Abstract: A personal care composition is provided and includes an effective amount of a repeat sequence protein polymer. The personal care composition may be a hair care composition, a skin care composition, a nail care composition, a cosmetic composition, or an over-the-counter pharmaceutical composition.
Abstract: Methods are provided for drying a particle. Specifically, there is provided a spray-dried diketopiperazine-insulin particle formulation having improved aerodynamic performance and in which the active agent is more stabile and efficiently delivered as compared to that of the lyophilized diketopiperazine-insulin formulation. The dry powders have utility as pharmaceutical formulations for pulmonary delivery.
Abstract: The present invention provides a peptide which selectively adsorbs an anti-?1 adrenoreceptor antibody being one of the contributing factors in dilated cardiomyopathy. The peptide of the invention can be immobilized on a carrier in a short period of time with rarely inducing side reactions, and adsorbent for adsorbing an anti-?1 adrenoreceptor antibody can be produced with good efficiency by using the peptide. In addition, the present invention provides an adsorbent comprising such peptide immobilized on a carrier, an adsorber wherein such adsorbent is used, and a method for adsorbing an anti-?1 adrenoreceptor antibody. The adsorbent and adsorber according to the invention can efficiently deprive an anti-?1 adrenoreceptor antibody-containing liquid, in particular body fluid, of the antibody.
Abstract: The present invention includes methods of treatment and compositions for treating diseases related to the activity of a histone deacetylase in a subject by administering to the subject an effective amount of a modified FK228 compound comprising an amino acid conjugate which constitutes an amino thiol, a hydroxy thiol, a dithiol, or a hydroxamic acid, instead of a hydroxy-mercapto-heptenoic acid moiety in FK228.
Type:
Grant
Filed:
June 23, 2008
Date of Patent:
October 11, 2011
Assignee:
Board of Regents, The University of Texas System
Abstract: The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the enzyme Thimet oligopeptidase, or TOP. Also disclosed are methods of designing prodrugs by utilizing TOP-cleavable sequences within the conjugate and methods of treating patients with prodrugs of the invention.
Type:
Grant
Filed:
August 14, 2008
Date of Patent:
October 11, 2011
Assignee:
Medarex, Inc.
Inventors:
Vincent Dubois, Ann Marie Fernandez, Sanjeev Gangwar, Evan Lewis, Thomas J. Lobl, Matthew H. Nieder, Lesley B. Pickford, Andre Trouet, Geoffrey T. Yarranton
Abstract: The present invention provides a novel chimeric compound comprising an agonist opioid receptor binding moiety at its N-terminus and an antagonist neurokinin-1 (NK1) receptor binding moiety at its C-terminus for producing analgesia, a pharmaceutical composition comprising the chimeric compound, a method of making the compound, and a method of treating pain using the novel chimeric compounds.
Type:
Grant
Filed:
June 8, 2007
Date of Patent:
September 27, 2011
Assignee:
The University of Arizona
Inventors:
Victor Hruby, Padma Nair, Takashi Yamamoto
Abstract: The present invention relates to the field of neuropathological disorders involving impaired locomotor functions. More specifically, the present invention relates to a composition and method for inducing and restoring locomotor functions, such as basic walking movements in the lower extremities of chronic spinal cord injured animals, such as paraplegic or tetraplegic individuals.
Abstract: A method of treating a blistering disorder, which includes administering to a target tissue in a subject in need thereof an effective amount of a composition that inhibits activation of the HSP27 phosphorylation pathway.
Type:
Grant
Filed:
December 2, 2005
Date of Patent:
August 30, 2011
Assignee:
The University of North Carolina at Chapel Hill
Inventors:
David Scott Rubenstein, Paula Berkowitz, Peiqi Hu, Luis Alberto Diaz
Abstract: ?-peptide regions of polypeptides can serve as structural mimics of ?-helices in wild type proteins. Because ?-helices of one protein often bind to a target protein in a biological pathway, a polypeptide that contains a helical ?-peptide region can be used to disrupt this type of protein-protein binding. As a result, polypeptides that contain a helical ?-peptide region can be used to treat conditions involving this type of protein-protein binding, such as viral infections and cell proliferation.
Type:
Grant
Filed:
April 21, 2005
Date of Patent:
August 30, 2011
Assignee:
Yale University
Inventors:
Alanna Schepartz Shrader, Scott A. Hart, Joshua A. Kritzer, Olen M. Stephens
Abstract: For the separation, removal, isolation, purification, characterization, identification or quantification of plasminogen or a protein that is a plasminogen analogue, an affinity adsorbent is used that is a compound of formula (II) wherein one X is N and the other is N, C—Cl or C—CN; A is a support matrix, optionally linked to the triazine ring by a spacer; Z is O, S or N—R and R is H, C1-6 alkyl, C1-6 hydroxyalkyl, benzyl or &bgr;-phenylethyl; B is an optionally substituted hydrocarbon linkage containing from 1 to 10 carbon atoms; D is H, OH or a primary amino, secondary amino, tertiary amino, quaternary ammonium, imidazole, guanidino or amidino group; or B-D is —CHCOOH—(CH2)3-4—NH2; and q is 2 to 6.
Type:
Grant
Filed:
May 9, 2006
Date of Patent:
August 16, 2011
Assignee:
Prometic Biosciences Ltd.
Inventors:
Jason Richard Betley, James Christopher Pearson, Claudia Hildegard Kuhn, Baldev Singh Baines
Abstract: The present invention provides methods of assembling oligopeptides or polypeptides in a native chemical ligation reaction that eliminates the formation of unwanted side products resulting from the presence of an unprotected acidic C-terminal oligopeptide thioester. An important aspect of the present invention is providing side chain protected acidic C-terminal oligopeptide thioesters. The present invention is useful in methods for chemical synthesis of oligopeptides, polypeptides and proteins and improves the efficiency of native chemical ligation reactions, particularly where aspartyl or glutamyl peptide fragments are used to assemble an oligopeptide, polypeptide or protein product.
Type:
Grant
Filed:
June 9, 2003
Date of Patent:
July 28, 2009
Assignee:
Amylin Pharmaceuticals, Inc.
Inventors:
Paolo Botti, Matteo Villain, Sonia Manganiello, Hubert Gaertner
Abstract: The present invention provides AA targeting compounds which comprise AA targeting agent-linker conjugates which are linked to a combining site of an antibody. Various uses of the compounds are provided, including methods to treat disorders connected to abnormal angiogenesis.
Type:
Grant
Filed:
March 3, 2006
Date of Patent:
April 21, 2009
Assignee:
Covx Technologies Ireland Limited
Inventors:
Curt W. Bradshaw, Venkata Ramana Doppalapudi, Jing-Yu Lai, John Rizzo
Abstract: The present invention relates to an antimicrobial peptide isolated from Halocynthia aurantium, more particularly, to an antimicrobial peptide isolated from the body fluid of Halocynthia aurantium and an antimicrobial agent comprising the same as an active ingredient. The antimicrobial peptide of the present invention shows excellent antimicrobial activity under strong acidic and basic environments. Moreover, it also shows strong antimicrobial activity against resistant bacteria. So, it can be used usefully as a natural antimicrobial agent.
Type:
Grant
Filed:
November 22, 2002
Date of Patent:
March 17, 2009
Assignee:
Industry-Academic Cooperation Foundation, Hoseo University
Inventors:
In-Hee Lee, Seok-Min Son, Woong-Sik Jang, Kyu-Nam Kim
Abstract: Computational analysis was used to derive structural peptide formulas SALIVAR, SALIVAL, SALIVAN characterizing common repetitive fragments that reconstruct a large number of salivary proline rich proteins. Short repetitive sequences and variants of the mucin (MUKOSEPT) and collagen (PROCOL ?) have been also derived. The purpose of the derived sequences is the modulation of cell and tissue growth, division and differentiation.
Type:
Grant
Filed:
November 29, 2001
Date of Patent:
December 16, 2008
Inventors:
Zlatko Ademovic, Nikola Stambuk, Pasko Konjevoda, Darko Mikus
Abstract: The invention relates to methods of using Cav2.2 subunit calcium channel modulators to treat painful and non-painful lower urinary tract disorders and the related genitourinary tract disorders vulvodynia and vulvar vestibulitis in normal and spinal cord injured patients.
Type:
Grant
Filed:
June 8, 2006
Date of Patent:
December 2, 2008
Assignee:
Dynogen Pharmaceuticals, Inc.
Inventors:
Matthew Oliver Fraser, Karl Bruce Thor, Edward C. Burgard
Abstract: A delivery system. The delivery system includes a carrier or an active compound and a glutathione or a glutathione derivative grafted thereon. The invention also provides a compound including a moiety comprising a vitamin E derivative or a phospholipid derivative, a polyethylene glycol (PEG) or a polyethylene glycol derivative bonded thereto, and a glutathione (GSH) or a glutathione derivative bonded to the polyethylene glycol or the polyethylene glycol derivative.
Type:
Grant
Filed:
December 19, 2005
Date of Patent:
November 4, 2008
Assignee:
Industrial Technology Research Institute
Abstract: The present invention is directed to the use of a class of peptide compounds for treating primary or/and secondary dyskinesias such as tardive dyskinesia.
Abstract: The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.
Type:
Grant
Filed:
October 27, 2005
Date of Patent:
August 19, 2008
Assignee:
Affymax, Inc.
Inventors:
Christopher P. Holmes, Qun Yin, Guy Lalonde, Peter J. Schatz, David Tumelty, Balu Palani, Genet Zemede