    Date of Patent: June 3, 2014
    Inventor: Allan Mishra