Patents Examined by Sarae Bausch
  • Patent number: 9890431
    Abstract: The present invention provides a method and a kit for detecting a S. pneumoniae nucleic acid in a sample. The method comprises the steps of isolating said nucleic acid and detecting hybridization between the S. pneumoniae nucleic acid and a labeled probe, wherein the detection of hybridization comprises detecting a change in signal from the labeled probe during or after hybridization relative to the labeled probe signal before hybridization. The method of the present invention is characterized in that said nucleic acid is a ribonucleic acid, which isolation comprises the addition of acidic phenol to said sample and the purification of said ribonucleic acid.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: February 13, 2018
    Inventors: Pierre-Alexandre Drèze, Pierre Smeesters, Lena Demazy, Laurence Van Melderen
  • Patent number: 9863952
    Abstract: Disclosed is a method of diagnosing the presence of higher grade astrocytoma/glioblastoma (GBM) or lower-grade astrocytoma (DA or AA) in a human subject using secreted or plasma membrane associated biomarkers, which involves the detection of the expression levels of said genes, alone or in combination, in either tumor tissue samples or body fluids and a diagnostic kit thereof.
    Type: Grant
    Filed: March 31, 2009
    Date of Patent: January 9, 2018
    Assignee: Council of Scientific & Industrial Research
    Inventors: Kumaravel Somasundaram, Paturu Kondaiah, Vani Santosh, Sridevi Hegde, Alangar Sathyaranjandas Hegde, Manchanahalli Rangaswamy Satyanarayana Rao
  • Patent number: 9816149
    Abstract: The present invention relates to a method for differentiating in a subject with HR-HPV between a severe form of HR-HPV infection and a mild form of HR-HPV infection. It further is concerned with a composition comprising a probe oligonucleotide mixture, a device, and a kit for use in conjunction with the method of the invention.
    Type: Grant
    Filed: May 4, 2011
    Date of Patent: November 14, 2017
    Assignee: Deutsches Krebsforschungzentrum
    Inventors: Markus Schmitt, Lutz Gissmann, Michael Pawlita, Daniela Hoefler
  • Patent number: 9771618
    Abstract: Clinical tests for testing therapeutic sensitivity of cancerous breast tissue and methods and kits for performing the same are described herein. Embodiments of the present invention are directed to methods for predicting the efficacy of treatment of breast cancer. In addition, certain embodiments are directed to a kit for testing therapeutic sensitivity of breast cancer tissue.
    Type: Grant
    Filed: August 19, 2010
    Date of Patent: September 26, 2017
    Assignee: Bioarray Genetics, Inc.
    Inventors: Marcia V. Fournier, Katherine J. Martin
  • Patent number: 9663822
    Abstract: Methods of capturing two or more nucleic acids simultaneously from a single sample are provided. Different nucleic acids are captured through cooperative hybridization events on different subsets of particles or at different selected positions on a spatially addressable solid support. Methods of capturing one or more long nucleic acids and methods of capturing one or more nucleic acid for sequencing are also provided. Compositions, kits, and systems related to the methods are also described.
    Type: Grant
    Filed: December 12, 2013
    Date of Patent: May 30, 2017
    Assignee: Affymetrix, Inc.
    Inventors: Yuling Luo, Yunqing Ma, Gary McMaster, Quan Ngoc Nguyen, Frank Witney, Wen Yang
  • Patent number: 9631234
    Abstract: An isolated nucleic acid molecule comprising the nucleotide sequence set forth in SEQ ID NO: 1.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: April 25, 2017
    Assignee: Central Adelaide Local Health Network Incorporated
    Inventors: Jozef Gecz, Petter Stromme
  • Patent number: 9631236
    Abstract: The present invention is based in part on the discovery of a panel of miRs whose levels are increased or decreased in the circulation of chronic systolic HF patients. Accordingly, an extensive panel of miRs was screened in the sera of stable chronic systolic HF patients and the results were compared to an age, gender and ethnically matched control group.
    Type: Grant
    Filed: May 23, 2012
    Date of Patent: April 25, 2017
    Assignees: Rosetta Genomics Ltd., MOR Research Applications Ltd.
    Inventors: Yaron Goren, Ofer Amir
  • Patent number: 9593384
    Abstract: The present invention is directed to the discovery of single nucleotide polymorphisms (SNPs) in the presence of metronidazole-resistant Trichomonas vaginalis. The presence of G76C, C213G, or C318A (SNP) in tvntr 4 or the presence of A238T, G427C, or T476C (SNP) in tvntr6 provides a reliable biomarker for the presence of metronidazole-resistant Trichomonas vaginalis. The present invention further provides reagents used for detecting the SNPs to screen subjects for metronidazole resistance in Trichomonas vaginalis.
    Type: Grant
    Filed: April 22, 2014
    Date of Patent: March 14, 2017
    Assignee: Medical Diagnostic Laboratories, LLC
    Inventors: David W Hilbert, Scott E Gygax, Martin E. Adelson, Eli Mordechai, Jessica Schuyler, Teresa Paulish-Miller
  • Patent number: 9567637
    Abstract: The present invention provides a method of diagnosing a cerebrovascular disease in a human comprising the steps of: (a) measuring a mutation of HTRA1 gene in a test sample from said human; and (b) determining if the mutation of HTRA1 gene in said test sample correlates with a cerebrovascular disease in said human.
    Type: Grant
    Filed: April 20, 2010
    Date of Patent: February 14, 2017
    Inventors: Shoji Tsuji, Osamu Onodera
  • Patent number: 9534260
    Abstract: This application provides materials and methods for the detection of the aad-12 gene and event pDAB4472-1606 in biological samples derived from plants.
    Type: Grant
    Filed: October 18, 2012
    Date of Patent: January 3, 2017
    Assignee: Dow AgroSciences LLC
    Inventors: Chandra-Shekara A. Channabasavaradhya, Andrew Greenwald
  • Patent number: 9499856
    Abstract: Methods for treating patients with squamous cell lung cancer, including detecting the presence of mutations in the discoidin domain receptor 2 (DDR2) gene.
    Type: Grant
    Filed: May 1, 2013
    Date of Patent: November 22, 2016
    Assignees: The Board Institute, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Matthew Meyerson, Peter Hammerman, Alexis Ramos
  • Patent number: 9441275
    Abstract: A method for predicting a subject's risk factors for CYP3A4-related disorders includes detecting the allelic status of a SNP in a nucleic acid sample of the subject.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: September 13, 2016
    Assignee: Ohio State Innovation Foundation
    Inventors: Wolfgang Sadee, Danxin Wang
  • Patent number: 9322064
    Abstract: This invention relates generally to the THAP1 gene and mutations in this gene, as well as the THAP1 protein and mutations in this protein, that are associated with dystonia. The invention relates to the identification, isolation, cloning and characterization of the DNA sequence corresponding to the wild type and mutant THAP1 genes, as well as isolation and characterization of their transcripts and gene products. The invention further relates to methods and kits useful for detecting mutations in THAP1 that are associated with dystonia, as well as to methods and kits useful for diagnosing dystonia. The present invention also relates to therapies for treating dystonia, including gene therapeutics and protein/antibody based therapeutics.
    Type: Grant
    Filed: October 23, 2013
    Date of Patent: April 26, 2016
    Assignees: Icahn School of Medicine at Mount Sinai, Beth Israel Medical Center
    Inventors: Laurie Ozelius, Susan Bressman
  • Patent number: 9150788
    Abstract: The present invention relates to a non-amphiphile-based water-in-water emulsion composition. The non-amphiphile-based water-in-water emulsion composition includes a water-soluble polymer, a non-amphiphilic lyotropic mesogen encapsulated by the water-soluble polymer; and water. In one embodiment, the non-amphiphilic lyotropic mesogen includes, without limitation, a lyotropic chromonic liquid crystal, and more specifically disodium cromoglycate (DSCG). In another embodiment, the water-soluble polymer can include, without limitation, a polyacrylamide, a polyol, a polyvinylpyrrolidone, a polysaccharide, or a water-soluble fluoride-bearing polymer. The present invention also relates to a porous hydrogel made with the use of the non-amphiphile-based water-in-water emulsion. The present invention further relates to using the emulsion and hydrogel for various applications.
    Type: Grant
    Filed: September 18, 2008
    Date of Patent: October 6, 2015
    Assignee: Syracuse University
    Inventors: Yan-Yeung Luk, Karen A. Simon, Dacheng Ren
  • Patent number: 9133520
    Abstract: The present disclosure describes the identification of single nucleotide polymorphisms (SNPs) in inflammatory diseases and uses thereof, and methods of screening for, diagnosing, identifying susceptibility to or detecting a risk of developing an inflammatory disease comprising detecting the presence or absence of at least one SNP identified in a gene associated with inflammatory disease.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: September 15, 2015
    Assignee: University of Guelph
    Inventors: Chris P. Verschoor, Niel A. Karrow
  • Patent number: 9090946
    Abstract: Disclosed are primer set compositions, methods and kits for human identification using the highly complex sequence locus, SE33 (ACTBP2) in single and multiplex PCR reactions. Additionally, disclosed are three newly discovered single nucleotide polymorphisms (SNPs) within the SE33 locus that can cause discordance seen as mobility shift or allelic dropout. Also disclosed are kits useful in human identification.
    Type: Grant
    Filed: September 21, 2011
    Date of Patent: July 28, 2015
    Inventors: Robert Green, Dennis Wang, Julio Mulero, Robert Lagace
  • Patent number: 9080212
    Abstract: Single nucleotide polymorphic sites at positions 19069 and 25402 of the bovine STAT3 gene are associated with improved fertilization rate and/or improved embryo survival rate. The interactions between these two polymorphisms, and between them and the bovine STAT1 gene and fertilization and early embryonic survival rates were also disclosed. The interactions between STAT3 SNPs, and between STAT1 and STAT3 SNP19069 were highly significant for embryonic survival rate. Also disclosed are nucleic acid molecules, kits, methods of genotyping and marker assisted bovine breeding methods.
    Type: Grant
    Filed: September 15, 2010
    Date of Patent: July 14, 2015
    Assignee: Wisconsin Alumni Research Foundation
    Inventor: Hasan Khatib
  • Patent number: 9005900
    Abstract: Methods of using TLE3 as a marker for predicting the likelihood that a patient's cancer will respond to chemotherapy. Methods of using TLE3 as a marker for selecting a chemotherapy for a cancer.
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: April 14, 2015
    Assignee: Clarient Diagnostic Services, Inc.
    Inventors: Brian Z. Ring, Douglas T. Ross, Robert S. Seitz, Rodney A. Beck
  • Patent number: 8999635
    Abstract: The present invention relates to the identification of loss-of-function mutations in the filaggrin gene and their use in diagnosing ichthyosis vulgaris and/or susceptibility to other diseases including atopic dermatitis (eczema), asthma, psoriasis and allergies (including food allergy).
    Type: Grant
    Filed: December 15, 2006
    Date of Patent: April 7, 2015
    Assignee: University Court of The University of Dundee
    Inventors: William Henry Irwin McLean, Frances Jane Dorothy Smith
  • Patent number: 8808985
    Abstract: The present invention discloses certain genetic variants as susceptibility variants for peripheral arterial disease (PAD) and abdominal aortic aneurysm (AAA). The invention relates to risk management using such variants. The invention further relates to kits for use in risk assessment of PAD and AAA.
    Type: Grant
    Filed: April 1, 2009
    Date of Patent: August 19, 2014
    Assignee: deCODE Genetics ehf.
    Inventors: Thorgeir Thorgeirsson, Patrick Sulem, Frank Geller, Kristinn P. Magnusson