Abstract: A method of treating or preventing a vaginal disease and/or a vaginal discomfort in a patient in need thereof, the method comprising administering a vaginal composition comprising isomaltulose to the vagina of the patient to restore and/or maintain Lactobacilli in the vagina, and/or to restore and/or maintain the vaginal acidity, wherein the content of the isomaltulose ranges from 0.05% (w/w) to 20.0% (w/w).

Abstract: A composition includes a plurality of particulate coated hydrogel microparticles, each of the microparticles including a hydrogel inner core and a particulate shell defined by a plurality of solid nanoparticles, the particulate shell inhibiting aggregation of the microparticles in an aqueous medium and being permeable to allow release of agents from the hydrogel inner core.

Abstract: Process for the preparation of layered particles are provided. Layered particles prepared by such processes are also provided.

Abstract: The present disclosure relates to a composition for preventing hair loss or promoting hair growth, which contains a mixture of cucumber, eggplant and snail extracts as an active ingredient. The composition according to the present disclosure, which contains a mixture of cucumber, eggplant and snail extracts as an active ingredient, has been confirmed to increase the expression of hepatocyte growth factor (HGF), keratinocyte growth factor (KGF) and insulin-like growth factor 1 (IGF-1) in dermal papilla cells which are known to play a critical role in the induction of new hair follicles and maintenance of hair growth, exhibit hair-growing effect comparable to that of minoxidil in a hair growth test for depilated 6-week-old C57BL/6 mice, and exhibit hair loss-improving effect in a clinical test for human. Accordingly, it can be usefully used as a cosmetic composition or a pharmaceutical composition for external application to skin for preventing hair loss or promoting hair growth.

Abstract: The present invention relates to biocompatible protein-based particles and their methods of preparation and use. More specifically the present invention relates protein-based particles including protein matrix, spread matrix and/or biocoacervate materials derived from one or more biocompatible purified proteins combined with one or more biocompatible solvents that are used to replace or repair tissue and/or bone in treatments for spinal disc(s), joint(s) (e.g. knee, hip, finger, ankle, elbow, shoulder . . . ) and organ(s) (e.g. bladder, lips, vagina, penis, urethra . . . ). In various embodiments of the present invention the protein-based particles may also include one or more pharmacologically active agents and/or one or more additives.

Abstract: A composition for alleviating or treating asthma is proposed. A composition for alleviating or treating asthma contains, as an active ingredient, a concentrate obtained by distilling an extract obtained by extracting a herb medicine complex containing dried Rehmanniae radix, Cyperus rotundus L., Paeonia lactiflora Pall., Zingiber officinale Roscoe, Angelica gigas root, Carthamus tinctorius L., and Glycyrrhiza uralensis Fisch., using an extraction solvent, and can be provided in the form of an oriental pharmacopuncture solution or an injection.

Abstract: A composition for protecting liver, protecting intestines and enhancing immunity for freshwater fish is disclosed, including the following raw materials in parts by weight: 15˜27 parts of Andrographis herba, 18˜22 parts of Isatidis folium, 10˜15 parts of Polygonum hydropiper, 8˜12 parts of Rheum palmatum L., and 8˜12 parts of Galla chinensis. And the preparation and the application of the composition are disclosed. The composition of the disclosure has the effect of resisting bacteria, scavenge free radicals, clearing heat, detoxifying, preventing and treating enteritis and the like, which can effectively improve the immunity of the freshwater fish and ensure the health of the organism.

Abstract: The present invention provides cnidimoside A for use in the treatment of urinary conditions such as overactive bladder and related syndromes. The invention also relates to methods of treatment of overactive bladder using cnidimoside A. The compound can be administered purified or as a plant extract.

Abstract: An effervescent tablet that exhibits rapid disintegration is disclosed. The effervescent tablet includes an effervescent agent that includes an acid and a base, a crystalline sugar binder selected from the group consisting of crystalline dextrose, crystalline sucrose, crystalline fructose, and combinations thereof, the crystalline sugar binder being essentially free of excipients, a sweetener that includes at least one of Stevia and Monk fruit, a flavor agent that includes a gum Arabic carrier, and optionally a lubricant derived from rice hulls (e.g., a multi-component integral lubricant).

Abstract: The present invention provides random copolymers containing zwitterions and one or more functional agents, and methods of preparing such random copolymers.

Abstract: The present invention relates to a drug for treating leukopenia, its preparation method and use thereof. The drug of the invention is prepared from 200-30 parts by weight of Folium Epimedii, 100-160 parts by weight of Fructus Psoraleae, 60-120 parts by weight of Radix Aconiti Lateralis Preparata (Processed), 200-300 parts by weight of Fructus Lycii, 200-300 parts by weight of Radix Astragali, 200-300 parts by weight of Caulis Spatholobi, 200-300 parts by weight of Radix Rubiae, 100-160 parts by weight of Radix Angelicae Sinensis, 200-300 parts by weight of Rhizoma Phragmitis, 100-160 parts by weight of Radix Ophiopogonis and 100-160 parts by weight of Radix et Rhizoma Glycyrrhizae. The drug of the invention comprises chemical substances with weight ratios as follows: Leucine:guanosine:psoralenoside:isopsoralenoside:calycosin-7-glucoside:liquiritin:icariin A:1,3-dihydroxyl-2-hydroxymethylanthraquinone:epimedin A:epimedin B:epimedin C:icariin:1,3,6-trihydroxy-2-methylanthraquinone:glycyrrhizic acid=(0.13-0.

Abstract: Disclosed a plant-derived exosome as well as a preparation method and an application thereof in preparation of drugs or scaffolds for animal tissue regeneration therapy. The preparation method includes: soaking and infiltrating any part of a natural plant with a 2-(N-morpholine) ethanesulfonic acid buffer solution; removing a supernatant; collecting a wet treated sample; refrigerating, centrifuging and extracting the sample to obtain apoplastic fluid, wherein the soaking and infiltrating method is as follows: vacuum supply is performed within 6-24 h after soaking for 2-5 times, vacuum supply time is independently 5-15 s each time, and interval time between two adjacent times of vacuum supply is independently 10 s-1 min; and centrifuging the apoplastic fluid at an ultra-high speed to obtain the plant-derived exosome, wherein ultra-high speed centrifugation conditions are as follows: centrifugal force is not lower than 100000 g, centrifugation time is 1-7 h, and a temperature is 0-4° C.

Abstract: The invention relates to a surgical or wound dressing comprising a sheet of gellan gum and an antifibrotic agent. Methods of producing dressings comprising gellan gums and biologically active agents area also produced.

Abstract: This invention provides novel solid pharmaceutical compositions and processes for the bulk production of said compositions. This invention also provides methods of using the pharmaceutical compositions in the treatment of cancer.

Abstract: A bioink composition and a 3D bioprinted scar tissue model with the bioink composition closely replicates the physiological and architectural characteristics of naturally occurring scar tissue. The 3D bioprinted scar tissue can be used to test scar resolution treatments among others. Also provided is a method of fabricating the 3D bioprinted scar tissue along with an apparatus for bioprinting the 3D bioprinted scar tissue.

Abstract: The disclosure relates to a traditional Chinese medicine composition and product for improving sleep by balancing yin and yang, a method for making the same and use thereof, and belongs to the technical field of traditional Chinese medicine. The disclosure provides a traditional Chinese medicine composition for improving sleep by balancing yin and yang, which has reasonable compatibility of all herbal medicines, nourishes yin to suppress yang, tonifies blood and promotes blood, regulates qi and soothes the nerves, and has the functions of reconciling yin and yang and balancing qi and blood. The composition may fundamentally improve sleep quality, with an effective rate of 100%. At the same time, all the medicines in the prescription are raw materials of medicine food homology, which are safe and effective, not cause side effects and mental dependence on the human body, and may be taken for a long time.

Abstract: Compositions for treatment of cystinosis, products for administering eye drops, and products for storing contact lenses are provided. Compositions include solutions that can contain an effective amount of cysteamine to treat cystinosis, and an oil with a lower density than the solution. Also provided is a product including a bottle for containing a solution, the bottle being substantially free of O2. Also provided is a contact lens holder for storing one or more contact lenses in a solution, the holder including barrier layers reducing the amount of O2 entering the contact lens holder.

Abstract: The present invention relates to a product containing an extract of Rhodiola and an extract of Astragalus as products to be combined for simultaneous administration, separately or staggered over time, in the treatment of a neurodegenerative disease, and in particular for the treatment of Alzheimer's disease and Parkinson's disease.

Abstract: Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.

Abstract: Described herein are particles including gold and an oleo-gum resin and/or a derivative of an oleo-gum resin. The particles may be gold nanoparticles and the oleo-gum resin may be frankincense and/or myrrh. Also described herein are methods of preparing such particles, compositions including such particles and methods of using particles and compositions of the present invention.