Patents Examined by Savitha M Rao
  • Treatment for bacterial infections with salicylic acid analogs
    Patent number: 11400102
    Abstract: Methods and compositions are provided for the reduction in virulence of a bacterium by interfering with the biosynthesis of yersiniabactin using salicylic acid or an analog thereof. Also provided are methods of treating a bacterial infection in a subject in need thereof.
    Type: Grant
    Filed: May 22, 2020
    Date of Patent: August 2, 2022
    Assignee: Washington University
    Inventor: Jeffrey P. Henderson
  • Methods and compositions for treating chemotherapy-induced diarrhea
    Patent number: 11389424
    Abstract: Presented herein are methods for treating diarrhea by administering to a patient in need thereof, an inhibitor of chloride-ion transport in an amount sufficient to treat diarrhea. Treatment of diarrhea includes the treatment of the diarrhea as well as the pain, abdominal discomfort and other symptoms associated with diarrhea. In one embodiment, the inhibitor of chloride-ion transport is crofelemer.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: July 19, 2022
    Assignee: NAPO PHARMACEUTICALS, INC.
    Inventor: Lisa A. Conte
  • Inhibitors of mechanotransduction to treat pain and modulate touch perception
    Patent number: 11384071
    Abstract: Chemical compounds that are useful as inhibitors of mechanotransduction in the treatment of pain and modulation of touch perception and topical administration of the compounds described herein in the treatment of pain and modulation of touch perception.
    Type: Grant
    Filed: December 7, 2017
    Date of Patent: July 12, 2022
    Assignee: MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT
    Inventors: Gary Richard Lewin, Kathryn Anne Poole, Christiane Wetzel, Liudmila Lapatsina
  • Pharmaceutical composition for topical wound treatment
    Patent number: 11382913
    Abstract: A pharmaceutical composition for topical wound treatment comprising one or more nitrogenous heterocyclic compound of 5 or 6 atoms with imide group; one or more deoxyribonuclease enzyme with activity pH between 4.5 and 6.5; and one or more carboxylic acid; kits and process to obtain this pharmaceutical composition and uses for wounds treatment.
    Type: Grant
    Filed: May 18, 2021
    Date of Patent: July 12, 2022
    Assignees: CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS, UNIVERSIDAD NACIONAL DE TUCUMAN, UNITECH INC.
    Inventors: Alberto Ramos Vernieri, Maria De Los Angeles Lazarte, Romina Mabel Chavez Jara, Nicolas Abel Cerusico
  • Anti-virulence compositions and methods
    Patent number: 11382882
    Abstract: A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) includes administering to the bacterium an amount of AgrA antagonist effective to inhibit the synthesis of one or more virulence factors by the bacterium.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: July 12, 2022
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventor: Menachem Shoham
  • Methods of reducing the risk of cardiovascular events in a subject
    Patent number: 11369582
    Abstract: In various embodiments, the present disclosure provides methods reducing the risk of cardiovascular events in a subject on statin therapy by administering to the subject a pharmaceutical composition comprising about 1 g to about 4 g of eicosapentaenoic acid ethyl ester or a derivative thereof.
    Type: Grant
    Filed: September 8, 2021
    Date of Patent: June 28, 2022
    Assignee: Amarin Pharmaceuticals Ireland Limited
    Inventor: Paresh Soni
  • PSMA binding ligand-linker conjugates and methods for using
    Patent number: 11369590
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Grant
    Filed: June 25, 2021
    Date of Patent: June 28, 2022
    Assignee: Purdue Research Foundation
    Inventors: Philip Stewart Low, Sumith A. Kularatne
  • Composition for curing migraine headaches
    Patent number: 11369619
    Abstract: The invention is directed to methods and compositions for curing migraine headaches. In particular, compositions are described involving the combination of dexamethasone, lidocaine, and thiamine. The compositions are administered to patients having migraines having trigeminal or occipital neuralgia by subcutaneous injection during a single treatment session, a combination of dexamethasone, lidocaine and thiamine to several craniofacial nerves.
    Type: Grant
    Filed: September 28, 2020
    Date of Patent: June 28, 2022
    Assignee: Cure Migrane World Wide & Research, LLC
    Inventor: Faro Owiesy
  • Treatment of human coronavirus infections using alpha-glucosidase glycoprotein processing inhibitors
    Patent number: 11369592
    Abstract: The present invention concerns the use of an alpha-glucosidase glycoprotein processing inhibitor for the treatment or prevention of human coronavirus infections, such as SARS-CoV-2 or SARS-CoV-2 variant infections. Aspects of the invention include methods for treating or preventing coronavirus infection, or a symptom thereof, by administering an alpha-glucosidase glycoprotein processing inhibitor, such as castanospermine, or a pharmaceutically acceptable salt, derivative, or prodrug thereof, to a human subject; methods for inhibiting human coronavirus infection in a human cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits for treating or preventing human coronavirus infection.
    Type: Grant
    Filed: February 19, 2021
    Date of Patent: June 28, 2022
    Assignee: FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventors: Eric Holmes, Gary Ostrander, Geoffrey Stuart Dow
  • Crystalline forms
    Patent number: 11365209
    Abstract: The invention relates to crystalline forms of 4-((R)-2-{[6-((S)-3-methoxy-pyrrolidin-1-yl)-2-phenyl-pyrimidine-4-carbonyl]-amino}-3-phosphono-propionyl)-piperazine-1-carboxylic acid butyl ester hydrochloride, processes for the preparation thereof, pharmaceutical compositions comprising said crystalline forms, pharmaceutical compositions prepared from such crystalline forms and their use as a medicament, especially as a P2Y12 receptor antagonist.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: June 21, 2022
    Assignee: IDORSIA PHARMACEUTICALS LTD
    Inventors: Daniel Leuenberger, Stefan Reber, Markus Von Raumer
  • Combination therapy for treatment of cancer
    Patent number: 11364222
    Abstract: Compositions, combinations and methods comprising a CDK4/6 inhibitor of Formula D with a selective estrogen receptor downregulator of Formula A, B or C that are advantageous for the treatment of abnormal cellular proliferation, including a cancer or a tumor.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: June 21, 2022
    Assignee: G1 Therapeutics, Inc.
    Inventors: Jay C. Strum, Gregory R. Thatcher, Rui Xiong, Jiong Zhao, Debra A. Tonetti
  • Methods for the treatment of abnormal involuntary movement disorders
    Patent number: 11357772
    Abstract: Disclosed herein are new dosage regimens for deuterium-substituted benzoquinoline compounds, and methods for the treatment of abnormal muscular activity, movement disorders, and related conditions.
    Type: Grant
    Filed: January 21, 2021
    Date of Patent: June 14, 2022
    Assignee: AUSPEX PHARMACEUTICALS, INC.
    Inventors: David Stamler, Michael Huang
  • Amino acid compositions for the amelioration of symptoms of hangover
    Patent number: 11357747
    Abstract: The subject invention provides therapeutic compositions, and uses thereof for the treatment or amelioration of symptoms of a disease selected from the group consisting of: Ebola virus infection, HIV infection, ataxia, environmental enteropathy, cancer, hangover, inflammatory disease, and porcine epidemic diarrhea. In preferred embodiments, the composition includes a combination of one or more amino acids selected from the group comprising lysine, aspartic acid, glycine, isoleucine, threonine, tyrosine, valine, tryptophan, asparagine and/or serine.
    Type: Grant
    Filed: August 7, 2020
    Date of Patent: June 14, 2022
    Assignees: ENTRINSIC, INC., UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
    Inventors: Sadasivan Vidyasagar, Stephen J. Gatto, Daniel B. Dennison
  • Analogs of 3,5-dihydroxypentanoate for bone formation
    Patent number: 11344548
    Abstract: A method for treating low bone mineral density associated with osteopenia, osteoporosis, and other diseases is disclosed. The method comprises administrating a composition comprising a 3,5-dihydroxypentanoic acid derivative according to Formula I to a mammal. A compound of 3,5-dihydroxypentanoic acid derivative having a structure according to Formula I or Formula II is also disclosed.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: May 31, 2022
    Assignee: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Hui-Ting Chen, Kuang-Chan Hsieh, Chai-Lin Kao, Je-Ken Chang, Mei-Ling Ho
  • disinfectant
    Patent number: 11337423
    Abstract: A method of disinfecting Candida auris is disclosed including treating a surface with a solution comprising 3,4-Dihydroxybenzoic acid ethyl ester. The solution may further include protocatechuic acid. The solution may include an alcohol. The alcohol may include methanol, ethanol, or isopropyl alcohol. The surface may include a solid surface, a porous or semi-porous surface, or a cloth-like surface. The surface may include a surface on skin, clothes, masks, a medical device, food processing equipment, hearing aid or a surgical implant. The surface may include a surface in a healthcare facility.
    Type: Grant
    Filed: June 30, 2021
    Date of Patent: May 24, 2022
    Inventor: Lanny Leo Johnson
  • External use composition comprising paeonol and panthenol or pharmaceutically acceptable salts thereof as active ingredients
    Patent number: 11337942
    Abstract: Provided are a medical ointment of a novel combination containing paeonol and a pharmaceutical use thereof. The medical ointment of a novel combination includes paeonol and panthenol, and further includes at least one selected from Centella asiatica, coenzyme Q10, neomycin sulfate, and pharmaceutically acceptable salts of these. In the medical ointment of a novel combination, specific ingredients that are effective for local pain relief are mixed with ingredients having other effects in a certain ratio to address the problems of the cut treatment ointment of the related art, so that excellent effects may be obtained in relieving itching and reducing pain while inflammation is effectively treated.
    Type: Grant
    Filed: December 14, 2021
    Date of Patent: May 24, 2022
    Assignee: GENTRIBIO INC.
    Inventors: Chang Keun Yoon, Hong Gyum Kim
  • Use of ciclopirox as a modulator of the heme group biosynthesis and in the treatment of porphyrias and other diseases
    Patent number: 11337966
    Abstract: The present invention relates to the use of the compound ciclopirox or a pharmaceutically acceptable salt or solvate thereof for the treatment and/or prevention of a disease caused by dysregulated heme group biosynthesis, with the proviso that said disease is not congenital erythropoietic porphyria.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: May 24, 2022
    Assignee: ASOCIACIÓN CENTRO DE INVESTIGACIÓN COOPERATIVA EN BIOCIENCIAS-CIC BIOGUNE
    Inventors: Oscar Millet Aguilar-Galindo, Arantza Sanz Parra, Ana Laín Torre, Pedro David Urquiza Ortiz, Juan Manuel Falcón Pérez, Joaquín Castilla Castrillón, Itxaso San Juan Quintana, Ganeko Bernardo-Seisdedos
  • Compounds and methods for kinase modulation, and indications therefor
    Patent number: 11337976
    Abstract: Compounds active on protein kinases are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: May 24, 2022
    Assignee: Plexxikon Inc.
    Inventors: Prabha N. Ibrahim, Chao Zhang, Wayne Spevak, Jiazhong Zhang, Guoxian Wu, Jack Lin, Hanna Cho, Marika Nespi, Songyuan Shi, Todd Ewing, Ying Zhang
  • Epinephrine formulations
    Patent number: 11337938
    Abstract: Pharmaceutical compositions comprising epinephrine, methods of administration, and methods of making the same. Compositions may comprise at least one of an active agent, a pH raising agent, an antioxidant, a transition metal complexing agent, a pH lowering agent, a tonicity regulating agent, optionally a preservative, and optionally a solvent.
    Type: Grant
    Filed: March 12, 2020
    Date of Patent: May 24, 2022
    Assignee: PAR PHARMACEUTICAL, INC.
    Inventors: Suketu Sanghvi, Vinayagam Kannan, Matthew Kenney
  • Polyoxometalate complexes and uses in managing cancer
    Patent number: 11331297
    Abstract: The disclosure relates polyoxometalate complexes and uses in the management, treatment, or prevention of cancer. In certain embodiments, the polyoxometalate complexes comprise polydentate oxygen bridging ligands such as those of the following formula: [POM{(OCH2)3CX}2], [M6O13{(OCH2)3CX}2], [V6O13 {(OCH2)3CX}2], salts, or derivatives thereof wherein POM is a polyoxometalate, M is a metal, and X is defined herein. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising polyoxometalate complexes disclosed herein.
    Type: Grant
    Filed: October 26, 2017
    Date of Patent: May 17, 2022
    Assignee: Emory University
    Inventors: Jie Song, Shuming Nie, Craig Hill